Gene: LY96

23643
ESOP-1|MD-2|MD2|ly-96
lymphocyte antigen 96
protein-coding
8q21.11
Ensembl:ENSG00000154589 MIM:605243 Vega:OTTHUMG00000164504 UniprotKB:Q9Y6Y9
NC_000008.11
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.730e-1 (AD)  1.032e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NCF40.875
SERPINA10.874
FCGR2A0.874
MS4A6A0.872
PARVG0.869
PTPRC0.869
CSF2RB0.865
GPR650.865
SASH30.864
CTSS0.862

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH4-0.506
F7-0.503
KREMEN2-0.489
NEUROD6-0.488
KCNIP3-0.487
LRTM2-0.485
ZSCAN1-0.484
KCNK4-0.471
TPBGL-0.466
ST6GAL2-0.464

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00295MorphineSmall Molecule57-27-2Approved|InvestigationalTarget
DB00333MethadoneSmall Molecule76-99-3ApprovedTarget
DB027673-Hydroxy-Myristic AcidSmall MoleculeExperimentalTarget
DB03017Lauric AcidSmall Molecule143-07-7Approved|ExperimentalTarget
DB08231Myristic acidSmall Molecule544-63-8ExperimentalTarget
ID Drug Name Action PubMed
C0006039621-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one"1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one binds to LY96 protein"28063877
C0006039621-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one"1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [Lipopolysaccharides binds to LY96 protein]"28063877
C0006039621-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one"1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [HMGB1 protein binds to LY96 protein binds to TLR4 protein]]"29111459
C0006039621-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one"1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [LY96 protein binds to TLR4 protein]]"28063877
C0006039621-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one"1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [LY96 protein binds to TLR4 protein binds to HMGB1 protein]]"28063877
C0006039621-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one"1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [NOX4 protein binds to LY96 protein binds to TLR4 protein]]"29111459
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of LY96 mRNA28329830
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of LY96 mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of LY96 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LY96 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of LY96 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LY96 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of LY96 mRNA21420995|2669055
D000082AcetaminophenAcetaminophen affects the expression of LY96 mRNA17562736
D000241AdenosineAdenosine results in increased expression of LY96 mRNA21538184
D016604Aflatoxin B1Aflatoxin B1 affects the expression of LY96 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LY96 mRNA21632981|2164198
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [IFNG protein results in increased expression of LY96 protein]"21572044
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of LY96 mRNA24449571
C006632arsenic trioxide[arsenic trioxide co-treated with Bortezomib] results in increased expression of LY96 mRNA25913414
C006632arsenic trioxidearsenic trioxide results in increased expression of LY96 mRNA26705709|2782922
D001379AzathioprineAzathioprine results in increased expression of LY96 mRNA22623647
C547126AZM551248AZM551248 results in increased expression of LY96 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LY96 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LY96 mRNA22228805
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of LY96 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of LY96 mRNA25047013|2768578
C006780bisphenol Abisphenol A results in increased expression of LY96 mRNA25181051
D001786Blood GlucoseLY96 results in increased susceptibility to [Oxygen deficiency co-treated with Blood Glucose deficiency]28063877
D000069286Bortezomib[arsenic trioxide co-treated with Bortezomib] results in increased expression of LY96 mRNA25913414
D020122tert-Butylhydroperoxide"1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [HMGB1 protein binds to LY96 protein binds to TLR4 protein]]"29111459
D020122tert-Butylhydroperoxide"1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [LY96 protein binds to TLR4 protein]]"28063877
D020122tert-Butylhydroperoxide"1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [LY96 protein binds to TLR4 protein binds to HMGB1 protein]]"28063877
D020122tert-Butylhydroperoxide"1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [NOX4 protein binds to LY96 protein binds to TLR4 protein]]"29111459
D020122tert-ButylhydroperoxideLY96 protein affects the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]29111459
D020122tert-ButylhydroperoxideLY96 protein affects the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]29111459
D020122tert-ButylhydroperoxideLY96 protein affects the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein]29111459
D020122tert-ButylhydroperoxideLY96 protein affects the reaction [tert-Butylhydroperoxide results in increased expression of CXCL8 mRNA]29111459
D020122tert-ButylhydroperoxideLY96 protein affects the reaction [tert-Butylhydroperoxide results in increased expression of IL1B mRNA]29111459
D020122tert-ButylhydroperoxideLY96 protein affects the reaction [tert-Butylhydroperoxide results in increased expression of IL6 mRNA]29111459
D020122tert-ButylhydroperoxideLY96 protein affects the reaction [tert-Butylhydroperoxide results in increased expression of NOX4 protein]29111459
D020122tert-ButylhydroperoxideLY96 protein affects the reaction [tert-Butylhydroperoxide results in increased expression of TNF mRNA]29111459
D020122tert-ButylhydroperoxideLY96 protein affects the reaction [tert-Butylhydroperoxide results in increased secretion of IL1B protein]29111459
D020122tert-ButylhydroperoxideLY96 protein affects the reaction [tert-Butylhydroperoxide results in increased secretion of TNF protein]29111459
D020122tert-ButylhydroperoxideLY96 protein promotes the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein]28063877
D020122tert-ButylhydroperoxideLY96 protein promotes the reaction [tert-Butylhydroperoxide results in increased expression of CASP3 protein modified form]28063877
D020122tert-ButylhydroperoxideLY96 protein promotes the reaction [tert-Butylhydroperoxide results in increased expression of CXCL8 mRNA]28063877
D020122tert-ButylhydroperoxideLY96 protein promotes the reaction [tert-Butylhydroperoxide results in increased expression of CXCL8 protein]28063877
D020122tert-ButylhydroperoxideLY96 protein promotes the reaction [tert-Butylhydroperoxide results in increased expression of ICAM1 mRNA]28063877
D020122tert-ButylhydroperoxideLY96 protein promotes the reaction [tert-Butylhydroperoxide results in increased expression of IL1B mRNA]28063877
D020122tert-ButylhydroperoxideLY96 protein promotes the reaction [tert-Butylhydroperoxide results in increased expression of IL1B protein]28063877
D020122tert-ButylhydroperoxideLY96 protein promotes the reaction [tert-Butylhydroperoxide results in increased expression of IL6 mRNA]28063877
D020122tert-ButylhydroperoxideLY96 protein promotes the reaction [tert-Butylhydroperoxide results in increased expression of PTGS2 mRNA]28063877
D020122tert-ButylhydroperoxideLY96 protein promotes the reaction [tert-Butylhydroperoxide results in increased expression of VCAM1 mRNA]28063877
D020122tert-ButylhydroperoxideLY96 protein promotes the reaction [tert-Butylhydroperoxide results in increased phosphorylation of MAPK8 protein]28063877
D020122tert-ButylhydroperoxideLY96 protein promotes the reaction [tert-Butylhydroperoxide results in increased phosphorylation of MAPK9 protein]28063877
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide promotes the reaction [HMGB1 protein binds to LY96 protein binds to TLR4 protein]29111459
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide promotes the reaction [LY96 protein binds to TLR4 protein]28063877
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide promotes the reaction [LY96 protein binds to TLR4 protein binds to HMGB1 protein]28063877
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide promotes the reaction [NOX4 protein binds to LY96 protein binds to TLR4 protein]29111459
C018475butyraldehydebutyraldehyde results in increased expression of LY96 mRNA26079696
D002104CadmiumCadmium results in increased expression of LY96 mRNA21120746
D019256Cadmium ChlorideCadmium Chloride results in increased expression of LY96 mRNA26352046
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of LY96 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of LY96 mRNA27339419
C018021cobaltous chloridecobaltous chloride results in increased activity of [TLR4 protein binds to LY96 protein]25803856
C018021cobaltous chloridecobaltous chloride results in increased expression of LY96 mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of LY96 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of LY96 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of LY96 mRNA20106945|2163298
D003703DemecolcineDemecolcine results in increased expression of LY96 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of LY96 mRNA28628672
D004041Dietary FatsDietary Fats results in decreased expression of LY96 mRNA18042831|2501614
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of LY96 mRNA21527772
D002117CalcitriolCalcitriol results in increased expression of LY96 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of LY96 mRNA21592394
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of LY96 mRNA25380136
D004317Doxorubicin[Doxorubicin co-treated with Fungal Polysaccharides] results in decreased expression of LY96 mRNA27181935
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of LY96 mRNA23649840
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of LY96 mRNA28329830
D005557FormaldehydeFormaldehyde results in increased expression of LY96 mRNA23649840|2766457
D037741FullerenesFullerenes analog results in increased expression of LY96 mRNA22342292
D062610Fungal Polysaccharides[Doxorubicin co-treated with Fungal Polysaccharides] results in decreased expression of LY96 mRNA27181935
D005839GentamicinsGentamicins results in increased expression of LY96 mRNA22061828
D006034Glycyrrhetinic Acid"Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [TLR4 protein binds to LY96 protein]]"28213090
C016517indole-3-carbinolindole-3-carbinol affects the expression of LY96 mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of LY96 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LY96 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of LY96 mRNA28628672
C008261lead acetatelead acetate results in increased expression of LY96 mRNA20542052
C040142lipid A precursors, bacterial"lipid A precursors, bacterial inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of [TLR4 protein binds to LY96 protein]]"25803856
C482199lipopolysaccharide, E coli O55-B5"[lipopolysaccharide, E coli O55-B5 co-treated with FSHB protein] results in decreased expression of LY96 mRNA"22771338
C482199lipopolysaccharide, E coli O55-B5"lipid A precursors, bacterial inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of [TLR4 protein binds to LY96 protein]]"25803856
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased activity of [TLR4 protein binds to LY96 protein]"25803856
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of LY96 mRNA"19503810
C440499lipopolysaccharide, Escherichia coli O111 B4"[TLR4 protein co-treated with LY96 protein co-treated with CD14 protein] results in increased susceptibility to lipopolysaccharide, Escherichia coli O111 B4"23680697
C440499lipopolysaccharide, Escherichia coli O111 B4"[[TLR4 protein co-treated with LY96 protein co-treated with CD14 protein] results in increased susceptibility to lipopolysaccharide, Escherichia coli O111 B4] which results in increased expression of CXCL8 mRNA"23680697
C440499lipopolysaccharide, Escherichia coli O111 B4"Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [TLR4 protein binds to LY96 protein]]"28213090
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [TLR4 protein binds to LY96 protein]"28213090
D008070Lipopolysaccharides"1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [Lipopolysaccharides binds to LY96 protein]"28063877
D008070LipopolysaccharidesLipopolysaccharides binds to LY96 protein28063877
D008070LipopolysaccharidesLY96 exon mutant form results in decreased susceptibility to Lipopolysaccharides16367934
D008070LipopolysaccharidesLY96 protein mutant form results in decreased susceptibility to Lipopolysaccharides16367934
D008070LipopolysaccharidesLY96 protein promotes the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]20700758
D008070Lipopolysaccharides[LY96 protein results in increased expression of CD14 mRNA] which results in increased susceptibility to Lipopolysaccharides20700758
D008070Lipopolysaccharides[LY96 protein results in increased expression of TLR4 mRNA] which results in increased susceptibility to Lipopolysaccharides20700758
D008070LipopolysaccharidesLY96 protein results in increased susceptibility to Lipopolysaccharides16367934
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [TLR4 protein binds to LY96 protein]21936536
D008070Lipopolysaccharidesphosphatidylinositol dimannoside analog inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to LY96 protein]]21936536
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of LY96 mRNA26378955
D008550MelatoninMelatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of LY96 protein]28238930
D008550MelatoninMelatonin inhibits the reaction [tetrachlorobenzoquinone results in increased localization of LY96 protein]27413111
D008550MelatoninMelatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]]28238930
D008627Mercuric ChlorideMercuric Chloride results in increased expression of LY96 mRNA16507785
D008694MethamphetamineMethamphetamine results in increased expression of LY96 mRNA25290377
D008727MethotrexateMethotrexate results in decreased expression of LY96 mRNA17400583
C002950methylformamidemethylformamide affects the expression of LY96 mRNA17040096
C002950methylformamidemethylformamide analog affects the expression of LY96 mRNA17040096
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of LY96 mRNA23649840
C523799MRK 003MRK 003 results in decreased expression of LY96 mRNA21169257
D009151Mustard GasMustard Gas results in increased expression of LY96 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LY96 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of LY96 mRNA25380136
C022838nickel chloridenickel chloride results in increased activity of [TLR4 protein binds to LY96 protein]25803856
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of LY96 mRNA20971185
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of LY96 mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of LY96 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of LY96 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of LY96 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of LY96 mRNA]17655762
D010100OxygenLY96 results in increased susceptibility to [Oxygen deficiency co-treated with Blood Glucose deficiency]28063877
D000073878Palm OilPalm Oil results in decreased expression of LY96 mRNA18042831
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of LY96 mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of LY96 mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of LY96 mRNA]17655762
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of LY96 mRNA26705709
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of LY96 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of LY96 mRNA19270015|1948288
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LY96 mRNA"27188386
C054977phosphatidylinositol dimannosidephosphatidylinositol dimannoside analog binds to LY96 protein21936536
C054977phosphatidylinositol dimannosidephosphatidylinositol dimannoside analog inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to LY96 protein]]21936536
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of LY96 mRNA21334430
D011239PrednisolonePrednisolone results in decreased expression of LY96 mRNA17379860
C005556propionaldehydepropionaldehyde results in increased expression of LY96 mRNA26079696
D011794QuercetinQuercetin results in increased expression of LY96 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of LY96 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of LY96 mRNA25351596
D012834SilverSilver results in increased expression of LY96 mRNA22342292
C017947sodium arsenitesodium arsenite results in increased expression of LY96 mRNA23876855
C016104sodium bichromatesodium bichromate results in decreased expression of LY96 mRNA17685462
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of LY96 mRNA26378955
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of LY96 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of LY96 mRNA21592394
C000591600tetrachlorobenzoquinoneMelatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of LY96 protein]28238930
C000591600tetrachlorobenzoquinoneMelatonin inhibits the reaction [tetrachlorobenzoquinone results in increased localization of LY96 protein]27413111
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased expression of LY96 protein28238930
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased localization of LY96 protein27413111
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LY96 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LY96 mRNA25613284
D013792ThalidomideThalidomide results in decreased expression of LY96 mRNA26006729|2621778
C009495titanium dioxidetitanium dioxide results in increased expression of LY96 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of LY96 mRNA20133372
C024746tobacco tartobacco tar results in decreased expression of LY96 mRNA19559774
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of LY96 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of LY96 mRNA29024780
C057693troglitazonetroglitazone results in increased expression of LY96 mRNA25572481
D014635Valproic AcidValproic Acid results in decreased expression of LY96 mRNA29154799
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of LY96 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of LY96 mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of LY96 mRNA]17655762
D014750VincristineVincristine results in increased expression of LY96 mRNA23649840
D014800Vitallium[TLR4 protein co-treated with LY96 protein co-treated with CD14 protein] results in increased susceptibility to Vitallium analog23680697
D014800Vitallium[[TLR4 protein co-treated with LY96 protein co-treated with CD14 protein] results in increased susceptibility to Vitallium analog] which results in increased expression of CXCL8 mRNA23680697
D015032ZincZinc affects the expression of LY96 mRNA16979875

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001875lipopolysaccharide receptor activity-IDA19252480  
GO:0005515protein binding-IPI17803912  19060881  19252480  20547845  22474354  22532668  
GO:0015026coreceptor activity-TAS10359581  
GO ID GO Term Qualifier Evidence PubMed
GO:0002224toll-like receptor signaling pathway-TAS-  
GO:0002755MyD88-dependent toll-like receptor signaling pathway-TAS-  
GO:0002756MyD88-independent toll-like receptor signaling pathway-TAS-  
GO:0006954inflammatory response-IEA-  
GO:0006968cellular defense response-TAS10359581  
GO:0007166cell surface receptor signaling pathway-TAS10359581  
GO:0007249I-kappaB kinase/NF-kappaB signaling-TAS-  
GO:0031663lipopolysaccharide-mediated signaling pathway-IEA-  
GO:0031666positive regulation of lipopolysaccharide-mediated signaling pathway-IEA-  
GO:0032496response to lipopolysaccharide-IDA12594207  
GO:0032497detection of lipopolysaccharide-IDA19252480  
GO:0032760positive regulation of tumor necrosis factor production-ISS-  
GO:0034128negative regulation of MyD88-independent toll-like receptor signaling pathway-TAS-  
GO:0034142toll-like receptor 4 signaling pathway-ISS-  
GO:0034142toll-like receptor 4 signaling pathway-TAS-  
GO:0035666TRIF-dependent toll-like receptor signaling pathway-TAS-  
GO:0045087innate immune response-IEA-  
GO:0070266necroptotic process-TAS-  
GO:0097190apoptotic signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0010008endosome membrane-TAS-  
GO:0031226intrinsic component of plasma membrane-IDA11274165  
GO:0046696lipopolysaccharide receptor complex-IDA11274165  19252480  
KEGG ID KEGG Term
hsa04620Toll-like receptor signaling pathway
hsa05130Pathogenic Escherichia coli infection
hsa05145Toxoplasmosis
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-1236974ER-Phagosome pathwayTAS
R-HSA-1236975Antigen processing-Cross presentationTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-140534Ligand-dependent caspase activationTAS
R-HSA-1643685DiseaseTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168181Toll Like Receptor 7/8 (TLR7/8) CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-2562578TRIF-mediated programmed cell deathTAS
R-HSA-5260271Diseases of Immune SystemTAS
R-HSA-5357769Caspase activation via extrinsic apoptotic signalling pathwayTAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-5602358Diseases associated with the TLR signaling cascadeTAS
R-HSA-5602498MyD88 deficiency (TLR2/4)TAS
R-HSA-5603041IRAK4 deficiency (TLR2/4)TAS
R-HSA-5686938Regulation of TLR by endogenous ligandTAS
R-HSA-9014325TICAM1,TRAF6-dependent induction of TAK1 complexTAS
R-HSA-936964Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonTAS
R-HSA-937041IKK complex recruitment mediated by RIP1TAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS
R-HSA-937072TRAF6-mediated induction of TAK1 complex within TLR4 complexTAS
R-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationTAS
R-HSA-975155MyD88 dependent cascade initiated on endosomeTAS
R-HSA-975163IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24954085Novel genetic variants modify the effect of smoking on carotid plaque burden in Hispanics. (2014 Sep 15)Della-Morte DJ Neurol Sci
24776844Associations between functional polymorphisms in the NFkappaB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease. (2014 Dec)Bank SPharmacogenomics J