Gene: RAB38

23682
NY-MEL-1|rrGTPbp
RAB38, member RAS oncogene family
protein-coding
11q14.2
Ensembl:ENSG00000123892 MIM:606281 Vega:OTTHUMG00000167288 UniprotKB:P57729
NC_000011.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.836e-1 (AD)  7.205e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs302665chr11:88146459 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SIGLEC70.776
ARL110.76
ARHGAP150.755
KYNU0.747
DAPP10.747
CD1D0.744
NABP10.74
SNX200.74
MS4A4A0.737
TLR80.735

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARSF-0.421
HES5-0.366
WNT7A-0.361
PYGM-0.339
CPLX3-0.335
WFDC1-0.326
HPDL-0.323
ATP2C2-0.316
KCNIP3-0.306
SLC13A5-0.298

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of RAB38 mRNA"26377693
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of RAB38 mRNA"21346803
C5850042-monochloropropanediol2-monochloropropanediol results in decreased expression of RAB38 mRNA28522335
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAB38 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAB38 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of RAB38 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of RAB38 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of RAB38 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RAB38 gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of RAB38 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RAB38 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RAB38 mRNA20064835
C006780bisphenol Abisphenol A results in decreased expression of RAB38 mRNA25181051
D002065BuspironeBuspirone results in decreased expression of RAB38 mRNA24136188
C084597chlorcyclizinechlorcyclizine results in increased expression of RAB38 mRNA21058326
C100187chloropicrinchloropicrin results in decreased expression of RAB38 mRNA26352163
D003687DehydroepiandrosteroneDehydroepiandrosterone results in decreased expression of RAB38 mRNA16940010
D003907DexamethasoneDexamethasone results in decreased expression of RAB38 mRNA22733784
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of RAB38 mRNA28962523
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of RAB38 mRNA21852083
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of RAB38 mRNA17005392
D005485FlutamideFlutamide results in decreased expression of RAB38 mRNA24793618
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of RAB38 mRNA21782745
D005897GlafenineGlafenine results in decreased expression of RAB38 mRNA24136188
C412815GW 4064GW 4064 results in increased expression of RAB38 mRNA26655953
D017313FenretinideFenretinide results in decreased expression of RAB38 mRNA28973697
C045463leflunomideleflunomide results in decreased expression of RAB38 mRNA24136188
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of RAB38 mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RAB38 mRNA23179753
D008774MethylphenidateMethylphenidate results in increased expression of RAB38 mRNA22470460
C523799MRK 003RAB38 results in decreased susceptibility to MRK 00319903844
C051752nefazodonenefazodone results in decreased expression of RAB38 mRNA24136188
C012655nimesulidenimesulide results in decreased expression of RAB38 mRNA24136188
D010098OxycodoneOxycodone results in decreased expression of RAB38 mRNA23439660
D010100OxygenOxygen deficiency results in decreased expression of RAB38 mRNA20880076
D010126OzoneOzone results in decreased expression of RAB38 mRNA16330353
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of RAB38 mRNA19162173
C006253pirinixic acidpirinixic acid results in decreased expression of RAB38 mRNA19162173
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of RAB38 mRNA22714537
D011441PropylthiouracilPropylthiouracil results in increased expression of RAB38 mRNA24780913
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of RAB38 mRNA21852083
D015474IsotretinoinIsotretinoin results in decreased expression of RAB38 mRNA20436886
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RAB38 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of RAB38 mRNA25351596
C017947sodium arsenitesodium arsenite results in decreased expression of RAB38 mRNA28595984
D053260SootSoot results in decreased expression of RAB38 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RAB38 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RAB38 mRNA21215274
D019284ThapsigarginThapsigargin results in decreased expression of RAB38 protein24648495
C402769tipifarnibtipifarnib results in increased expression of RAB38 mRNA16403772
D014212TretinoinTretinoin results in increased expression of RAB38 mRNA20488242
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of RAB38 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of RAB38 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAB38 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of RAB38 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of RAB38 mRNA23179753|2627250
D014635Valproic AcidValproic Acid affects the expression of RAB38 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RAB38 gene25560391
C111237vorinostatvorinostat results in increased expression of RAB38 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IBA21873635  
GO:0003924GTPase activity-NAS10910072  
GO:0005515protein binding-IPI22511774  
GO:0005525GTP binding-NAS10910072  22511774  
GO:0030742GTP-dependent protein binding-IPI22511774  
GO:0035612AP-2 adaptor complex bindingNOTIDA22511774  
GO:0035650AP-1 adaptor complex binding-IPI22511774  
GO:0035651AP-3 adaptor complex binding-IPI22511774  
GO:0036461BLOC-2 complex binding-IPI22511774  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IBA21873635  
GO:0007005mitochondrion organization-IMP25767741  
GO:0007264small GTPase mediated signal transduction-NAS10910072  
GO:0015031protein transport-NAS10910072  
GO:0016192vesicle-mediated transport-IEA-  
GO:0032438melanosome organization-IBA21873635  
GO:0032482Rab protein signal transduction-IBA21873635  
GO:0035646endosome to melanosome transport-IMP22511774  
GO:0043687post-translational protein modification-TAS-  
GO:0060155platelet dense granule organization-IEA-  
GO:0072657protein localization to membrane-IMP22511774  25767741  
GO:0090383phagosome acidification-IMP21255211  
GO:1903232melanosome assembly-IDA23084991  
GO:1903232melanosome assembly-IMP22511774  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA25767741  
GO:0005764lysosome-IDA25767741  
GO:0005769early endosome-IDA22511774  
GO:0005783endoplasmic reticulum-IEA-  
GO:0005802trans-Golgi network-IBA21873635  
GO:0005802trans-Golgi network-IEA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0012505endomembrane system-IBA21873635  
GO:0016020membrane-IDA22511774  
GO:0030670phagocytic vesicle membrane-IEA-  
GO:0031905early endosome lumenNOTIDA22511774  
GO:0033162melanosome membrane-IDA23084991  
GO:0033162melanosome membrane-TAS-  
GO:0042470melanosome-IBA21873635  
GO:0042470melanosome-IDA22511774  
GO:0044233ER-mitochondrion membrane contact site-IDA25767741  
GO:0045335phagocytic vesicle-IDA21255211  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8873719RAB geranylgeranylationTAS
R-HSA-8876198RAB GEFs exchange GTP for GDP on RABsTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal