Gene: ALOX12

239
12-LOX|12S-LOX|LOG12
arachidonate 12-lipoxygenase, 12S type
protein-coding
17p13.1
Ensembl:ENSG00000108839 MIM:152391 Vega:OTTHUMG00000102088 UniprotKB:P18054
NC_000017.11
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.681e-1 (AD)  2.071e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TICRR0.544
ASB160.524
SZT20.523
FBXW80.518
MDC10.514
FCHSD10.509
RGL40.508
SGSH0.508
NBPF90.505
WDR900.499

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHRNA5-0.254
OR4F5-0.237
OR4F29-0.218
OR13C9-0.193
IFNA2-0.181
LILRA4-0.165
MYZAP-0.156
KLRC2-0.149
OR4K13-0.149
SERPINC1-0.148

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0368372,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX12 protein"23238474
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of ALOX12 mRNA"26186136
C045543acetone phenylhydrazoneacetone phenylhydrazone results in decreased activity of ALOX12 protein3928952
D016718Arachidonic AcidALOX12 protein affects the metabolism of Arachidonic Acid8305483
D016718Arachidonic AcidALOX12 protein results in increased metabolism of Arachidonic Acid17027136
D016718Arachidonic AcidALOX12 protein affects the susceptibility to Arachidonic Acid19373248
C006680baicalein"baicalein inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]"17027136
C006680baicaleinbaicalein results in decreased activity of ALOX12 protein17027136|2323847
C006680baicaleinbaicalein results in decreased activity of ALOX12 protein12582831
C011677benoxaprofenbenoxaprofen results in decreased activity of ALOX12 protein3928952
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of ALOX12 mRNA26377693
D001554BenzeneBenzene results in decreased expression of ALOX12 mRNA19162166
C099952bifenthrinbifenthrin results in decreased expression of ALOX12 mRNA26071804
C006780bisphenol Abisphenol A results in decreased expression of ALOX12 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of ALOX12 mRNA26141625
D000069286BortezomibALOX12 gene SNP results in increased susceptibility to Bortezomib20864405
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ALOX12 mRNA18804290
D002330CarmustineALOX12 protein affects the susceptibility to Carmustine19373248
D002330CarmustineCarmustine results in decreased expression of ALOX12 mRNA16005536
C026690cerous chloride[cerous chloride co-treated with lanthanum chloride] results in decreased expression of ALOX12 mRNA28954213
C026690cerous chloridecerous chloride results in decreased expression of ALOX12 mRNA28954213
D002713ChlorineChlorine results in decreased expression of ALOX12 mRNA22533443
C029892cupric chloridecupric chloride results in increased expression of ALOX12 mRNA21072851
D002945CisplatinCisplatin results in increased expression of ALOX12 mRNA15464296
D0157724,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine"4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine results in decreased activity of ALOX12 protein"3928952
D002117CalcitriolCalcitriol results in decreased expression of ALOX12 mRNA16002434
D004147DioxinsDioxins affects the expression of ALOX12 mRNA20463971
C004848dithioldithiol results in decreased activity of ALOX12 protein3928952
D004237DiuronDiuron results in decreased expression of ALOX12 mRNA21551480
D004281Docosahexaenoic AcidsALOX12 protein affects the metabolism of Docosahexaenoic Acids8305483
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ALOX12 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ALOX12 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALOX12 mRNA17942748
D011345FenofibrateFenofibrate results in increased expression of ALOX12 mRNA12759900
D005419FlavonoidsFlavonoids results in decreased expression of ALOX12 mRNA18035473
D019833GenisteinGenistein results in decreased expression of ALOX12 mRNA22553218
D019803Glutathione DisulfideALOX12 protein affects the susceptibility to Glutathione Disulfide19373248
D019803Glutathione DisulfideGlutathione Disulfide results in increased activity of ALOX12 protein19373248
D019803Glutathione DisulfideGlutathione Disulfide results in increased glutathionylation of ALOX12 protein19373248
D01937712-Hydroxy-5,8,10,14-eicosatetraenoic Acid"ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid"17027136
D01937712-Hydroxy-5,8,10,14-eicosatetraenoic Acid"baicalein inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]"17027136
D01937712-Hydroxy-5,8,10,14-eicosatetraenoic Acid"kaempferol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]"17027136
D01937712-Hydroxy-5,8,10,14-eicosatetraenoic Acid"Masoprocol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]"17027136
D01937712-Hydroxy-5,8,10,14-eicosatetraenoic Acid"Quercetin inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]"17027136
D01937712-Hydroxy-5,8,10,14-eicosatetraenoic Acid"resveratrol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]"17027136
D017313FenretinideFenretinide results in increased expression of ALOX12 mRNA28973697
D007052IbuprofenIbuprofen results in increased expression of ALOX12 mRNA28201806
D007213IndomethacinIndomethacin results in decreased activity of ALOX12 protein3928952
C006552kaempferol"kaempferol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]"17027136
C006552kaempferolkaempferol results in decreased activity of ALOX12 protein17027136
C028521lanthanum chloride[cerous chloride co-treated with lanthanum chloride] results in decreased expression of ALOX12 mRNA28954213
D009637Masoprocol"Masoprocol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]"17027136
D009637MasoprocolMasoprocol results in decreased activity of ALOX12 protein17027136|2323847
D009637MasoprocolMasoprocol results in decreased activity of ALOX12 protein3928952|9258337
D008727MethotrexateMethotrexate results in decreased expression of ALOX12 mRNA17400583
D008727MethotrexateMethotrexate results in decreased expression of ALOX12 mRNA16005536
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ALOX12 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ALOX12 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of ALOX12 promoter"26251327
D009151Mustard GasMustard Gas results in increased expression of ALOX12 mRNA15674844
C056614N-(3-phenoxycinnamyl)acetohydroxamic acidN-(3-phenoxycinnamyl)acetohydroxamic acid results in decreased activity of ALOX12 protein8305483
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ALOX12 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ALOX12 mRNA"25554681
C085219N-benzyl-N-hydroxy-5-phenylpentamideN-benzyl-N-hydroxy-5-phenylpentamide results in decreased activity of ALOX12 protein9258337
D009532NickelNickel results in decreased expression of ALOX12 mRNA24768652
D009538NicotineNicotine results in increased expression of ALOX12 mRNA16254210
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ALOX12 mRNA25729387
D010396PenicillaminePenicillamine results in decreased expression of ALOX12 mRNA19575532
D010396PenicillaminePenicillamine results in increased expression of ALOX12 mRNA19575532
C023036perfluorooctanoic acid[perfluorooctanoic acid co-treated with PPARA] results in increased expression of ALOX12 mRNA20118188
C015429phenidonephenidone results in decreased activity of ALOX12 protein3928952
D010852PicrotoxinPicrotoxin results in increased expression of ALOX12 mRNA15170462
C006253pirinixic acidpirinixic acid results in increased expression of ALOX12 mRNA20813756
D010972Platelet Activating FactorPlatelet Activating Factor results in increased expression of ALOX12 mRNA16386258
D059808PolyphenolsPolyphenols results in decreased expression of ALOX12 mRNA16293270
D011794Quercetin"Quercetin inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]"17027136
D011794QuercetinQuercetin results in decreased activity of ALOX12 protein17027136
C059514resveratrol"resveratrol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]"17027136
C059514resveratrolresveratrol results in decreased activity of ALOX12 protein17027136
C059514resveratrolresveratrol results in decreased expression of ALOX12 protein25116358
C017947sodium arsenite[CARM1 mutant form co-treated with sodium arsenite] results in increased expression of ALOX12 mRNA23699174
