Gene: ALOX5AP

241
FLAP
arachidonate 5-lipoxygenase activating protein
protein-coding
13q12.3
Ensembl:ENSG00000132965 MIM:603700 Vega:OTTHUMG00000016677 UniprotKB:P20292
NG_011963.2
PubMed
0   ANCO-SNPs
ND
10   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.189e-1 (AD)  4.560e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LAPTM50.953
FCER1G0.943
ITGB20.94
C1QC0.938
SASH30.933
LAIR10.931
C1QB0.931
C1QA0.93
LAT20.928
FCGR2A0.925

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZSCAN1-0.46
ATP2C2-0.456
KCNIP3-0.451
ST6GAL2-0.443
HES5-0.435
TMEM191C-0.43
MARCH4-0.429
NEUROD6-0.422
DLK2-0.418
SLC7A4-0.417

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04929DG031Small Molecule-InvestigationalTarget
DB05225AM103Small Molecule-InvestigationalTarget
DB06346FiboflaponSmall Molecule936350-00-4InvestigationalTarget
ID Drug Name Action PubMed
C0636091,2-dimethyl-4-nitrobenzene"1,2-dimethyl-4-nitrobenzene results in decreased expression of ALOX5AP mRNA"19784758
C0793152-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid results in decreased activity of ALOX5AP protein9113110
C0793152-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid[2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid results in decreased activity of ALOX5AP protein] which results in decreased abundance of Leukotriene C49113110
C0793152-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid binds to and results in decreased activity of ALOX5AP protein12649539
C0793152-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ALOX5AP protein]16033810
C0793152-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid results in decreased activity of ALOX5AP protein16033810
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of ALOX5AP mRNA19191707
D000082AcetaminophenAcetaminophen affects the expression of ALOX5AP mRNA17562736
D000082AcetaminophenAcetaminophen affects the expression of ALOX5AP mRNA19784758
D000082AcetaminophenAcetaminophen results in decreased expression of ALOX5AP mRNA19784758
D000082AcetaminophenAcetaminophen results in increased expression of ALOX5AP mRNA19784758
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ALOX5AP mRNA21641981
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ALOX5AP mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ALOX5AP mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of ALOX5AP mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ALOX5AP mRNA24449571
C000228aristolochic acid Iaristolochic acid I results in increased expression of ALOX5AP protein21658425
C000228aristolochic acid IMK-886 inhibits the reaction [aristolochic acid I results in increased expression of ALOX5AP protein]21658425
C000228aristolochic acid IU 0126 inhibits the reaction [aristolochic acid I results in increased expression of ALOX5AP protein]21658425
C006632arsenic trioxidearsenic trioxide results in decreased expression of ALOX5AP mRNA19128835
C006632arsenic trioxidearsenic trioxide results in increased expression of ALOX5AP mRNA15070760|1576101
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of ALOX5AP mRNA15894607
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of ALOX5AP mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ALOX5AP mRNA22228805
D004958EstradiolEstradiol results in increased expression of ALOX5AP mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of ALOX5AP mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ALOX5AP gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ALOX5AP promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ALOX5AP mRNA27339419
D002251Carbon Tetrachloride2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ALOX5AP protein]16033810
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ALOX5AP mRNA12734012
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ALOX5AP mRNA16644059|1978475
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ALOX5AP protein16033810
D002273CarcinogensCarcinogens results in decreased expression of ALOX5AP mRNA22269147
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ALOX5AP mRNA20938992
C055162clopidogrelclopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5AP mRNA]19172522
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALOX5AP mRNA]11007951
D003520CyclophosphamideCyclophosphamide results in decreased expression of ALOX5AP mRNA17403535
D016572CyclosporineCyclosporine results in increased expression of ALOX5AP mRNA25562108
D003907DexamethasoneDexamethasone results in increased expression of ALOX5AP mRNA22733784
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ALOX5AP mRNA27392435
D002945CisplatinCisplatin results in increased expression of ALOX5AP mRNA27594783
D002945CisplatinCisplatin results in increased expression of ALOX5AP mRNA15464296|1547189
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ALOX5AP mRNA16931933
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ALOX5AP mRNA16931933
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of ALOX5AP mRNA16931933
D004041Dietary FatsDietary Fats results in decreased expression of ALOX5AP mRNA18042831
D002117CalcitriolCalcitriol results in decreased expression of ALOX5AP mRNA26485663
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of ALOX5AP mRNA16507463
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ALOX5AP mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ALOX5AP mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ALOX5AP mRNA16079270
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ALOX5AP mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ALOX5AP mRNA20938992
C039281furanfuran results in increased expression of ALOX5AP mRNA27387713
C039281furanfuran results in increased methylation of ALOX5AP gene22079235
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of ALOX5AP mRNA22634610
D006540HerbicidesALOX5AP gene SNP affects the susceptibility to Herbicides22919386
D007975Leukotriene B4ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]9609743
D007975Leukotriene B4L 655238 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]9609743
D007975Leukotriene B4MK-886 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]9609743
D006581HexachlorobenzeneHexachlorobenzene affects the expression of ALOX5AP mRNA15159207
D006632HistamineALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]9609743
D006632HistamineL 655238 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]9609743
D006632HistamineMK-886 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]9609743
D017313FenretinideFenretinide results in decreased expression of ALOX5AP mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ALOX5AP mRNA15761015
D019469Indinavir[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ALOX5AP mRNA16931933
C075954indolo(3,2-b)carbazole"indolo(3,2-b)carbazole results in increased expression of ALOX5AP mRNA"18762178
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ALOX5AP mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ALOX5AP mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ALOX5AP mRNA23086925
D007608Kainic AcidKainic Acid results in increased expression of ALOX5AP mRNA19700661
C095607L 655238L 655238 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]9609743
D008070Lipopolysaccharidesclopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5AP mRNA]19172522
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ALOX5AP mRNA21461237
D018021Lithium ChlorideLithium Chloride results in increased expression of ALOX5AP mRNA23527032
D017997Leukotriene C4[2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid results in decreased activity of ALOX5AP protein] which results in decreased abundance of Leukotriene C49113110
D017997Leukotriene C4[MK-886 results in decreased activity of ALOX5AP protein] which results in decreased abundance of Leukotriene C49113110
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of ALOX5AP mRNA20843944
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ALOX5AP mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ALOX5AP mRNA23649840
C078266MK 0591MK 0591 binds to and results in decreased activity of ALOX5AP protein8147271
C060893MK-886MK-886 results in decreased activity of ALOX5AP protein7522174
C060893MK-886MK-886 binds to and results in decreased activity of ALOX5AP protein8666909
C060893MK-886MK-886 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]9609743
C060893MK-886MK-886 results in decreased activity of ALOX5AP protein12629151|9113110
C060893MK-886[MK-886 results in decreased activity of ALOX5AP protein] which results in decreased abundance of Leukotriene C49113110
C060893MK-886MK-886 results in decreased activity of ALOX5AP protein7990266
C060893MK-886MK-886 results in decreased activity of ALOX5AP protein8058773
C060893MK-886MK-886 inhibits the reaction [aristolochic acid I results in increased expression of ALOX5AP protein]21658425
C060893MK-886MK-886 results in decreased activity of ALOX5AP protein15888248|1782787
C523799MRK 003ALOX5AP results in increased susceptibility to MRK 00319903844
D009153MutagensMutagens results in decreased expression of ALOX5AP mRNA22269147
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ALOX5AP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ALOX5AP mRNA"25554681|2562005
D009532NickelNickel results in increased expression of ALOX5AP mRNA25583101
C029938nickel sulfatenickel sulfate results in decreased expression of ALOX5AP mRNA16780908
D009578NitrobenzenesNitrobenzenes analog results in decreased expression of ALOX5AP mRNA19784758
D000073878Palm OilPalm Oil results in decreased expression of ALOX5AP mRNA18042831
D010278ParathionParathion results in decreased expression of ALOX5AP mRNA19784758
D010396PenicillaminePenicillamine results in increased expression of ALOX5AP mRNA19575532
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ALOX5AP mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of ALOX5AP mRNA19482888
D010852PicrotoxinPicrotoxin results in increased expression of ALOX5AP mRNA15170462
C006253pirinixic acidpirinixic acid results in decreased expression of ALOX5AP mRNA17426115
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ALOX5AP mRNA22714537
C005556propionaldehydepropionaldehyde results in increased expression of ALOX5AP mRNA26079696
D011794QuercetinQuercetin results in decreased expression of ALOX5AP mRNA21632981
D017382Reactive Oxygen SpeciesReactive Oxygen Species affects the expression of ALOX5AP mRNA15761015
C059514resveratrolresveratrol results in increased expression of ALOX5AP mRNA25905778
D019258Saquinavir[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ALOX5AP mRNA16931933
D012822Silicon DioxideSilicon Dioxide results in increased expression of ALOX5AP mRNA23221170
D012822Silicon DioxideSilicon Dioxide results in increased expression of ALOX5AP mRNA21602193
D012834SilverSilver results in increased expression of ALOX5AP mRNA27131904
D019821SimvastatinSimvastatin results in increased expression of ALOX5AP mRNA17183729
C017947sodium arsenitesodium arsenite results in decreased expression of ALOX5AP mRNA16507463
D012999SomanSoman results in increased expression of ALOX5AP mRNA19281266
C016766sulforafansulforafan results in increased expression of ALOX5AP mRNA26833863
C061133tamibarotenetamibarotene results in increased expression of ALOX5AP mRNA15498508
D013629TamoxifenTamoxifen affects the expression of ALOX5AP mRNA17555576
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALOX5AP mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ALOX5AP mRNA11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ALOX5AP mRNA18762178
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ALOX5AP mRNA21570461|2892240
D013752TetracyclineTetracycline results in decreased expression of ALOX5AP mRNA16917069
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ALOX5AP mRNA25613284
D013853ThioacetamideThioacetamide results in decreased expression of ALOX5AP mRNA19784758
C009495titanium dioxidetitanium dioxide results in increased expression of ALOX5AP mRNA23409001|2355797
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ALOX5AP mRNA22363418
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of ALOX5AP mRNA15894607
D014212TretinoinTretinoin results in increased expression of ALOX5AP mRNA15498508|1589460
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ALOX5AP mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of ALOX5AP mRNA28973697
C113580U 0126U 0126 inhibits the reaction [aristolochic acid I results in increased expression of ALOX5AP protein]21658425
C025643vinclozolinvinclozolin affects the expression of ALOX5AP mRNA19015723|2303416
C029297vinylidene chloridevinylidene chloride results in increased expression of ALOX5AP mRNA26682919
D014859WarfarinWarfarin results in increased expression of ALOX5AP mRNA16698924
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ALOX5AP mRNA16931933
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ALOX5AP mRNA16931933
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of ALOX5AP mRNA16931933
C088658zoledronic acidzoledronic acid results in increased expression of ALOX5AP mRNA20977926|2471476

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004364glutathione transferase activity-IBA21873635  
GO:0004464leukotriene-C4 synthase activity-IBA21873635  
GO:0004602glutathione peroxidase activity-IBA21873635  
GO:0005515protein binding-IPI19233132  
GO:0008047enzyme activator activity-IEA-  
GO:0047485protein N-terminus binding-IPI19233132  
GO:0050544arachidonic acid binding-IDA8440384  
GO ID GO Term Qualifier Evidence PubMed
GO:0019370leukotriene biosynthetic process-IBA21873635  
GO:0019370leukotriene biosynthetic process-IDA2300173  
GO:0043085positive regulation of catalytic activity-IEA-  
GO:0070207protein homotrimerization-IPI17600184  
GO:0071277cellular response to calcium ion-IDA2300173  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-IBA21873635  
GO:0005635nuclear envelope-IDA19233132  
GO:0005635nuclear envelope-TAS-  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA19233132  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
GO:0031965nuclear membrane-IDA8245774  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-2142688Synthesis of 5-eicosatetraenoic acidsTAS
R-HSA-2142691Synthesis of Leukotrienes (LT) and Eoxins (EX)TAS
R-HSA-2142700Synthesis of Lipoxins (LX)TAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS
R-HSA-9018678Biosynthesis of specialized proresolving mediators (SPMs)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17387518Association of ALOX5AP with ischemic stroke: a population-based case-control study. (2007 Jun)Kaushal RHum Genet
23746795Association of ALOX5AP1 SG13S114T/A variant with ischemic stroke, stroke subtypes and aspirin resistance. (2013 Aug 15)Sharma VJ Neurol Sci
25010723Are ALOX5AP gene SNPs a risk or protective factor for stroke? (2014 Sep 10)Papapostolou AGene
18398440Ischaemic stroke in hypertensive patients is associated with variations in the PDE4D genome region. (2008 Sep)Lovkvist HEur J Hum Genet
25902778Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk. (2015 Jun)Merhi MInflamm Res
22206291The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers. (2011 Dec 29)Tulah ASBMC Med Genet
16778124Genetic variants of arachidonate 5-lipoxygenase-activating protein, and risk of incident myocardial infarction and ischemic stroke: a nested case-control approach. (2006 Aug)Zee RYStroke
24411318Synergistic effect of ALOX5AP polymorphisms and cigarette smoking on the risk of atherosclerotic cerebral infarction in a Northern Han Chinese population. (2014 Jun)Yao QJ Clin Neurosci
18775537Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia. (2009 Apr)van der Net JBAtherosclerosis
22537113Association between arachidonate 5-lipoxygenase-activating protein (ALOX5AP) and lung function in a Korean population. (2012 Aug)Ro MScand J Immunol