Gene: BRD1

23774
BRL|BRPF1|BRPF2
bromodomain containing 1
protein-coding
22q13.33
Ensembl:ENSG00000100425 MIM:604589 Vega:OTTHUMG00000150288 UniprotKB:O95696
NC_000022.11
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.453e-1 (AD)  6.212e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYVN10.916
LRRC410.91
CDK130.907
ZNF3840.907
QSOX20.903
DIDO10.901
TNRC6A0.9
RNF2160.899
SMPD40.899
ZZEF10.898

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.641
OR4F29-0.595
MTRNR2L9-0.323
MTRNR2L10-0.302
OR4F16-0.293
KLRC2-0.288
MTRNR2L6-0.287
TRDN-0.241
KLRB1-0.24
RSPO1-0.236

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of BRD1 mRNA28329830
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BRD1 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of BRD1 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BRD1 mRNA"27188386
D001151ArsenicArsenic affects the methylation of BRD1 gene25304211
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BRD1 mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of BRD1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of BRD1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of BRD1 mRNA21297351
D016572CyclosporineCyclosporine results in decreased methylation of BRD1 promoter27989131
D016572CyclosporineCyclosporine results in increased expression of BRD1 mRNA20106945|2556210
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of BRD1 mRNA23640034
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of BRD1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of BRD1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of BRD1 mRNA27392435
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of BRD1 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of BRD1 mRNA22079256
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of BRD1 mRNA28329830
D005557FormaldehydeFormaldehyde results in decreased expression of BRD1 mRNA20655997
C010974glyphosateglyphosate results in increased expression of BRD1 mRNA26302742
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of BRD1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound binds to BRD1 protein20871596
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of BRD1 promoter18448484
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of BRD1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of BRD1 mRNA19167457
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of BRD1 mRNA"12756304
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of BRD1 mRNA17560707
C006253pirinixic acidpirinixic acid results in decreased expression of BRD1 mRNA20813756
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of BRD1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of BRD1 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in decreased expression of BRD1 protein23718831
D012402RotenoneRotenone results in decreased expression of BRD1 mRNA19013527
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of BRD1 promoter18448484
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BRD1 mRNA21215274
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BRD1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of BRD1 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BRD1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of BRD1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of BRD1 mRNA23179753|2627250
D014635Valproic AcidValproic Acid affects the expression of BRD1 mRNA17963808
C025643vinclozolinvinclozolin results in decreased expression of BRD1 mRNA23034163
D019287Zinc SulfateZinc Sulfate results in increased expression of BRD1 mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0042393histone binding-IDA21880731  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0035902response to immobilization stress-IEA-  
GO:0043966histone H3 acetylation-IDA16387653  
GO:0051602response to electrical stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10602503  21880731  
GO:0005634nucleus-TAS10602503  
GO:0016607nuclear speck-IDA-  
GO:0030425dendrite-IEA-  
GO:0043204perikaryon-IEA-  
GO:0070776MOZ/MORF histone acetyltransferase complex-IDA16387653  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3214847HATs acetylate histonesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-6804758Regulation of TP53 Activity through AcetylationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28393332Cocaine Administration and Its Withdrawal Enhance the Expression of Genes Encoding Histone-Modifying Enzymes and Histone Acetylation in the Rat Prefrontal Cortex. (2017 Jul)Sadakierska-Chudy ANeurotox Res