Gene: BACE1

23621
ASP2|BACE|HSPC104
beta-secretase 1
protein-coding
11q23.3
Ensembl:ENSG00000186318 MIM:604252 Vega:OTTHUMG00000160636 UniprotKB:P56817
NG_029372.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.699e-1 (AD)  2.853e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EXOC6B0.931
IFT800.926
SNX300.926
AGTPBP10.926
RAPGEF50.92
TGOLN20.918
FAM13C0.917
UVRAG0.916
TRAPPC100.912
ANAPC50.911

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.57
OR4F5-0.56
MTRNR2L6-0.357
MTRNR2L10-0.352
EVC2-0.332
MTRNR2L9-0.331
MTRNR2L8-0.319
FOXJ1-0.313
PDZK1IP1-0.312
MTRNR2L2-0.302

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02378MMI-175Small MoleculeExperimentalTarget
DB06073CTS-21166Small Molecule-InvestigationalTarget
DB06930N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamideSmall MoleculeExperimentalTarget
DB07019N-[(5R,14R)-5-AMINO-5,14-DIMETHYL-4-OXO-3-OXA-18-AZATRICYCLO[15.3.1.1~7,11~]DOCOSA-1(21),7(22),8,10,17,19-HEXAEN-19-YL]-N-METHYLMETHANESULFONAMIDESmall MoleculeExperimentalTarget
DB07089N-[amino(imino)methyl]-2-[2-(2-chlorophenyl)-4-(4-propoxyphenyl)-3-thienyl]acetamideSmall MoleculeExperimentalTarget
DB071104-(4-FLUOROBENZYL)PIPERIDINESmall MoleculeExperimentalTarget
DB07175N-{2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamideSmall MoleculeExperimentalTarget
DB072066-[2-(1H-INDOL-6-YL)ETHYL]PYRIDIN-2-AMINESmall MoleculeExperimentalTarget
DB072456-[2-(3'-METHOXYBIPHENYL-3-YL)ETHYL]PYRIDIN-2-AMINESmall MoleculeExperimentalTarget
DB07281N~3~-BENZYLPYRIDINE-2,3-DIAMINESmall MoleculeExperimentalTarget
DB07284N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINESmall MoleculeExperimentalTarget
DB07303N~3~-[3-(5-METHOXYPYRIDIN-3-YL)BENZYL]PYRIDINE-2,3-DIAMINESmall MoleculeExperimentalTarget
DB073454-(2-aminoethyl)-2-cyclohexylphenolSmall MoleculeExperimentalTarget
DB073464-(2-aminoethyl)-2-ethylphenolSmall MoleculeExperimentalTarget
DB074154-[(1S)-1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nitrophenyl)ethyl]-1H-imidazol-2-amineSmall MoleculeExperimentalTarget
DB07519(6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-oneSmall MoleculeExperimentalTarget
DB075352-amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-oneSmall MoleculeExperimentalTarget
DB07573(2S)-1-(2,5-dimethylphenoxy)-3-morpholin-4-ylpropan-2-olSmall MoleculeExperimentalTarget
DB07734N-(1-benzylpiperidin-4-yl)-4-sulfanylbutanamideSmall MoleculeExperimentalTarget
DB07735N-[1-(2,6-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamideSmall MoleculeExperimentalTarget
DB07736(2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamideSmall MoleculeExperimentalTarget
DB07737(2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamideSmall MoleculeExperimentalTarget
DB07738N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamideSmall MoleculeExperimentalTarget
DB07874(6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-oneSmall MoleculeExperimentalTarget
DB07993N~3~-[3-(1H-INDOL-6-YL)BENZYL]PYRIDINE-2,3-DIAMINESmall MoleculeExperimentalTarget
DB07994N~3~-[5-(1H-INDOL-6-YL)-2-(PYRIDIN-2-YLMETHOXY)BENZYL]PYRIDINE-2,3-DIAMINESmall MoleculeExperimentalTarget
DB087493-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDESmall MoleculeExperimentalTarget
DB12285VerubecestatSmall Molecule1286770-55-5InvestigationalTarget
ID Drug Name Action PubMed
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Copper results in increased expression of BACE1 mRNA]18583042
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of BACE1 mRNA"19167446
C07699627-hydroxycholesterol27-hydroxycholesterol results in increased expression of BACE1 protein19126211
C07699627-hydroxycholesterol27-hydroxycholesterol results in increased expression of BACE1 protein20157255
C5844272-amino-1,3',3'-trimethyl-7'-(pyrimidin-5-yl)-3',4'-dihydro-2'H-spiro(imidazole-4,1'-naphthalen)-5(1H)-one"2-amino-1,3',3'-trimethyl-7'-(pyrimidin-5-yl)-3',4'-dihydro-2'H-spiro(imidazole-4,1'-naphthalen)-5(1H)-one results in decreased activity of BACE1 protein"23584887
C5844272-amino-1,3',3'-trimethyl-7'-(pyrimidin-5-yl)-3',4'-dihydro-2'H-spiro(imidazole-4,1'-naphthalen)-5(1H)-one"[2-amino-1,3',3'-trimethyl-7'-(pyrimidin-5-yl)-3',4'-dihydro-2'H-spiro(imidazole-4,1'-naphthalen)-5(1H)-one results in decreased activity of BACE1 protein] which affects the metabolism of APP protein"23584887
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BACE1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BACE1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BACE1 mRNA"27188386
C5490664-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [S100B protein results in increased expression of BACE1 protein]"23541064
C5490664-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine results in decreased expression of BACE1 protein"23541064
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BACE1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BACE1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BACE1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of BACE1 mRNA22230336
D000171AcroleinAcrolein results in increased expression of BACE1 protein23296102
D000171AcroleinAcrolein results in increased expression of BACE1 protein23296102
D012435S-AdenosylhomocysteineS-Adenosylhomocysteine results in increased expression of BACE1 protein19635394
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of BACE1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of BACE1 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of BACE1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of BACE1 mRNA19770486
D024502alpha-Tocopherolalpha-Tocopherol inhibits the reaction [Oxygen deficiency results in increased expression of BACE1 mRNA]19196431
C010845aluminum chloride[aluminum chloride co-treated with APP protein modified form] results in decreased expression of BACE1 mRNA20111991
C010845aluminum chloride[aluminum chloride co-treated with APP protein modified form] results in decreased expression of BACE1 protein20111991
C010845aluminum chloride[aluminum chloride co-treated with APP protein modified form] results in increased expression of BACE1 mRNA20111991
C010845aluminum chloridealuminum chloride results in increased expression of BACE1 mRNA28552514
C010845aluminum chlorideGenistein inhibits the reaction [aluminum chloride results in increased expression of BACE1 mRNA]28552514
C010845aluminum chloridePlant Extracts inhibits the reaction [aluminum chloride results in increased expression of BACE1 protein]28552514
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BACE1 mRNA16483693
D052157Aptamers, Nucleotide"Aptamers, Nucleotide inhibits the reaction [CCS protein binds to BACE1 protein]"16888322
D001151Arsenic[Arsenic co-treated with Cadmium co-treated with Lead] promotes the reaction [BACE1 protein results in increased metabolism of APP protein]25288670
D001151ArsenicArsenic results in increased activity of BACE1 protein29155576
C006632arsenic trioxidearsenic trioxide results in decreased expression of BACE1 mRNA22521957
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BACE1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of BACE1 mRNA"26238291
D001688Biological ProductsBiological Products results in decreased expression of BACE1 protein23041113
D001688Biological Products[Biological Products results in decreased expression of BACE1 protein] which results in decreased secretion of APP protein modified form23041113
C006780bisphenol Abisphenol A results in decreased expression of BACE1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of BACE1 mRNA29097150
C018475butyraldehydebutyraldehyde results in decreased expression of BACE1 mRNA26079696
D002104Cadmium[Arsenic co-treated with Cadmium co-treated with Lead] promotes the reaction [BACE1 protein results in increased metabolism of APP protein]25288670
C469298CEP-11004CEP-11004 inhibits the reaction [Copper results in increased expression of BACE1 mRNA]18583042
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of BACE1 gene20938992
D002994ClofibrateClofibrate results in increased expression of BACE1 mRNA23811191
D003300Copper2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Copper results in increased expression of BACE1 mRNA]18583042
D003300CopperCEP-11004 inhibits the reaction [Copper results in increased expression of BACE1 mRNA]18583042
D003300CopperCopper results in increased expression of BACE1 mRNA18583042
D003300CopperCurcumin inhibits the reaction [Copper results in increased expression of BACE1 mRNA]18583042
D003300Copperferulic acid inhibits the reaction [Copper results in increased expression of BACE1 mRNA]18583042
D003300CopperMinocycline inhibits the reaction [Copper results in increased expression of BACE1 mRNA]18583042
D003300CopperSB 203580 inhibits the reaction [Copper results in increased expression of BACE1 mRNA]18583042
D003300CopperBACE1 protein binds to [CCS protein binds to Copper]16545469
D003300CopperCopper binds to BACE1 protein16545469
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of BACE1 mRNA"19167446
C029892cupric chloridecupric chloride results in increased expression of BACE1 mRNA22542740
C029892cupric chloridecupric chloride results in increased expression of BACE1 protein22542740
D003474CurcuminCurcumin inhibits the reaction [Copper results in increased expression of BACE1 mRNA]18583042
D016572CyclosporineCyclosporine results in decreased expression of BACE1 mRNA20106945
D003634DDTDDT results in increased expression of BACE125720399
D003907Dexamethasone[APP protein alternative form co-treated with Dexamethasone] results in increased expression of BACE1 mRNA22484447
D003907Dexamethasoneginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in increased expression of BACE1 mRNA]22484447
D003907DexamethasoneHuang Qi inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in increased expression of BACE1 mRNA]22484447
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of BACE1 mRNA25607892
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of BACE1 mRNA25607892
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of BACE1 mRNA25607892
C051904dinophysistoxin 1dinophysistoxin 1 results in decreased expression of BACE1 mRNA28939011
D004050DitiocarbDitiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA]28242320
C118739entinostatentinostat results in decreased expression of BACE1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BACE1 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of BACE1 mRNA22079256
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of BACE1 mRNA25607892
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of BACE1 mRNA29097150
C004999ferulic acidferulic acid inhibits the reaction [Copper results in increased expression of BACE1 mRNA]18583042
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of BACE1 gene20938992
C039281furanfuran results in decreased expression of BACE1 mRNA25539665
D019833GenisteinGenistein inhibits the reaction [aluminum chloride results in increased expression of BACE1 mRNA]28552514
C035054ginsenoside Rg1ginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in increased expression of BACE1 mRNA]22484447
C584426GNE-629GNE-629 results in decreased activity of BACE1 protein23584887
C584426GNE-629[GNE-629 results in decreased activity of BACE1 protein] which affects the metabolism of APP protein23584887
C081021Go 6976"Go 6976 inhibits the reaction [Phorbol 12,13-Dibutyrate affects the localization of BACE1 protein]"19476501
D006046Gold[Gold co-treated with Polyethylene Glycols] results in decreased expression of BACE1 mRNA19695318
C119543GW0072GW0072 inhibits the reaction [Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]]14586007
C119543GW0072GW0072 inhibits the reaction [Indomethacin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]]14586007
C119543GW0072GW0072 inhibits the reaction [Ibuprofen results in decreased expression of BACE1 mRNA]16407166
C027492Huang QiHuang Qi inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in increased expression of BACE1 mRNA]22484447
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of BACE1 mRNA19376150
D007052IbuprofenGW0072 inhibits the reaction [Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]]14586007
D007052IbuprofenIbuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of and results in increased activity of BACE1 protein]14586007
D007052IbuprofenIbuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]14586007
D007052IbuprofenIbuprofen results in decreased activity of BACE1 protein14586007
D007052IbuprofenIbuprofen results in decreased expression of BACE1 mRNA14586007
D007052IbuprofenGW0072 inhibits the reaction [Ibuprofen results in decreased expression of BACE1 mRNA]16407166
D007052IbuprofenIbuprofen results in decreased expression of BACE1 mRNA16407166
D007052IbuprofenIbuprofen results in decreased expression of BACE1 mRNA16407166
C056599icariinicariin inhibits the reaction [APP protein alternative form results in increased expression of BACE1 mRNA]19782061
D007213IndomethacinGW0072 inhibits the reaction [Indomethacin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]]14586007
D007213IndomethacinIndomethacin results in decreased expression of BACE1 mRNA16407166
D007530IsofluraneIsoflurane results in increased expression of BACE1 protein17287498
D048628KetolidesKetolides analog results in decreased expression of BACE1 mRNA24967691
D007854LeadLead results in increased expression of BACE1 protein22272629
D007854Lead[Arsenic co-treated with Cadmium co-treated with Lead] promotes the reaction [BACE1 protein results in increased metabolism of APP protein]25288670
C008261lead acetatelead acetate results in increased expression of BACE1 mRNA23867794
C008261lead acetatelead acetate results in increased expression of BACE1 protein23867794
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of BACE1 mRNA25607892
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of BACE1 mRNA"24972896
D008070LipopolysaccharidesDitiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA]28242320
