Gene: LDOC1

23641
BCUR1|Mar7|Mart7|RTL7|SIRH7
LDOC1, regulator of NFKB signaling
protein-coding
Xq27.1
Ensembl:ENSG00000182195 MIM:300402 Vega:OTTHUMG00000022558 UniprotKB:O95751
NC_000023.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC22A170.97
OTUB10.969
TMEM59L0.964
MAPRE30.962
UCHL10.96
BSCL20.96
AP2M10.957
PLD30.957
RNF1870.957
BABAM10.957

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.676
OR4F29-0.641
TFPI2-0.442
KCNJ15-0.422
IL18RAP-0.414
CXCR2-0.412
PABPC4L-0.401
EBF1-0.394
SIX1-0.389
REST-0.388

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of LDOC1 mRNA26690555
C006632arsenic trioxidearsenic trioxide results in increased expression of LDOC1 mRNA25258189
C547126AZM551248AZM551248 results in decreased expression of LDOC1 mRNA22323515
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LDOC1 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of LDOC1 mRNA19619570|2118537
C006780bisphenol Abisphenol A results in decreased expression of LDOC1 mRNA25181051
D016572CyclosporineCyclosporine results in decreased expression of LDOC1 mRNA27989131
D004041Dietary FatsDietary Fats results in decreased expression of LDOC1 mRNA25016146
D015735MifepristoneMifepristone results in decreased expression of LDOC1 mRNA17584828
D010936Plant ExtractsPlant Extracts results in decreased expression of LDOC1 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of LDOC1 mRNA22714537
D018038Sodium SeleniteSodium Selenite results in decreased expression of LDOC1 mRNA18175754
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LDOC1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LDOC1 mRNA19619570
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of LDOC1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to LDOC1 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LDOC1 mRNA22298810
D014635Valproic AcidValproic Acid results in increased expression of LDOC1 mRNA29154799
D014638VanadatesVanadates results in increased expression of LDOC1 mRNA22714537
C088658zoledronic acidzoledronic acid results in decreased expression of LDOC1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15670815  16189514  17500595  19060904  25416956  25910212  
26871637  27107014  
GO ID GO Term Qualifier Evidence PubMed
GO:0001893maternal placenta development-IEA-  
GO:0008285negative regulation of cell proliferation-TAS10403563  
GO:0060137maternal process involved in parturition-IEA-  
GO:1903547regulation of growth hormone activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005730nucleolus-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26317789LDOC1 silenced by cigarette exposure and involved in oral neoplastic transformation. (2015 Sep 22)Lee CHOncotarget
23362108Epigenetic regulation of the X-linked tumour suppressors BEX1 and LDOC1 in oral squamous cell carcinoma. (2013 Jul)Lee CHJ Pathol