Gene: EML2

24139
ELP70|EMAP-2|EMAP2
echinoderm microtubule associated protein like 2
protein-coding
19q13.32
Ensembl:ENSG00000125746 MIM:617494 Vega:OTTHUMG00000182127 UniprotKB:O95834
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.835e-1 (AD)  3.003e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AATK0.882
MAP7D10.881
ROGDI0.88
GNAZ0.875
SRCIN10.875
DOHH0.874
DCTN10.872
KLC40.871
ARHGEF20.87
LARP60.869

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.591
OR4F5-0.591
MTRNR2L6-0.435
MTRNR2L10-0.426
GJB2-0.403
MTRNR2L9-0.402
ALAS2-0.393
KCNJ15-0.387
MTRNR2L8-0.378
S100A12-0.375

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of EML2 mRNA"23829299
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of EML2 mRNA"24680724
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of EML2 mRNA"21346803
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of EML2 mRNA"19561079
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EML2 mRNA22100608
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of EML2 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EML2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of EML2 mRNA24449571
D001151ArsenicArsenic affects the expression of EML2 protein24675094
C006632arsenic trioxidearsenic trioxide results in increased expression of EML2 protein25419056
C015001arsenitearsenite results in increased methylation of EML2 promoter23974009
D001280AtrazineAtrazine results in increased expression of EML2 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of EML2 mRNA22323515
C006780bisphenol Abisphenol A affects the expression of EML2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of EML2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of EML2 mRNA25181051
D002737ChloropreneChloroprene results in decreased expression of EML2 mRNA23125180
D016572CyclosporineCyclosporine results in increased expression of EML2 mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of EML2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of EML2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of EML2 mRNA27392435
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EML2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EML2 mRNA17942748
D005472FluorouracilEML2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]17327601
D002955LeucovorinEML2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]17327601
D005839GentamicinsGentamicins results in increased expression of EML2 protein22061828
C492448ICG 001ICG 001 results in increased expression of EML2 mRNA26191083
C051890irinotecanEML2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]17327601
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of EML2 mRNA27392435
C544151jinfukangjinfukang results in increased expression of EML2 mRNA27392435
D007854LeadLead affects the expression of EML2 mRNA28903495
D007854LeadLead results in decreased expression of EML2 mRNA19921347
D008345ManganeseManganese results in increased expression of EML2 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of EML2 mRNA17175027
D008694MethamphetamineMethamphetamine results in increased expression of EML2 mRNA26307267
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of EML2 mRNA24810058
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of EML2 protein24625837
D009020MorphineMorphine results in increased expression of EML2 protein23056601
D010100OxygenOxygen deficiency results in increased expression of EML2 mRNA17175027
C006253pirinixic acidpirinixic acid results in increased expression of EML2 mRNA22484513
D011794QuercetinQuercetin results in increased expression of EML2 mRNA21632981
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of EML2 mRNA19244175
D012643SeleniumSelenium results in increased expression of EML2 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of EML2 mRNA25895662
C009277sodium arsenatesodium arsenate results in decreased expression of EML2 mRNA21795629
D014284TriiodothyronineTriiodothyronine results in increased expression of EML2 mRNA23397585
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EML2 mRNA24680724
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EML2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EML2 mRNA22298810
D019284ThapsigarginThapsigargin results in increased expression of EML2 mRNA22378314
C009495titanium dioxidetitanium dioxide results in decreased expression of EML2 mRNA23557971
D014050TolueneToluene results in increased expression of EML2 mRNA22967744
D014241TrichloroethyleneTrichloroethylene results in increased expression of EML2 mRNA25549359
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of EML2 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of EML2 mRNA22378314
C025643vinclozolinvinclozolin affects the expression of EML2 mRNA19015723
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of EML2 mRNA19244175
D014810Vitamin EVitamin E results in increased expression of EML2 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0008017microtubule binding-IBA21873635  
GO:0008017microtubule binding-IDA11694528  
GO:0008022protein C-terminus binding-IEA-  
GO:0015631tubulin binding-IDA24706829  
GO ID GO Term Qualifier Evidence PubMed
GO:0007601visual perception-TAS10521658  
GO:0007605sensory perception of sound-TAS10521658  
GO:0010968regulation of microtubule nucleation-IDA11694528  
GO:0031115negative regulation of microtubule polymerization-IDA11694528  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005874microtubule-IEA-  
GO:0005875microtubule associated complex-TAS10521658  
GO:0015630microtubule cytoskeleton-IBA21873635  
GO:0072686mitotic spindlecolocalizes_withIDA11694528  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23665419Prenatal smoke exposure: effects on infant auditory system and placental gene expression. (2013 Jul-Aug)Katbamna BNeurotoxicol Teratol