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA28242320
D008070Lipopolysaccharidespimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA]28242320
D008345ManganeseManganese results in increased expression of BACE1 mRNA18583042
C521476memoquinmemoquin results in decreased activity of BACE1 protein22054058
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of BACE1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of BACE1 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of BACE1 mRNA24118919|2800136
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of BACE1 mRNA"20188158
D008911MinocyclineMinocycline inhibits the reaction [Copper results in increased expression of BACE1 mRNA]18583042
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of BACE1 mRNA27321306
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of BACE1 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of BACE1 mRNA"25620056
D009288NaproxenNaproxen results in decreased expression of BACE1 mRNA16407166
C057222neferineneferine results in decreased activity of BACE1 protein20736023
C414614OM99-2OM99-2 analog binds to and results in decreased activity of BACE1 protein15582402
C414614OM99-2OM99-2 binds to and results in decreased activity of BACE1 protein15582402
D010100Oxygenalpha-Tocopherol inhibits the reaction [Oxygen deficiency results in increased expression of BACE1 mRNA]19196431
D010100OxygenCAT protein inhibits the reaction [Oxygen deficiency results in increased expression of BACE1 mRNA]19196431
D010100OxygenHIF1A protein affects the reaction [Oxygen deficiency results in increased expression of BACE1 mRNA]19196431
D010100OxygenHIF1A protein affects the reaction [Oxygen deficiency results in increased expression of BACE1 protein]19196431
D010100OxygenMAPK8 protein affects the reaction [Oxygen deficiency results in increased expression of BACE1 protein]19196431
D010100OxygenMAPK9 protein affects the reaction [Oxygen deficiency results in increased expression of BACE1 protein]19196431
D010100OxygenOxygen deficiency results in increased expression of BACE1 mRNA19196431
D010100OxygenOxygen deficiency results in increased expression of BACE1 protein19196431
D010100OxygenRotenone inhibits the reaction [Oxygen deficiency results in increased expression of BACE1 mRNA]19196431
D010634PhenobarbitalPhenobarbital affects the expression of BACE1 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BACE1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of BACE1 mRNA26272509
C031503phenylpiperazinephenylpiperazine analog results in decreased activity of BACE1 protein16412632
D015240Phorbol 12,13-Dibutyrate"Go 6976 inhibits the reaction [Phorbol 12,13-Dibutyrate affects the localization of BACE1 protein]"19476501
D015240Phorbol 12,13-Dibutyrate"Phorbol 12,13-Dibutyrate affects the localization of BACE1 protein"19476501
C004479pimagedinepimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA]28242320
C060836pioglitazonepioglitazone inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of and results in increased activity of BACE1 protein]14586007
C060836pioglitazonepioglitazone results in decreased activity of BACE1 protein14586007
C060836pioglitazonepioglitazone results in decreased expression of BACE1 mRNA14586007
C060836pioglitazonepioglitazone results in decreased expression of BACE1 mRNA15817521|1640716
C060836pioglitazonepioglitazone results in decreased expression of BACE1 protein15817521
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of BACE1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of BACE1 mRNA18301758|2381119
D010936Plant ExtractsPlant Extracts inhibits the reaction [aluminum chloride results in increased expression of BACE1 protein]28552514
D011092Polyethylene Glycols[Gold co-treated with Polyethylene Glycols] results in decreased expression of BACE1 mRNA19695318
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of BACE1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of BACE1 mRNA22714537
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of BACE1 mRNA22079256
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of BACE1 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of BACE1 mRNA25607892
C045950propiconazolepropiconazole results in decreased expression of BACE1 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of BACE1 mRNA24780913
C000597862rhamnazinrhamnazin results in decreased activity of BACE1 protein26297990
D012402RotenoneRotenone inhibits the reaction [Oxygen deficiency results in increased expression of BACE1 mRNA]19196431
C093642SB 203580SB 203580 inhibits the reaction [Copper results in increased expression of BACE1 mRNA]18583042
C515112schaftosideschaftoside results in decreased activity of BACE1 protein26297990
C009250sevofluranesevoflurane results in increased expression of BACE1 protein19433662
C009250sevofluranesevoflurane results in increased expression of BACE1 protein19433662
D012834SilverSilver results in decreased expression of BACE1 mRNA27131904
C017947sodium arsenitesodium arsenite results in increased expression of BACE1 mRNA17879257
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BACE1 mRNA21570461
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of BACE1 protein]]23541064
D013849ThimerosalThimerosal results in decreased expression of BACE1 mRNA27188386
D013853ThioacetamideThioacetamide results in decreased expression of BACE1 mRNA23411599
C009500tolfenamic acidtolfenamic acid results in decreased expression of BACE1 mRNA24462621
C009500tolfenamic acidtolfenamic acid results in decreased expression of BACE1 protein24462621
D014212TretinoinTretinoin affects the localization of BACE1 protein19476501
D014212TretinoinTretinoin results in increased expression of BACE1 mRNA16279945|1947650
D014212TretinoinTretinoin results in increased expression of BACE1 protein19476501
D014212TretinoinTretinoin results in increased expression of BACE1 mRNA19476501
D014212TretinoinTretinoin results in increased expression of BACE1 protein19476501
D014241TrichloroethyleneTrichloroethylene results in increased methylation of BACE1 gene27618143
D014266TrientineTetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of BACE1 protein]]23541064
D014266TrientineTrientine inhibits the reaction [S100B protein results in increased expression of BACE1 protein]23541064
D014266TrientineTrientine results in decreased expression of BACE1 protein23541064
D014266TrientineTrientine results in decreased expression of BACE1 protein23541064
D014315TriterpenesTriterpenes results in decreased activity of BACE1 protein28698023
C057693troglitazonetroglitazone results in decreased expression of BACE1 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BACE1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of BACE1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of BACE1 mRNA23179753|2438349
D014638VanadatesVanadates results in increased expression of BACE1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of BACE1 gene25560391
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of BACE1 mRNA25607892
C025643vinclozolinvinclozolin affects the expression of BACE1 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in increased expression of BACE1 mRNA26682919
C111237vorinostatvorinostat results in decreased expression of BACE1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-IBA21873635  
GO:0001540amyloid-beta binding-IPI16407538  
GO:0004190aspartic-type endopeptidase activity-IBA21873635  
GO:0004190aspartic-type endopeptidase activity-IDA10531052  
GO:0005515protein binding-IPI16407538  17573534  19011241  22709416  24612608  25957769  
27179792  
GO:0008233peptidase activity-IDA8562317  
GO:0008798beta-aspartyl-peptidase activity-TAS-  
GO:0019899enzyme binding-IPI12586838  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IBA21873635  
GO:0006508proteolysis-IDA10531052  
GO:0006509membrane protein ectodomain proteolysis-IBA21873635  
GO:0006509membrane protein ectodomain proteolysis-IDA18353773  
GO:0006509membrane protein ectodomain proteolysis-TAS12354787  
GO:0044267cellular protein metabolic process-TAS-  
GO:0050435amyloid-beta metabolic process-IBA21873635  
GO:0050435amyloid-beta metabolic process-IDA15080893  
GO:0050804modulation of chemical synaptic transmission-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005768endosome-IDA10531052  
GO:0005769early endosome-IDA24305806  
GO:0005770late endosome-IDA24612608  
GO:0005771multivesicular body-IDA24612608  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005794Golgi apparatus-IBA21873635  
GO:0005794Golgi apparatus-IDA10531052  11466313  12586838  
GO:0005802trans-Golgi network-IDA11466313  
GO:0005886plasma membrane-IDA24612608  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA12586838  
GO:0009986cell surface-IEA-  
GO:0010008endosome membrane-TAS-  
GO:0016021integral component of membrane-NAS10531052  
GO:0030424axon-IEA-  
GO:0030659cytoplasmic vesicle membrane-IEA-  
GO:0045121membrane raft-IEA-  
GO:0070931Golgi-associated vesicle lumen-TAS-  
KEGG ID KEGG Term
hsa05010Alzheimer's disease
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-977225Amyloid fiber formationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29114105Neuregulin 3 Signaling Mediates Nicotine-Dependent Synaptic Plasticity in the Orbitofrontal Cortex and Cognition. (2018 May)Zhou LNeuropsychopharmacology