Gene: SSBP2

23635
HSPC116|SOSS-B2
single stranded DNA binding protein 2
protein-coding
5q14.1
Ensembl:ENSG00000145687 MIM:607389 Vega:OTTHUMG00000119039 UniprotKB:P81877
NG_051589.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.264e-1 (AD)  4.795e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCAMP10.946
CD470.938
ATF20.937
FAM8A10.934
TRIM230.933
WASL0.933
AASDHPPT0.932
LRP110.932
CASD10.931
GOPC0.93

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.559
OR4F29-0.51
CSAG1-0.401
FZD10-0.356
MTRNR2L8-0.349
MTRNR2L6-0.34
MTRNR2L10-0.336
AJUBA-0.334
RAI14-0.327
MAGEA12-0.326

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SSBP2 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SSBP2 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SSBP2 mRNA"19167446
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SSBP2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SSBP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SSBP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SSBP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SSBP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SSBP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SSBP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SSBP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SSBP2 mRNA"27188386
C496492abrineabrine results in increased expression of SSBP2 mRNA22595364
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SSBP2 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of SSBP2 mRNA21757418
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SSBP2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of SSBP2 mRNA26705709
D001280AtrazineAtrazine results in increased expression of SSBP2 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of SSBP2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SSBP2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SSBP2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SSBP2 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SSBP2 mRNA"19150397
D004958EstradiolEstradiol results in decreased expression of SSBP2 mRNA26865669|2871154
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of SSBP2 mRNA26496021
C044887beta-methylcholinebeta-methylcholine affects the expression of SSBP2 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of SSBP2 mRNA28711546
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SSBP2 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of SSBP2 mRNA26063408
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of SSBP2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of SSBP2 mRNA25181051
D002104CadmiumCadmium results in decreased expression of SSBP2 mRNA23369406
D002220CarbamazepineCarbamazepine affects the expression of SSBP2 mRNA25979313
D002996ClomipheneClomiphene results in increased expression of SSBP2 mRNA26865669
D003300CopperCopper results in increased expression of SSBP2 mRNA24403277
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SSBP2 mRNA"19167446
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SSBP2 mRNA23640034
C014347decitabine[decitabine affects the methylation of SSBP2 promoter] which affects the expression of SSBP2 mRNA18559593|1855959
C014347decitabine[decitabine affects the methylation of SSBP2 promoter] which affects the expression of SSBP2 protein18559593|1855959
C014347decitabinedecitabine results in increased expression of SSBP2 mRNA19194470
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SSBP2 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SSBP2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SSBP2 mRNA22023808
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SSBP2 mRNA21527772
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of SSBP2 mRNA26865669
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of SSBP2 mRNA"22485181
C118739entinostatentinostat results in decreased expression of SSBP2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SSBP2 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SSBP2 mRNA22079256
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SSBP2 mRNA17942748
D008656MestranolMestranol results in decreased expression of SSBP2 mRNA26865669
D005557FormaldehydeFormaldehyde results in decreased expression of SSBP2 mRNA23649840
C070081fulvestrantfulvestrant results in increased expression of SSBP2 mRNA26865669
D019833GenisteinGenistein results in decreased expression of SSBP2 mRNA26865669
D006589HexestrolHexestrol results in decreased expression of SSBP2 mRNA26865669
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SSBP2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SSBP2 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SSBP2 mRNA27392435
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of SSBP2 mRNA"24972896
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SSBP2 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SSBP2 mRNA"20188158|2625132
C008493methylselenic acidmethylselenic acid results in increased expression of SSBP2 mRNA18548127
D009532NickelNickel results in decreased expression of SSBP2 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in decreased expression of SSBP2 mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SSBP2 mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SSBP2 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of SSBP2 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SSBP2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SSBP2 mRNA26272509
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SSBP2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SSBP2 mRNA22079256|2271453
D011441PropylthiouracilPropylthiouracil results in increased expression of SSBP2 mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of SSBP2 mRNA26865669
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SSBP2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SSBP2 mRNA25351596
D012834SilverSilver results in decreased expression of SSBP2 mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SSBP2 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SSBP2 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SSBP2 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of SSBP2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SSBP2 mRNA19933214
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SSBP2 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of SSBP2 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SSBP2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of SSBP2 mRNA26272509
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of SSBP2 mRNA19042947
D014635Valproic AcidValproic Acid results in decreased expression of SSBP2 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased expression of SSBP2 mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0003697single-stranded DNA binding-NAS12079286  
GO:0005515protein binding-IPI27107014  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-NAS12079286  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20658532Cigarette smoke induces promoter methylation of single-stranded DNA-binding protein 2 in human esophageal squamous cell carcinoma. (2011 May 15)Huang YInt J Cancer