Gene: ARHGAP8

23779
BPGAP1|PP610
Rho GTPase activating protein 8
protein-coding
22q13.31
Ensembl:ENSG00000241484 MIM:609405 Vega:OTTHUMG00000030234 UniprotKB:P85298
NC_000022.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.138e-2 (AD)  8.917e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16992796chr22:44787134 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD720.569
FUT50.567
SLC2A40.557
SCML10.547
STAT5A0.541
MAP3K80.54
TEAD30.532
CDK20.531
TNFRSF6B0.524
SPTSSA0.521

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
N6AMT1-0.401
LHFPL5-0.353
ATP2C2-0.35
ZNF605-0.346
ADRA2C-0.343
ZBTB12-0.341
PCDHA1-0.338
KNCN-0.336
KLRG1-0.332
HNF1A-0.332

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ARHGAP8 mRNA"28903501
D000082AcetaminophenAcetaminophen results in decreased expression of ARHGAP8 mRNA29067470
D020106AcrylamideAcrylamide results in increased expression of ARHGAP8 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ARHGAP8 gene28458013
D001151ArsenicArsenic affects the methylation of ARHGAP8 gene25304211
C006780bisphenol Abisphenol A results in increased expression of ARHGAP8 mRNA25594700
C006780bisphenol Abisphenol A affects the expression of ARHGAP8 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ARHGAP8 gene28505145
D002737ChloropreneChloroprene results in decreased expression of ARHGAP8 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in decreased expression of ARHGAP8 mRNA19376846
D002945CisplatinCisplatin results in increased expression of ARHGAP8 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of ARHGAP8 mRNA25016146
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARHGAP8 mRNA17942748
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ARHGAP8 mRNA26752646
C523799MRK 003ARHGAP8 results in decreased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ARHGAP8 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ARHGAP8 mRNA"25554681
D009525NiacinNiacin results in increased expression of ARHGAP8 mRNA20303128
C006253pirinixic acidpirinixic acid results in increased expression of ARHGAP8 mRNA23811191
D011441PropylthiouracilPropylthiouracil results in increased expression of ARHGAP8 mRNA24780913
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of ARHGAP8 mRNA21427059
D012906SmokeSmoke results in decreased expression of ARHGAP8 mRNA21095227
C017947sodium arsenitesodium arsenite affects the methylation of ARHGAP8 gene28589171
C061133tamibarotenetamibarotene results in increased expression of ARHGAP8 mRNA17229644
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARHGAP8 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ARHGAP8 mRNA20159946
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARHGAP8 mRNA22298810
D013853ThioacetamideThioacetamide results in increased methylation of ARHGAP8 promoter27914986
C009495titanium dioxidetitanium dioxide results in increased expression of ARHGAP8 mRNA23557971
D014212TretinoinTretinoin results in increased expression of ARHGAP8 mRNA20488242
C012589trichostatin Atrichostatin A results in increased expression of ARHGAP8 mRNA24935251
C406224valdecoxibvaldecoxib results in increased expression of ARHGAP8 mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of ARHGAP8 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of ARHGAP8 mRNA21427059
C025643vinclozolinvinclozolin results in increased expression of ARHGAP8 mRNA23034163
D014810Vitamin EVitamin E results in increased expression of ARHGAP8 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IDA20179103  
GO:0005096GTPase activator activity-TAS-  
GO:0005515protein binding-IPI20179103  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IEA-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA20179103  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal