Gene: ZMYND8

23613
PRKCBP1|PRO2893|RACK7
zinc finger MYND-type containing 8
protein-coding
20q13.12
Ensembl:ENSG00000101040 MIM:615713 Vega:OTTHUMG00000032667 UniprotKB:Q9ULU4
NC_000020.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.864e-1 (AD)  7.893e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6122571chr20:47277392 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg12303084chr20:45985741ZMYND81.400e-18Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GTF3C10.845
OGT0.833
N4BP10.826
WDR330.822
MAP3K40.82
KDM2A0.82
CDK130.818
MKL10.817
RNF240.815
CNOT40.814

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.63
OR4F29-0.599
FOLR1-0.228
SLC22A6-0.221
CNBD2-0.219
HES5-0.216
NXNL1-0.214
PDE11A-0.213
GSDMC-0.21
XPNPEP2-0.206

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ZMYND8 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of ZMYND8 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ZMYND8 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ZMYND8 mRNA21298039
C006632arsenic trioxidearsenic trioxide results in increased expression of ZMYND8 mRNA20458559
C547126AZM551248AZM551248 results in increased expression of ZMYND8 mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ZMYND8 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ZMYND8 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ZMYND8 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ZMYND8 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZMYND8 mRNA"19150397|2001819
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ZMYND8 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ZMYND8 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of ZMYND8 mRNA21932408
C006780bisphenol Abisphenol A results in decreased methylation of ZMYND8 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of ZMYND8 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ZMYND8 gene28505145
D000069286BortezomibBortezomib results in decreased expression of ZMYND8 mRNA20977926
D002220CarbamazepineCarbamazepine affects the expression of ZMYND8 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ZMYND8 mRNA17484886
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ZMYND8 mRNA27858113
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of ZMYND8 mRNA15467011
D016572CyclosporineCyclosporine results in decreased expression of ZMYND8 mRNA25562108
D003703DemecolcineDemecolcine results in increased expression of ZMYND8 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ZMYND8 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ZMYND8 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ZMYND8 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ZMYND8 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ZMYND8 mRNA19561079
D002945CisplatinCisplatin results in increased expression of ZMYND8 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of ZMYND8 mRNA28302478
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ZMYND8 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ZMYND8 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ZMYND8 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZMYND8 mRNA17942748
D018120FinasterideFinasteride results in increased expression of ZMYND8 mRNA24136188
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of ZMYND8 mRNA]15016801
D005557FormaldehydeFormaldehyde results in decreased expression of ZMYND8 mRNA20655997|2341626
C551027GANT 61GANT 61 results in increased expression of ZMYND8 mRNA22265815
D019833GenisteinGenistein results in increased expression of ZMYND8 protein24552547
D017313FenretinideFenretinide results in increased expression of ZMYND8 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ZMYND8 mRNA26846883
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ZMYND8 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ZMYND8 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ZMYND8 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ZMYND8 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ZMYND8 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of ZMYND8 mRNA26733615
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of ZMYND8 mRNA]26733615
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ZMYND8 mRNA21949397|2308692
C561695(+)-JQ1 compoundpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of ZMYND8 mRNA]26733615
D007649KetamineKetamine results in decreased expression of ZMYND8 mRNA20080153
C045463leflunomideleflunomide results in increased expression of ZMYND8 mRNA24136188
D008070LipopolysaccharidesLipopolysaccharides results in decreased methylation of ZMYND8 gene21212295
D018021Lithium ChlorideLithium Chloride results in decreased expression of ZMYND8 mRNA15711924
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ZMYND8 mRNA26378955
D008694MethamphetamineMethamphetamine results in increased expression of ZMYND8 mRNA26307267
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ZMYND8 mRNA28001369
D008777MethyltestosteroneMethyltestosterone results in decreased expression of ZMYND8 mRNA29191790
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of ZMYND8 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ZMYND8 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ZMYND8 mRNA"25554681
D009538NicotineNicotine results in increased expression of ZMYND8 mRNA16949557
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ZMYND8 mRNA25729387
C496932panobinostat(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of ZMYND8 mRNA]26733615
C496932panobinostatpanobinostat affects the expression of ZMYND8 mRNA26733615
C496932panobinostatpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of ZMYND8 mRNA]26733615
D010416PentachlorophenolPentachlorophenol results in increased expression of ZMYND8 mRNA23892564
D010634PhenobarbitalPhenobarbital results in decreased expression of ZMYND8 mRNA19270015
D010795Phthalic AcidsPhthalic Acids results in decreased expression of ZMYND8 mRNA21061450
D010795Phthalic AcidsPhthalic Acids results in increased expression of ZMYND8 mRNA15728792
D010894PiroxicamPiroxicam results in decreased expression of ZMYND8 mRNA21858171
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ZMYND8 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ZMYND8 mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of ZMYND8 mRNA23012394
D011441PropylthiouracilPropylthiouracil results in increased expression of ZMYND8 mRNA24780913
D012715Sesame OilSesame Oil results in increased expression of ZMYND8 mRNA29191790
C017947sodium arsenitesodium arsenite affects the expression of ZMYND8 mRNA19590694
D012999SomanSoman results in decreased expression of ZMYND8 mRNA19281266
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ZMYND8 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZMYND8 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZMYND8 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZMYND8 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ZMYND8 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ZMYND8 mRNA15328365
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ZMYND8 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of ZMYND8 gene26756918
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ZMYND8 mRNA25729387
D014212TretinoinTretinoin promotes the reaction [ZMYND8 protein binds to DRD2 gene]26655721
D014212TretinoinTretinoin promotes the reaction [ZMYND8 protein binds to DRD2 promoter]26655721
D014212TretinoinTretinoin promotes the reaction [ZMYND8 protein binds to MAPT gene]26655721
D014212TretinoinTretinoin promotes the reaction [ZMYND8 protein binds to MAPT promoter]26655721
D014212TretinoinTretinoin promotes the reaction [ZMYND8 protein binds to SCN2A gene]26655721
D014212TretinoinTretinoin promotes the reaction [ZMYND8 protein binds to SCN2A promoter]26655721
D014212TretinoinTretinoin promotes the reaction [ZMYND8 protein binds to SNAP25 gene]26655721
D014212TretinoinTretinoin promotes the reaction [ZMYND8 protein binds to SNAP25 promoter]26655721
D014212TretinoinTretinoin promotes the reaction [ZMYND8 protein binds to TUBB3 gene]26655721
D014212TretinoinTretinoin promotes the reaction [ZMYND8 protein binds to TUBB3 promoter]26655721
D014212TretinoinTretinoin results in increased expression of ZMYND8 mRNA26655721
D014212TretinoinTretinoin results in increased expression of ZMYND8 protein26655721
D014212TretinoinZMYND8 protein affects the reaction [Tretinoin results in decreased expression of REST mRNA]26655721
D014212TretinoinZMYND8 protein affects the reaction [Tretinoin results in increased expression of DRD2 mRNA]26655721
D014212TretinoinZMYND8 protein affects the reaction [Tretinoin results in increased expression of MAPT mRNA]26655721
D014212TretinoinZMYND8 protein affects the reaction [Tretinoin results in increased expression of SCN2A mRNA]26655721
D014212TretinoinZMYND8 protein affects the reaction [Tretinoin results in increased expression of SNAP25 mRNA]26655721
D014212TretinoinZMYND8 protein affects the reaction [Tretinoin results in increased expression of TUBB3 mRNA]26655721
C012589trichostatin Atrichostatin A results in increased expression of ZMYND8 mRNA24935251
C012589trichostatin Atrichostatin A results in decreased expression of ZMYND8 mRNA15901671
C057693troglitazonetroglitazone results in decreased expression of ZMYND8 mRNA28973697
D014415TunicamycinTunicamycin results in decreased expression of ZMYND8 mRNA17127020
D014635Valproic AcidValproic Acid affects the expression of ZMYND8 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ZMYND8 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in decreased expression of ZMYND8 mRNA15901671
C025643vinclozolinvinclozolin affects the expression of ZMYND8 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of ZMYND8 mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of ZMYND8 mRNA20566332
D014750VincristineVincristine results in increased expression of ZMYND8 mRNA23649840
C111237vorinostatvorinostat results in decreased expression of ZMYND8 mRNA22083351

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003714transcription corepressor activity-ISS-  
GO:0005515protein binding-IPI15095401  16147992  
GO:0035064methylated histone binding-IDA27477906  
GO:0046872metal ion binding-IEA-  
GO:0047485protein N-terminus binding-IEA-  
GO:0070491repressing transcription factor binding-ISS-  
GO:0070577lysine-acetylated histone binding-IDA27477906  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0030336negative regulation of cell migration-IMP27477906  
GO:0051491positive regulation of filopodium assembly-IEA-  
GO:0060999positive regulation of dendritic spine development-IEA-  
GO:0098815modulation of excitatory postsynaptic potential-IEA-  
GO:1902897regulation of postsynaptic density protein 95 clustering-IEA-  
GO:1902952positive regulation of dendritic spine maintenance-IEA-  
GO:1903758negative regulation of transcription from RNA polymerase II promoter by histone modification-IMP27477906  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA27477906  
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-IEA-  
GO:0043197dendritic spine-IEA-  
GO:0043198dendritic shaft-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal