Gene info: ID 23657

Gene: SLC7A11

GENE ID: 23657

Synonyms: CCBR1|xCT

Description: solute carrier family 7 member 11

Gene type: protein-coding

Location: 4q28.3

dbXrefs: Ensembl:ENSG00000151012 MIM:607933 Vega:OTTHUMG00000133396 UniprotKB:Q9UPY5

RefSeq: NC_000004.12

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.000e-1 (AD) 9.805e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs11723658	chr4:138236842 (GRCh38.p7)	C>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg00534274	chr4:139163341	SLC7A11	Promoter	7.890e-4	Alcohol use disorders	26763658
cg06690548	chr4:139162808	SLC7A11		1.240e-31	Alcohol consumption per day	27843151
cg04487857	chr4:139096540	SLC7A11		2.650e-9	Alcohol consumption der day	27843151
cg06690548	chr4:139162808	SLC7A11		3.860e-9	Alcohol consumption der day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ARHGEF26	0.925
NOTCH2	0.909
PREX2	0.906
BMPR1B	0.9
GLI3	0.895
CYBRD1	0.89
SDC2	0.889
ELOVL2	0.888
TRPS1	0.882
SLC4A4	0.882

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CACNA1F	-0.512
NRG1	-0.484
AGMAT	-0.481
RTP1	-0.471
TRABD2A	-0.471
QRFPR	-0.47
OSBPL10	-0.467
NELL1	-0.465
CALHM1	-0.465
GALNT14	-0.465

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01098	Rosuvastatin	Small Molecule	287714-41-4	Approved	Transporter
DB04348	Taurocholic Acid	Small Molecule	81-24-3	Experimental	Transporter
DB05540	Alanosine	Small Molecule	5854-93-3	Investigational	Transporter
DB08834	Tauroursodeoxycholic acid	Small Molecule	14605-22-2	Approved\|Investigational	Transporter
DB00138	Cystine	Small Molecule	56-89-3	Approved\|Nutraceutical	Target
DB00142	Glutamic Acid	Small Molecule	56-86-0	Approved\|Nutraceutical	Target
DB00740	Riluzole	Small Molecule	1744-22-5	Approved\|Investigational	Target
DB00795	Sulfasalazine	Small Molecule	599-79-1	Approved	Target
DB06151	Acetylcysteine	Small Molecule	616-91-1	Approved\|Investigational	Target
DB11590	Thimerosal	Small Molecule	54-64-8	Approved	Target

ID	Drug Name	Action	PubMed
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of SLC7A11 mRNA"	27071940
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of SLC7A11 mRNA]"	27071940
C012277	1,2-diamino-4-nitrobenzene	"1,2-diamino-4-nitrobenzene results in increased expression of SLC7A11 mRNA"	26198647
C050642	1,2-dihydroxynaphthalene	"1,2-dihydroxynaphthalene analog results in increased expression of SLC7A11 mRNA"	25807370
C050642	1,2-dihydroxynaphthalene	"1,2-dihydroxynaphthalene analog results in increased expression of SLC7A11 protein"	25807370
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of SLC7A11 mRNA	25596134
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of SLC7A11 mRNA	25596134
C015262	1,6-hexamethylene diisocyanate	"1,6-hexamethylene diisocyanate results in increased expression of SLC7A11 mRNA"	24211530
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of SLC7A11 mRNA	28329830
C051246	1-methylanthracene	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of SLC7A11 mRNA]	28329830
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of SLC7A11 mRNA"	19095052
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SLC7A11 mRNA"	25305463
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SLC7A11 mRNA"	19114083
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of SLC7A11 mRNA"	19167446
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SLC7A11 mRNA"	19167446
C076159	2,3-dichloro-1-propanol	"2,3-dichloro-1-propanol results in increased expression of SLC7A11 mRNA"	25424538
C036990	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of SLC7A11 mRNA"	20816883
C029216	2-amino-3-methylimidazo(4,5-f)quinoline	"2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of SLC7A11 mRNA"	26198647
C073225	2-amino-4-methylphenol	SLC7A11 gene SNP affects the susceptibility to 2-amino-4-methylphenol	25622337
C091423	2-chloromethylpyridine	2-chloromethylpyridine results in increased expression of SLC7A11 mRNA	26198647
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased expression of SLC7A11 mRNA	19183254
C026114	2-xylene	2-xylene results in increased expression of SLC7A11 mRNA	20359517
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl affects the expression of SLC7A11 mRNA"	20638727
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SLC7A11 mRNA"	19692669\|2314675
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA]	19015640
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA]	19015640
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
C013813	4-anisidine	4-anisidine results in increased expression of SLC7A11 mRNA	26198647
C079693	4-carboxyphenylglycine	4-carboxyphenylglycine results in decreased activity of SLC7A11 protein	20007406
C027576	4-hydroxy-2-nonenal	[APC protein mutant form results in increased expression of SLC7A11 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal	21967605
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
C030735	7-aminocephalosporanic acid	7-aminocephalosporanic acid results in increased expression of SLC7A11 mRNA	24211530
D000082	Acetaminophen	Acetaminophen affects the expression of SLC7A11 mRNA	25458485
D000082	Acetaminophen	Acetaminophen results in increased expression of SLC7A11 mRNA	21420995\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of SLC7A11 mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [elesclomol results in increased expression of SLC7A11 mRNA]	18723479
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cocaine results in decreased expression of SLC7A11 protein]	19717140
D000171	Acrolein	Acrolein results in increased expression of SLC7A11 mRNA	24211530
D020106	Acrylamide	Acrylamide results in increased expression of SLC7A11 mRNA	23287710
D020106	Acrylamide	Acrylamide results in increased expression of SLC7A11 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of SLC7A11 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of SLC7A11 mRNA	21632981
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of SLC7A11 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of SLC7A11 mRNA	22100608\|2715375
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of SLC7A11 mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of SLC7A11 mRNA	23630614
D000393	Air Pollutants	Air Pollutants results in increased expression of SLC7A11 mRNA	23649983
D000393	Air Pollutants	Air Pollutants results in increased expression of SLC7A11 protein	23649983
D018350	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Propofol results in decreased expression of SLC7A11 protein]	28663055
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of SLC7A11 mRNA	28522335
D024502	alpha-Tocopherol	[alpha-Tocopherol co-treated with Paraquat] results in increased expression of SLC7A11 mRNA	24530478
D024502	alpha-Tocopherol	[alpha-Tocopherol co-treated with Paraquat] results in increased expression of SLC7A11 protein	24530478
C455846	aluminum citrate	aluminum citrate results in decreased expression of SLC7A11 mRNA	16443240
C455846	aluminum citrate	aluminum citrate results in decreased expression of SLC7A11 protein	16443240
C455846	aluminum citrate	SLC7A11 protein results in increased uptake of aluminum citrate	16443240
C018453	ammonium hexachloroplatinate	ammonium hexachloroplatinate results in increased expression of SLC7A11 mRNA	24211530
D000667	Ampicillin	Ampicillin results in decreased expression of SLC7A11 mRNA	21632981\|2619864
C030419	andrographolide	andrographolide results in increased expression of SLC7A11 mRNA	19737545
D016718	Arachidonic Acid	Arachidonic Acid results in increased expression of SLC7A11 mRNA	16704987
D001151	Arsenic	Arsenic affects the methylation of SLC7A11 gene	25304211
D001152	Arsenicals	Arsenicals results in increased expression of SLC7A11 mRNA	28625800
C006632	arsenic trioxide	arsenic trioxide results in increased expression of SLC7A11 mRNA	19128835\|2382409
C006632	arsenic trioxide	SLC7A11 protein results in decreased susceptibility to arsenic trioxide	20707922
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the expression of SLC7A11 mRNA"	25757056
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of SLC7A11 mRNA	26198647
D001280	Atrazine	Atrazine results in increased expression of SLC7A11 mRNA	25929836
C406592	azaspiracid	azaspiracid results in increased expression of SLC7A11 mRNA	28939011
D001379	Azathioprine	Azathioprine results in decreased expression of SLC7A11 mRNA	19192274
D001379	Azathioprine	Azathioprine results in increased expression of SLC7A11 mRNA	22623647\|2619864
C487081	belinostat	belinostat results in decreased expression of SLC7A11 mRNA	27188386
C030935	benz(a)anthracene	benz(a)anthracene results in decreased expression of SLC7A11 mRNA	26377693
D001554	Benzene	Benzene results in increased expression of SLC7A11 mRNA	20359517\|2184381
C029876	benzidine	benzidine results in increased expression of SLC7A11 mRNA	26198647
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of SLC7A11 mRNA	20106945\|2171491
D001564	Benzo(a)pyrene	Benzo(a)pyrene metabolite results in decreased expression of SLC7A11 mRNA	24356939
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SLC7A11 mRNA	20064835\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SLC7A11 mRNA	19770486\|2156981
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC7A11 mRNA"	19150397\|2001819
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SLC7A11 mRNA	25566086
D004958	Estradiol	Estradiol affects the expression of SLC7A11 mRNA	22574217
D004958	Estradiol	Estradiol results in decreased expression of SLC7A11 mRNA	16474171\|1916744
D004958	Estradiol	Estradiol results in increased expression of SLC7A11 mRNA	15159206\|2010694
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in increased expression of SLC7A11 mRNA	26496021
C053541	bicalutamide	bicalutamide results in increased expression of SLC7A11 mRNA	15638997
D001663	Bilirubin	Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]	22216172
D001663	Bilirubin	[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine	22216172
D001663	Bilirubin	[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione	22216172
D001663	Bilirubin	[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide	22216172
D001663	Bilirubin	Bilirubin results in increased expression of SLC7A11 mRNA	22216172
C452139	BIRB 796	BIRB 796 results in increased expression of SLC7A11 mRNA	21328587
C006780	bisphenol A	bisphenol A affects the expression of SLC7A11 mRNA	20170705
C006780	bisphenol A	bisphenol A results in decreased expression of SLC7A11 mRNA	16474171\|2067851
C006780	bisphenol A	bisphenol A results in increased expression of SLC7A11 mRNA	29275510
C006780	bisphenol A	bisphenol A affects the expression of SLC7A11 mRNA	25181051
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in increased expression of SLC7A11 mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of SLC7A11 mRNA	26982218
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in decreased expression of SLC7A11 mRNA	26198647
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of SLC7A11 mRNA	22079614
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of SLC7A11 mRNA	12414654\|2341063
C018475	butyraldehyde	butyraldehyde results in decreased expression of SLC7A11 mRNA	26079696
D002104	Cadmium	Cadmium results in decreased expression of SLC7A11 mRNA	24376830
D002104	Cadmium	Cadmium results in increased expression of SLC7A11 mRNA	21172416\|2336940
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SLC7A11 mRNA	25596134
C459604	candoxin	candoxin results in increased expression of SLC7A11 mRNA	16309724
D002185	Cannabidiol	Cannabidiol results in increased expression of SLC7A11 mRNA	21542829
C005563	captax	captax results in increased expression of SLC7A11 mRNA	24211530
D002220	Carbamazepine	Carbamazepine affects the expression of SLC7A11 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of SLC7A11 mRNA	27339419
D002443	Ceftriaxone	Ceftriaxone inhibits the reaction [Cocaine results in decreased expression of SLC7A11 protein]	19717140
C517733	chlorantranilipole	chlorantranilipole results in increased expression of SLC7A11 mRNA	25424538
C004656	chloroacetaldehyde	chloroacetaldehyde results in increased expression of SLC7A11 mRNA	25596134
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of SLC7A11 mRNA	26272509
C100187	chloropicrin	chloropicrin results in increased expression of SLC7A11 mRNA	24211530
D002737	Chloroprene	Chloroprene results in increased expression of SLC7A11 mRNA	23125180
C023676	chloroquine diphosphate	chloroquine diphosphate results in decreased expression of SLC7A11 mRNA	19192274
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of SLC7A11 mRNA	25424538
D004390	Chlorpyrifos	[Chlorpyrifos co-treated with NGF protein] results in decreased expression of SLC7A11 mRNA	20600679
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of SLC7A11 mRNA	20600679
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLC7A11 mRNA	20938992
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased expression of SLC7A11 mRNA	17178418\|2421153
C018021	cobaltous chloride	cobaltous chloride results in increased expression of SLC7A11 mRNA	22941251\|2435693
C018021	cobaltous chloride	cobaltous chloride results in increased expression of SLC7A11 mRNA	24386269
D003042	Cocaine	Acetylcysteine inhibits the reaction [Cocaine results in decreased expression of SLC7A11 protein]	19717140
D003042	Cocaine	Ceftriaxone inhibits the reaction [Cocaine results in decreased expression of SLC7A11 protein]	19717140
D003042	Cocaine	Cocaine results in decreased expression of SLC7A11 protein	19717140
D003300	Copper	Copper results in increased expression of SLC7A11 mRNA	24403277
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of SLC7A11 mRNA	20971185
D003300	Copper	Copper deficiency results in increased expression of SLC7A11 mRNA	26033743
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of SLC7A11 mRNA	20599845
D019327	Copper Sulfate	Copper Sulfate results in increased expression of SLC7A11 mRNA	19549813\|2059984
D003372	Coumaphos	Coumaphos results in increased expression of SLC7A11 mRNA	26198647
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SLC7A11 mRNA"	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of SLC7A11 mRNA	19167446
C013453	cresidine	cresidine results in decreased expression of SLC7A11 mRNA	26198647
D003471	Cuprizone	Cuprizone results in increased expression of SLC7A11 mRNA	26577399\|2752363
D003474	Curcumin	Curcumin results in increased expression of SLC7A11 mRNA	17999991
D003474	Curcumin	Curcumin results in increased expression of SLC7A11 mRNA	19183254
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of SLC7A11 mRNA	17654400
D003520	Cyclophosphamide	Cyclophosphamide affects the expression of SLC7A11 mRNA	23824090
D003520	Cyclophosphamide	Cyclophosphamide metabolite results in decreased expression of SLC7A11 mRNA	24356939
D016572	Cyclosporine	Cyclosporine results in increased expression of SLC7A11 mRNA	19159671\|2010694
D016572	Cyclosporine	Cyclosporine results in increased expression of SLC7A11 mRNA	19770486
D016572	Cyclosporine	Cyclosporine results in increased expression of SLC7A11 mRNA	25596134
C017160	cypermethrin	cypermethrin results in increased expression of SLC7A11 mRNA	25424538
D003553	Cystine	[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine	22216172
D003553	Cystine	[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione	22216172
D003553	Cystine	[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide	22216172
D003553	Cystine	[diethyl maleate results in increased expression of SLC7A11 mRNA] which results in increased uptake of Cystine	12235164
D003553	Cystine	[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine	19576933
D003553	Cystine	Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]	19576933
D003634	DDT	DDT results in increased expression of SLC7A11 mRNA	26198647
D013759	Dronabinol	Dronabinol results in increased expression of SLC7A11 mRNA	21542829
D013759	Dronabinol	Dronabinol results in increased expression of SLC7A11 mRNA	16616335
D003703	Demecolcine	Demecolcine results in increased expression of SLC7A11 mRNA	23649840
D003976	Diazinon	Diazinon results in increased expression of SLC7A11 mRNA	24356939\|2619864
C020735	dibutyldichlorotin	dibutyldichlorotin results in increased expression of SLC7A11 mRNA	24356939
D002945	Cisplatin	Cisplatin results in decreased expression of SLC7A11 mRNA	26198647
D002945	Cisplatin	Cisplatin results in increased expression of SLC7A11 mRNA	27594783
D002945	Cisplatin	SLC7A11 protein affects the susceptibility to Cisplatin	16217747
D002945	Cisplatin	Cisplatin results in increased expression of SLC7A11 mRNA	21151649
D004008	Diclofenac	Diclofenac results in decreased expression of SLC7A11 mRNA	19192274
D004026	Dieldrin	[Dieldrin co-treated with NGF protein] results in increased expression of SLC7A11 mRNA	20600679
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of SLC7A11 mRNA	26033743
C014476	diethyl maleate	diethyl maleate results in increased expression of SLC7A11 mRNA	12235164
C014476	diethyl maleate	[diethyl maleate results in increased expression of SLC7A11 mRNA] which results in increased uptake of Cystine	12235164
C014476	diethyl maleate	diethyl maleate results in increased expression of SLC7A11 mRNA	12235164
C014476	diethyl maleate	NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA]	12235164
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of SLC7A11 mRNA	26198647
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of SLC7A11 mRNA	15159206
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of SLC7A11 mRNA	26198647
D004178	Diquat	Diquat results in increased expression of SLC7A11 mRNA	21172416
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of SLC7A11 mRNA"	23811387
C512195	elesclomol	Acetylcysteine inhibits the reaction [elesclomol results in increased expression of SLC7A11 mRNA]	18723479
C512195	elesclomol	elesclomol results in increased expression of SLC7A11 mRNA	18723479
D004726	Endosulfan	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of SLC7A11 mRNA	26159488
C118739	entinostat	entinostat results in increased expression of SLC7A11 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
D004811	Epichlorohydrin	Epichlorohydrin results in increased expression of SLC7A11 mRNA	24211530
D004964	Estriol	Estriol results in increased expression of SLC7A11 mRNA	15159206
D004970	Estrone	Estrone results in increased expression of SLC7A11 mRNA	15159206
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of SLC7A11 mRNA	20170705
C040833	ethyl acrylate	ethyl acrylate results in decreased expression of SLC7A11 mRNA	26198647
C004912	ethylbenzene	ethylbenzene results in increased expression of SLC7A11 mRNA	20359517
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of SLC7A11 mRNA	23649840
D005054	Eugenol	Eugenol results in increased expression of SLC7A11 mRNA	26198647
D015025	Zearalenone	Zearalenone results in increased expression of SLC7A11 mRNA	25424538
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of SLC7A11 mRNA	28329830
C007738	fluoranthene	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of SLC7A11 mRNA]	28329830
D005473	Fluoxetine	Fluoxetine results in increased expression of SLC7A11 mRNA	24356939
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLC7A11 mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of SLC7A11 mRNA	23649840
D005557	Formaldehyde	Formaldehyde results in increased expression of SLC7A11 mRNA	20884683
D008299	Maleic Anhydrides	Maleic Anhydrides results in increased expression of SLC7A11 mRNA	24211530
C106014	gedunin	gedunin results in increased expression of SLC7A11 mRNA	17010675
D019833	Genistein	Genistein results in decreased expression of SLC7A11 mRNA	16474171
D005978	Glutathione	[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione	22216172
D005978	Glutathione	[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide	22216172
D005978	Glutathione	[SLC7A11 gene mutant form results in increased susceptibility to Paraquat] which results in decreased abundance of Glutathione	23085521
D005978	Glutathione	SLC7A11 results in increased abundance of Glutathione	19015640
D005978	Glutathione	[SLC7A11 results in increased abundance of Glutathione] which results in decreased abundance of Reactive Oxygen Species	19015640
D005978	Glutathione	[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione	19015640
D005978	Glutathione	[[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione] which results in increased abundance of Reactive Oxygen Species	19015640
C071834	glycidamide	glycidamide results in increased expression of SLC7A11 mRNA	17822822\|2328771
C004312	glycidol	glycidol results in increased expression of SLC7A11 mRNA	24915197
D006052	Gold Sodium Thiomalate	Gold Sodium Thiomalate results in decreased expression of SLC7A11 mRNA	19192274
D006861	Hydrogen Peroxide	[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide	22216172
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of SLC7A11 mRNA	23410634
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of SLC7A11 mRNA	18951874
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of SLC7A11 mRNA	12414654
D006997	Hypochlorous Acid	Hypochlorous Acid results in increased expression of SLC7A11 mRNA	19376150
D007052	Ibuprofen	Ibuprofen results in increased expression of SLC7A11 mRNA	25596134
C492448	ICG 001	ICG 001 results in increased expression of SLC7A11 mRNA	26191083
D007213	Indomethacin	Indomethacin results in increased expression of SLC7A11 mRNA	17401462
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SLC7A11 mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of SLC7A11 mRNA	22904298\|2479639
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of SLC7A11 mRNA]	25890327
C410337	K 7174	K 7174 results in increased expression of SLC7A11 mRNA	24086573
C008261	lead acetate	lead acetate results in increased expression of SLC7A11 mRNA	22839698\|2756223
C008261	lead acetate	lead acetate results in increased expression of SLC7A11 mRNA	25270620
C045463	leflunomide	leflunomide results in increased expression of SLC7A11 mRNA	28988120
D001556	Lindane	Lindane results in increased expression of SLC7A11 mRNA	24356939\|2619864
D008070	Lipopolysaccharides	(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of SLC7A11 mRNA]	25890327
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SLC7A11 mRNA	25890327
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SLC7A11 mRNA	26378955
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SLC7A11 mRNA	21641980
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SLC7A11 mRNA	26378955
C042720	mercuric bromide	mercuric bromide results in increased expression of SLC7A11 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
D008687	Metformin	Metformin results in increased expression of SLC7A11 mRNA	25596134
D008694	Methamphetamine	Methamphetamine results in increased expression of SLC7A11 mRNA	28619521
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLC7A11 mRNA	20938992
D008727	Methotrexate	Methotrexate results in decreased expression of SLC7A11 mRNA	19192274
D008753	Methylenebis(chloroaniline)	Methylenebis(chloroaniline) results in increased expression of SLC7A11 mRNA	26198647
D008752	Methylene Chloride	Methylene Chloride results in increased expression of SLC7A11 mRNA	20359517
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of SLC7A11 mRNA	23103053
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of SLC7A11 mRNA	23179753\|2627250
C004925	methylmercuric chloride	SLC7A11 gene SNP affects the susceptibility to methylmercuric chloride	25622337
C004925	methylmercuric chloride	[methylmercuric chloride affects the localization of NFE2L2 protein] which results in increased expression of SLC7A11 mRNA	20421342
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of SLC7A11 mRNA	22129749
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of SLC7A11 mRNA	18815141\|2135116
D008767	Methylmercury Compounds	NFE2L2 mRNA affects the reaction [Methylmercury Compounds results in increased expression of SLC7A11 mRNA]	21351162
D020366	Methylmethacrylate	Methylmethacrylate results in increased expression of SLC7A11 mRNA	16916219
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of SLC7A11 mRNA	24810058
D008775	Methylprednisolone	Methylprednisolone results in decreased expression of SLC7A11 mRNA	19192274
D016685	Mitomycin	Mitomycin results in decreased expression of SLC7A11 mRNA	26198647
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of SLC7A11 mRNA	24356939
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of SLC7A11 mRNA	23876855
C437683	motexafin gadolinium	motexafin gadolinium results in increased expression of SLC7A11 mRNA	16357179
C437683	motexafin gadolinium	[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC7A11 mRNA	16357179
D009173	Mycophenolic Acid	Mycophenolic Acid results in decreased expression of SLC7A11 mRNA	24356939
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of SLC7A11 mRNA"	25554681
C031721	naphthalene	naphthalene analog results in increased expression of SLC7A11 mRNA	24976557
D009285	Naphthoquinones	Naphthoquinones results in increased expression of SLC7A11 mRNA	23811387
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of SLC7A11 mRNA	19812364
D009532	Nickel	Nickel results in increased expression of SLC7A11 mRNA	24768652\|2558310
C022838	nickel chloride	nickel chloride results in increased expression of SLC7A11 mRNA	17312168
C022838	nickel chloride	nickel chloride affects the expression of SLC7A11 mRNA	22110744
C029938	nickel sulfate	nickel sulfate results in increased expression of SLC7A11 mRNA	22714537
C014112	N-methyl-4-aminophenol	SLC7A11 gene SNP affects the susceptibility to N-methyl-4-aminophenol	25622337
C025256	nonylphenol	nonylphenol results in increased expression of SLC7A11 mRNA	15159206
C570897	NSC668394	NSC668394 results in increased expression of SLC7A11 mRNA	27137931
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of SLC7A11 mRNA	20971185
C025589	ochratoxin A	ochratoxin A affects the expression of SLC7A11 mRNA	23824090
D010069	Oxadiazoles	[Oxadiazoles analog co-treated with FGF2 protein] results in increased expression of SLC7A11 mRNA	23212921
D010100	Oxygen	Oxygen deficiency results in decreased expression of SLC7A11 mRNA	25596134\|2651600
D010126	Ozone	Ozone results in increased expression of SLC7A11 mRNA	28652203
D010126	Ozone	Ozone results in increased expression of SLC7A11 mRNA	17095637
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of SLC7A11 mRNA	26272509
D010269	Paraquat	[alpha-Tocopherol co-treated with Paraquat] results in increased expression of SLC7A11 mRNA	24530478
D010269	Paraquat	[alpha-Tocopherol co-treated with Paraquat] results in increased expression of SLC7A11 protein	24530478
D010269	Paraquat	Paraquat results in increased expression of SLC7A11 mRNA	23085521
D010269	Paraquat	SLC7A11 gene mutant form results in increased susceptibility to Paraquat	23085521
D010269	Paraquat	[SLC7A11 gene mutant form results in increased susceptibility to Paraquat] which results in decreased abundance of Glutathione	23085521
D052638	Particulate Matter	Particulate Matter results in increased expression of SLC7A11 mRNA	21703343\|2308503
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of SLC7A11 mRNA	18593933
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether analog results in increased expression of SLC7A11 mRNA	19095052
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of SLC7A11 mRNA	26705709
D010634	Phenobarbital	Phenobarbital results in increased expression of SLC7A11 mRNA	19084549
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC7A11 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of SLC7A11 mRNA	19482888
D019800	Phenol	Phenol results in increased expression of SLC7A11 mRNA	26198647
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of SLC7A11 mRNA	26272509
D010894	Piroxicam	Piroxicam results in decreased expression of SLC7A11 mRNA	19192274
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls analog results in decreased expression of SLC7A11 mRNA	16474171
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of SLC7A11 mRNA	23608068
D011239	Prednisolone	Prednisolone results in decreased expression of SLC7A11 mRNA	19192274
D011239	Prednisolone	Prednisolone results in increased expression of SLC7A11 mRNA	24356939
D011374	Progesterone	Progesterone results in increased expression of SLC7A11 mRNA	18037150
D015742	Propofol	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Propofol results in decreased expression of SLC7A11 protein]	28663055
D015742	Propofol	Propofol results in decreased expression of SLC7A11 protein	28663055
D011441	Propylthiouracil	Propylthiouracil results in increased expression of SLC7A11 mRNA	24780913
D011794	Quercetin	Quercetin results in increased expression of SLC7A11 mRNA	21632981\|2619864
C049331	racecadotril	racecadotril results in increased expression of SLC7A11 mRNA	25424538
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of SLC7A11 mRNA	16497877
D017382	Reactive Oxygen Species	[SLC7A11 results in increased abundance of Glutathione] which results in decreased abundance of Reactive Oxygen Species	19015640
D017382	Reactive Oxygen Species	[[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione] which results in increased abundance of Reactive Oxygen Species	19015640
C031389	resorcinol	resorcinol results in decreased expression of SLC7A11 mRNA	22623647\|2619864
C064116	S-(1,1,2,2-tetrafluoroethyl)cysteine	"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of SLC7A11 mRNA"	16678137
C093642	SB 203580	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of SLC7A11 mRNA]	28329830
D012643	Selenium	SLC7A11 mRNA results in increased import of Selenium	28070112
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of SLC7A11 mRNA	19073995
D012834	Silver	Silver results in increased expression of SLC7A11 mRNA	26014281\|2895954
D012834	Silver	Silver results in increased expression of SLC7A11 mRNA	27131904
C403258	si-wu-tang	si-wu-tang results in increased expression of SLC7A11 mRNA	21464939
C017947	sodium arsenite	sodium arsenite affects the methylation of SLC7A11 gene	28589171
C017947	sodium arsenite	sodium arsenite results in increased expression of SLC7A11 mRNA	20886546\|2128196
C017947	sodium arsenite	sodium arsenite results in increased expression of SLC7A11	29204679
C016104	sodium bichromate	sodium bichromate affects the expression of SLC7A11 mRNA	22110744
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of SLC7A11 mRNA	27257137
D018038	Sodium Selenite	Sodium Selenite results in increased expression of SLC7A11 mRNA	24383545
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SLC7A11 mRNA	26378955
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SLC7A11 mRNA	21641980
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SLC7A11 mRNA	26378955
D012460	Sulfasalazine	Sulfasalazine results in decreased activity of SLC7A11 protein	20007406
D012460	Sulfasalazine	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA]	19015640
D012460	Sulfasalazine	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA]	19015640
D012460	Sulfasalazine	Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]	19576933
D012460	Sulfasalazine	Sulfasalazine results in decreased activity of SLC7A11 protein	19015640
D012460	Sulfasalazine	[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione	19015640
D012460	Sulfasalazine	[[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione] which results in increased abundance of Reactive Oxygen Species	19015640
D012460	Sulfasalazine	[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein	19015640
D012460	Sulfasalazine	[[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA	19015640
D012460	Sulfasalazine	[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA	19015640
D012460	Sulfasalazine	[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA	19015640
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of SLC7A11 mRNA	25424538
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of SLC7A11 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of SLC7A11 mRNA	26159488
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SLC7A11 mRNA	20106945\|2229881
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SLC7A11 mRNA	21632981
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SLC7A11 mRNA	26159488
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SLC7A11 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SLC7A11 mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of SLC7A11 mRNA	17200146\|2619864
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of SLC7A11 mRNA	17200146
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SLC7A11 mRNA	25613284
C020809	tetrathiomolybdate	tetrathiomolybdate analog results in increased expression of SLC7A11 mRNA	19323979
D013893	Thiram	Thiram results in increased expression of SLC7A11 mRNA	24211530
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of SLC7A11 mRNA	22363418\|2740439
D014028	Tobacco Smoke Pollution	NFE2L2 protein promotes the reaction [Tobacco Smoke Pollution affects the expression of SLC7A11 mRNA]	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of SLC7A11 mRNA	20133372
D014050	Toluene	Toluene results in increased expression of SLC7A11 mRNA	20359517\|2824598
D014212	Tretinoin	Tretinoin results in decreased expression of SLC7A11 mRNA	21934132\|2372400
C034613	triacsin C	triacsin C results in increased expression of SLC7A11 mRNA	16704987
D014241	Trichloroethylene	Trichloroethylene results in increased expression of SLC7A11 mRNA	20359517
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of SLC7A11 mRNA	24935251\|2627250
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of SLC7A11 mRNA	19042947
C050414	tripterine	SLC7A11 protein results in decreased susceptibility to tripterine	20007406
C050414	tripterine	tripterine results in increased expression of SLC7A11 mRNA	17010675
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of SLC7A11 mRNA	29024780
D014415	Tunicamycin	Tunicamycin results in increased expression of SLC7A11 mRNA	17127020
D014520	Urethane	Urethane results in increased expression of SLC7A11 mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of SLC7A11 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of SLC7A11 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in decreased expression of SLC7A11 mRNA	24896083
C100058	vanillin	vanillin results in increased expression of SLC7A11 mRNA	17178418
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of SLC7A11 gene	25560391
D014750	Vincristine	Vincristine results in increased expression of SLC7A11 mRNA	23649840
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of SLC7A11 mRNA	12414654\|2341063
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC7A11 mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of SLC7A11 mRNA	26272509
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of SLC7A11 mRNA	18593933
D019345	Zinc Acetate	[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC7A11 mRNA	16357179
D019345	Zinc Acetate	Zinc Acetate results in increased expression of SLC7A11 mRNA	16357179
D015054	Zymosan	Zymosan results in increased expression of SLC7A11 mRNA	17200146
D015054	Zymosan	SLC7A11 gene mutant form inhibits the reaction [Zymosan results in increased activity of CASP3 protein]	17200146
D015054	Zymosan	Zymosan results in increased expression of SLC7A11 mRNA	17200146

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	21397861
GO:0015179	L-amino acid transmembrane transporter activity	-	IBA	21873635
GO:0015327	cystine:glutamate antiporter activity	-	TAS	10206947

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003333	amino acid transmembrane transport	-	IBA	21873635
GO:0006979	response to oxidative stress	-	IEA	-
GO:0007420	brain development	-	IEA	-
GO:0009636	response to toxic substance	-	IDA	17575980
GO:0015813	L-glutamate transmembrane transport	-	IEA	-
GO:0035094	response to nicotine	-	IEA	-
GO:0050900	leukocyte migration	-	TAS	-
GO:0070306	lens fiber cell differentiation	-	IEA	-
GO:0070527	platelet aggregation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005791	rough endoplasmic reticulum	-	IEA	-
GO:0005856	cytoskeleton	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0009986	cell surface	-	IDA	25063885
GO:0016021	integral component of membrane	-	TAS	10206947

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-202733	Cell surface interactions at the vascular wall	TAS
R-HSA-210991	Basigin interactions	TAS
R-HSA-352230	Amino acid transport across the plasma membrane	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides	TAS
R-HSA-425407	SLC-mediated transmembrane transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29789716	xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression. (2018 May 23)	Ji X	Oncogene