Gene: SLC17A8

246213
DFNA25|VGLUT3
solute carrier family 17 member 8
protein-coding
12q23.1
Ensembl:ENSG00000179520 MIM:607557 Vega:OTTHUMG00000170358 UniprotKB:Q8NDX2
NG_021175.1
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.695e-1 (AD)  4.234e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB3B0.733
TENM10.705
SEMA3E0.703
CYP26A10.683
CHRM20.677
COL25A10.67
TLL10.666
GRIK30.654
MCTP20.65
GRIN3A0.65

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZIC2-0.423
IMPA2-0.415
ZIC5-0.399
RFX2-0.378
STON2-0.376
NBPF10-0.375
TNFRSF11B-0.375
VIM-0.372
GLIS3-0.367
LGALS3-0.366

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SLC17A8 mRNA"28903501
D000082AcetaminophenAcetaminophen results in decreased expression of SLC17A8 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of SLC17A8 mRNA17562736
D000109AcetylcholineSLC17A8 protein affects the secretion of Acetylcholine18278042
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SLC17A8 mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC17A8 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of SLC17A8 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC17A8 mRNA27195522
C006780bisphenol Abisphenol A results in decreased expression of SLC17A8 mRNA25181051
D001973Bromodeoxyuridine[Bromodeoxyuridine co-treated with furan] affects the expression of SLC17A8 mRNA24910943
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC17A8 mRNA]20360939
D004390Chlorpyrifos[Chlorpyrifos co-treated with NGF protein] results in increased expression of SLC17A8 mRNA20600679
D004390ChlorpyrifosChlorpyrifos results in decreased expression of SLC17A8 mRNA20600679
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SLC17A8 mRNA20938992
D003042CocaineSLC17A8 protein affects the susceptibility to Cocaine18278042
D003976Diazinon[Diazinon co-treated with NGF protein] results in decreased expression of SLC17A8 mRNA20600679
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of SLC17A8 mRNA28962523
D004041Dietary FatsDietary Fats results in decreased expression of SLC17A8 mRNA22609946|2501614
D004052Diethylnitrosaminecaffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC17A8 mRNA]20360939
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SLC17A8 mRNA20360939
C024565ethylene dichlorideethylene dichloride results in decreased expression of SLC17A8 mRNA28189721
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of SLC17A8 gene18305245
D005492Folic AcidFolic Acid results in increased expression of SLC17A8 mRNA25006883
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SLC17A8 mRNA20938992
C039281furan[Bromodeoxyuridine co-treated with furan] affects the expression of SLC17A8 mRNA24910943
D006220HaloperidolSLC17A8 protein affects the susceptibility to Haloperidol18278042
D007854LeadLead affects the expression of SLC17A8 mRNA28903495
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of SLC17A8 mRNA22563483
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SLC17A8 mRNA20938992
C500085muraglitazarmuraglitazar results in decreased expression of SLC17A8 mRNA21515302
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SLC17A8 mRNA27935865
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of SLC17A8 mRNA22563483
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SLC17A8 mRNA27935865
C006253pirinixic acidpirinixic acid results in decreased expression of SLC17A8 mRNA20813756
D010936Plant ExtractsPlant Extracts results in decreased expression of SLC17A8 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC17A8 mRNA24780913
C089730rosiglitazonerosiglitazone results in decreased expression of SLC17A8 mRNA21515302
D013629TamoxifenTamoxifen results in decreased expression of SLC17A8 mRNA25123088
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of SLC17A8 mRNA25975270
D014241TrichloroethyleneTrichloroethylene results in increased expression of SLC17A8 mRNA25549359
C057693troglitazonetroglitazone results in decreased expression of SLC17A8 mRNA21515302
D014635Valproic AcidValproic Acid results in increased expression of SLC17A8 mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SLC17A8 gene25560391
D015215ZidovudineZidovudine results in increased expression of SLC17A8 mRNA24292225

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005313L-glutamate transmembrane transporter activity-IBA21873635  
GO:0005313L-glutamate transmembrane transporter activity-TAS-  
GO:0005326neurotransmitter transporter activity-IBA21873635  
GO:0015293symporter activity-IEA-  
GO:0022857transmembrane transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0003407neural retina development-IEA-  
GO:0006811ion transport-TAS-  
GO:0006814sodium ion transport-IEA-  
GO:0006820anion transport-IBA21873635  
GO:0007420brain development-IEA-  
GO:0007605sensory perception of sound-IEA-  
GO:0015813L-glutamate transmembrane transport-IEA-  
GO:0035249synaptic transmission, glutamatergic-IBA21873635  
GO:0050803regulation of synapse structure or activity-IBA21873635  
GO:0090102cochlea development-IEA-  
GO:0098700neurotransmitter loading into synaptic vesicle-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005771multivesicular body-IEA-  
GO:0016021integral component of membrane-IBA21873635  
GO:0030054cell junction-IEA-  
GO:0030285integral component of synaptic vesicle membrane-IBA21873635  
GO:0030672synaptic vesicle membrane-IBA21873635  
GO:0030672synaptic vesicle membrane-TAS-  
GO:0043204perikaryon-IEA-  
GO:0043679axon terminus-IEA-  
GO:0060076excitatory synapse-IBA21873635  
GO:0060076excitatory synapse-IEA-  
GO:0097440apical dendrite-IEA-  
GO:0097441basal dendrite-IEA-  
GO:0097451glial limiting end-foot-IEA-  
GO:1990030pericellular basket-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-428643Organic anion transportersTAS
R-HSA-5619076Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)TAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26239290The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens. (2015 Nov)Sakae DYMol Psychiatry