Gene: STH

246744
MAPTIT
saitohin
protein-coding
17q21.31
Ensembl:ENSG00000256762 MIM:607067 Vega:OTTHUMG00000168633 UniprotKB:Q8IWL8
NC_000017.11
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ERVW-10.654
ERVH48-10.623
C9orf1310.617
SPDYE10.598
OR10K10.596
TMEM2470.588
SPDYE60.584
TMPPE0.584
HOXC120.583
BTBD180.582

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GMFG-0.319
C1orf141-0.291
KLRC3-0.275
LRRC70-0.272
STARD6-0.269
KLRC2-0.267
RGS10-0.266
RNASE6-0.265
CDNF-0.265
RPGRIP1-0.262

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of STH mRNA21298039
C030419andrographolideandrographolide results in increased expression of STH mRNA19737545

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16186110  
GO ID GO Term Qualifier Evidence PubMed
GO:0048026positive regulation of mRNA splicing, via spliceosome-IGI16186110  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA16186110  
GO:0005737cytoplasm-IDA16186110  
GO:0048471perinuclear region of cytoplasm-IDA16186110  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
181772[Plasma ACTH, STH and other hormone levels in various groups under chlormethiazole, haloperidol or reserpine load in alchohol delirium, alcoholic hallucinations, and chronic alcoholism]. (1976 Jan)Dobrzanski TPsychiatr Neurol Med Psychol (Leipz)
15529573Feasibility study of substitution hormonal therapy on cardiovascular diseases in post-menopausal women (part II). (2000-2001)Gutiu IARom J Intern Med
7455580Effect of cigarette smoking on the blood glucose level in normals and diabetics. (1980 Oct-Dec)Bornemisza PMed Interne
2839820[Neuroendocrine regulation of immunogenesis in alcoholism]. (1988 Mar-Apr)Aliev NAProbl Endokrinol (Mosk)