C017947sodium arsenite[PRMT1 mutant form co-treated with sodium arsenite] results in increased expression of ALOX12 mRNA23699174
C017947sodium arsenitesodium arsenite results in increased expression of ALOX12 mRNA28229933
C017947sodium arsenitesodium arsenite results in decreased expression of ALOX12 mRNA25065748
D012999SomanSoman results in increased expression of ALOX12 mRNA19281266
D014284TriiodothyronineTriiodothyronine results in increased expression of ALOX12 mRNA22281776
D013629TamoxifenTamoxifen affects the expression of ALOX12 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ALOX12 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALOX12 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of ALOX12 mRNA25975270
D013866ThioguanineThioguanine results in decreased expression of ALOX12 mRNA16005536
C009495titanium dioxidetitanium dioxide results in decreased expression of ALOX12 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ALOX12 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ALOX12 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of ALOX12 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of ALOX12 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004052arachidonate 12-lipoxygenase activity-IDA1851637  2217179  2377602  8319693  
GO:0004052arachidonate 12-lipoxygenase activity-TAS-  
GO:0005506iron ion binding-IEA-  
GO:0005515protein binding-IPI10727209  
GO:0016165linoleate 13S-lipoxygenase activity-IDA8319693  
GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen-TAS-  
GO:0047977hepoxilin-epoxide hydrolase activity-ISS-  
GO:0051120hepoxilin A3 synthase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0010656negative regulation of muscle cell apoptotic process-IMP23578768  
GO:0019369arachidonic acid metabolic process-IDA1851637  8319693  
GO:0019369arachidonic acid metabolic process-ISS-  
GO:0019372lipoxygenase pathway-IDA8319693  
GO:0019372lipoxygenase pathway-TAS-  
GO:0019395fatty acid oxidation-IMP15111312  
GO:0042554superoxide anion generation-NAS15107407  
GO:0042759long-chain fatty acid biosynthetic process-TAS-  
GO:0043651linoleic acid metabolic process-IDA8319693  
GO:0043651linoleic acid metabolic processNOTIDA1851637  
GO:0051121hepoxilin metabolic process-TAS-  
GO:0051122hepoxilin biosynthetic process-ISS-  
GO:0061436establishment of skin barrier-ISS-  
GO:0090331negative regulation of platelet aggregation-ISS-  
GO:1901751leukotriene A4 metabolic process-IDA8250832  
GO:1901751leukotriene A4 metabolic processNOTIDA1851637  
GO:2001301lipoxin biosynthetic process-TAS-  
GO:2001303lipoxin A4 biosynthetic process-IDA8250832  
GO:2001306lipoxin B4 biosynthetic process-IDA8250832  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA8319693  
GO:0005829cytosol-IDA8912711  15107407  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IDA8912711  
GO:0042383sarcolemma-IDA15107407  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-2142696Synthesis of Hepoxilins (HX) and Trioxilins (TrX)TAS
R-HSA-2142700Synthesis of Lipoxins (LX)TAS
R-HSA-2142712Synthesis of 12-eicosatetraenoic acid derivativesTAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS
R-HSA-9018677Biosynthesis of DHA-derived SPMsTAS
R-HSA-9018678Biosynthesis of specialized proresolving mediators (SPMs)TAS
R-HSA-9018683Biosynthesis of DPA-derived SPMsTAS
R-HSA-9025094Biosynthesis of DPAn-3 SPMsTAS
R-HSA-9025106Biosynthesis of DPAn-6 SPMsTAS
R-HSA-9026290Biosynthesis of DPAn-3-derived maresinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22678777PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer. (2013 Jan)Habermann NGenes Nutr
22323304DNA hypomethylation at ALOX12 is associated with persistent wheezing in childhood. (2012 May 1)Morales EAm J Respir Crit Care Med
20061896ALOX12 gene is associated with the onset of natural menopause in white women. (2010 Jan-Feb)Liu PMenopause
29196930Association of ALOX12 gene polymorphism with all-cause and cardiovascular mortality in diabetic nephropathy. (2018 Feb)Roumeliotis AKInt Urol Nephrol