Gene: IL27

246778
IL-27|IL-27A|IL27A|IL27p28|IL30|p28
interleukin 27
protein-coding
16p12.1-p11.2
Ensembl:ENSG00000197272 MIM:608273 Vega:OTTHUMG00000097023 UniprotKB:Q8NEV9
NC_000016.10
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.426e-1 (AD)  4.282e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IDO10.939
KRTAP20-10.93
RUFY40.923
ZBP10.919
CCL70.911
CYP19A10.91
CCL80.904
SIGLEC120.887
LGALS140.876
LAMP30.862

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP6V1E2-0.268
HCN2-0.265
SNX22-0.259
WNT7A-0.254
KCNIP3-0.254
NME5-0.251
ARSE-0.251
ATP2C2-0.246
ELFN2-0.245
SCRT1-0.245

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of IL27 mRNA19191707
C006780bisphenol Abisphenol A results in decreased methylation of IL27 promoter27312807
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of IL27 mRNA17557909
C436346I-152 compoundI-152 compound promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of and results in increased secretion of IL27 protein]23536773
C474021indirubin-3'-monoximeindirubin-3'-monoxime results in decreased expression of IL27 protein21948866
C474021indirubin-3'-monoximeLipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of IL27 protein]21948866
C016517indole-3-carbinolindole-3-carbinol results in decreased expression of IL27 mRNA21948866
C016517indole-3-carbinolLipopolysaccharides affects the susceptibility to [indole-3-carbinol results in decreased expression of IL27 mRNA]21948866
D008070LipopolysaccharidesI-152 compound promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of and results in increased secretion of IL27 protein]23536773
D008070LipopolysaccharidesLipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of IL27 protein]21948866
D008070LipopolysaccharidesLipopolysaccharides affects the susceptibility to [indole-3-carbinol results in decreased expression of IL27 mRNA]21948866
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL27 mRNA19426678|2658214
D008070LipopolysaccharidesLipopolysaccharides results in increased secretion of IL27 protein22118570
D008070LipopolysaccharidesLuteolin inhibits the reaction [Lipopolysaccharides results in increased expression of IL27 mRNA]19426678
D008070Lipopolysaccharidesresveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL27 protein]22118570
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL27 mRNA21742974
D008070LipopolysaccharidesMIRLET7I mRNA affects the reaction [Lipopolysaccharides results in increased expression of IL27 mRNA]21742974
D047311LuteolinLuteolin inhibits the reaction [Lipopolysaccharides results in increased expression of IL27 mRNA]19426678
D047311LuteolinLuteolin inhibits the reaction [Poly I-C results in increased expression of IL27 mRNA]19426678
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of IL27 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IL27 mRNA"25620056
D010269ParaquatParaquat results in increased expression of IL27 mRNA22938100
D011070Poly I-CLuteolin inhibits the reaction [Poly I-C results in increased expression of IL27 mRNA]19426678
D011070Poly I-CPoly I-C results in increased expression of IL27 mRNA19426678
C059514resveratrolresveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL27 protein]22118570
D012834SilverSilver results in increased expression of IL27 mRNA27131904
D019821SimvastatinIL27 affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]18453621
D019821SimvastatinIL27 affects the reaction [Simvastatin results in decreased expression of RORC mRNA]18453621
D019821SimvastatinIL27 affects the reaction [Simvastatin results in decreased secretion of IL17A protein]18453621
D019821SimvastatinSimvastatin results in increased expression of IL27 mRNA18453621
D019821SimvastatinSimvastatin results in increased secretion of IL27 protein18453621
D018038Sodium SeleniteSodium Selenite results in increased expression of IL27 mRNA18175754
C061133tamibarotenetamibarotene results in decreased expression of IL27 mRNA20861477
C009495titanium dioxidetitanium dioxide affects the expression of IL27 mRNA19695317
C009495titanium dioxidetitanium dioxide results in increased secretion of IL27 protein20005940
C040654titanium nickelidetitanium nickelide analog results in increased expression of IL2722287114
D014635Valproic AcidValproic Acid results in increased methylation of IL27 gene29154799
D014635Valproic AcidValproic Acid affects the expression of IL27 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-ISS-  
GO:0005125cytokine activity-IEA-  
GO:0005515protein binding-IPI20974977  
GO:0045523interleukin-27 receptor binding-IBA21873635  
GO:0045523interleukin-27 receptor binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002230positive regulation of defense response to virus by host-IEA-  
GO:0006954inflammatory response-IEA-  
GO:0009617response to bacterium-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0042129regulation of T cell proliferation-IBA21873635  
GO:0042129regulation of T cell proliferation-ISS-  
GO:0045078positive regulation of interferon-gamma biosynthetic process-IBA21873635  
GO:0045078positive regulation of interferon-gamma biosynthetic process-IDA12734330  
GO:0045087innate immune response-IEA-  
GO:0045625regulation of T-helper 1 cell differentiation-IBA21873635  
GO:0045625regulation of T-helper 1 cell differentiation-IDA12734330  
GO:0070106interleukin-27-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-ISS-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-447115Interleukin-12 family signalingIEA
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-9020956Interleukin-27 signalingTAS
R-HSA-9020956Interleukin-27 signalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27994590Cigarette Smoke Induction of Interleukin-27/WSX-1 Regulates the Differentiation of Th1 and Th17 Cells in a Smoking Mouse Model of Emphysema. (2016)Qiu SLFront Immunol
28631723Pharmacogenetic biomarkers of response in Crohn's disease. (2018 Jan)Linares-Pineda TMPharmacogenomics J
27684606Effects of cigarette smoking on cardiovascular-related protein profiles in two community-based cohort studies. (2016 Nov)Huang BAtherosclerosis
22430805Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: an epigenome-wide association study. (2012 Mar)Langevin SMEpigenetics
26771213Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. (2016 Jul 1)Hobbs BDAm J Respir Crit Care Med