Gene: ALOX5

240
5-LO|5-LOX|5LPG|LOG5
arachidonate 5-lipoxygenase
protein-coding
10q11.21
Ensembl:ENSG00000012779 MIM:152390 Vega:OTTHUMG00000018081 UniprotKB:P09917
NG_011437.1
PubMed
ND
2   
NA (AD)  4.219e-1 (ND)   (Frontal_Cortex)
6.001e-1 (AD)  7.251e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTPRC0.934
HCK0.922
TLR10.92
BTK0.919
LAIR10.916
NCKAP1L0.916
WAS0.914
DOCK20.914
RASGRP40.913
HCLS10.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT7A-0.45
KCNIP3-0.437
MAGIX-0.425
ASPDH-0.417
ZNF835-0.406
CHRNA4-0.402
ARSF-0.402
ATP2C2-0.4
NEUROD6-0.397
CPLX3-0.396

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00163Vitamin ESmall Molecule59-02-9Approved|NutraceuticalTarget
DB00179MasoprocolSmall Molecule27686-84-6Approved|InvestigationalTarget
DB00233Aminosalicylic AcidSmall Molecule65-49-6ApprovedTarget
DB00244MesalazineSmall Molecule89-57-6ApprovedTarget
DB00471MontelukastSmall Molecule158966-92-8ApprovedTarget
DB00586DiclofenacSmall Molecule15307-86-5ApprovedTarget
DB00711DiethylcarbamazineSmall Molecule90-89-1Approved|InvestigationalTarget
DB00744ZileutonSmall Molecule111406-87-2Approved|Investigational|WithdrawnTarget
DB00795SulfasalazineSmall Molecule599-79-1ApprovedTarget
DB00939Meclofenamic acidSmall Molecule644-62-2ApprovedTarget
DB01014BalsalazideSmall Molecule80573-04-2Approved|InvestigationalTarget
DB01017MinocyclineSmall Molecule10118-90-8Approved|InvestigationalTarget
DB01892HyperforinSmall Molecule11079-53-1NutraceuticalTarget
DB02709ResveratrolSmall Molecule501-36-0Approved|Experimental|InvestigationalTarget
DB04725LicofeloneSmall Molecule156897-06-2InvestigationalTarget
DB05431MLN-977Small Molecule-InvestigationalTarget
DB09285MorniflumateSmall Molecule65847-85-0ApprovedTarget
DB11994DiacereinSmall Molecule13739-02-1Approved|InvestigationalTarget
DB13174RheinSmall Molecule478-43-3ExperimentalTarget
DB14001alpha-Tocopherol succinateSmall Molecule4345-03-3Approved|NutraceuticalTarget
DB14002D-alpha-Tocopherol acetateSmall Molecule58-95-7Approved|NutraceuticalTarget
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalEnzyme
DB09285MorniflumateSmall Molecule65847-85-0ApprovedEnzyme
DB11133Omega-3 fatty acidsSmall Molecule329042-31-1Approved|NutraceuticalEnzyme
DB13168Omega-6 fatty acidsSmall MoleculeNutraceuticalEnzyme
ID Drug Name Action PubMed
C02508615-hydroperoxy-5,8,11,13-eicosatetraenoic acid"ALOX5 protein results in increased metabolism of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid"7929400
C02508615-hydroperoxy-5,8,11,13-eicosatetraenoic acid"[ALOX5 protein results in increased metabolism of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid] which results in increased abundance of Leukotriene B4 analog"7929400
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"[benoxaprofen results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"2849922
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"[Masoprocol results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"2849922
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"[RS 43179 results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"2849922
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"[tenidap results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"2849922
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"15-hydroxy-5,8,11,13-eicosatetraenoic acid results in decreased activity of ALOX5 protein"2849922
C06289417-hydroxy-4,7,10,13,15,19-docosahexaenoic acid"17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid results in decreased expression of ALOX5 protein"17056761
C5203231-oleoyl-2-acetoyl-sn-glycerol1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]]18218859
C5203231-oleoyl-2-acetoyl-sn-glycerol1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein]]18218859
C5203231-oleoyl-2-acetoyl-sn-glycerol1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]]18218859
C5203231-oleoyl-2-acetoyl-sn-glycerol1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [Propranolol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]]18218859
C4001841-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of ALOX5 mRNA16386258
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ALOX5 mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ALOX5 mRNA"23146750
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of ALOX5 protein]20153347
C0368372,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX5 protein"23238474|2724698
C0368372,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX5 protein"2724698
C0368372,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX5 protein"2724698
C0368372,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX5 protein"25432964|7812673
C0368372,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX5 protein"2724698
C0368372,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX5 protein"2724698
C0368372,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX5 protein"17925309
C5485442-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid"2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid results in decreased activity of ALOX5 protein"19934399
C5587462-(4-chlorophenyl)-5-(4-methoxybenzylidene)-5H-thiazol-4-one2-(4-chlorophenyl)-5-(4-methoxybenzylidene)-5H-thiazol-4-one results in decreased activity of ALOX5 protein21341744
C0639182-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-3-methylindole"2-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-3-methylindole results in decreased activity of ALOX5 protein"7812673
C0793152-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid results in decreased activity of ALOX5 protein12954791
C0793152-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ALOX5 protein]16033810
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ALOX5 mRNA"20816883
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased expression of ALOX5 mRNA20840853
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased expression of ALOX5 mRNA20382172
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased expression of ALOX5 protein20382172
C0312782-chloroethyl ethyl sulfideSB 203580 inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of ALOX5 mRNA]20382172
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of ALOX5 protein26194647
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ALOX5 mRNA16788091
C5507244-(3-(4-(1-methyl-1H-pyrazol-5-yl)phenylthio)phenyl)-tetrahydro-2H-pyran-4-carboxamide4-(3-(4-(1-methyl-1H-pyrazol-5-yl)phenylthio)phenyl)-tetrahydro-2H-pyran-4-carboxamide results in decreased activity of ALOX5 protein21739938
C1191304-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamideALOX5 protein affects the reaction [4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide affects the expression of CCL2 mRNA]17766677
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALOX5 mRNA"27188386
C0275764-hydroxy-2-nonenalALOX5 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]19837106
C0123584-hydroxycyclophosphamide[afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of ALOX5 mRNA25833159
C1168245-((1,5-bis(4-methoxyphenyl)pyrazol-3-yl)dimethoxymethyl)-2-chlorobenzamide"5-((1,5-bis(4-methoxyphenyl)pyrazol-3-yl)dimethoxymethyl)-2-chlorobenzamide results in decreased activity of ALOX5 protein"9831321
C1168245-((1,5-bis(4-methoxyphenyl)pyrazol-3-yl)dimethoxymethyl)-2-chlorobenzamide"[5-((1,5-bis(4-methoxyphenyl)pyrazol-3-yl)dimethoxymethyl)-2-chlorobenzamide results in decreased activity of ALOX5 protein] which results in decreased abundance of Eicosanoids"9831321
C0586915-hexyloxy-3',4'-dihydroxy-6,7-dimethoxyflavone 4'-phosphate"5-hexyloxy-3',4'-dihydroxy-6,7-dimethoxyflavone 4'-phosphate analog results in decreased activity of ALOX5 protein"2724698
C0586915-hexyloxy-3',4'-dihydroxy-6,7-dimethoxyflavone 4'-phosphate"5-hexyloxy-3',4'-dihydroxy-6,7-dimethoxyflavone 4'-phosphate analog results in decreased activity of ALOX5 protein"2724698
C0586915-hexyloxy-3',4'-dihydroxy-6,7-dimethoxyflavone 4'-phosphate"5-hexyloxy-3',4'-dihydroxy-6,7-dimethoxyflavone 4'-phosphate analog results in decreased activity of ALOX5 protein"2724698
C0586915-hexyloxy-3',4'-dihydroxy-6,7-dimethoxyflavone 4'-phosphate"5-hexyloxy-3',4'-dihydroxy-6,7-dimethoxyflavone 4'-phosphate analog results in decreased activity of ALOX5 protein"2724698
C0586915-hexyloxy-3',4'-dihydroxy-6,7-dimethoxyflavone 4'-phosphate"5-hexyloxy-3',4'-dihydroxy-6,7-dimethoxyflavone 4'-phosphate analog results in decreased activity of ALOX5 protein"2724698
C0220225-hydroxy-6,8,11,14-eicosatetraenoic acid"ALOX5 protein results in increased chemical synthesis of 5-hydroxy-6,8,11,14-eicosatetraenoic acid"18295198
C0476515-hydroxyeicosatetraenoic acid lactone5-hydroxyeicosatetraenoic acid lactone results in decreased activity of ALOX5 protein12629151
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALOX5 mRNA"27188386
C0683146-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]]18218859
C0683146-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]18218859
C082739A 78773[[A 78773 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B411529688
C082739A 78773A 78773 results in decreased activity of ALOX5 protein11529688
C496492abrineabrine results in increased expression of ALOX5 mRNA22595364
D000082AcetaminophenAcetaminophen affects the expression of ALOX5 mRNA17562736
C045543acetone phenylhydrazoneacetone phenylhydrazone results in decreased activity of ALOX5 protein3928952
D000171Acrolein2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of ALOX5 protein]20153347
D000171AcroleinAcrolein results in increased activity of ALOX5 protein20153347
D000171AcroleinAcrolein results in increased expression of ALOX5 mRNA20153347
D000171AcroleinAcrolein results in increased expression of ALOX5 protein20153347
D000171Acroleintyrphostin AG 1478 inhibits the reaction [Acrolein results in increased expression of ALOX5 protein]20153347
D020106AcrylamideAcrylamide results in decreased expression of ALOX5 mRNA28959563
D000227Adenine NucleotidesAdenine Nucleotides binds to ALOX5 protein7577949
C016601afimoxifene[afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of ALOX5 mRNA25833159
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ALOX5 mRNA22100608
C412373AG 1879AG 1879 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]14569062
C412373AG 1879[tyrphostin AG 1478 co-treated with AG 1879] inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]14569062
D000447AldehydesAldehydes results in increased expression of ALOX5 mRNA25014914
C049740alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanolalpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol results in decreased activity of ALOX5 protein12629151
C049740alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanolalpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol results in decreased activity of ALOX5 protein18927292
D000535AluminumAluminum results in increased expression of ALOX5 mRNA27368151
D000535AluminumAluminum results in increased expression of ALOX5 protein27368151
D000535Aluminumcaffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 mRNA]27368151
D000535Aluminumcaffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 protein]27368151
C010845aluminum chloridealuminum chloride results in increased expression of ALOX5 mRNA18482095
C010845aluminum chloridealuminum chloride results in increased expression of ALOX5 protein18482095
C010845aluminum chloridecaffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 mRNA]18482095
C010845aluminum chloridecaffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 protein]18482095
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ALOX5 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ALOX5 mRNA24449571
D016718Arachidonic AcidALOX5 protein results in increased metabolism of Arachidonic Acid18295198
D016718Arachidonic AcidArachidonic Acid inhibits the reaction [L 708714 binds to ALOX5 protein]7577949
D016718Arachidonic AcidCJ 13610 inhibits the reaction [ALOX5 protein results in increased metabolism of Arachidonic Acid]18295198
D016718Arachidonic Acid[sodium arsenite co-treated with Platelet Activating Factor co-treated with Arachidonic Acid] results in increased phosphorylation of and results in increased activity of ALOX5 protein10779545
D016718Arachidonic Acid[Sorbitol co-treated with Calcimycin co-treated with Arachidonic Acid] affects the localization of ALOX5 protein11698504
D016718Arachidonic Acidzileuton inhibits the reaction [ALOX5 protein results in increased metabolism of Arachidonic Acid]18295198
D016718Arachidonic Acid[zileuton results in decreased activity of ALOX5 protein] which affects the abundance of Arachidonic Acid9495842
D016718Arachidonic Acid[zileuton results in decreased activity of ALOX5 protein] which results in decreased susceptibility to Arachidonic Acid7592874
D016718Arachidonic AcidALOX5 protein affects the metabolism of Arachidonic Acid22613217
D016718Arachidonic AcidALOX5 protein results in increased metabolism of Arachidonic Acid18951527
D016718Arachidonic Acid[Diamide co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D016718Arachidonic Acid[Hydrogen Peroxide co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D016718Arachidonic Acid[oxophenylarsine co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D016718Arachidonic Acid[Potassium Chloride co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D016718Arachidonic AcidSB 203580 inhibits the reaction [[Hydrogen Peroxide co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein]11698504
D016718Arachidonic AcidSB 203580 inhibits the reaction [[Sodium Chloride co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein]11698504
D016718Arachidonic Acid[sodium arsenite co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D016718Arachidonic Acid[Sodium Chloride co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D016718Arachidonic Acid[Sorbitol co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D016718Arachidonic Acid[Sorbitol co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D016718Arachidonic AcidThapsigargin promotes the reaction [[Sorbitol co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein]11698504
D016718Arachidonic Acid[TNF protein co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D016718Arachidonic Acid[Vanadates co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D001151ArsenicArsenic affects the expression of ALOX5 mRNA18414638
C517830arzanolarzanol results in decreased activity of ALOX5 protein20933508
C038044baicalinbaicalin inhibits the reaction [Hydrogen Peroxide affects the localization of and results in increased activity of ALOX5 protein]20139896
C011677benoxaprofenbenoxaprofen results in decreased activity of ALOX5 protein2849922|3020588
C011677benoxaprofen[benoxaprofen results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B42849922
C011677benoxaprofen"[benoxaprofen results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"2849922
C011677benoxaprofenbenoxaprofen results in decreased activity of ALOX5 protein2724698|3928952
C011677benoxaprofenbenoxaprofen results in decreased activity of ALOX5 protein6131964
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of ALOX5 mRNA26377693
D001554BenzeneALOX5 gene SNP affects the susceptibility to Benzene21540635
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ALOX5 mRNA26377693
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of ALOX5 mRNA19737606
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [Calcitriol results in increased expression of ALOX5 mRNA]19244278
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to ALOX5 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ALOX5 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ALOX5 mRNA19770486|2373587
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ALOX5 mRNA22300585
D004958EstradiolEstradiol results in decreased expression of ALOX5 protein17143502
D004958EstradiolEstradiol results in increased expression of ALOX5 mRNA19484750
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Calcimycin results in increased phosphorylation of and results in increased activity of ALOX5 protein]10779545
C006780bisphenol Abisphenol A results in increased methylation of ALOX5 gene28505145
C500927bolinaquinonebolinaquinone inhibits the reaction [Calcimycin results in increased activity of ALOX5 protein]12604694
D0200011-Butanol1-Butanol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]18218859
D0200011-Butanol1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein]18218859
D0200011-Butanol1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]]18218859
D0200011-Butanol1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein]]18218859
D002084Butylated HydroxytolueneButylated Hydroxytoluene affects the localization of ALOX5 protein12376474
D002084Butylated HydroxytolueneCelecoxib inhibits the reaction [Butylated Hydroxytoluene affects the localization of ALOX5 protein]12376474
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ALOX5 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of ALOX5 mRNA26079696
C080871BW B70CBW B70C results in decreased activity of ALOX5 protein23238474
D002104CadmiumCadmium results in increased expression of ALOX5 protein26424772
D002104Cadmiumflavocoxid inhibits the reaction [Cadmium results in increased expression of ALOX5 protein]26424772
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ALOX5 mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ALOX5 protein26424772
D019256Cadmium Chlorideflavocoxid inhibits the reaction [Cadmium Chloride results in increased expression of ALOX5 protein]26424772
C040048caffeic acidcaffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 mRNA]18482095
C040048caffeic acidcaffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 protein]18482095
C040048caffeic acidcaffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 mRNA]27368151
C040048caffeic acidcaffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 protein]27368151
C040048caffeic acidcaffeic acid inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein]18951527
C040048caffeic acidcaffeic acid inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]18951527
C040048caffeic acidcaffeic acid results in decreased activity of ALOX5 protein18482095|1895152
D000001Calcimycin1-Butanol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]18218859
D000001Calcimycin1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]]18218859
D000001Calcimycin1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]]18218859
D000001Calcimycin1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [Propranolol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]]18218859
D000001Calcimycin6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]18218859
D000001Calcimycinbisindolylmaleimide I inhibits the reaction [Calcimycin results in increased phosphorylation of and results in increased activity of ALOX5 protein]10779545
D000001Calcimycinbolinaquinone inhibits the reaction [Calcimycin results in increased activity of ALOX5 protein]12604694
D000001CalcimycinCalcimycin results in increased activity of ALOX5 protein11698504|1847547
D000001CalcimycinCalcimycin results in increased activity of and results in increased localization of ALOX5 protein18218859
D000001CalcimycinCalcimycin results in increased phosphorylation of and results in increased activity of ALOX5 protein10779545
D000001CalcimycinPropranolol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]18218859
D000001CalcimycinSB 203580 inhibits the reaction [Calcimycin results in increased phosphorylation of and results in increased activity of ALOX5 protein]10779545
D000001Calcimycin[Sorbitol co-treated with Calcimycin co-treated with Arachidonic Acid] affects the localization of ALOX5 protein11698504
D000001Calcimycintert-Butyl Alcohol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]18218859
D000001Calcimycin[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of ALOX5 protein11698504
D000001CalcimycinU 0126 inhibits the reaction [Calcimycin results in increased phosphorylation of and results in increased activity of ALOX5 protein]10779545
D000001Calcimycin[zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Platelet Activating Factor]8387780
D000001Calcimycin[[A 78773 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B411529688
D000001CalcimycinCalcimycin results in increased activity of and results in increased localization of ALOX5 protein9445378
D000001Calcimycin[Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] which results in increased abundance of Leukotriene B49445378
D000001Calcimycin[Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] which results in increased abundance of Leukotriene C49445378
D000001CalcimycinCalcimycin results in increased expression of ALOX5 mRNA18083043
D000001CalcimycinCalcimycin results in increased expression of ALOX5 protein18083043
D000001CalcimycinCalcimycin results in increased localization of and results in increased activity of ALOX5 protein7665580
D000001CalcimycinCCL5 protein promotes the reaction [Calcimycin results in increased expression of ALOX5 mRNA]18083043
D000001CalcimycinCCL5 protein promotes the reaction [Calcimycin results in increased expression of ALOX5 protein]18083043
D000001Calcimycin[[CMI 392 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B411529688
D000001CalcimycinDexamethasone inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 protein]18083043
D000001CalcimycinMasoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 mRNA]18083043
D000001CalcimycinMasoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 protein]18083043
D000001Calcimycin[[zileuton co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B411529688
D000001Calcimycin[zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Leukotriene B4]18475545
D000001Calcimycin[Diamide co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D000001Calcimycin[Hydrogen Peroxide co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D000001Calcimycin[oxophenylarsine co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D000001Calcimycin[Potassium Chloride co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D000001CalcimycinSB 203580 inhibits the reaction [[Hydrogen Peroxide co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein]11698504
D000001CalcimycinSB 203580 inhibits the reaction [[Sodium Chloride co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein]11698504
D000001Calcimycin[sodium arsenite co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D000001Calcimycin[Sodium Chloride co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D000001Calcimycin[Sorbitol co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D000001Calcimycin[TNF protein co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D000001Calcimycin[Vanadates co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D002118CalciumCalcium promotes the reaction [L 708714 binds to ALOX5 protein]7577949
D002211Capsaicin[Capsaicin co-treated with Curcumin] results in decreased activity of ALOX5 protein16956363
D002211CapsaicinCapsaicin results in decreased activity of ALOX5 protein16956363
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ALOX5 protein25432964
D002251Carbon TetrachloridePTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of ALOX5 protein]25432964
D002251Carbon TetrachlorideSC 560 promotes the reaction [Carbon Tetrachloride results in increased expression of ALOX5 protein]25432964
D002251Carbon Tetrachloride2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ALOX5 protein]16033810
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ALOX5 protein16033810
D000068579CelecoxibCelecoxib inhibits the reaction [Butylated Hydroxytoluene affects the localization of ALOX5 protein]12376474
D017332CetirizineCetirizine analog results in decreased activity of ALOX5 protein15482930
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ALOX5 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ALOX5 mRNA28472532
C496810CJ 13610CJ 13610 inhibits the reaction [ALOX5 protein results in increased metabolism of Arachidonic Acid]18295198
C496810CJ 13610CJ 13610 results in decreased activity of ALOX5 protein18295198
C496810CJ 13610CJ 13610 results in decreased activity of ALOX5 protein17766677
C496810CJ 13610CJ 13610 results in decreased activity of ALOX5 protein18295198
C112433CMI 392[[CMI 392 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B411529688
C112433CMI 392CMI 392 results in decreased activity of ALOX5 protein11529688|9599246
C423222cotylenin Acotylenin A results in increased expression of ALOX5 mRNA16129123
C030123coumarincoumarin results in increased expression of ALOX5 mRNA18480146
D003474Curcumin[Capsaicin co-treated with Curcumin] results in decreased activity of ALOX5 protein16956363
D003474CurcuminCurcumin results in decreased activity of ALOX5 protein16956363
D003474CurcuminCurcumin results in decreased expression of ALOX518462866
C109268darbufelonedarbufelone results in decreased activity of ALOX5 protein21341744
D003907DexamethasoneDexamethasone inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 protein]18083043
D003958Diamide[Diamide co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ALOX5 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ALOX5 mRNA27392435|2759478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ALOX5 mRNA26924002
D004026DieldrinDieldrin results in decreased expression of ALOX5 mRNA28385952
D004041Dietary Fats[AGT protein affects the susceptibility to Dietary Fats] which affects the expression of ALOX5 mRNA26704350
D004041Dietary FatsDietary Fats results in increased expression of ALOX5 mRNA25016146
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ALOX5 mRNA24535843
D0157724,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine"4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine results in decreased activity of ALOX5 protein"3020588
D0157724,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine"4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine results in decreased activity of ALOX5 protein"3145369|7990266
D0157724,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine"4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine results in decreased activity of ALOX5 protein"3928952
D002117CalcitriolBenzo(a)pyrene promotes the reaction [Calcitriol results in increased expression of ALOX5 mRNA]19244278
D002117CalcitriolCalcitriol analog results in increased activity of ALOX5 protein10799658
D002117CalcitriolCalcitriol results in increased expression of ALOX5 mRNA16002434|1612912
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of ALOX5 mRNA26924002
D004121Dimethyl Sulfoxide"[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of ALOX5 protein"23751068
D004121Dimethyl Sulfoxide"resveratrol inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of ALOX5 protein]"23751068
D004121Dimethyl Sulfoxide"Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of ALOX5 protein]"23751068
C007488dinitrobenzenesulfonic acidALOX5 protein affects the reaction [dinitrobenzenesulfonic acid affects the localization of OCLN protein]16670640
C007488dinitrobenzenesulfonic acidALOX5 protein affects the reaction [dinitrobenzenesulfonic acid affects the localization of TJP1 protein]16670640
C007488dinitrobenzenesulfonic acidALOX5 protein affects the reaction [dinitrobenzenesulfonic acid results in increased activity of MPO protein]15821759
C007488dinitrobenzenesulfonic acidALOX5 protein affects the reaction [dinitrobenzenesulfonic acid results in increased expression of ICAM1 protein]15821759
C007488dinitrobenzenesulfonic acidALOX5 protein affects the reaction [dinitrobenzenesulfonic acid results in increased expression of SELE protein]15821759
C007488dinitrobenzenesulfonic acidALOX5 protein affects the reaction [dinitrobenzenesulfonic acid results in increased expression of SELP protein]15821759
C007488dinitrobenzenesulfonic acidALOX5 protein affects the reaction [dinitrobenzenesulfonic acid results in increased expression of VCAM1 protein]15821759
C007488dinitrobenzenesulfonic acidALOX5 protein affects the susceptibility to dinitrobenzenesulfonic acid16670640
C004848dithioldithiol results in decreased activity of ALOX5 protein3928952
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in decreased expression of ALOX5 protein17056761
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased activity of ALOX5 protein"19066064
C083427(E)-3-((((6-(2-carboxyethenyl)-5-((8-(4-methoxyphenyl)octyl)oxy)-2-pyridinyl)methyl)thio)methyl)benzoic acid(E)-3-((((6-(2-carboxyethenyl)-5-((8-(4-methoxyphenyl)octyl)oxy)-2-pyridinyl)methyl)thio)methyl)benzoic acid results in decreased activity of ALOX5 protein10477044
C064507E 6080E 6080 results in decreased activity of ALOX5 protein7812673
C042986ebselenebselen results in decreased activity of ALOX5 protein7590103
C121361efletirizineefletirizine analog results in decreased activity of ALOX5 protein15482930
C025421eicosa-8,11,14-trien-5-ynoic acid"eicosa-8,11,14-trien-5-ynoic acid results in decreased activity of ALOX5 protein"12582831
D015777Eicosanoids"[5-((1,5-bis(4-methoxyphenyl)pyrazol-3-yl)dimethoxymethyl)-2-chlorobenzamide results in decreased activity of ALOX5 protein] which results in decreased abundance of Eicosanoids"9831321
D015777Eicosanoids[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Eicosanoids9831321
D004726EndosulfanEndosulfan results in increased expression of ALOX5 mRNA26615145
C031818enterotoxin B, staphylococcal"[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of ALOX5 protein"23751068
C031818enterotoxin B, staphylococcal"resveratrol inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of ALOX5 protein]"23751068
C031818enterotoxin B, staphylococcal"Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of ALOX5 protein]"23751068
C118739entinostatentinostat results in increased expression of ALOX5 mRNA27188386
D000431EthanolEthanol results in increased expression of ALOX5 mRNA28069986
D005015EthoxyquinEthoxyquin results in decreased activity of ALOX5 protein3928952
C544478flavocoxidflavocoxid inhibits the reaction [Cadmium Chloride results in increased expression of ALOX5 protein]26424772
C544478flavocoxidflavocoxid inhibits the reaction [Cadmium results in increased expression of ALOX5 protein]26424772
D005419FlavonoidsFlavonoids results in increased expression of ALOX5 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ALOX5 mRNA20938992
D009240N-Formylmethionine Leucyl-PhenylalanineALOX5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]11116075
D009240N-Formylmethionine Leucyl-PhenylalanineN-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of ALOX5 protein10779545
D009240N-Formylmethionine Leucyl-PhenylalanineSB 203580 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of ALOX5 protein]10779545
D009240N-Formylmethionine Leucyl-Phenylalanine[zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4]9495842
C006312FPL 55712FPL 55712 results in decreased activity of ALOX5 protein2724698
C006312FPL 55712FPL 55712 results in decreased activity of ALOX5 protein2724698
C006312FPL 55712FPL 55712 results in decreased activity of ALOX5 protein2724698
C006312FPL 55712FPL 55712 results in decreased activity of ALOX5 protein2724698
C039281furanfuran results in increased expression of ALOX5 mRNA27387713
C046905glucosamine 6-O-sulfateglucosamine 6-O-sulfate inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5 mRNA]21877189
D005947Glucosecaffeic acid inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]18951527
D005947Glucose[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein18951527
D005947Glucosephenylmethylpyrazolone inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]18951527
D005947GlucoseSB 203580 inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]18951527
D007975Leukotriene B4"ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased abundance of Leukotriene B4]"15501964
D007975Leukotriene B4ALOX5 protein results in increased chemical synthesis of Leukotriene B418096136
D007975Leukotriene B4ALOX5 protein results in increased secretion of Leukotriene B411325678
D007975Leukotriene B4ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]9609743
D007975Leukotriene B4[benoxaprofen results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B42849922
D007975Leukotriene B4[Hydrogen Peroxide results in increased activity of ALOX5 protein] which results in increased chemical synthesis of Leukotriene B410491155
D007975Leukotriene B4kaempferol inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]18096136
D007975Leukotriene B4Luteolin inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]18096136
D007975Leukotriene B4[Masoprocol results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B42849922
D007975Leukotriene B4quercetin 3-O-glucuronide inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]18096136
D007975Leukotriene B4quercetin 3'-sulfate inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]18096136
D007975Leukotriene B4Quercetin inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]18096136
D007975Leukotriene B4resveratrol inhibits the reaction [[Hydrogen Peroxide results in increased activity of ALOX5 protein] which results in increased chemical synthesis of Leukotriene B4]10491155
D007975Leukotriene B4[RS 43179 results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B42849922
D007975Leukotriene B4[Tamoxifen results in increased expression of ALOX5 protein] which results in increased abundance of Leukotriene B49742967
D007975Leukotriene B4[tenidap results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B42849922
D007975Leukotriene B4"zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased abundance of Leukotriene B4]]"15501964
D007975Leukotriene B4zileuton inhibits the reaction [ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]9609743
D007975Leukotriene B4[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B411286996|1781415
D007975Leukotriene B4ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4]12794006
D007975Leukotriene B4zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4]]12794006
D007975Leukotriene B4[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B49593866
D007975Leukotriene B4[[A 78773 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B411529688
D007975Leukotriene B4ALOX5 protein promotes the reaction [CXCL8 protein results in increased abundance of Leukotriene B4]8058773
D007975Leukotriene B4[Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] which results in increased abundance of Leukotriene B49445378
D007975Leukotriene B4[[CMI 392 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B411529688
D007975Leukotriene B4"[lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4"12388339
D007975Leukotriene B4[tepoxalin results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4]9223651
D007975Leukotriene B4"tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4]"12388339
D007975Leukotriene B4[troglitazone results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B410694244
D007975Leukotriene B4[[zileuton co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B411529688
D007975Leukotriene B4[zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Leukotriene B4]18475545
D007975Leukotriene B4[zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4]9223651
D007975Leukotriene B4[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B410694244
D007975Leukotriene B4ALOX5 protein results in increased chemical synthesis of Leukotriene B420436887
D007975Leukotriene B4"[ALOX5 protein results in increased metabolism of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid] which results in increased abundance of Leukotriene B4 analog"7929400
D006632HistamineALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]9609743
D006632Histaminezileuton inhibits the reaction [ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]9609743
D006861Hydrogen PeroxideALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]10698703
D006861Hydrogen PeroxideHydrogen Peroxide results in increased activity of ALOX5 protein10491155
D006861Hydrogen Peroxide[Hydrogen Peroxide results in increased activity of ALOX5 protein] which results in increased chemical synthesis of Leukotriene B410491155
D006861Hydrogen PeroxideMasoprocol inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]]10698703
D006861Hydrogen Peroxideresveratrol inhibits the reaction [[Hydrogen Peroxide results in increased activity of ALOX5 protein] which results in increased chemical synthesis of Leukotriene B4]10491155
D006861Hydrogen Peroxidezileuton inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]]10698703
D006861Hydrogen Peroxidebaicalin inhibits the reaction [Hydrogen Peroxide affects the localization of and results in increased activity of ALOX5 protein]20139896
D006861Hydrogen Peroxidecaffeic acid inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein]18951527
D006861Hydrogen PeroxideHydrogen Peroxide affects the localization of ALOX5 protein18951527
D006861Hydrogen PeroxideHydrogen Peroxide affects the localization of and results in increased activity of ALOX5 protein20139896
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased activity of ALOX5 protein12388339
D006861Hydrogen Peroxidephenylmethylpyrazolone inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein]18951527
D006861Hydrogen PeroxideSB 203580 inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein]18951527
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D006861Hydrogen PeroxideSB 203580 inhibits the reaction [[Hydrogen Peroxide co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein]11698504
D006877Hydroxamic AcidsHydroxamic Acids analog results in decreased activity of ALOX5 protein7922131
D006893Hydroxyeicosatetraenoic AcidsALOX5 protein results in increased metabolism of Hydroxyeicosatetraenoic Acids metabolite11861792
D006893Hydroxyeicosatetraenoic AcidsMK-886 inhibits the reaction [ALOX5 protein results in increased metabolism of Hydroxyeicosatetraenoic Acids metabolite]11861792
D006918HydroxyureaHydroxyurea inhibits the reaction [L 708714 binds to ALOX5 protein]7577949
C069794ICI 211965ICI 211965 results in decreased activity of ALOX5 protein8452572
C075799ICI D2138ICI D2138 results in decreased activity of ALOX5 protein7522174|9580604
C075799ICI D2138ICI D2138 inhibits the reaction [L 708714 binds to ALOX5 protein]7577949
C075799ICI D2138ICI D2138 results in decreased activity of ALOX5 protein18475545
C075799ICI D2138ICI D2138 results in decreased activity of ALOX5 protein11509739
D007213IndomethacinIndomethacin results in decreased activity of ALOX5 protein3928952
D007213Indomethacin[tepoxalin results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4]9223651
D007213Indomethacin[zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4]9223651
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ALOX5 mRNA25613284
C402944JHW 015JHW 015 inhibits the reaction [JUN protein modified form binds to ALOX5 promoter]23539630
C402944JHW 015JHW 015 inhibits the reaction [JUN protein modified form results in increased expression of ALOX5 mRNA]23539630
C402944JHW 015JHW 015 results in decreased expression of ALOX5 mRNA23539630
C402944JHW 015JHW 015 results in decreased expression of ALOX5 protein23539630
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ALOX5 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ALOX5 mRNA23086925
C006552kaempferolkaempferol inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]18096136
D007608Kainic AcidKainic Acid results in increased expression of ALOX5 mRNA17139192
C080279L 689065L 689065 results in decreased activity of ALOX5 protein8452572
C096344L 708714Arachidonic Acid inhibits the reaction [L 708714 binds to ALOX5 protein]7577949
C096344L 708714Calcium promotes the reaction [L 708714 binds to ALOX5 protein]7577949
C096344L 708714Hydroxyurea inhibits the reaction [L 708714 binds to ALOX5 protein]7577949
C096344L 708714ICI D2138 inhibits the reaction [L 708714 binds to ALOX5 protein]7577949
C096344L 708714L 708714 binds to and results in decreased activity of ALOX5 protein7577949
C096344L 708714zileuton inhibits the reaction [L 708714 binds to ALOX5 protein]7577949
D017999Leukotriene E4[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene E410764316|8621850
D017999Leukotriene E4ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]12794006
D017999Leukotriene E4zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]]12794006
D015289LeukotrienesALOX5 protein results in increased chemical synthesis of Leukotrienes18951527
C433788lipopolysaccharide, E. coli O26-B6"ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased abundance of Leukotriene B4]"15501964
C433788lipopolysaccharide, E. coli O26-B6"zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased abundance of Leukotriene B4]]"15501964
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 affects the expression of ALOX5 protein"11561080
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of ALOX5 protein"12388339
C440499lipopolysaccharide, Escherichia coli O111 B4"[lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4"12388339
C440499lipopolysaccharide, Escherichia coli O111 B4"tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4]"12388339
C440499lipopolysaccharide, Escherichia coli O111 B4"zileuton inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of ALOX5 protein]"12388339
C440499lipopolysaccharide, Escherichia coli O111 B4"zileuton inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of ALOX5 protein]"11561080
D008070Lipopolysaccharidesglucosamine 6-O-sulfate inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5 mRNA]21877189
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ALOX5 mRNA21877189
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of and results in increased activity of ALOX5 protein10779545
D008070LipopolysaccharidesEPHX2 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5 protein]19896470
D008070LipopolysaccharidesEPHX2 gene mutant form promotes the reaction [MK-886 inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5 protein]]19896470
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ALOX5 mRNA20453108
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ALOX5 protein19896470
D008070LipopolysaccharidesMK-886 inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5 protein]19896470
C040527lipoxin A4ALOX5 protein affects the abundance of lipoxin A415326064
C040527lipoxin A4zileuton inhibits the reaction [ALOX5 protein affects the abundance of lipoxin A4]15326064
D017336LoratadineLoratadine analog results in decreased activity of ALOX5 protein15482930
D019808LosartanLosartan results in decreased expression of ALOX5 protein21377515
D017572Leukotriene A4ALOX5 protein results in increased chemical synthesis of Leukotriene A418295198
D017997Leukotriene C4[zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4]9495842
D017997Leukotriene C4[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene C410764316
D017997Leukotriene C4ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene C4]12794006
D017997Leukotriene C4zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene C4]]12794006
D017997Leukotriene C4[Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] which results in increased abundance of Leukotriene C49445378
D017998Leukotriene D4ALOX5 protein results in increased abundance of Leukotriene D412629151
D017998Leukotriene D4[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene D410764316
D017998Leukotriene D4ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4]12794006
D017998Leukotriene D4zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4]]12794006
D047311LuteolinLuteolin inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]18096136
C032881lysophosphatidic acidALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]10698703
C032881lysophosphatidic acidMasoprocol inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]]10698703
C032881lysophosphatidic acidzileuton inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]]10698703
D009637MasoprocolMasoprocol results in decreased activity of ALOX5 protein2724698
D009637MasoprocolALOX5 protein affects the susceptibility to Masoprocol19503098
D009637MasoprocolMasoprocol inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]]10698703
D009637MasoprocolMasoprocol results in decreased activity of ALOX5 protein10698703|2724698
D009637Masoprocol[Masoprocol results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B42849922
D009637Masoprocol"[Masoprocol results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"2849922
D009637MasoprocolMasoprocol results in decreased activity of ALOX5 protein2724698
D009637MasoprocolMasoprocol results in decreased activity of ALOX5 protein2724698
D009637MasoprocolMasoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 mRNA]18083043
D009637MasoprocolMasoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 protein]18083043
D009637MasoprocolMasoprocol results in decreased activity of ALOX5 protein2724698|3928952
D009637MasoprocolMasoprocol results in decreased activity of ALOX5 protein19194550|3145369
C077265MCI 826MCI 826 results in decreased activity of ALOX5 protein2724698
C077265MCI 826MCI 826 results in decreased activity of ALOX5 protein2724698
D008469Meclofenamic AcidMeclofenamic Acid results in decreased activity of ALOX5 protein3020588
D008555MelittenMelitten results in increased activity of ALOX5 protein18475477
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ALOX5 mRNA20938992
D008727MethotrexateALOX5 protein affects the susceptibility to Methotrexate16217747
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ALOX5 mRNA28001369
C060893MK-886MK-886 results in decreased activity of ALOX5 protein8482329
C060893MK-886MK-886 inhibits the reaction [ALOX5 protein results in increased metabolism of Hydroxyeicosatetraenoic Acids metabolite]11861792
C060893MK-886MK-886 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]20061081
C060893MK-886EPHX2 gene mutant form promotes the reaction [MK-886 inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5 protein]]19896470
C060893MK-886MK-886 inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5 protein]19896470
C060893MK-886MK-886 results in decreased activity of ALOX5 protein14726295|9445378
C060893MK-886MK-886 results in decreased activity of ALOX5 protein14569062|2006108
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ALOX5 mRNA26924002
C093875montelukastALOX5 gene SNP affects the susceptibility to montelukast16293801
C568512N-(3-aminopropyl)-N-(1-(5-benzyl-3-methyl-4-oxo-(1,2)thiazolo(5,4-d)pyrimidin-6-yl)-2-methylpropyl)-4-methylbenzamide"N-(3-aminopropyl)-N-(1-(5-benzyl-3-methyl-4-oxo-(1,2)thiazolo(5,4-d)pyrimidin-6-yl)-2-methylpropyl)-4-methylbenzamide results in decreased activity of ALOX5 protein"21899292
C056614N-(3-phenoxycinnamyl)acetohydroxamic acidN-(3-phenoxycinnamyl)acetohydroxamic acid results in decreased activity of ALOX5 protein1318347
C056614N-(3-phenoxycinnamyl)acetohydroxamic acidN-(3-phenoxycinnamyl)acetohydroxamic acid results in decreased activity of ALOX5 protein21323313|2146616
C056614N-(3-phenoxycinnamyl)acetohydroxamic acidN-(3-phenoxycinnamyl)acetohydroxamic acid results in decreased activity of ALOX5 protein11529688
C056614N-(3-phenoxycinnamyl)acetohydroxamic acidN-(3-phenoxycinnamyl)acetohydroxamic acid results in decreased activity of ALOX5 protein21341744
C018845nafazatromnafazatrom results in decreased activity of ALOX5 protein3145369
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ALOX5 mRNA"25554681
D009532NickelNickel results in increased expression of ALOX5 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of ALOX5 mRNA19167457
D009538NicotineAG 1879 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]14569062
D009538NicotineMK-886 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]20061081
D009538NicotineNicotine results in increased expression of ALOX5 mRNA20061081
D009538NicotineNicotine results in increased expression of ALOX5 protein14569062|2006108
D009538Nicotine[tyrphostin AG 1478 co-treated with AG 1879] inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]14569062
D009538Nicotinetyrphostin AG 1478 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]14569062
D009538NicotineU 0126 inhibits the reaction [Nicotine results in increased expression of ALOX5 mRNA]20061081
D009569Nitric OxideNitric Oxide promotes the reaction [Reactive Oxygen Species results in decreased activity of ALOX5 protein]12388339
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of ALOX5 mRNA17616710
C025589ochratoxin Aochratoxin A affects the expression of ALOX5 mRNA26505656
C025589ochratoxin Aochratoxin A results in decreased expression of ALOX5 mRNA26505656
D009822Oils, Volatile"Oils, Volatile results in decreased activity of ALOX5 protein"19066064
C484027oligofectamineoligofectamine results in increased expression of ALOX5 mRNA14668052
D010047OvalbuminALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4]12794006
D010047OvalbuminALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene C4]12794006
D010047OvalbuminALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4]12794006
D010047OvalbuminALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]12794006
D010047OvalbuminOvalbumin results in increased expression of ALOX5 mRNA12794006
D010047Ovalbuminzileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4]]12794006
D010047Ovalbuminzileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene C4]]12794006
D010047Ovalbuminzileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4]]12794006
D010047Ovalbuminzileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]]12794006
D010047Ovalbuminzileuton inhibits the reaction [Ovalbumin results in increased expression of ALOX5 mRNA]12794006
C030110oxaliplatinoxaliplatin results in increased expression of ALOX5 mRNA25729387
C029341oxophenylarsine[oxophenylarsine co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D010100OxygenOxygen deficiency results in increased expression of ALOX5 mRNA26516004
D010100Oxygencaffeic acid inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]18951527
D010100Oxygen[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein18951527
D010100Oxygenphenylmethylpyrazolone inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]18951527
D010100OxygenSB 203580 inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]18951527
C046012pentanalpentanal results in increased expression of ALOX5 mRNA26079696
D030421Peroxynitrous AcidPeroxynitrous Acid results in decreased activity of ALOX5 protein12388339
D030421Peroxynitrous AcidPeroxynitrous Acid results in increased nitrosation of and affects the expression of ALOX5 protein11561080
D030421Peroxynitrous Acidzileuton inhibits the reaction [Peroxynitrous Acid results in increased nitrosation of ALOX5 protein]11561080
D030421Peroxynitrous AcidPeroxynitrous Acid results in increased nitrosation of ALOX5 protein12388339
D030421Peroxynitrous Acidzileuton inhibits the reaction [Peroxynitrous Acid results in increased nitrosation of ALOX5 protein]12388339
D010578PetroleumALOX5 gene SNP affects the susceptibility to Petroleum22919386
C015429phenidonephenidone results in decreased activity of ALOX5 protein7990266
C015429phenidonephenidone results in decreased activity of ALOX5 protein3928952
C005435phenylmethylpyrazolonephenylmethylpyrazolone inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein]18951527
C005435phenylmethylpyrazolonephenylmethylpyrazolone inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]18951527
D010743PhospholipidsPhospholipids results in increased expression of ALOX5 protein11937571
C006253pirinixic acidpirinixic acid analog results in decreased activity of ALOX5 protein18710209|1905832
D010938Plant OilsPlant Oils results in decreased activity of ALOX5 protein19066064
D010972Platelet Activating FactorPlatelet Activating Factor results in increased expression of ALOX5 mRNA16386258
D010972Platelet Activating Factor[sodium arsenite co-treated with Platelet Activating Factor co-treated with Arachidonic Acid] results in increased phosphorylation of and results in increased activity of ALOX5 protein10779545
D010972Platelet Activating Factor[zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Platelet Activating Factor]8387780
C443641poly(propyleneimine)poly(propyleneimine) analog results in decreased expression of ALOX5 mRNA16308212
D011189Potassium Chloride[Potassium Chloride co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ALOX5 mRNA22698814
C005556propionaldehydepropionaldehyde results in increased expression of ALOX5 mRNA26079696
D011433Propranolol1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [Propranolol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]]18218859
D011433PropranololPropranolol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]18218859
C513428pyrachlostrobinpyrachlostrobin results in increased expression of ALOX5 mRNA27029645
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [JUN protein modified form binds to ALOX5 promoter]23539630
C432165pyrazolanthronepyrazolanthrone results in decreased expression of ALOX5 protein23539630
D011794QuercetinQuercetin inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]18096136
D011794QuercetinQuercetin results in decreased activity of ALOX5 protein3145369
C443401quercetin 3-O-glucuronidequercetin 3-O-glucuronide inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]18096136
C531389quercetin 3'-sulfatequercetin 3'-sulfate inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]18096136
D017382Reactive Oxygen SpeciesNitric Oxide promotes the reaction [Reactive Oxygen Species results in decreased activity of ALOX5 protein]12388339
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in decreased activity of ALOX5 protein12388339
C059514resveratrolresveratrol binds to and results in decreased activity of ALOX5 protein10491155
C059514resveratrolresveratrol inhibits the reaction [[Hydrogen Peroxide results in increased activity of ALOX5 protein] which results in increased chemical synthesis of Leukotriene B4]10491155
C059514resveratrol"resveratrol inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of ALOX5 protein]"23751068
C089730rosiglitazoneALOX5 affects the susceptibility to rosiglitazone19321784
C045954RS 43179RS 43179 results in decreased activity of ALOX5 protein2849922
C045954RS 43179[RS 43179 results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B42849922
C045954RS 43179"[RS 43179 results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"2849922
C067525S(alpha)-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acidS(alpha)-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acid results in decreased activity of ALOX5 protein8482329
C067525S(alpha)-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acidS(alpha)-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acid results in decreased activity of ALOX5 protein8113982
C093642SB 203580SB 203580 inhibits the reaction [Calcimycin results in increased phosphorylation of and results in increased activity of ALOX5 protein]10779545
C093642SB 203580SB 203580 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of ALOX5 protein]10779545
C093642SB 203580SB 203580 inhibits the reaction [sodium arsenite results in increased activity of ALOX5 protein]10779545
C093642SB 203580SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of ALOX5 protein]10779545
C093642SB 203580SB 203580 inhibits the reaction [Sorbitol results in increased activity of ALOX5 protein]10779545
C093642SB 203580SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of ALOX5 protein]10779545
C093642SB 203580SB 203580 inhibits the reaction [Thapsigargin results in increased phosphorylation of and results in increased activity of ALOX5 protein]10779545
C093642SB 203580SB 203580 inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of ALOX5 protein]10779545
C093642SB 203580SB 203580 results in decreased phosphorylation of and results in decreased activity of ALOX5 protein10779545
C093642SB 203580SB 203580 inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of ALOX5 mRNA]20382172
C093642SB 203580SB 203580 inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein]18951527
C093642SB 203580SB 203580 inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]18951527
C093642SB 203580SB 203580 inhibits the reaction [[Hydrogen Peroxide co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein]11698504
C093642SB 203580SB 203580 inhibits the reaction [[Sodium Chloride co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein]11698504
C115461SC 560SC 560 promotes the reaction [Carbon Tetrachloride results in increased expression of ALOX5 protein]25432964
D012643Selenium[Vitamin E co-treated with Selenium] results in decreased expression of ALOX5 mRNA22223226
D012643Selenium[Vitamin E co-treated with Selenium] results in decreased expression of ALOX5 protein22223226
C078903seocalcitolseocalcitol results in increased expression of ALOX5 mRNA12040012
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ALOX5 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of ALOX5 mRNA21602193
C017947sodium arseniteSB 203580 inhibits the reaction [sodium arsenite results in increased activity of ALOX5 protein]10779545
C017947sodium arseniteSB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of ALOX5 protein]10779545
C017947sodium arsenite[sodium arsenite co-treated with Platelet Activating Factor co-treated with Arachidonic Acid] results in increased phosphorylation of and results in increased activity of ALOX5 protein10779545
C017947sodium arsenitesodium arsenite results in increased phosphorylation of and results in increased activity of ALOX5 protein10779545
C017947sodium arsenitesodium arsenite results in increased expression of ALOX5 mRNA25065748
C017947sodium arsenite[sodium arsenite co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
C016104sodium bichromatesodium bichromate results in decreased expression of ALOX5 mRNA17685462
D012965Sodium Chloride[AGT protein co-treated with Sodium Chloride] affects the expression of ALOX5 mRNA27225954
D012965Sodium ChlorideSB 203580 inhibits the reaction [[Sodium Chloride co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein]11698504
D012965Sodium Chloride[Sodium Chloride co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D013012SorbitolSB 203580 inhibits the reaction [Sorbitol results in increased activity of ALOX5 protein]10779545
D013012Sorbitol[Sorbitol co-treated with Calcimycin co-treated with Arachidonic Acid] affects the localization of ALOX5 protein11698504
D013012SorbitolSorbitol results in increased phosphorylation of and results in increased activity of ALOX5 protein10779545
D013012Sorbitol[Sorbitol co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D013012Sorbitol[Sorbitol co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D013012SorbitolThapsigargin promotes the reaction [[Sorbitol co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein]11698504
D013629TamoxifenTamoxifen results in increased expression of ALOX5 protein9742967
D013629Tamoxifen[Tamoxifen results in increased expression of ALOX5 protein] which results in increased abundance of Leukotriene B49742967
C062866tenidaptenidap results in decreased activity of ALOX5 protein2849922
C062866tenidap[tenidap results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B42849922
C062866tenidap"[tenidap results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"2849922
C073135tepoxalintepoxalin results in decreased activity of ALOX5 protein12629151
C073135tepoxalintepoxalin results in decreased activity of ALOX5 protein9223651
C073135tepoxalin[tepoxalin results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4]9223651
D020002tert-Butyl Alcoholtert-Butyl Alcohol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]18218859
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ALOX5 mRNA28487374
D013749TetrachlorodibenzodioxinAHR mRNA promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ALOX5 mRNA]28487374
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ALOX5 mRNA28487374
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ALOX5 protein28487374
D013755Tetradecanoylphorbol AcetateSB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of ALOX5 protein]10779545
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of ALOX5 protein11698504
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of ALOX5 protein10779545
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ALOX5 mRNA25613284
C480958tetrakis(4-benzoic acid)porphyrin"tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4]"12388339
D019284Thapsigargin1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein]18218859
D019284Thapsigargin1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein]]18218859
D019284ThapsigarginSB 203580 inhibits the reaction [Thapsigargin results in increased phosphorylation of and results in increased activity of ALOX5 protein]10779545
D019284ThapsigarginThapsigargin results in increased activity of and results in increased localization of ALOX5 protein18218859
D019284ThapsigarginThapsigargin results in increased phosphorylation of and results in increased activity of ALOX5 protein10779545
D019284ThapsigarginThapsigargin promotes the reaction [[Sorbitol co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein]11698504
D013849ThimerosalThimerosal results in decreased expression of ALOX5 mRNA27188386
C009495titanium dioxidetitanium dioxide results in decreased expression of ALOX5 mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of ALOX5 mRNA23409001
D014212TretinoinTretinoin results in increased expression of ALOX5 mRNA16129123
D014222Triamcinolone Acetonide"Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of ALOX5 protein]"23751068
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of ALOX5 mRNA19042947
C057693troglitazonetroglitazone results in decreased activity of ALOX5 protein10694244|1711357
C057693troglitazone[troglitazone results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B410694244
C101044tyrphostin AG 1478[tyrphostin AG 1478 co-treated with AG 1879] inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]14569062
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]14569062
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [Acrolein results in increased expression of ALOX5 protein]20153347
C113580U 0126U 0126 inhibits the reaction [Calcimycin results in increased phosphorylation of and results in increased activity of ALOX5 protein]10779545
C113580U 0126U 0126 inhibits the reaction [Nicotine results in increased expression of ALOX5 mRNA]20061081
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALOX5 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of ALOX5 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of ALOX5 gene29154799
D014638Vanadates[Vanadates co-treated with Calcimycin co-treated with Arachidonic Acid] results in increased activity of ALOX5 protein11698504
D014810Vitamin EVitamin E results in decreased activity of ALOX5 protein11325678|1220081
D014810Vitamin E[Vitamin E co-treated with Selenium] results in decreased expression of ALOX5 mRNA22223226
D014810Vitamin E[Vitamin E co-treated with Selenium] results in decreased expression of ALOX5 protein22223226
C063449zileutonzileuton results in decreased activity of ALOX5 protein1618819
C063449zileutonzileuton results in decreased activity of ALOX5 protein7522174|7644563|
C063449zileutonALOX5 gene SNP affects the susceptibility to zileuton19214143
C063449zileuton"zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased abundance of Leukotriene B4]]"15501964
C063449zileutonzileuton inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]]10698703
C063449zileutonzileuton inhibits the reaction [ALOX5 protein results in increased metabolism of Arachidonic Acid]18295198
C063449zileutonzileuton inhibits the reaction [ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]9609743
C063449zileutonzileuton inhibits the reaction [L 708714 binds to ALOX5 protein]7577949
C063449zileutonzileuton results in decreased activity of ALOX5 protein10377029|1069870
C063449zileuton[zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Platelet Activating Factor]8387780
C063449zileuton[zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4]9495842
C063449zileuton[zileuton results in decreased activity of ALOX5 protein] which affects the abundance of Arachidonic Acid9495842
C063449zileuton[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B411286996|1781415
C063449zileuton[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene C410764316
C063449zileuton[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene D410764316
C063449zileuton[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene E410764316|8621850
C063449zileuton[zileuton results in decreased activity of ALOX5 protein] which results in decreased susceptibility to Arachidonic Acid7592874
C063449zileutonzileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4]]12794006
C063449zileutonzileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene C4]]12794006
C063449zileutonzileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4]]12794006
C063449zileutonzileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]]12794006
C063449zileutonzileuton inhibits the reaction [Ovalbumin results in increased expression of ALOX5 mRNA]12794006
C063449zileutonzileuton results in decreased activity of ALOX5 protein11694324|1188653
C063449zileuton[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B49593866
C063449zileuton[zileuton results in decreased activity of ALOX5 protein] which results in decreased expression of NOS111694324
C063449zileutonzileuton results in decreased activity of ALOX5 protein9831321
C063449zileuton[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Eicosanoids9831321
C063449zileutonzileuton binds to and results in decreased activity of ALOX5 protein12649539
C063449zileuton[[zileuton co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B411529688
C063449zileutonzileuton inhibits the reaction [ALOX5 protein affects the abundance of lipoxin A4]15326064
C063449zileutonzileuton inhibits the reaction [IL13 protein results in increased expression of ALOX5 mRNA]12654629
C063449zileuton"zileuton inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of ALOX5 protein]"12388339
C063449zileuton"zileuton inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of ALOX5 protein]"11561080
C063449zileutonzileuton inhibits the reaction [Peroxynitrous Acid results in increased nitrosation of ALOX5 protein]11561080
C063449zileutonzileuton results in decreased activity of ALOX5 protein10694244|1472629
C063449zileuton[zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Leukotriene B4]18475545
C063449zileuton[zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4]9223651
C063449zileuton[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B410694244
C063449zileutonzileuton results in decreased expression of ALOX5 mRNA19309543
C063449zileutonzileuton results in decreased activity of ALOX5 protein11509739
C063449zileutonzileuton inhibits the reaction [Peroxynitrous Acid results in increased nitrosation of ALOX5 protein]12388339
C063449zileutonzileuton results in decreased activity of ALOX5 protein15935457|1667064
D015032ZincZinc deficiency results in increased expression of ALOX5 mRNA22171008
C088450ZM 230487ZM 230487 results in decreased activity of ALOX5 protein7522174
C088658zoledronic acidzoledronic acid results in increased expression of ALOX5 mRNA24714768
D015054ZymosanALOX5 protein affects the reaction [Zymosan results in increased expression of ICAM1 protein]15241586
D015054ZymosanALOX5 protein affects the reaction [Zymosan results in increased expression of SELP protein]15241586

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004051arachidonate 5-lipoxygenase activity-IDA21233389  
GO:0004051arachidonate 5-lipoxygenase activity-TAS-  
GO:0005506iron ion binding-IDA21233389  
GO:0005515protein binding-IPI11297527  11785969  16924104  19233132  24860872  25416956  
25910212  
GO ID GO Term Qualifier Evidence PubMed
GO:0002540leukotriene production involved in inflammatory response-IEA-  
GO:0006691leukotriene metabolic process-TAS3422434  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0019370leukotriene biosynthetic process-IDA21233389  
GO:0019372lipoxygenase pathway-TAS-  
GO:0035655interleukin-18-mediated signaling pathway-TAS-  
GO:0042759long-chain fatty acid biosynthetic process-TAS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA22664934  
GO:0005635nuclear envelope-IDA19233132  
GO:0005635nuclear envelope-TAS-  
GO:0005641nuclear envelope lumen-IDA8245774  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA19233132  
GO:0005829cytosol-TAS-  
GO:0016363nuclear matrix-IDA19233132  
GO:0031965nuclear membrane-IDA8245774  
GO:0034774secretory granule lumen-TAS-  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
hsa05145Toxoplasmosis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1430728MetabolismTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-2142688Synthesis of 5-eicosatetraenoic acidsTAS
R-HSA-2142691Synthesis of Leukotrienes (LT) and Eoxins (EX)TAS
R-HSA-2142700Synthesis of Lipoxins (LX)TAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-8978868Fatty acid metabolismTAS
R-HSA-9012546Interleukin-18 signalingTAS
R-HSA-9018676Biosynthesis of D-series resolvinsTAS
R-HSA-9018677Biosynthesis of DHA-derived SPMsTAS
R-HSA-9018678Biosynthesis of specialized proresolving mediators (SPMs)TAS
R-HSA-9018679Biosynthesis of EPA-derived SPMsTAS
R-HSA-9018682Biosynthesis of maresinsTAS
R-HSA-9018683Biosynthesis of DPA-derived SPMsTAS
R-HSA-9018896Biosynthesis of E-series 18(S)-resolvinsTAS
R-HSA-9020265Biosynthesis of aspirin-triggered D-series resolvinsTAS
R-HSA-9023661Biosynthesis of E-series 18(R)-resolvinsTAS
R-HSA-9025094Biosynthesis of DPAn-3 SPMsTAS
R-HSA-9026286Biosynthesis of DPAn-3-derived protectins and resolvinsTAS
R-HSA-9026290Biosynthesis of DPAn-3-derived maresinsTAS
R-HSA-9026403Biosynthesis of DPAn-3-derived 13-series resolvinsTAS
R-HSA-9027604Biosynthesis of electrophilic ?-3 PUFA oxo-derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22678777PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer. (2013 Jan)Habermann NGenes Nutr
27990118Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies. (2016)Thompson MDFront Pharmacol