Gene: BHMT2

23743
-
betaine--homocysteine S-methyltransferase 2
protein-coding
5q14.1
Ensembl:ENSG00000132840 MIM:605932 Vega:OTTHUMG00000108158 UniprotKB:Q9H2M3
NG_029157.1
PubMed
0   ANCO-SNPs
ND
2   
9.286e-1 (AD)  4.953e-1 (ND)   (Frontal_Cortex)
4.902e-1 (AD)  5.264e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF2170.748
ZFP36L10.732
CD3020.731
PRKD30.729
RREB10.724
CMTM60.72
EPS80.719
YAP10.716
MAML20.712
ANO60.71

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.422
PPEF1-0.416
NEUROD6-0.408
TMEFF2-0.407
KCNB2-0.405
GALNT14-0.403
ATOH7-0.398
HAS1-0.393
E2F1-0.392
ADTRP-0.385

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00134MethionineSmall Molecule63-68-3Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of BHMT2 mRNA"28903501
C4901661-(4-methoxyphenyl)piperazine1-(4-methoxyphenyl)piperazine results in decreased expression of BHMT2 mRNA26821219
C0780921-piperonylpiperazine1-piperonylpiperazine results in decreased expression of BHMT2 mRNA26821219
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of BHMT2 mRNA"21724226
D000082AcetaminophenAcetaminophen results in decreased expression of BHMT2 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of BHMT2 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of BHMT2 mRNA17562736
D000082AcetaminophenBHMT2 protein results in increased metabolism of and results in increased susceptibility to Acetaminophen19923254
D012436S-AdenosylmethionineS-Adenosylmethionine inhibits the reaction [BHMT2 protein results in increased metabolism of Vitamin U]18230605
D016604Aflatoxin B1Aflatoxin B1 affects the expression of BHMT2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of BHMT2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of BHMT2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BHMT2 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to BHMT2 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BHMT2 mRNA19770486
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BHMT2 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of BHMT2 mRNA27685785
C006780bisphenol Abisphenol A affects the methylation of BHMT2 promoter27415467
C006780bisphenol Abisphenol A results in decreased expression of BHMT2 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of BHMT2 mRNA27339419
D019327Copper SulfateCopper Sulfate results in increased expression of BHMT2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of BHMT2 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of BHMT2 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of BHMT2 mRNA19770486
C093628cyproconazolecyproconazole results in decreased expression of BHMT2 mRNA22334560
C014347decitabinedecitabine results in increased expression of BHMT2 mRNA15251184
C014347decitabine[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of BHMT2 mRNA15251184
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BHMT2 mRNA28628672
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of BHMT2 mRNA28943392
C109476epoxiconazoleepoxiconazole results in decreased expression of BHMT2 mRNA22334560
C039281furanfuran results in increased methylation of BHMT2 gene22079235
D005839GentamicinsGentamicins results in decreased expression of BHMT2 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of BHMT2 mRNA24136188
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BHMT2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BHMT2 mRNA28628672
D008694MethamphetamineMethamphetamine affects the expression of BHMT2 mRNA19564919
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] affects the expression of BHMT2 mRNA19564919
D008715MethionineMethionine inhibits the reaction [BHMT2 protein results in increased metabolism of Vitamin U]18230605
C461488N-benzylpiperazineN-benzylpiperazine results in decreased expression of BHMT2 mRNA26821219
C012655nimesulidenimesulide results in decreased expression of BHMT2 mRNA24136188
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of BHMT2 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of BHMT2 mRNA19710929
D011192Potassium DichromatePotassium Dichromate results in increased expression of BHMT2 mRNA23608068
C045950propiconazolepropiconazole results in decreased expression of BHMT2 mRNA21278054|2233456
C015586propiverinepropiverine binds to BHMT2 protein29273565
D011794QuercetinQuercetin results in decreased expression of BHMT2 mRNA21632981
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] affects the expression of BHMT2 mRNA19564919
C534628SCH 23390SCH 23390 affects the expression of BHMT2 mRNA19564919
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of BHMT2 mRNA23806026|2589566
C017947sodium arsenitesodium arsenite results in increased expression of BHMT2 mRNA25493608
D012969Sodium FluorideSodium Fluoride results in decreased expression of BHMT2 mRNA27862939
C004648testosterone enanthatetestosterone enanthate affects the expression of BHMT2 mRNA17440010
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of BHMT2 mRNA15251184
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BHMT2 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BHMT2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BHMT2 mRNA21724226
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BHMT2 mRNA18465118
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of BHMT2 mRNA28943392
D014640VancomycinVancomycin results in increased expression of BHMT2 mRNA18930951
C029297vinylidene chloridevinylidene chloride results in decreased expression of BHMT2 mRNA26682919
D014814Vitamin UBHMT2 protein results in increased metabolism of Vitamin U18230605
D014814Vitamin UMethionine inhibits the reaction [BHMT2 protein results in increased metabolism of Vitamin U]18230605
D014814Vitamin US-Adenosylmethionine inhibits the reaction [BHMT2 protein results in increased metabolism of Vitamin U]18230605

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008270zinc ion binding-IDA18230605  
GO:0047150betaine-homocysteine S-methyltransferase activity-IBA21873635  
GO:0047150betaine-homocysteine S-methyltransferase activityNOTIDA18230605  
GO:0061627S-methylmethionine-homocysteine S-methyltransferase activity-IBA21873635  
GO:0061627S-methylmethionine-homocysteine S-methyltransferase activity-IDA18230605  
GO:0061627S-methylmethionine-homocysteine S-methyltransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000096sulfur amino acid metabolic process-TAS-  
GO:0006577amino-acid betaine metabolic processNOTIDA18230605  
GO:0032259methylation-IEA-  
GO:0033477S-methylmethionine metabolic process-IDA18230605  
GO:0046500S-adenosylmethionine metabolic process-IDA18230605  
GO:0071267L-methionine salvage-IDA18230605  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1614635Sulfur amino acid metabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21254359Folate pathway and nonsyndromic cleft lip and palate. (2011 Jan)Blanton SHBirth Defects Res A Clin Mol Teratol
18635682Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. (2008 Nov)Giusti BJ Med Genet