Gene: ALOX15

246
12-LOX|15-LOX|15-LOX-1|LOG15
arachidonate 15-lipoxygenase
protein-coding
17p13.2
Ensembl:ENSG00000161905 MIM:152392 Vega:OTTHUMG00000090746 UniprotKB:P16050
NC_000017.11
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.482e-1 (AD)  8.257e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DCLK30.672
TRIM170.633
RGS140.632
ONECUT20.625
PASK0.613
TRIM110.61
WDR660.608
HIC20.604
KCNA40.599
KRTAP5-10.597

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.405
LRRCC1-0.396
COPZ2-0.389
CDNF-0.387
DPH6-0.386
ALDH1A1-0.384
SEPT10-0.383
CC2D2B-0.378
TRDN-0.376
ANXA4-0.368

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02709ResveratrolSmall Molecule501-36-0Approved|Experimental|InvestigationalTarget
DB08492(2E)-3-(2-OCT-1-YN-1-YLPHENYL)ACRYLIC ACIDSmall MoleculeExperimentalTarget
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C06604911,12,15-trihydroxyeicosatrienoic acid"[ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 11,12,15-trihydroxyeicosatrienoic acid"21193584
C05128311,14,15-trihydroxyeicosa-5,8,12-trienoic acid"[ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 11,14,15-trihydroxyeicosa-5,8,12-trienoic acid"21193584
C02434813-hydroxy-9,11-octadecadienoic acid"[caffeic acid results in decreased activity of ALOX15 protein] which results in decreased chemical synthesis of 13-hydroxy-9,11-octadecadienoic acid"11406566
C02434813-hydroxy-9,11-octadecadienoic acid"[caffeic acid results in decreased activity of ALOX15 protein] which results in increased abundance of 13-hydroxy-9,11-octadecadienoic acid"15574791
C02434813-hydroxy-9,11-octadecadienoic acid"[Masoprocol results in decreased activity of ALOX15 protein] which results in increased abundance of 13-hydroxy-9,11-octadecadienoic acid"15574791
C02434813-hydroxy-9,11-octadecadienoic acid"[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of ALOX15 protein] which results in increased chemical synthesis of 13-hydroxy-9,11-octadecadienoic acid"11406566
C02434813-hydroxy-9,11-octadecadienoic acid"[Sulindac results in increased expression of ALOX15 protein] which results in increased chemical synthesis of 13-hydroxy-9,11-octadecadienoic acid"11406566
C02434813-hydroxy-9,11-octadecadienoic acid"[vorinostat results in increased expression of ALOX15 protein] which results in increased abundance of 13-hydroxy-9,11-octadecadienoic acid"15574791
C52881315-hydroxy-11,12-epoxyeicosatrienoic acid"[ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 15-hydroxy-11,12-epoxyeicosatrienoic acid"21193584
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"ALOX15 protein results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"23872364
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"[ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"21193584
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"ALOX15 protein results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"18984061
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"cinnamyl-3,4-dihydroxycyanocinnamate inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]"18984061
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"Masoprocol inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]"18984061
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"18984061
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA"18984061
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 protein"18984061
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"ALOX15 protein results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"2849922
C0909373-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole results in increased expression of ALOX15 protein16166323
C439285(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride results in increased expression of ALOX15 mRNA16166323
C439285(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride results in increased expression of ALOX15 protein16166323
C1156268,12-iso-isoprostane F2alpha-VI"ALOX15 mutant form inhibits the reaction [APOE mutant form results in increased abundance of 8,12-iso-isoprostane F2alpha-VI]"16303615
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"8-((4-chlorophenyl)thio)cyclic-3',5'-GMP results in increased expression of ALOX15 mRNA"16166323
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"8-((4-chlorophenyl)thio)cyclic-3',5'-GMP results in increased expression of ALOX15 protein"16166323
C0908608-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate"8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate inhibits the reaction [sulindac sulfone results in increased phosphorylation of ALOX15 protein]"16166323
D000082AcetaminophenAcetaminophen results in decreased expression of ALOX15 mRNA26690555
D000082AcetaminophenAcetaminophen results in decreased expression of ALOX15 mRNA20100502
D000109Acetylcholine[ALOX15 protein affects the metabolism of Arachidonic Acid] which affects the susceptibility to Acetylcholine21193584
D020106AcrylamideAcrylamide results in decreased expression of ALOX15 mRNA28959563
C034201adolapinadolapin results in decreased activity of ALOX15 protein2996298
D024502alpha-TocopherolALOX15 protein results in increased degradation of alpha-Tocopherol9448720
D024502alpha-Tocopherolalpha-Tocopherol inhibits the reaction [ALOX15 protein results in increased abundance of cholesteryl ester hydroperoxide]9448720
D024502alpha-TocopherolAscorbic Acid inhibits the reaction [ALOX15 protein results in increased degradation of alpha-Tocopherol]9448720
D024502alpha-Tocopherolquercetin 3-O-glucopyranoside inhibits the reaction [ALOX15 protein results in increased degradation of alpha-Tocopherol]9448720
D024502alpha-Tocopherolquercetin 4'-O-glucopyranoside inhibits the reaction [ALOX15 protein results in increased degradation of alpha-Tocopherol]9448720
D024502alpha-Tocopherolquercetin 7-O-glucopyranoside inhibits the reaction [ALOX15 protein results in increased degradation of alpha-Tocopherol]9448720
D024502alpha-TocopherolQuercetin inhibits the reaction [ALOX15 protein results in increased degradation of alpha-Tocopherol]9448720
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ALOX15 mRNA21298039
D016718Arachidonic AcidALOX15 protein affects the metabolism of Arachidonic Acid8305483
D016718Arachidonic AcidALOX15 protein results in increased metabolism of Arachidonic Acid23872364
D016718Arachidonic Acid[IL4 protein co-treated with Arachidonic Acid] results in increased activity of ALOX15 protein11861792
D016718Arachidonic Acid[IL4 protein co-treated with Arachidonic Acid] results in increased expression of ALOX15 mRNA11861792
D016718Arachidonic Acid[ALOX15 protein affects the metabolism of Arachidonic Acid] which affects the susceptibility to Acetylcholine21193584
D016718Arachidonic Acid"[ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 11,12,15-trihydroxyeicosatrienoic acid"21193584
D016718Arachidonic Acid"[ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 11,14,15-trihydroxyeicosa-5,8,12-trienoic acid"21193584
D016718Arachidonic Acid"[ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid"21193584
D016718Arachidonic Acid"[ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 15-hydroxy-11,12-epoxyeicosatrienoic acid"21193584
D016718Arachidonic Acid"[ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"21193584
D016718Arachidonic Acid[ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 6-Ketoprostaglandin F1 alpha21193584
D016718Arachidonic Acid[ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of Dinoprostone21193584
D016718Arachidonic AcidALOX15 protein results in increased metabolism of and affects the susceptibility to Arachidonic Acid21193584
D001205Ascorbic AcidAscorbic Acid affects the activity of ALOX15 protein10995031
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [ALOX15 protein results in increased abundance of cholesteryl ester hydroperoxide]9448720
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [ALOX15 protein results in increased degradation of alpha-Tocopherol]9448720
C547126AZM551248AZM551248 results in decreased expression of ALOX15 mRNA22323515
C006680baicaleinbaicalein results in decreased activity of ALOX15 protein23238474
C099952bifenthrinbifenthrin results in increased expression of ALOX15 mRNA26071804
C006780bisphenol Abisphenol A results in decreased expression of ALOX15 mRNA25181051
D002084Butylated HydroxytolueneButylated Hydroxytoluene analog results in increased activity of ALOX15 protein7811748
C040048caffeic acidcaffeic acid inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased activity of ALOX15 protein]10904086
C040048caffeic acidcaffeic acid results in decreased activity of ALOX15 protein11406566
C040048caffeic acid[caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein]15574791
C040048caffeic acid"[caffeic acid results in decreased activity of ALOX15 protein] which results in decreased chemical synthesis of 13-hydroxy-9,11-octadecadienoic acid"11406566
C040048caffeic acid"[caffeic acid results in decreased activity of ALOX15 protein] which results in increased abundance of 13-hydroxy-9,11-octadecadienoic acid"15574791
C040048caffeic acidcaffeic acid results in decreased activity of ALOX15 protein15574791
D000074262Canola OilCanola Oil metabolite results in increased expression of ALOX15 mRNA27363782
D000074262Canola OilStarch analog inhibits the reaction [Canola Oil metabolite results in increased expression of ALOX15 mRNA]27363782
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ALOX15 mRNA12734012
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ALOX15 protein12629582
D002392CatechinCatechin results in decreased activity of ALOX15 protein10995031
C081459cholesteryl ester hydroperoxidealpha-Tocopherol inhibits the reaction [ALOX15 protein results in increased abundance of cholesteryl ester hydroperoxide]9448720
C081459cholesteryl ester hydroperoxideAscorbic Acid inhibits the reaction [ALOX15 protein results in increased abundance of cholesteryl ester hydroperoxide]9448720
C081459cholesteryl ester hydroperoxidequercetin 3-O-glucopyranoside inhibits the reaction [ALOX15 protein results in increased abundance of cholesteryl ester hydroperoxide]9448720
C081459cholesteryl ester hydroperoxidequercetin 4'-O-glucopyranoside inhibits the reaction [ALOX15 protein results in increased abundance of cholesteryl ester hydroperoxide]9448720
C081459cholesteryl ester hydroperoxidequercetin 7-O-glucopyranoside inhibits the reaction [ALOX15 protein results in increased abundance of cholesteryl ester hydroperoxide]9448720
C081459cholesteryl ester hydroperoxideQuercetin inhibits the reaction [ALOX15 protein results in increased abundance of cholesteryl ester hydroperoxide]9448720
C099255cinnamyl-3,4-dihydroxycyanocinnamate"cinnamyl-3,4-dihydroxycyanocinnamate inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]"18984061
C099255cinnamyl-3,4-dihydroxycyanocinnamate"cinnamyl-3,4-dihydroxycyanocinnamate results in decreased activity of ALOX15 protein"18984061
D003471CuprizoneCuprizone results in increased expression of ALOX15 mRNA27523638
C017154cyanidincyanidin results in decreased activity of ALOX15 protein3101704
D064791Desoxycorticosterone Acetate"ALOX15 protein affects the susceptibility to [Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary]"22467300
D004008DiclofenacDiclofenac results in increased expression of ALOX15 mRNA23939143
D004026DieldrinDieldrin affects the expression of ALOX15 mRNA22546817
D019422Dietary SucroseDietary Sucrose results in increased expression of ALOX15 mRNA26033743
C042986ebselenebselen results in decreased activity of ALOX15 protein7590103
C036251EPTCALOX15 gene SNP affects the susceptibility to EPTC22919386
D005620Freund's AdjuvantFreund's Adjuvant results in decreased expression of ALOX15 mRNA20846436
C069837fullerene C60fullerene C60 results in increased expression of ALOX15 mRNA19167457
D01937712-Hydroxy-5,8,10,14-eicosatetraenoic Acid"[ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid"21193584
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of ALOX15 mRNA15159207
C005499honokiolALOX15 protein promotes the reaction [honokiol results in decreased expression of PPARG protein]20649594
C005499honokiolALOX15 protein promotes the reaction [honokiol results in decreased expression of PTGS2 protein]20649594
C005499honokiolhonokiol results in increased expression of ALOX15 mRNA20649594
C005499honokiolhonokiol results in increased expression of ALOX15 protein20649594
C005499honokiol[honokiol results in increased expression of ALOX15 protein] which results in increased abundance of hydroxyoctadecadienoic acid20649594
C005499honokiolhonokiol results in increased expression of ALOX15 protein20649594
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in decreased expression of ALOX15 mRNA17183730
C495366hydroxyoctadecadienoic acid[honokiol results in increased expression of ALOX15 protein] which results in increased abundance of hydroxyoctadecadienoic acid20649594
C016517indole-3-carbinolindole-3-carbinol affects the expression of ALOX15 mRNA21396975
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of ALOX15 mRNA26752646
D0151216-Ketoprostaglandin F1 alpha[ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 6-Ketoprostaglandin F1 alpha21193584
C008261lead acetatelead acetate results in decreased expression of ALOX15 mRNA22641619
D008070Lipopolysaccharides[TLR4 gene mutant form co-treated with Lipopolysaccharides] results in increased expression of ALOX15 mRNA23000425
D019808LosartanLosartan results in decreased expression of ALOX15 mRNA15100363
D019808LosartanLosartan results in decreased expression of ALOX15 protein15100363
D009637Masoprocol"[Masoprocol results in decreased activity of ALOX15 protein] which results in increased abundance of 13-hydroxy-9,11-octadecadienoic acid"15574791
D009637MasoprocolMasoprocol results in decreased activity of ALOX15 protein23238474
D009637Masoprocol"Masoprocol inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]"18984061
D009637MasoprocolMasoprocol results in decreased activity of ALOX15 protein18984061
D009637MasoprocolMasoprocol results in decreased activity of ALOX15 protein15574791
D015122MercaptopurineMercaptopurine results in decreased expression of ALOX15 mRNA23358152
D008727MethotrexateMethotrexate results in decreased expression of ALOX15 mRNA24136188
C028577monobutyl phthalatemonobutyl phthalate affects the expression of ALOX15 mRNA19162170
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamidecaffeic acid inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased activity of ALOX15 protein]10904086
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideGATA6 protein inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of ALOX15 protein]11861401
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased activity of ALOX15 protein10904086
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of ALOX15 mRNA11861401
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of ALOX15 protein10904086|1140656
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide"[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of ALOX15 protein] which results in increased chemical synthesis of 13-hydroxy-9,11-octadecadienoic acid"11406566
C056614N-(3-phenoxycinnamyl)acetohydroxamic acidN-(3-phenoxycinnamyl)acetohydroxamic acid results in decreased activity of ALOX15 protein8305483
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ALOX15 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ALOX15 mRNA"25620056
D009532NickelNickel results in increased expression of ALOX15 mRNA25583101
D005996NitroglycerinNitroglycerin results in decreased expression of ALOX15 mRNA12102619
D019787Linoleic AcidALOX15 protein results in increased oxidation of Linoleic Acid25786526
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ALOX15 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of ALOX15 mRNA25729387
D010100OxygenALOX15 protein promotes the reaction [Oxygen deficiency results in decreased activity of KCNA5 protein]18984061
D010100Oxygen"cinnamyl-3,4-dihydroxycyanocinnamate inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]"18984061
D010100Oxygen"Masoprocol inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]"18984061
D010100OxygenOxygen deficiency results in increased activity of ALOX15 protein18984061
D010100Oxygen"[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid"18984061
D010100Oxygen"[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA"18984061
D010100Oxygen"[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 protein"18984061
D010269ParaquatAPOD protein affects the reaction [Paraquat results in decreased expression of ALOX15 mRNA]21688324
D010269ParaquatParaquat affects the reaction [APOD protein affects the expression of ALOX15 mRNA]21688324
D010269ParaquatParaquat results in decreased expression of ALOX15 mRNA21688324
D015232Dinoprostone[ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of Dinoprostone21193584
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ALOX15 mRNA23608068
D011341ProbucolProbucol results in increased activity of ALOX15 protein7811748
D011374ProgesteroneProgesterone affects the expression of ALOX15 mRNA17251523
D011374ProgesteroneProgesterone results in increased expression of ALOX15 mRNA21770760
D011441PropylthiouracilPropylthiouracil results in decreased expression of ALOX15 mRNA24780913
D011794QuercetinALOX15 protein results in increased degradation of Quercetin9448720
D011794QuercetinQuercetin inhibits the reaction [ALOX15 protein results in increased abundance of cholesteryl ester hydroperoxide]9448720
D011794QuercetinQuercetin inhibits the reaction [ALOX15 protein results in increased degradation of alpha-Tocopherol]9448720
D011794QuercetinQuercetin results in decreased activity of ALOX15 protein10995031
D011794QuercetinQuercetin results in decreased activity of ALOX15 protein3101704
C110309quercetin 3-O-glucopyranosideALOX15 protein results in increased degradation of quercetin 3-O-glucopyranoside9448720
C110309quercetin 3-O-glucopyranosidequercetin 3-O-glucopyranoside inhibits the reaction [ALOX15 protein results in increased abundance of cholesteryl ester hydroperoxide]9448720
C110309quercetin 3-O-glucopyranosidequercetin 3-O-glucopyranoside inhibits the reaction [ALOX15 protein results in increased degradation of alpha-Tocopherol]9448720
C110310quercetin 4'-O-glucopyranosideALOX15 protein results in increased degradation of quercetin 4'-O-glucopyranoside9448720
C110310quercetin 4'-O-glucopyranosidequercetin 4'-O-glucopyranoside inhibits the reaction [ALOX15 protein results in increased abundance of cholesteryl ester hydroperoxide]9448720
C110310quercetin 4'-O-glucopyranosidequercetin 4'-O-glucopyranoside inhibits the reaction [ALOX15 protein results in increased degradation of alpha-Tocopherol]9448720
C110311quercetin 7-O-glucopyranosideALOX15 protein results in increased degradation of quercetin 7-O-glucopyranoside9448720
C110311quercetin 7-O-glucopyranosidequercetin 7-O-glucopyranoside inhibits the reaction [ALOX15 protein results in increased abundance of cholesteryl ester hydroperoxide]9448720
C110311quercetin 7-O-glucopyranosidequercetin 7-O-glucopyranoside inhibits the reaction [ALOX15 protein results in increased degradation of alpha-Tocopherol]9448720
C059514resveratrolresveratrol binds to and results in decreased activity of ALOX15 protein10491155
D012431RutinRutin results in decreased activity of ALOX15 protein3101704
D012643SeleniumSelenium deficiency results in increased expression of ALOX15 mRNA11444866
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ALOX15 mRNA22431001
C017947sodium arsenitesodium arsenite affects the expression of ALOX15 mRNA29319823
C017947sodium arsenitesodium arsenite results in increased expression of ALOX15 mRNA25065748
D017673Sodium Chloride, Dietary"ALOX15 protein affects the susceptibility to [Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary]"22467300
D012969Sodium FluorideSodium Fluoride results in increased expression of ALOX15 mRNA22426295
D012969Sodium FluorideSodium Fluoride results in increased expression of ALOX15 protein22426295
D018038Sodium SeleniteALOX15 protein inhibits the reaction [Sodium Selenite results in decreased expression of ICAM1 mRNA]18045545
D018038Sodium SeleniteALOX15 protein inhibits the reaction [Sodium Selenite results in decreased expression of ICAM1 protein]18045545
D013213StarchStarch analog inhibits the reaction [Canola Oil metabolite results in increased expression of ALOX15 mRNA]27363782
D013467SulindacSulindac results in increased activity of ALOX15 protein10904086
D013467SulindacSulindac results in increased expression of ALOX15 protein10904086|1140656
D013467Sulindac"[Sulindac results in increased expression of ALOX15 protein] which results in increased chemical synthesis of 13-hydroxy-9,11-octadecadienoic acid"11406566
C025462sulindac sulfidesulindac sulfide results in increased expression of ALOX15 protein16166323
C025463sulindac sulfone"8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate inhibits the reaction [sulindac sulfone results in increased phosphorylation of ALOX15 protein]"16166323
C025463sulindac sulfoneGATA6 protein inhibits the reaction [sulindac sulfone results in increased expression of ALOX15 protein]11861401
C025463sulindac sulfonesulindac sulfone results in increased expression of ALOX15 mRNA11861401|1616632
C025463sulindac sulfonesulindac sulfone results in increased expression of ALOX15 protein11861401|1616632
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALOX15 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ALOX15 mRNA21215274
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ALOX15 mRNA25729387
D019772TopotecanTopotecan results in increased expression of ALOX15 mRNA25729387
D014212TretinoinTretinoin affects the expression of ALOX15 protein15996861
D014212TretinoinTretinoin affects the reaction [IL4 protein results in increased expression of ALOX15 protein]15996861
D014241TrichloroethyleneTrichloroethylene results in increased expression of ALOX15 mRNA28973375
D014241TrichloroethyleneTrichloroethylene results in increased methylation of ALOX15 gene27618143
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ALOX15 mRNA19042947
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in decreased expression of ALOX15 mRNA17183730
D014635Valproic AcidValproic Acid results in increased methylation of ALOX15 gene29154799
D000068756ValsartanValsartan inhibits the reaction [AGT protein results in increased activity of ALOX15 protein]9261183
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ALOX15 gene25560391
C025643vinclozolinvinclozolin results in increased expression of ALOX15 mRNA23034163
C111237vorinostat[caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein]15574791
C111237vorinostatvorinostat results in increased expression of ALOX15 protein15574791
C111237vorinostat"[vorinostat results in increased expression of ALOX15 protein] which results in increased abundance of 13-hydroxy-9,11-octadecadienoic acid"15574791
D015032ZincZinc affects the expression of ALOX15 mRNA16413754

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004052arachidonate 12-lipoxygenase activity-IDA1944593  
GO:0004052arachidonate 12-lipoxygenase activity-TAS-  
GO:0005506iron ion binding-ISS-  
GO:0005515protein binding-IPI21831839  
GO:0005546phosphatidylinositol-4,5-bisphosphate binding-IDA17052953  
GO:0047977hepoxilin-epoxide hydrolase activity-IEA-  
GO:0050473arachidonate 15-lipoxygenase activity-IDA1944593  17052953  
GO:0050473arachidonate 15-lipoxygenase activity-NAS3202857  
GO:0050473arachidonate 15-lipoxygenase activity-TAS-  
GO:0051120hepoxilin A3 synthase activity-IEA-  
GO:0097260eoxin A4 synthase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001503ossification-ISS-  
GO:0002820negative regulation of adaptive immune response-ISS-  
GO:0006646phosphatidylethanolamine biosynthetic process-ISS-  
GO:0006691leukotriene metabolic process-TAS-  
GO:0006954inflammatory response-TAS10200270  
GO:0010811positive regulation of cell-substrate adhesion-IDA11278875  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0019369arachidonic acid metabolic process-IDA1944593  17052953  
GO:0019369arachidonic acid metabolic process-NAS3202857  
GO:0019372lipoxygenase pathway-IDA1944593  
GO:0019372lipoxygenase pathway-TAS-  
GO:0030282bone mineralization-ISS-  
GO:0030838positive regulation of actin filament polymerization-ISS-  
GO:0034116positive regulation of heterotypic cell-cell adhesion-IEA-  
GO:0034976response to endoplasmic reticulum stress-ISS-  
GO:0035358regulation of peroxisome proliferator activated receptor signaling pathway-ISS-  
GO:0035963cellular response to interleukin-13-IMP21831839  
GO:0042060wound healing-ISS-  
GO:0042759long-chain fatty acid biosynthetic process-TAS-  
GO:0043277apoptotic cell clearance-ISS-  
GO:0051122hepoxilin biosynthetic process-ISS-  
GO:0055114oxidation-reduction process-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IMP21831839  
GO:0071277cellular response to calcium ion-IDA17052953  
GO:1901074regulation of engulfment of apoptotic cell-ISS-  
GO:2001303lipoxin A4 biosynthetic process-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005811lipid droplet-IDA19528634  
GO:0005829cytosol-IDA17052953  21831839  
GO:0005829cytosol-ISS-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-ISS-  
GO:0016020membrane-IDA21831839  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-IDA17052953  
KEGG ID KEGG Term
hsa00590Arachidonic acid metabolism
hsa00591Linoleic acid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1430728MetabolismTAS
R-HSA-168256Immune SystemTAS
R-HSA-2142691Synthesis of Leukotrienes (LT) and Eoxins (EX)TAS
R-HSA-2142712Synthesis of 12-eicosatetraenoic acid derivativesTAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-2142770Synthesis of 15-eicosatetraenoic acid derivativesTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-8978868Fatty acid metabolismTAS
R-HSA-9018677Biosynthesis of DHA-derived SPMsTAS
R-HSA-9018678Biosynthesis of specialized proresolving mediators (SPMs)TAS
R-HSA-9018679Biosynthesis of EPA-derived SPMsTAS
R-HSA-9018681Biosynthesis of protectinsTAS
R-HSA-9018683Biosynthesis of DPA-derived SPMsTAS
R-HSA-9018896Biosynthesis of E-series 18(S)-resolvinsTAS
R-HSA-9023661Biosynthesis of E-series 18(R)-resolvinsTAS
R-HSA-9025094Biosynthesis of DPAn-3 SPMsTAS
R-HSA-9025106Biosynthesis of DPAn-6 SPMsTAS
R-HSA-9026286Biosynthesis of DPAn-3-derived protectins and resolvinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22678777PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer. (2013 Jan)Habermann NGenes Nutr
19948975Integrative predictive model of coronary artery calcification in atherosclerosis. (2009 Dec 15)McGeachie MCirculation
20676957Two single nucleotide polymorphisms in ALOX15 are associated with risk of coronary artery disease in a Chinese Han population. (2010 Sep)Zhang KHeart Vessels