Gene: STX12

23673
STX13|STX14
syntaxin 12
protein-coding
1p35.3
Ensembl:ENSG00000117758 MIM:606892 Vega:OTTHUMG00000003730 UniprotKB:Q86Y82
NC_000001.11
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.497e-3 (AD)  2.704e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHMP2B0.958
KHDRBS10.947
WBP40.947
PPP6C0.946
C11orf580.945
TMEM30A0.941
CDC420.941
SKP10.94
GDI20.939
HNRNPDL0.939

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.765
OR4F29-0.756
MTRNR2L6-0.252
FOXJ1-0.238
MTRNR2L10-0.229
MTRNR2L9-0.229
MMP23B-0.2
EVC2-0.19
FAM151A-0.19
TTLL10-0.188

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of STX12 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of STX12 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of STX12 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of STX12 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of STX12 mRNA17562736
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of STX12 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of STX12 mRNA16483693
D001151ArsenicArsenic affects the methylation of STX12 gene25304211
D001280AtrazineAtrazine results in decreased expression of STX12 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of STX12 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STX12 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STX12 mRNA21839799
C044887beta-methylcholinebeta-methylcholine affects the expression of STX12 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of STX12 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of STX12 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of STX12 mRNA25181051
D000069286BortezomibBortezomib results in increased expression of STX12 mRNA20977926
C013418bromfenacoumbromfenacoum results in decreased expression of STX12 protein28903499
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of STX12 protein24527689
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of STX12 mRNA15467011
D016572CyclosporineCyclosporine results in increased expression of STX12 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of STX12 mRNA19770486
D003703DemecolcineDemecolcine results in increased expression of STX12 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of STX12 mRNA28628672
C000944dicrotophosdicrotophos results in decreased expression of STX12 mRNA28302478
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of STX12 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of STX12 mRNA23649840
C492448ICG 001ICG 001 results in decreased expression of STX12 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of STX12 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of STX12 mRNA28628672
C544151jinfukangjinfukang results in decreased expression of STX12 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of STX12 mRNA15182950
C410337K 7174K 7174 results in increased expression of STX12 mRNA24086573
D007657Ketone BodiesKetone Bodies results in decreased expression of STX12 mRNA16807920
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of STX12 protein26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of STX12 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of STX12 protein26558463
C008493methylselenic acidmethylselenic acid results in increased expression of STX12 mRNA18548127
D008777MethyltestosteroneMethyltestosterone results in increased expression of STX12 mRNA29191790
D009020MorphineMorphine results in increased expression of STX12 mRNA15183518
C051752nefazodonenefazodone results in increased expression of STX12 mRNA24136188
C507134ON 01910ON 01910 results in increased expression of STX12 mRNA22351695
D010634PhenobarbitalPhenobarbital affects the expression of STX12 mRNA23091169
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of STX12 mRNA22714537
C017947sodium arsenitesodium arsenite affects the methylation of STX12 gene28589171
D012999SomanSoman results in decreased expression of STX12 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STX12 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of STX12 mRNA16611356
C012589trichostatin Atrichostatin A affects the expression of STX12 mRNA28542535
D014520UrethaneUrethane results in increased expression of STX12 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of STX12 mRNA24935251
D014750VincristineVincristine results in increased expression of STX12 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000149SNARE binding-IBA21873635  
GO:0005484SNAP receptor activity-IBA21873635  
GO:0005515protein binding-IPI12191018  15469992  19546860  24095276  25416956  26359495  
GO ID GO Term Qualifier Evidence PubMed
GO:0000045autophagosome assembly-IMP24095276  
GO:0006886intracellular protein transport-IBA21873635  
GO:0006906vesicle fusion-IBA21873635  
GO:0033344cholesterol efflux-IDA15469992  
GO:0048278vesicle docking-IBA21873635  
GO:0050821protein stabilization-IDA15469992  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0000407phagophore assembly site-IMP24095276  
GO:0008021synaptic vesicle-IBA21873635  
GO:0012505endomembrane system-IBA21873635  
GO:0016021integral component of membrane-IBA21873635  
GO:0030285integral component of synaptic vesicle membrane-IBA21873635  
GO:0031083BLOC-1 complexcolocalizes_withIDA19546860  
GO:0031201SNARE complex-IBA21873635  
GO:0031201SNARE complex-IDA19546860  
GO:0031901early endosome membrane-IEA-  
GO:0031982vesicle-IMP24095276  
GO:0045121membrane raft-IDA15469992  
GO:0045335phagocytic vesicle-IDA15469992  
GO:0055038recycling endosome membrane-IEA-  
GO:0098837postsynaptic recycling endosome-IBA21873635  
KEGG ID KEGG Term
hsa04145Phagosome
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16462896Integrative strategies to identify candidate genes in rodent models of human alcoholism. (2006 Jan)Treadwell JAGenome