Gene info: ID 23765

Gene: IL17RA

GENE ID: 23765

Synonyms: CANDF5|CD217|CDw217|IL-17RA|IL17R|IMD51|hIL-17R

Description: interleukin 17 receptor A

Gene type: protein-coding

Location: 22q11.1

dbXrefs: Ensembl:ENSG00000177663 MIM:605461 Vega:OTTHUMG00000150026 UniprotKB:Q96F46

RefSeq: NG_028257.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : 7.376e-1 (AD) 3.192e-1 (ND) (Frontal_Cortex)

Pascal p-value : 3.966e-2 (AD) 3.320e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CFLAR	0.79
ARHGAP30	0.788
RHBDF2	0.78
IL4R	0.774
GPSM3	0.773
STK10	0.772
TNFRSF1B	0.77
DISP1	0.768
TEP1	0.764
MYO1F	0.763

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NEUROD6	-0.411
CRH	-0.409
DLX1	-0.376
ABCC12	-0.373
CPLX3	-0.37
LYPD8	-0.367
WNT7A	-0.363
KIT	-0.357
KCNC2	-0.354
PVALB	-0.351

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of IL17RA mRNA	28329830
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL17RA mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL17RA mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of IL17RA mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of IL17RA gene	27153756
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased expression of IL17RA mRNA"	23195993
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of IL17RA mRNA	24449571
D001554	Benzene	Benzene results in decreased expression of IL17RA mRNA	15120971\|1512265
D004958	Estradiol	Estradiol affects the expression of IL17RA mRNA	15598610
C006780	bisphenol A	bisphenol A results in increased expression of IL17RA mRNA	25181051
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of IL17RA mRNA	24763279
D019327	Copper Sulfate	Copper Sulfate results in increased expression of IL17RA mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in increased expression of IL17RA mRNA	23958496
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of IL17RA mRNA	17361019
D015127	9,10-Dimethyl-1,2-benzanthracene	"IL17RA results in increased susceptibility to [9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate]"	22359662
D004785	Environmental Pollutants	Environmental Pollutants affects the expression of IL17RA mRNA	19118595
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of IL17RA mRNA	12072388
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of IL17RA mRNA	28329830
C069837	fullerene C60	fullerene C60 results in increased expression of IL17RA mRNA	19167457
D005947	Glucose	Glucose results in increased expression of IL17RA mRNA	18310510
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of IL17RA mRNA	24763279
D017313	Fenretinide	Fenretinide results in increased expression of IL17RA mRNA	28973697
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL17RA mRNA	25613284
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL17RA mRNA"	18930950
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of IL17RA mRNA	25613284
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of IL17RA mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of IL17RA mRNA"	25554681\|2562005
C051752	nefazodone	nefazodone results in decreased expression of IL17RA mRNA	24136188
D009532	Nickel	Nickel results in decreased expression of IL17RA mRNA	23195993
D009532	Nickel	Nickel results in increased expression of IL17RA mRNA	24768652\|2558310
C028007	nickel monoxide	nickel monoxide results in increased expression of IL17RA mRNA	19167457
C016030	pantogab	pantogab results in increased expression of IL17RA mRNA	17379144
D015232	Dinoprostone	IL17RA gene mutant form inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]	22359662
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of IL17RA mRNA	28903501
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of IL17RA mRNA	21602193
D016559	Tacrolimus	Tacrolimus results in increased expression of IL17RA mRNA	23958496
D013629	Tamoxifen	Tamoxifen affects the expression of IL17RA mRNA	20937368
D013629	Tamoxifen	Tamoxifen results in increased expression of IL17RA mRNA	25123088
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of IL17RA mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of IL17RA mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of IL17RA mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	IL17RA gene mutant form inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CXCL10 mRNA]	22359662
D013755	Tetradecanoylphorbol Acetate	IL17RA gene mutant form inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CXCL16 mRNA]	22359662
D013755	Tetradecanoylphorbol Acetate	IL17RA gene mutant form inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CXCL9 mRNA]	22359662
D013755	Tetradecanoylphorbol Acetate	IL17RA gene mutant form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL1 mRNA]	22359662
D013755	Tetradecanoylphorbol Acetate	IL17RA gene mutant form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]	22359662
D013755	Tetradecanoylphorbol Acetate	IL17RA gene mutant form inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]	22359662
D013755	Tetradecanoylphorbol Acetate	IL17RA gene mutant form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of S100A8 mRNA]	22359662
D013755	Tetradecanoylphorbol Acetate	IL17RA gene mutant form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of S100A9 mRNA]	22359662
D013755	Tetradecanoylphorbol Acetate	IL17RA gene mutant form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of S100A9 protein]	22359662
D013755	Tetradecanoylphorbol Acetate	IL17RA gene mutant form results in decreased susceptibility to Tetradecanoylphorbol Acetate	22359662
D013755	Tetradecanoylphorbol Acetate	[IL17RA gene mutant form results in decreased susceptibility to Tetradecanoylphorbol Acetate] which results in decreased expression of IL1B protein	22359662
D013755	Tetradecanoylphorbol Acetate	[IL17RA gene mutant form results in decreased susceptibility to Tetradecanoylphorbol Acetate] which results in decreased expression of TNF protein	22359662
D013755	Tetradecanoylphorbol Acetate	"IL17RA results in increased susceptibility to [9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate]"	22359662
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL17RA mRNA	25613284
D013849	Thimerosal	Thimerosal results in decreased expression of IL17RA mRNA	27188386
C009495	titanium dioxide	titanium dioxide results in increased expression of IL17RA mRNA	27760801
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL17RA mRNA"	18930950
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL17RA mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of IL17RA mRNA	23179753\|2627250
D014635	Valproic Acid	Valproic Acid results in increased methylation of IL17RA gene	29154799

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005102	signaling receptor binding	-	IEA	-
GO:0005515	protein binding	-	IPI	21993848
GO:0030368	interleukin-17 receptor activity	-	IBA	21873635
GO:0030368	interleukin-17 receptor activity	-	NAS	9367539

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007166	cell surface receptor signaling pathway	-	NAS	9367539
GO:0032747	positive regulation of interleukin-23 production	-	IDA	21145111
GO:0050832	defense response to fungus	-	IEA	-
GO:0071621	granulocyte chemotaxis	-	IEA	-
GO:0072537	fibroblast activation	-	IDA	21145111
GO:0097400	interleukin-17-mediated signaling pathway	-	TAS	-
GO:1900017	positive regulation of cytokine production involved in inflammatory response	-	IEA	-
GO:2000664	positive regulation of interleukin-5 secretion	-	IEA	-
GO:2000667	positive regulation of interleukin-13 secretion	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	NAS	9367539

KEGG ID	KEGG Term
hsa04060	Cytokine-cytokine receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-168256	Immune System	TAS
R-HSA-448424	Interleukin-17 signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27399111	Common variants in IL-17A/IL-17RA axis contribute to predisposition to and progression of congestive heart failure. (2016 Jul)	Sandip C	Medicine (Baltimore)