Gene: MKRN2

23609
HSPC070|RNF62
makorin ring finger protein 2
protein-coding
3p25.2
Ensembl:ENSG00000075975 MIM:608426 Vega:OTTHUMG00000155371 UniprotKB:Q9H000
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
1.977e-1 (AD)  5.671e-1 (ND)   (Frontal_Cortex)
6.497e-1 (AD)  1.790e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13106chr3:12583081 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POLR2C0.928
BRAP0.927
TFG0.925
PRNP0.921
ADNP0.92
DCTN40.919
CAPRIN10.918
RANBP90.917
CDC5L0.914
LEPROTL10.913

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.716
OR4F29-0.67
KLRB1-0.317
SH2D1A-0.273
CETP-0.267
KLRF1-0.264
TBX21-0.253
C8orf74-0.252
KLF17-0.248
HMHB1-0.245

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MKRN2 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MKRN2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MKRN2 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of MKRN2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MKRN2 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MKRN2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of MKRN2 mRNA20458559
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MKRN2 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of MKRN2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of MKRN2 mRNA25181051
C018021cobaltous chloridecobaltous chloride results in increased expression of MKRN2 mRNA19376846
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of MKRN2 mRNA15467011
D019327Copper SulfateCopper Sulfate results in increased expression of MKRN2 mRNA19549813
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MKRN2 mRNA21266533
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MKRN2 mRNA"22485181
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MKRN2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MKRN2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MKRN2 mRNA17942748
D005485FlutamideFlutamide results in decreased expression of MKRN2 mRNA21525395
C410337K 7174K 7174 results in increased expression of MKRN2 mRNA24086573
D008727MethotrexateMethotrexate results in increased expression of MKRN2 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MKRN2 mRNA26011545
D010634PhenobarbitalPhenobarbital affects the expression of MKRN2 mRNA19159669
D013629TamoxifenTamoxifen affects the expression of MKRN2 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MKRN2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MKRN2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MKRN2 mRNA17942748
C024746tobacco tartobacco tar results in decreased expression of MKRN2 mRNA19559774
D014520UrethaneUrethane results in increased expression of MKRN2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of MKRN2 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of MKRN2 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22681889  
GO:0005515protein binding-IPI17500595  25416956  
GO:0016740transferase activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO:0016567protein ubiquitination-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IDA11597136  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal