Gene: MS4A6E

245802
-
membrane spanning 4-domains A6E
protein-coding
11q12.2
Ensembl:ENSG00000166926 MIM:608402 Vega:OTTHUMG00000167355 UniprotKB:Q96DS6
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.119e-1 (AD)  6.009e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FPR30.697
KYNU0.697
NOD20.675
SIGLEC70.666
ARHGAP150.666
ARL110.662
DENND2D0.656
GPR650.647
TLR10.644
MYO1G0.641

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ST6GAL2-0.305
SOHLH1-0.287
KCNIP3-0.287
RIMS1-0.28
FOXRED2-0.278
FEZF2-0.277
SDK2-0.273
CHRNA4-0.269
NEUROD6-0.265
ASIC1-0.261

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MS4A6E gene27153756
D001104ArbutinArbutin results in decreased expression of MS4A6E mRNA17103032
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MS4A6E mRNA"25102311
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MS4A6E mRNA"25102311

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget