Gene: TMEFF2

23671
CT120.2|HPP1|TENB2|TPEF|TR|TR-2
transmembrane protein with EGF like and two follistatin like domains 2
protein-coding
2q32.3
Ensembl:ENSG00000144339 MIM:605734 Vega:OTTHUMG00000132723 UniprotKB:Q9UIK5
NC_000002.12
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.731e-1 (AD)  8.992e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNAI10.902
RAB33A0.898
MFSD60.897
STK390.894
NKAIN20.882
C12orf760.88
RAP1GDS10.877
ANK30.875
YPEL20.871
SNCA0.867

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF135-0.575
RREB1-0.562
ZIC5-0.557
GJB2-0.554
INHBB-0.549
SLC2A4-0.548
CDC14A-0.542
LYN-0.531
RHOJ-0.529
MCC-0.524

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of TMEFF2 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TMEFF2 mRNA"27413110
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEFF2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEFF2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEFF2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEFF2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEFF2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEFF2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEFF2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEFF2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TMEFF2 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of TMEFF2 mRNA"19936710
D013196DihydrotestosteroneAR protein affects the reaction [Dihydrotestosterone results in increased expression of TMEFF2 protein]23405127
D013196Dihydrotestosteronebicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of TMEFF2 protein]23405127
D013196DihydrotestosteroneDactinomycin inhibits the reaction [Dihydrotestosterone results in increased expression of TMEFF2 mRNA]23405127
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of TMEFF2 mRNA23405127
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of TMEFF2 protein23405127
D013196DihydrotestosteroneTMEFF2 5' UTR affects the reaction [Dihydrotestosterone results in increased expression of TMEFF2 protein]23405127|2340512
D001151ArsenicArsenic affects the methylation of TMEFF2 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of TMEFF2 mRNA26705709
C015001arsenitearsenite results in increased methylation of TMEFF2 promoter23974009
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TMEFF2 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TMEFF2 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of TMEFF2 mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TMEFF2 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TMEFF2 mRNA21569818|2261060
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TMEFF2 mRNA27195522
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TMEFF2 mRNA"20018196|2038263
D004958EstradiolEstradiol results in increased expression of TMEFF2 mRNA19484750
C053541bicalutamidebicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of TMEFF2 protein]23405127
C006780bisphenol Abisphenol A results in decreased expression of TMEFF2 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of TMEFF2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TMEFF2 gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of TMEFF2 mRNA26079696
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TMEFF2 mRNA27858113
D003022Clotrimazole[Clotrimazole results in increased phosphorylation of EIF2A protein] which results in increased expression of TMEFF2 protein23405127
D003609DactinomycinDactinomycin inhibits the reaction [Dihydrotestosterone results in increased expression of TMEFF2 mRNA]23405127
D013759DronabinolDronabinol results in decreased expression of TMEFF2 mRNA16597638
C118739entinostatentinostat results in decreased expression of TMEFF2 mRNA27188386
C118739entinostatentinostat results in increased expression of TMEFF2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEFF2 mRNA"27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TMEFF2 mRNA23649840
D004397FonofosFonofos results in increased methylation of TMEFF2 promoter22847954
C039281furanfuran results in increased expression of TMEFF2 mRNA27387713
D007213IndomethacinIndomethacin results in decreased expression of TMEFF2 mRNA16984733
C544151jinfukangjinfukang results in decreased expression of TMEFF2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of TMEFF2 mRNA23430699
D007649KetamineKetamine results in decreased expression of TMEFF2 mRNA20080153
D007854LeadLead results in increased expression of TMEFF2 mRNA19921347
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of TMEFF2 mRNA"24972896
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TMEFF2 mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of TMEFF2 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TMEFF2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TMEFF2 mRNA"25554681
D010278ParathionParathion results in increased methylation of TMEFF2 promoter22847954
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of TMEFF2 mRNA23602845
D010476PerfumePerfume results in increased expression of TMEFF2 mRNA24768652
D010634PhenobarbitalPhenobarbital affects the expression of TMEFF2 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEFF2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TMEFF2 mRNA26272509
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TMEFF2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TMEFF2 mRNA23806026
C017947sodium arsenitesodium arsenite results in increased expression of TMEFF2 mRNA22714537
C012568terbufosterbufos results in increased methylation of TMEFF2 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TMEFF2 mRNA26290441
D013849ThimerosalThimerosal results in increased expression of TMEFF2 mRNA27188386
C009495titanium dioxidetitanium dioxide results in decreased expression of TMEFF2 mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TMEFF2 mRNA20133372
D014212TretinoinTretinoin results in increased expression of TMEFF2 mRNA21934132
D014212TretinoinTretinoin results in increased expression of TMEFF2 mRNA16604517
C012589trichostatin Atrichostatin A results in decreased expression of TMEFF2 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of TMEFF2 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TMEFF2 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEFF2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TMEFF2 mRNA23179753|2597931
D014635Valproic AcidValproic Acid results in decreased expression of TMEFF2 mRNA27188386|2800136
D014635Valproic AcidValproic Acid results in increased expression of TMEFF2 mRNA19101580|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TMEFF2 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEFF2 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of TMEFF2 mRNA27188386
C111237vorinostatvorinostat results in increased expression of TMEFF2 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0030336negative regulation of cell migration-IDA24632071  
GO:0044319wound healing, spreading of cells-IDA24632071  
GO:0045720negative regulation of integrin biosynthetic process-IMP24632071  
GO:0051497negative regulation of stress fiber assembly-IDA24632071  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0016021integral component of membrane-NAS10903839  10987305  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27799384Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study. (2016 Nov)Wilson SJEur Respir J