Gene: CEMIP2

23670
TMEM2
cell migration inducing hyaluronidase 2
protein-coding
9q21.13
Ensembl:ENSG00000135048 MIM:605835 Vega:OTTHUMG00000020000 UniprotKB:Q9UHN6
NG_053053.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.205e-1 (AD)  5.153e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1010434chr9:71710517 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of CEMIP2 mRNA"19095052
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CEMIP2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CEMIP2 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CEMIP2 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEMIP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEMIP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEMIP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEMIP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEMIP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEMIP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEMIP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEMIP2 mRNA"27188386
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CEMIP2 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CEMIP2 mRNA21632981|2187194
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CEMIP2 mRNA"26238291
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of CEMIP2 mRNA]24758408
D004958EstradiolEstradiol results in increased expression of CEMIP2 mRNA24758408
C006780bisphenol Abisphenol A affects the expression of CEMIP2 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CEMIP2 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of CEMIP2 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of CEMIP2 mRNA25979313
C018021cobaltous chloridecobaltous chloride results in decreased expression of CEMIP2 mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of CEMIP2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of CEMIP2 mRNA20106945|2214713
D016572CyclosporineCyclosporine results in increased expression of CEMIP2 mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CEMIP2 mRNA28628672
D002945CisplatinCisplatin results in increased expression of CEMIP2 mRNA27392435
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of CEMIP2 mRNA"27840820
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of CEMIP2 mRNA25380136
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CEMIP2 mRNA22079256
D005557FormaldehydeFormaldehyde results in decreased expression of CEMIP2 mRNA20655997
D005557FormaldehydeFormaldehyde results in increased expression of CEMIP2 mRNA23649840
C069837fullerene C60fullerene C60 affects the expression of CEMIP2 mRNA19167457
D005897GlafenineGlafenine results in increased expression of CEMIP2 mRNA24136188
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CEMIP2 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CEMIP2 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CEMIP2 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CEMIP2 mRNA21889194|2194939
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CEMIP2 mRNA28001369
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of CEMIP2 mRNA25380136
D009532NickelNickel results in increased expression of CEMIP2 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide affects the expression of CEMIP2 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CEMIP2 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of CEMIP2 mRNA24236059
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of CEMIP2 mRNA19095052
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEMIP2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CEMIP2 mRNA26272509
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CEMIP2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CEMIP2 mRNA22079256
D011441PropylthiouracilPropylthiouracil results in increased expression of CEMIP2 mRNA24780913
D011794QuercetinQuercetin results in increased expression of CEMIP2 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CEMIP2 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CEMIP2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CEMIP2 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CEMIP2 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CEMIP2 mRNA25729387
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEMIP2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CEMIP2 mRNA24935251|2627250
D014520UrethaneUrethane results in increased expression of CEMIP2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEMIP2 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of CEMIP2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of CEMIP2 mRNA23179753|2718838
C025643vinclozolinvinclozolin results in decreased expression of CEMIP2 mRNA23034163
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEMIP2 mRNA"27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004415hyalurononglucosaminidase activity-IDA28246172  
GO:0005509calcium ion binding-IDA28246172  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0030214hyaluronan catabolic process-IDA28246172  
GO:1903670regulation of sprouting angiogenesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-IDA28246172  
GO:0016021integral component of membrane-TAS10767548  
GO:0070062extracellular exosome-HDA19056867  20458337  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal