Gene: MTOR

2475
FRAP|FRAP1|FRAP2|RAFT1|RAPT1|SKS
mechanistic target of rapamycin kinase
protein-coding
1p36.22
Ensembl:ENSG00000198793 MIM:601231 Vega:OTTHUMG00000002001 UniprotKB:P42345
NG_033239.1
PubMed
CD|ND|AD
53   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.228e-1 (AD)  2.907e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIAA01000.96
LARP10.951
HERC20.949
SLC35E10.946
HIF1AN0.945
EXOC70.944
RALGAPB0.943
USP190.942
SUGP20.942
KPNA60.942

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.561
OR4F29-0.515
MYL3-0.387
HEY2-0.383
MTRNR2L6-0.377
SH2D1A-0.37
MTRNR2L9-0.358
CSAG1-0.358
ZNF114-0.357
TFPI2-0.357

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00337PimecrolimusSmall Molecule137071-32-0Approved|InvestigationalTarget
DB00877SirolimusSmall Molecule53123-88-9Approved|InvestigationalTarget
DB01590EverolimusSmall Molecule159351-69-6ApprovedTarget
DB04974AP1903Small Molecule-InvestigationalTarget
DB05210SF1126Small Molecule-InvestigationalTarget
DB05241XL765Small Molecule-InvestigationalTarget
DB06233RidaforolimusSmall Molecule572924-54-0InvestigationalTarget
DB06287TemsirolimusSmall Molecule162635-04-3ApprovedTarget
ID Drug Name Action PubMed
C5525301,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased phosphorylation of MTOR protein"26035713
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]"21544200
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]"21544200
C5696701-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one"1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one results in decreased activity of MTOR protein"21981714|2199829
C5532941-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one"1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[MTOR protein binds to RAPTOR protein] which binds to LARP1 protein]"25940091
C5532941-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one"1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased activity of MTOR protein"21322566
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone promotes the reaction [bisphenol A results in increased phosphorylation of MTOR protein]"28882636
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone promotes the reaction [Estradiol results in increased phosphorylation of MTOR protein]"28882636
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased phosphorylation of MTOR protein"28882636
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone] inhibits the reaction [Estradiol results in increased phosphorylation of MTOR protein]"28882636
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone] results in increased phosphorylation of MTOR protein"28882636
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of MTOR protein"21705713
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of MTOR protein modified form"21705713
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"CTNNB1 gene mutant form affects the susceptibility to [1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of MTOR protein]"21705713
C40193215,16-dihydrotanshinone I"15,16-dihydrotanshinone I results in decreased phosphorylation of MTOR protein"26282490
C09724015-deoxy-delta(12,14)-prostaglandin J2"[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of MTOR protein"16611854
C495172(19Z)-halichondramide(19Z)-halichondramide results in decreased expression of MTOR protein23147639
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with sorafenib] results in decreased activity of MTOR protein"23036488
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased activity of MTOR protein"23036488
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine affects the activity of MTOR protein"20129775
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased activity of MTOR protein"19509167
C5614542,4-difluoro-N-(2-(methyloxy)-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide"2,4-difluoro-N-(2-(methyloxy)-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide results in decreased activity of MTOR protein"22297110
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MTOR mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased phosphorylation of MTOR protein]19139269
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MTOR mRNA]23793038
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MTOR protein]23793038
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of MTOR protein17148679|2628249
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of MTOR protein19108833
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of MTOR protein19108833
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of MTOR protein]17623046
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the activity of MTOR protein20129775
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MTOR mRNA"21346803
C5250632'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone"2'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone results in decreased phosphorylation of MTOR protein"25643584
C0841792-phenyl-4-oxohydroquinoline2-phenyl-4-oxohydroquinoline analog results in increased phosphorylation of MTOR protein27769712
C5609053-(2-(dimethylamino)isopropoxy)-1-hydroxybenzo(b)naphtho(2,3-d)furan-6,11-dione"3-(2-(dimethylamino)isopropoxy)-1-hydroxybenzo(b)naphtho(2,3-d)furan-6,11-dione results in decreased activity of MTOR protein"21600193
C4824923,4,5,4'-tetramethoxystilbene"3,4,5,4'-tetramethoxystilbene results in decreased phosphorylation of MTOR protein"23770989
C5287403-(4-bromophenyl)-2-(ethylsulfonyl)-6-methylquinoxaline-1,4-dioxide"3-(4-bromophenyl)-2-(ethylsulfonyl)-6-methylquinoxaline-1,4-dioxide results in decreased phosphorylation of MTOR protein"20524035
C5005303-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide"3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide results in increased phosphorylation of MTOR protein"21349818
C5005303-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide"3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide results in increased phosphorylation of MTOR protein"21349818
C0259463-methyladenine3-methyladenine inhibits the reaction [MAP3K5 protein results in decreased phosphorylation of MTOR protein]20929985
C0259463-methyladenine3-methyladenine results in decreased phosphorylation of MTOR protein26804764
C0006020014-(3,5-dimethoxystyryl)phenyl acetate"4-(3,5-dimethoxystyryl)phenyl acetate results in increased phosphorylation of MTOR protein"26138072
C5688624-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline"[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone] inhibits the reaction [Estradiol results in increased phosphorylation of MTOR protein]"28882636
C5688624-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline"[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone] results in increased phosphorylation of MTOR protein"28882636
C5688624-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Estradiol results in increased phosphorylation of MTOR protein]"28882636
C5550214-acetylantroquinonol B4-acetylantroquinonol B results in decreased phosphorylation of MTOR protein28408137
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of MTOR mRNA12419474
C0652504-hydroxy-equilenin4-hydroxy-equilenin results in decreased expression of MTOR mRNA15135645
C0415944-nonylphenol4-nonylphenol results in decreased phosphorylation of MTOR protein26804764|2804198
C0415944-nonylphenol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]"28041982
C0415944-nonylphenolAcetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]26804764
C0415944-nonylphenolAICA ribonucleotide promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]28041982
C0415944-nonylphenolPRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]28041982
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of MTOR protein]28245985
C0297284-phenylenediamine4-phenylenediamine affects the phosphorylation of MTOR protein26784575
C546624(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol"(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol results in decreased activity of MTOR protein"21322566
C5732335,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one"5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one affects the phosphorylation of MTOR protein"24646949
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in decreased phosphorylation of MTOR protein]"19928762
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Cadmium results in decreased phosphorylation of MTOR protein]"21767558
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]"28041982
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of MTOR protein]]"23211629
C5582866,6'-bis(2,3-dimethoxybenzoyl)-alpha,alpha-trehalose"6,6'-bis(2,3-dimethoxybenzoyl)-alpha,alpha-trehalose analog results in decreased phosphorylation of MTOR protein"25148938
C5847556-bromo-8-ethoxy-3-nitro-2H-chromene6-bromo-8-ethoxy-3-nitro-2H-chromene results in decreased phosphorylation of MTOR protein24831963
C0030017-ketocholesterol7-ketocholesterol results in increased phosphorylation of MTOR protein20466046
C0030017-ketocholesteroltyrphostin AG 1478 inhibits the reaction [7-ketocholesterol results in increased phosphorylation of MTOR protein]20466046
C4996938-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one results in decreased activity of MTOR protein16302822
C5585299-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one"9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased activity of MTOR protein"22789543
C5585299-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one"9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one binds to and results in decreased activity of MTOR protein"21322566
D000079AcetaldehydeAcetaldehyde results in decreased phosphorylation of MTOR protein16962100
D000082AcetaminophenAcetaminophen results in decreased expression of MTOR mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of MTOR mRNA25704631
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of MTOR mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MTOR mRNA]17585979
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Biological Products results in decreased expression of MTOR protein modified form]28219700
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Butyric Acid results in decreased phosphorylation of MTOR protein]28600122
D000111AcetylcysteineAcetylcysteine inhibits the reaction [cucurbitacin E results in decreased phosphorylation of MTOR protein]27106530
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Estradiol results in increased phosphorylation of MTOR protein]23000059
D000111AcetylcysteineAcetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]26804764
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]21195169
C016601afimoxifeneMTOR results in decreased susceptibility to afimoxifene19016759
C016601afimoxifene[Sirolimus results in decreased activity of MTOR protein] which results in increased susceptibility to afimoxifene19016759
C031143AICA ribonucleotideAICA ribonucleotide results in decreased activity of MTOR protein19625624
C031143AICA ribonucleotideAICA ribonucleotide promotes the reaction [Cadmium results in decreased phosphorylation of MTOR protein]21767558
C031143AICA ribonucleotideAICA ribonucleotide promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]28041982
C031143AICA ribonucleotideAICA ribonucleotide results in decreased phosphorylation of MTOR protein27363783|2804198
C103303alitretinoin"[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of MTOR protein"16611854
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of MTOR protein]22266097
C005197alternariolalternariol results in decreased phosphorylation of MTOR protein25456271
D000596Amino AcidsAmino Acids deficiency inhibits the reaction [[MTOR protein binds to RAPTOR protein] which binds to LARP1 protein]25940091
D000602Amino Acids, Peptides, and Proteins"Amino Acids, Peptides, and Proteins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MTOR protein]"22003094
D000602Amino Acids, Peptides, and Proteins"Amino Acids, Peptides, and Proteins results in increased activity of MTOR protein"24599349
D000602Amino Acids, Peptides, and Proteins"resveratrol inhibits the reaction [Amino Acids, Peptides, and Proteins results in increased activity of MTOR protein]"24599349
D000638AmiodaroneAmiodarone inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]19771169
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MTOR mRNA16483693
D000735AndrostenedioneAndrostenedione affects the activity of MTOR protein16033851
D000735AndrostenedioneEverolimus inhibits the reaction [Androstenedione affects the activity of MTOR protein]16033851
D000735Androstenedione[letrozole co-treated with Everolimus] inhibits the reaction [Androstenedione affects the activity of MTOR protein]16033851
D000735Androstenedioneletrozole inhibits the reaction [Androstenedione affects the activity of MTOR protein]16033851
D000968Antimycin A[Antimycin A co-treated with Deoxyglucose] results in decreased phosphorylation of MTOR protein25087994
D000968Antimycin AQuercetin promotes the reaction [[Antimycin A co-treated with Deoxyglucose] results in decreased phosphorylation of MTOR protein]25087994
C558369antrocinantrocin results in decreased phosphorylation of MTOR protein21158420
C545357antroquinonolantroquinonol results in decreased phosphorylation of MTOR protein19723512
D016718Arachidonic Acid[Quercetin co-treated with Arachidonic Acid] results in decreased phosphorylation of MTOR protein20551291
C071942arctigeninarctigenin results in decreased phosphorylation of MTOR protein25380086
C071942arctigeninQuercetin promotes the reaction [arctigenin results in decreased phosphorylation of MTOR protein]25380086
D001151ArsenicArsenic affects the methylation of MTOR gene25304211
D001151ArsenicArsenic results in increased expression of MTOR protein25586904
C006632arsenic trioxidearsenic trioxide inhibits the reaction [sorafenib results in increased expression of MTOR protein]25416439
C006632arsenic trioxidearsenic trioxide results in decreased expression of MTOR protein25416439
C006632arsenic trioxidearsenic trioxide results in decreased phosphorylation of MTOR protein21594580|2544943
C006632arsenic trioxidearsenic trioxide results in decreased phosphorylation of MTOR protein20299303
C006632arsenic trioxidearsenic trioxide results in increased phosphorylation of and results in increased activity of MTOR protein17121928
D001241AspirinAspirin results in decreased phosphorylation of and results in increased expression of MTOR protein23363784
D001379AzathioprineAzathioprine results in increased phosphorylation of MTOR protein23958494
D001397Azoxymethane[Plant Extracts co-treated with Azoxymethane] results in decreased expression of MTOR mRNA23996930
D001397Azoxymethane[Plant Extracts co-treated with Azoxymethane] results in decreased phosphorylation of MTOR protein23996930
C006680baicaleinbaicalein results in decreased phosphorylation of and results in decreased activity of MTOR protein24560969
C060988baohuoside Ibaohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein]25119583
C060988baohuoside Ibaohuoside I results in decreased phosphorylation of MTOR protein25119583
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of MTOR mRNA]22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MTOR protein25897075
D004958Estradiol"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone promotes the reaction [Estradiol results in increased phosphorylation of MTOR protein]"28882636
D004958Estradiol"[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone] inhibits the reaction [Estradiol results in increased phosphorylation of MTOR protein]"28882636
D004958Estradiol"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Estradiol results in increased phosphorylation of MTOR protein]"28882636
D004958EstradiolAcetylcysteine inhibits the reaction [Estradiol results in increased phosphorylation of MTOR protein]23000059
D004958EstradiolEstradiol affects the activity of MTOR protein16033851
D004958EstradiolEstradiol results in increased activity of MTOR protein16024245
D004958EstradiolEstradiol results in increased phosphorylation of MTOR protein23000059|2888263
D004958EstradiolEverolimus inhibits the reaction [Estradiol affects the activity of MTOR protein]16033851
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of MTOR protein]23000059
D004958Estradiolletrozole inhibits the reaction [Estradiol affects the activity of MTOR protein]16033851
D004958Estradiol[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of MTOR protein22465879
C009479beta-thujaplicinbeta-thujaplicin results in decreased phosphorylation of MTOR protein25044443
D001647Bile Acids and SaltsBile Acids and Salts results in increased expression of MTOR protein modified form21127259
D001647Bile Acids and SaltsBile Acids and Salts results in increased phosphorylation of and results in increased activity of MTOR protein21127259
D001688Biological ProductsAcetylcysteine inhibits the reaction [Biological Products results in decreased expression of MTOR protein modified form]28219700
D001688Biological ProductsBiological Products results in decreased expression of MTOR protein modified form28219700
C006780bisphenol Abisphenol A affects the expression of MTOR mRNA21786754
C006780bisphenol A"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone promotes the reaction [bisphenol A results in increased phosphorylation of MTOR protein]"28882636
C006780bisphenol Abisphenol A results in increased phosphorylation of MTOR protein28882636
C006780bisphenol Abisphenol A results in decreased expression of MTOR mRNA26063408
C006780bisphenol Abisphenol A results in decreased methylation of MTOR promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of MTOR mRNA25181051|2729622
C006780bisphenol Abisphenol A results in decreased phosphorylation of MTOR protein26139607
C006780bisphenol AMTOR protein affects the susceptibility to bisphenol A26139607
C006780bisphenol Abisphenol A results in increased expression of MTOR mRNA26794494
C557045BO-1051ATM protein promotes the reaction [BO-1051 results in increased expression of MTOR protein modified form]21184746
C557045BO-1051BO-1051 results in increased expression of MTOR protein modified form21184746
C017092bromopyruvatebromopyruvate results in increased expression of MTOR protein modified form24307199
D0200011-Butanol1-Butanol affects the activity of MTOR protein16537399
D020148Butyric AcidAcetylcysteine inhibits the reaction [Butyric Acid results in decreased phosphorylation of MTOR protein]28600122
D020148Butyric AcidButyric Acid results in decreased phosphorylation of MTOR protein28600122
D002104Cadmium"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Cadmium results in decreased phosphorylation of MTOR protein]"21767558
D002104CadmiumAICA ribonucleotide promotes the reaction [Cadmium results in decreased phosphorylation of MTOR protein]21767558
D002104CadmiumCadmium results in decreased phosphorylation of and results in decreased expression of MTOR protein21767558
D002104CadmiumCadmium results in decreased phosphorylation of MTOR protein29111403
D002104CadmiumPRKAA1 mutant form inhibits the reaction [Cadmium results in decreased phosphorylation of MTOR protein]21767558
D002104CadmiumSTK11 mutant form inhibits the reaction [Cadmium results in decreased phosphorylation of MTOR protein]21767558
D019256Cadmium Chloride[Cadmium Chloride co-treated with TGFB1 protein] results in increased phosphorylation of MTOR protein28342888
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of MTOR protein18021293|2405757
D019256Cadmium Chloride"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]"21544200
D019256Cadmium Chloride[Cadmium Chloride co-treated with TGFB1 protein] results in increased phosphorylation of MTOR protein28342888
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of MTOR protein21544200
D019256Cadmium ChlorideEgtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]21544200
D019256Cadmium ChlorideSirolimus inhibits the reaction [[Cadmium Chloride co-treated with TGFB1 protein] results in increased phosphorylation of MTOR protein]28342888
D019256Cadmium ChlorideTrifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]21544200
D019256Cadmium Chloride"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]"21544200
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]21195169
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of MTOR protein18021293|2119516
D019256Cadmium ChlorideEgtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]21544200
D019256Cadmium ChlorideTrifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]21544200
D002110CaffeineCaffeine results in decreased activity of MTOR protein21081844
D002118CalciumCalcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]12935885
D002211Capsaicin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased phosphorylation of MTOR protein]19139269
D002211CapsaicinCapsaicin results in decreased phosphorylation of MTOR protein22226932
D002211CapsaicinCapsaicin results in increased phosphorylation of MTOR protein19139269
D002211Capsaicinwortmannin inhibits the reaction [Capsaicin results in increased phosphorylation of MTOR protein]19139269
D002246Carbon DisulfideCarbon Disulfide affects the phosphorylation of MTOR protein27530093
D002392Catechin[resveratrol co-treated with Quercetin co-treated with Catechin co-treated with gefitinib] results in decreased activity of MTOR protein23061908
D002392Catechin[resveratrol co-treated with Quercetin co-treated with Catechin] results in decreased activity of MTOR protein23061908
C100435chicoric acidchicoric acid inhibits the reaction [INS1 protein results in increased phosphorylation of MTOR protein]24244361
D005023Ethylene ChlorohydrinEthylene Chlorohydrin results in increased phosphorylation of MTOR protein26962056
D002738ChloroquineChloroquine inhibits the reaction [formosanin C results in decreased phosphorylation of MTOR protein]27180204
C002415cholesterol alpha-oxidecholesterol alpha-oxide results in increased phosphorylation of MTOR protein20466046
C002415cholesterol alpha-oxidetyrphostin AG 1478 inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MTOR protein]20466046
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of MTOR mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MTOR mRNA]17585979
D002994ClofibrateClofibrate results in decreased phosphorylation of MTOR protein16616211
C018021cobaltous chloridecobaltous chloride results in decreased activity of [MTOR protein binds to RAPTOR protein]24386346
C018021cobaltous chloridecobaltous chloride results in increased phosphorylation of MTOR protein25446852
C018021cobaltous chlorideFlavanones inhibits the reaction [cobaltous chloride results in increased phosphorylation of MTOR protein]25446852
C018021cobaltous chlorideginsenoside Rg1 inhibits the reaction [cobaltous chloride results in decreased activity of [MTOR protein binds to RAPTOR protein]]24386346
C018021cobaltous chloride[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of MTOR protein24989011
C018021cobaltous chlorideEverolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of MTOR protein]]24989011
C018021cobaltous chloriderhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of MTOR protein]24989011
D003300CopperCopper results in decreased expression of MTOR mRNA25461751
D003300Copper[Inositol co-treated with Copper] results in increased expression of MTOR mRNA25087001
D003345CorticosteroneCorticosterone results in decreased phosphorylation of MTOR protein21647420
C102326cucurbitacin EAcetylcysteine inhibits the reaction [cucurbitacin E results in decreased phosphorylation of MTOR protein]27106530
C102326cucurbitacin Ecucurbitacin E results in decreased phosphorylation of MTOR protein27106530
C102326cucurbitacin Ecucurbitacin E inhibits the reaction [Thioacetamide results in increased phosphorylation of MTOR protein]27363783
C102326cucurbitacin Ecucurbitacin E results in decreased phosphorylation of MTOR protein27363783
D003474CurcuminCurcumin analog inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MTOR protein]20554536
D003474CurcuminCurcumin analog results in decreased expression of MTOR mRNA26409325
D003474CurcuminCurcumin results in decreased phosphorylation of MTOR protein21450334
D003474CurcuminCurcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of MTOR protein]27363783
C057862cyanoginosin LRcyanoginosin LR results in increased expression of MTOR protein25497113
D016572CyclosporineCyclosporine affects the expression of MTOR protein24971338
D016572CyclosporineCyclosporine results in increased expression of MTOR mRNA24971338
C531198dactolisibdactolisib results in decreased activity of MTOR protein20129775
D000069439DasatinibDasatinib results in decreased phosphorylation of MTOR protein20629079
D003630DaunorubicinDaunorubicin results in increased phosphorylation of MTOR protein21898527
D003630DaunorubicinSirolimus inhibits the reaction [Daunorubicin results in increased phosphorylation of MTOR protein]21898527
C107676deguelindeguelin metabolite results in decreased expression of MTOR protein19139008
C107676deguelindeguelin results in decreased expression of MTOR protein19139008
D003847DeoxyglucoseDeoxyglucose results in decreased phosphorylation of and results in increased expression of MTOR protein23363784
D003847DeoxyglucoseDeoxyglucose results in increased phosphorylation of and results in increased activity of MTOR protein23041229
D003847Deoxyglucose[Antimycin A co-treated with Deoxyglucose] results in decreased phosphorylation of MTOR protein25087994
D003847DeoxyglucoseQuercetin promotes the reaction [[Antimycin A co-treated with Deoxyglucose] results in decreased phosphorylation of MTOR protein]25087994
C007262deoxynivalenoldeoxynivalenol results in decreased expression of MTOR mRNA26988607
D003907DexamethasoneDexamethasone results in increased expression of MTOR mRNA22733784
D016264Dextran SulfateDextran Sulfate results in increased expression of MTOR protein26074695
D016264Dextran Sulfateresveratrol inhibits the reaction [Dextran Sulfate results in increased expression of MTOR protein]26074695
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of MTOR protein23754639
D003958DiamideDiamide inhibits the reaction [MTOR protein binds to RPTOR protein]16183647
D003958DiamideDiamide results in increased activity of MTOR protein16183647
D003958Diamide[Diamide results in increased activity of MTOR protein] which results in increased phosphorylation of RPS6KB1 protein16183647
D003958DiamideMTOR mutant form inhibits the reaction [Diamide results in increased phosphorylation of RPS6KB1 protein]16183647
D002945CisplatinCisplatin affects the phosphorylation of MTOR protein24799992
D002945CisplatinCisplatin affects the reaction [Melatonin results in increased phosphorylation of MTOR protein]24799992
D002945CisplatinCisplatin promotes the reaction [temsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]]21358348
D002945CisplatinCisplatin promotes the reaction [temsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6 protein]]21358348
D002945CisplatinCisplatin results in decreased expression of MTOR protein26201060
D002945CisplatinCisplatin results in decreased phosphorylation of MTOR protein18058806
D002945CisplatinCisplatin results in increased phosphorylation of MTOR protein20935474
D002945Cisplatin[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in decreased expression of MTOR protein21191146
D002945CisplatinSirolimus promotes the reaction [Cisplatin results in decreased phosphorylation of MTOR protein]18058806
D002945CisplatinTopotecan inhibits the reaction [Cisplatin results in increased phosphorylation of MTOR protein]20935474
C000944dicrotophosdicrotophos results in increased expression of MTOR mRNA28302478
D004026DieldrinDieldrin results in increased expression of MTOR protein modified form28385952
D004041Dietary FatsDietary Fats results in increased expression of MTOR mRNA24025686
D004041Dietary FatsDietary Fats results in increased expression of MTOR protein24025686
D004041Dietary FatsQuercetin inhibits the reaction [Dietary Fats results in increased expression of MTOR mRNA]24025686
D004041Dietary FatsQuercetin inhibits the reaction [Dietary Fats results in increased expression of MTOR protein]24025686
D004051Diethylhexyl Phthalate2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MTOR mRNA]23793038
D004051Diethylhexyl Phthalate2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MTOR protein]23793038
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of MTOR mRNA23793038
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of MTOR protein23793038
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of MTOR mRNA24804967
D004052DiethylnitrosamineDiethylnitrosamine affects the phosphorylation of MTOR protein24535843
C472036dihydromyricetindihydromyricetin results in decreased phosphorylation of and results in decreased activity of MTOR protein24444546
D004112DimercaprolDimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]]16183647
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MTOR mRNA"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MTOR protein modified form"21785161
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of MTOR protein modified form"21785161
D007980LevodopaLevodopa results in increased activity of MTOR protein19622830
D004298DopamineDopamine results in decreased phosphorylation of MTOR protein19410601
D004317DoxorubicinDoxorubicin results in decreased activity of and results in decreased phosphorylation of MTOR protein19103993
D004317DoxorubicinDoxorubicin results in decreased phosphorylation of MTOR protein26450947
D004317DoxorubicinMTOR protein results in decreased susceptibility to Doxorubicin19103993
D004317DoxorubicinDoxorubicin results in decreased phosphorylation of MTOR protein19801490
D004317DoxorubicinMTOR protein promotes the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNI3 protein]]19801490
D004317DoxorubicinMTOR protein promotes the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNT2 protein]]19801490
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein]19801490
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased expression of MTOR mRNA"27369806
D004533Egtazic AcidEgtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]21544200
D004533Egtazic AcidEgtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]21544200
C572014E platinumE platinum results in decreased phosphorylation of MTOR protein22322152
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in decreased phosphorylation of MTOR protein21655094|2589560
D000069347Erlotinib Hydrochlorideresveratrol promotes the reaction [Erlotinib Hydrochloride results in decreased phosphorylation of MTOR protein]25895606
D000431EthanolEthanol results in decreased phosphorylation of MTOR protein23448468
D000431EthanolPRKAA2 protein affects the reaction [Ethanol results in decreased phosphorylation of MTOR protein]23448468
D000431EthanolEthanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]12935885
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MTOR mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MTOR mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MTOR mRNA17942748
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of MTOR gene15485918|1672432
D005047EtoposideEtoposide results in increased phosphorylation of MTOR protein27769712
D000068338EverolimusEverolimus inhibits the reaction [Androstenedione affects the activity of MTOR protein]16033851
D000068338EverolimusEverolimus inhibits the reaction [Estradiol affects the activity of MTOR protein]16033851
D000068338EverolimusEverolimus inhibits the reaction [MTOR results in decreased susceptibility to trabectedin]21622721
D000068338EverolimusEverolimus results in decreased activity of MTOR21622721
D000068338EverolimusEverolimus results in decreased activity of MTOR protein16033851|2089017
D000068338Everolimus[letrozole co-treated with Everolimus] inhibits the reaction [Androstenedione affects the activity of MTOR protein]16033851
D000068338EverolimusEverolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of MTOR protein]]24989011
D000068338EverolimusEverolimus results in decreased activity of MTOR19549709
D000068338EverolimusEverolimus results in decreased activity of MTOR protein16951235
C069346fascaplysinefascaplysine analog results in decreased expression of MTOR protein28756150
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride results in decreased phosphorylation of MTOR protein25939952
D044950FlavanonesFlavanones inhibits the reaction [cobaltous chloride results in increased phosphorylation of MTOR protein]25446852
D044950FlavanonesFlavanones results in decreased phosphorylation of MTOR protein25446852
D005473Fluoxetine[Fluoxetine co-treated with Methylphenidate] results in increased expression of MTOR mRNA21753012
D005473Fluoxetine[Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of MTOR protein21753012
C067584formosanin CChloroquine inhibits the reaction [formosanin C results in decreased phosphorylation of MTOR protein]27180204
C067584formosanin Cformosanin C results in decreased phosphorylation of MTOR protein27180204
C058728fosbretabulinfosbretabulin results in increased phosphorylation of MTOR protein24321340
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of MTOR protein]23000059
C070081fulvestrantMTOR results in decreased susceptibility to fulvestrant19016759
C070081fulvestrant[Sirolimus results in decreased activity of MTOR protein] which results in increased susceptibility to fulvestrant19016759
C037032galangingalangin results in decreased phosphorylation of MTOR protein25450235
C419708gefitinibgefitinib results in decreased phosphorylation of MTOR protein21655094
C419708gefitinib[resveratrol co-treated with Quercetin co-treated with Catechin co-treated with gefitinib] results in decreased activity of MTOR protein23061908
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of MTOR protein]22144680
C007845gingerolgingerol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MTOR protein]27451028
C007845gingerolgingerol results in decreased expression of MTOR protein modified form28249781
C035054ginsenoside Rg1ginsenoside Rg1 inhibits the reaction [cobaltous chloride results in decreased activity of [MTOR protein binds to RAPTOR protein]]24386346
C035054ginsenoside Rg1ginsenoside Rg1 results in increased activity of [MTOR protein binds to RAPTOR protein]24386346
D005947GlucoseGlucose results in increased activity of MTOR protein19765649
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased activity of MTOR protein]19765649
D005947GlucoseGlucose results in increased expression of MTOR protein22561310
D005947GlucoseGlucose results in increased expression of MTOR protein modified form22561310
D005947Glucose[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [[Glucose co-treated with INS protein] results in increased expression of PTEN protein]18303120
D005947Glucose[Sirolimus results in decreased activity of MTOR protein] promotes the reaction [INS protein results in increased transport of Glucose]18303120
D006046Gold[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of MTOR protein27470402
C059922gossypetin"gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in decreased phosphorylation of MTOR protein]"25622137
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of MTOR protein24960055
C089796hexabromocyclododecanehexabromocyclododecane results in increased expression of MTOR protein24960055
D006581HexachlorobenzeneHexachlorobenzene results in decreased expression of MTOR mRNA15159207
D012701Serotoninsarpogrelate inhibits the reaction [Serotonin results in increased activity of MTOR protein]27133527
D012701SerotoninSerotonin results in increased activity of MTOR protein27133527
D012701SerotoninSirolimus inhibits the reaction [Serotonin results in increased activity of MTOR protein]27133527
D006861Hydrogen Peroxidegingerol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MTOR protein]27451028
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of MTOR protein27451028
D006861Hydrogen PeroxideCAT protein inhibits the reaction [[Rotenone results in increased abundance of Hydrogen Peroxide] inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]]25304210
D006861Hydrogen PeroxideCAT protein inhibits the reaction [[Rotenone results in increased abundance of Hydrogen Peroxide] inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6KB1 protein]]25304210
D006861Hydrogen PeroxideMTOR protein inhibits the reaction [Rotenone results in increased abundance of Hydrogen Peroxide]25304210
D006861Hydrogen Peroxide[Rotenone results in increased abundance of Hydrogen Peroxide] inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]25304210
D006861Hydrogen Peroxide[Rotenone results in increased abundance of Hydrogen Peroxide] inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6KB1 protein]25304210
D004441EcdysteroneEcdysterone results in decreased expression of MTOR mRNA15776001
D007052IbuprofenIbuprofen results in increased expression of MTOR mRNA28201806
D000068877Imatinib MesylateImatinib Mesylate promotes the reaction [NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of MTOR protein]]16740780
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of MTOR protein19208803
D000068877Imatinib Mesylatetetraarsenic tetrasulfide promotes the reaction [Imatinib Mesylate results in decreased expression of MTOR protein]19208803
C572449INK128INK128 results in decreased phosphorylation of MTOR protein26536665
D007294Inositol[Inositol co-treated with Copper] results in increased expression of MTOR mRNA25087001
D058085Iron CompoundsIron Compounds results in decreased expression of MTOR protein28483490
D007545Isoproterenol2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of MTOR protein]17623046
D007545IsoproterenolIsoproterenol results in increased phosphorylation of MTOR protein17623046|2504521
D007545IsoproterenolSirolimus inhibits the reaction [Isoproterenol results in increased phosphorylation of MTOR protein]17623046|2504521
D007545IsoproterenolTNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased phosphorylation of MTOR protein]]25045214
C541932Ku 0063794Ku 0063794 results in decreased activity of MTOR protein21322566
C490728lapatinib[lapatinib results in decreased susceptibility to lapatinib] which results in increased phosphorylation of MTOR protein26643609
C490728lapatinibNiclosamide inhibits the reaction [[lapatinib results in decreased susceptibility to lapatinib] which results in increased phosphorylation of MTOR protein]26643609
D007854LeadLead affects the expression of MTOR mRNA28903495
C008261lead acetatelead acetate results in decreased phosphorylation of MTOR protein22811615
C008261lead acetatelead acetate results in increased expression of MTOR mRNA29273543
C017461lead nitratelead nitrate results in increased phosphorylation of MTOR protein27762461
C017461lead nitratepuerarin inhibits the reaction [lead nitrate results in increased phosphorylation of MTOR protein]27762461
C067431letrozole[letrozole co-treated with Everolimus] inhibits the reaction [Androstenedione affects the activity of MTOR protein]16033851
C067431letrozoleletrozole inhibits the reaction [Androstenedione affects the activity of MTOR protein]16033851
C067431letrozoleletrozole inhibits the reaction [Estradiol affects the activity of MTOR protein]16033851
C002385linsidominelinsidomine results in increased oxidation of MTOR protein28086193
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of MTOR mRNA"24972896
D008070Lipopolysaccharides4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of MTOR protein]28245985
D008070Lipopolysaccharides"Amino Acids, Peptides, and Proteins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MTOR protein]"22003094
D008070LipopolysaccharidesLipopolysaccharides results in decreased phosphorylation of MTOR protein28245985
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of MTOR protein22003094
D008070Lipopolysaccharides[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol affects the susceptibility to Lipopolysaccharides]22363816
D008070Lipopolysaccharides[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]22363816
D008070Lipopolysaccharides[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]22363816
D008070Lipopolysaccharides[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]22363816
D008070Lipopolysaccharides[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]22363816
D008070Lipopolysaccharides[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]22363816
D008070Lipopolysaccharides[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]22363816
D008070Lipopolysaccharides[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]22363816
D008070Lipopolysaccharides[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]22363816
D008070Lipopolysaccharides[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA mRNA]]22363816
D008070Lipopolysaccharides[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]]22363816
D008070Lipopolysaccharides[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]22363816
D008070Lipopolysaccharides[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]22363816
D008070Lipopolysaccharides[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CREB1 protein]]22363816
D008070Lipopolysaccharides[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]22363816
D008070Lipopolysaccharides[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]22363816
D008070Lipopolysaccharides[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]22363816
D008094Lithium[Lithium results in decreased activity of GSK3B protein] which results in increased activity of MTOR protein17921520
C032881lysophosphatidic acidlysophosphatidic acid results in increased phosphorylation of MTOR protein14769825
D008294MalathionMalathion results in decreased expression of MTOR mRNA26494550
D008298MaleatesMaleates results in decreased phosphorylation of MTOR protein21976531
C569869malondialdehyde-low density lipoprotein, human"gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in decreased phosphorylation of MTOR protein]"25622137
C569869malondialdehyde-low density lipoprotein, human"malondialdehyde-low density lipoprotein, human results in decreased phosphorylation of MTOR protein"25622137
D008344ManebManeb promotes the reaction [Paraquat results in increased expression of MTOR protein]22292029
D008344ManebManeb results in increased expression of MTOR protein22292029
D008344ManebParaquat promotes the reaction [Maneb results in increased expression of MTOR protein]22292029
D008345ManganeseManganese results in decreased phosphorylation of MTOR protein17043766
D008345ManganeseManganese results in increased phosphorylation of MTOR protein17043766
D008345ManganeseManganese results in increased expression of MTOR mRNA23997110
C025340manganese chloridemanganese chloride results in decreased phosphorylation of MTOR protein23604964
C025340manganese chloridemanganese chloride results in increased phosphorylation of MTOR protein23604964
C520506manganese tetrakis-(N-ethyl-2 pyridyl) porphyrinmanganese tetrakis-(N-ethyl-2 pyridyl) porphyrin results in increased phosphorylation of and results in decreased activity of MTOR protein23682840
D008550MelatoninCisplatin affects the reaction [Melatonin results in increased phosphorylation of MTOR protein]24799992
D008550MelatoninMelatonin promotes the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]19054297
D008550MelatoninMelatonin results in increased activity of MTOR protein19054297
D008550MelatoninMelatonin results in increased phosphorylation of MTOR protein24799992
D008687MetforminMetformin results in decreased phosphorylation of and results in increased expression of MTOR protein23363784
D008687MetforminMetformin results in decreased phosphorylation of MTOR protein27363783
D008694MethamphetamineMethamphetamine inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]19054297
D008694MethamphetamineMethamphetamine results in decreased phosphorylation of MTOR protein19054297
D008694MethamphetamineDDIT4 protein promotes the reaction [Methamphetamine results in decreased phosphorylation of MTOR protein]26825372
D008694MethamphetamineMethamphetamine results in decreased phosphorylation of MTOR protein23041169|2682537
D008694MethamphetamineTaurine inhibits the reaction [Methamphetamine results in decreased phosphorylation of MTOR protein]23041169
C042405methyl caffeatemethyl caffeate analog results in decreased phosphorylation of MTOR protein25481497
C054634methyllycaconitinemethyllycaconitine results in increased phosphorylation of MTOR protein24012499
C054634methyllycaconitineMTOR mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]24012499
C004925methylmercuric chloridemethylmercuric chloride results in decreased phosphorylation of MTOR protein28821999
D008770Methylnitrosourea[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of MTOR protein22465879
D008770Methylnitrosourea[Methylnitrosourea co-treated with Testosterone] results in increased expression of MTOR protein25164625
D008770MethylnitrosoureaQuercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of MTOR protein]25164625
D008774Methylphenidate[Fluoxetine co-treated with Methylphenidate] results in increased expression of MTOR mRNA21753012
D008774Methylphenidate[Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of MTOR protein21753012
D008774MethylphenidateMethylphenidate affects the expression of MTOR mRNA21753012
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MTOR protein25017139
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of MTOR protein26648565
D0156551-Methyl-4-phenylpyridiniumRTN4 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MTOR protein]26648565
D0156551-Methyl-4-phenylpyridiniumSirolimus inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MTOR protein]26648565
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects the phosphorylation of MTOR protein"20382208
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of MTOR protein]22144680
D015735MifepristoneMifepristone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of MTOR protein]22266097
C008548morinmorin results in increased expression of MTOR mRNA28689916
C523799MRK 003MRK 003 affects the activity of MTOR protein19246562
C558744N-(6-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)benzo(d)thiazol-2-yl)acetamideN-(6-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)benzo(d)thiazol-2-yl)acetamide results in decreased activity of MTOR protein21332118|2161223
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MTOR mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased activity of MTOR protein"29112861
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MTOR mRNA"25554681
C005274naringinnaringin inhibits the reaction [TNF protein results in increased phosphorylation of MTOR protein]19810018
C528561navitoclaxMTOR protein affects the susceptibility to navitoclax28947240
C528561navitoclax[MTOR protein affects the susceptibility to navitoclax] which affects the cleavage of PARP1 protein28947240
C528561navitoclax[MTOR protein affects the susceptibility to navitoclax] which affects the expression of BIRC5 protein28947240
C546012N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamideN-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide results in decreased phosphorylation of MTOR protein27470402
D009525NiacinNiacin results in decreased phosphorylation of and results in decreased activity of MTOR protein12837665
D009534NiclosamideNiclosamide inhibits the reaction [[lapatinib results in decreased susceptibility to lapatinib] which results in increased phosphorylation of MTOR protein]26643609
D009534NiclosamideNiclosamide inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]19771169
D009534NiclosamideNiclosamide results in decreased phosphorylation of MTOR protein26703449
D009538NicotineNicotine results in decreased expression of MTOR mRNA26776438
D009569Nitric Oxide[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]22363816
C025256nonylphenolnonylphenol results in decreased expression of MTOR mRNA27832966
C025256nonylphenolnonylphenol results in decreased expression of MTOR protein27832966
C025256nonylphenolnonylphenol results in decreased expression of MTOR protein modified form27832966
C025256nonylphenolnonylphenol results in decreased phosphorylation of MTOR protein27832966
C512715NSC-87877NSC-87877 inhibits the reaction [[HLA-G protein results in increased phosphorylation of and results in increased activity of PTPN11 protein] which results in decreased phosphorylation of and results in decreased activity of MTOR protein]21887223
C502355NVP ADW742Imatinib Mesylate promotes the reaction [NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of MTOR protein]]16740780
C502355NVP ADW742NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of MTOR protein]16740780
C025589ochratoxin Aochratoxin A results in increased phosphorylation of MTOR protein25002221
D009828Oleanolic AcidOleanolic Acid analog results in decreased phosphorylation of MTOR protein26612655
D009842OligopeptidesOligopeptides analog results in decreased phosphorylation of MTOR protein24875536
C507134ON 01910ON 01910 results in decreased phosphorylation of MTOR protein19198627|2531676
C000594117ON123300ON123300 results in decreased phosphorylation of MTOR protein26174628
C568605OSI 027OSI 027 results in decreased activity of MTOR protein21322566
C529674OSU-HDAC42 compoundOSU-HDAC42 compound results in decreased phosphorylation of MTOR protein20962572
C030110oxaliplatinoxaliplatin results in increased phosphorylation of MTOR protein19147571
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MTOR mRNA25729387
C029341oxophenylarsineDimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]]16183647
C029341oxophenylarsineMTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]16183647
C029341oxophenylarsineoxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]16183647
C029341oxophenylarsineoxophenylarsine results in increased activity of MTOR protein16183647
C029341oxophenylarsine[oxophenylarsine results in increased activity of MTOR protein] which results in increased phosphorylation of RPS6KB1 protein16183647
D010100OxygenCurcumin analog inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MTOR protein]20554536
D010100Oxygen[Oxygen deficiency co-treated with Sirolimus] results in decreased expression of MTOR protein17968710
D010100OxygenOxygen deficiency results in increased expression of MTOR mRNA17968710
D010100OxygenOxygen deficiency results in increased phosphorylation of MTOR protein20554536|2868414
D010100OxygenOxygen results in increased phosphorylation of MTOR protein19587783
D010100Oxygenshikonin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MTOR protein]28684144
D010100OxygenSirolimus inhibits the reaction [Oxygen deficiency results in increased expression of MTOR mRNA]17968710
D017239PaclitaxelPaclitaxel results in increased phosphorylation of MTOR protein27769712
D019308Palmitic AcidPalmitic Acid results in increased activity of MTOR protein27133527
D019308Palmitic Acidsarpogrelate inhibits the reaction [Palmitic Acid results in increased activity of MTOR protein]27133527
D019308Palmitic AcidSirolimus inhibits the reaction [Palmitic Acid results in increased activity of MTOR protein]27133527
D010269ParaquatParaquat affects the expression of MTOR mRNA27220436
D010269ParaquatParaquat results in decreased phosphorylation of MTOR protein17341480|2092998
D010269ParaquatManeb promotes the reaction [Paraquat results in increased expression of MTOR protein]22292029
D010269ParaquatParaquat promotes the reaction [Maneb results in increased expression of MTOR protein]22292029
D010269ParaquatParaquat results in decreased expression of MTOR mRNA21371552
D010269ParaquatParaquat results in decreased phosphorylation of MTOR protein25092649|2724669
D010269ParaquatParaquat results in increased expression of MTOR protein22292029
D010269ParaquatTLR4 protein affects the reaction [Paraquat results in decreased phosphorylation of MTOR protein]27246695
D010269ParaquatParaquat results in increased phosphorylation of MTOR protein27324791
D010269ParaquatSirolimus inhibits the reaction [Paraquat results in increased phosphorylation of MTOR protein]27324791
C062258Pasteurella multocida toxinPasteurella multocida toxin results in increased phosphorylation of MTOR protein26369790
C000610380p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane"p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane results in decreased phosphorylation of MTOR protein"26035713
D010480PerhexilinePerhexiline inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]19771169
C105905perifosine[perifosine co-treated with temsirolimus] results in decreased activity of MTOR protein21267448
D015232Dinoprostone[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]22363816
D010656PhenylephrinePhenylephrine results in increased phosphorylation of MTOR protein17976640
D010656Phenylephrinewortmannin inhibits the reaction [Phenylephrine results in increased phosphorylation of MTOR protein]17976640
D010656PhenylephrineCalcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]12935885
D010656PhenylephrineEthanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]12935885
D010656Phenylephrine[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein12935885
D010712Phosphatidic AcidsPhosphatidic Acids results in increased phosphorylation of MTOR protein18621911
D010712Phosphatidic Acids[Phosphatidic Acids results in increased phosphorylation of MTOR protein] which results in increased phosphorylation of RPS6KB1 protein18621911
D010712Phosphatidic Acids[Phosphatidic Acids results in increased phosphorylation of MTOR protein] which results in increased phosphorylation of RPS6 protein18621911
D010712Phosphatidic AcidsMTOR protein affects the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]12087098
D010712Phosphatidic AcidsPhosphatidic Acids results in increased activity of MTOR protein16537399
D010712Phosphatidic AcidsPhosphatidic Acids inhibits the reaction [Simvastatin results in increased activity of MTOR protein]23817226
D017319Photosensitizing AgentsPhotosensitizing Agents results in decreased expression of and results in decreased phosphorylation of MTOR protein19125612
D017319Photosensitizing Agents[Sirolimus co-treated with Photosensitizing Agents] affects the phosphorylation of MTOR protein19125612
C522973PI103PI103 inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein]21187475
C522973PI103[sorafenib co-treated with PI103] inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein]21187475
C522973PI103PI103 results in decreased activity of MTOR protein19584227
C544306PI 540PI 540 results in decreased activity of MTOR protein19584227
D010862Pilocarpine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of MTOR protein]]"23211629
D010862PilocarpinePilocarpine results in increased phosphorylation of MTOR protein23211629
D010862Pilocarpineresveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of MTOR protein]23211629
C006253pirinixic acidpirinixic acid results in increased expression of MTOR mRNA18301758|2381119
D010936Plant Extracts[Plant Extracts co-treated with Azoxymethane] results in decreased expression of MTOR mRNA23996930
D010936Plant Extracts[Plant Extracts co-treated with Azoxymethane] results in decreased phosphorylation of MTOR protein23996930
C108953platycodin Dplatycodin D results in decreased phosphorylation of MTOR protein23867902
C108953platycodin Dplatycodin D inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein]23867902
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls results in decreased expression of MTOR protein24960055
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls results in increased expression of MTOR protein24960055
C572919PP242PP242 results in decreased activity of MTOR protein23440206
C572919PP242PP242 results in decreased activity of MTOR protein21322566
D017035PravastatinPravastatin results in increased phosphorylation of MTOR protein15625077
D011374ProgesteroneProgesterone results in decreased expression of MTOR mRNA23541542
D011374Progesterone[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of MTOR protein22465879
C033607puerarinpuerarin results in increased phosphorylation of MTOR protein27796870
C033607puerarinSirolimus inhibits the reaction [puerarin results in increased phosphorylation of MTOR protein]27796870
C033607puerarinpuerarin inhibits the reaction [lead nitrate results in increased phosphorylation of MTOR protein]27762461
C010423pyrithione zincpyrithione zinc results in decreased expression of MTOR protein21557991
D011794Quercetin[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of MTOR protein27470402
D011794Quercetin[Quercetin co-treated with Arachidonic Acid] results in decreased phosphorylation of MTOR protein20551291
D011794QuercetinQuercetin inhibits the reaction [VEGFA protein results in increased phosphorylation of MTOR protein]23094058
D011794QuercetinQuercetin promotes the reaction [arctigenin results in decreased phosphorylation of MTOR protein]25380086
D011794QuercetinQuercetin results in decreased phosphorylation of MTOR protein23094058|2529387
D011794QuercetinQuercetin inhibits the reaction [Dietary Fats results in increased expression of MTOR mRNA]24025686
D011794QuercetinQuercetin inhibits the reaction [Dietary Fats results in increased expression of MTOR protein]24025686
D011794QuercetinQuercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of MTOR protein]25164625
D011794QuercetinQuercetin promotes the reaction [[Antimycin A co-treated with Deoxyglucose] results in decreased phosphorylation of MTOR protein]25087994
D011794Quercetin[resveratrol co-treated with Quercetin co-treated with Catechin co-treated with gefitinib] results in decreased activity of MTOR protein23061908
D011794Quercetin[resveratrol co-treated with Quercetin co-treated with Catechin] results in decreased activity of MTOR protein23061908
C110310quercetin 4'-O-glucopyranosidequercetin 4'-O-glucopyranoside analog inhibits the reaction [VEGFA protein results in increased phosphorylation of MTOR protein]22348123
D017382Reactive Oxygen Species[Sirolimus results in decreased phosphorylation of MTOR protein] which results in decreased chemical synthesis of Reactive Oxygen Species20680277
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]25554529
C059514resveratrol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in decreased phosphorylation of MTOR protein]"19928762
C059514resveratrolNiacinamide inhibits the reaction [resveratrol results in decreased phosphorylation of MTOR protein]19928762
C059514resveratrolPRKAA1 protein promotes the reaction [resveratrol results in decreased phosphorylation of and results in decreased activity of MTOR protein]19928762
C059514resveratrolPTEN protein promotes the reaction [resveratrol results in decreased phosphorylation of MTOR protein]21168265
C059514resveratrolresveratrol affects the expression of MTOR mRNA18586690
C059514resveratrolresveratrol promotes the reaction [Erlotinib Hydrochloride results in decreased phosphorylation of MTOR protein]25895606
C059514resveratrolresveratrol promotes the reaction [temozolomide results in decreased phosphorylation of MTOR protein]22530672
C059514resveratrolresveratrol results in decreased activity of MTOR protein21321189|2257422
C059514resveratrol[resveratrol results in decreased activity of MTOR protein] which results in decreased expression of DDIT3 protein21321189
C059514resveratrol[resveratrol results in decreased activity of MTOR protein] which results in decreased expression of PKM mRNA22574221
C059514resveratrol[resveratrol results in decreased activity of MTOR protein] which results in decreased expression of PKM protein22574221
C059514resveratrol[resveratrol results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6KB1 protein22574221
C059514resveratrolresveratrol results in decreased expression of MTOR protein modified form17825886|2223458
C059514resveratrolresveratrol results in decreased phosphorylation of and results in decreased activity of MTOR protein19928762
C059514resveratrolresveratrol results in decreased phosphorylation of and results in increased expression of MTOR protein23363784
C059514resveratrolresveratrol results in decreased phosphorylation of MTOR protein21168265|2117945
C059514resveratrol[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein20169165
C059514resveratrol[[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6 protein20169165
C059514resveratrolresveratrol results in increased expression of MTOR mRNA12002526
C059514resveratrolTSC2 protein promotes the reaction [[[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6 protein]20169165
C059514resveratrolresveratrol inhibits the reaction [Dextran Sulfate results in increased expression of MTOR protein]26074695
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased activity of MTOR protein]19765649
C059514resveratrolresveratrol inhibits the reaction [TNF protein results in decreased phosphorylation of MTOR protein]24534773
C059514resveratrolresveratrol inhibits the reaction [TNF protein results in increased phosphorylation of MTOR protein]22069489
C059514resveratrolresveratrol promotes the reaction [MTOR protein binds to DEPTOR protein]20851890
C059514resveratrolresveratrol promotes the reaction [temozolomide results in decreased phosphorylation of MTOR protein]22530672
C059514resveratrol[resveratrol results in decreased activity of MTOR protein] inhibits the reaction [Tunicamycin results in increased expression of DDIT3 mRNA]21321189
C059514resveratrol[resveratrol results in decreased activity of MTOR protein] inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]21321189
C059514resveratrol[resveratrol results in decreased activity of MTOR protein] inhibits the reaction [Tunicamycin results in increased expression of XBP1 mRNA alternative form]21321189
C059514resveratrolresveratrol results in decreased phosphorylation of and results in decreased activity of MTOR protein23274061
C059514resveratrolresveratrol results in decreased phosphorylation of MTOR protein20851890|2622330
C059514resveratrol[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein21321189
C059514resveratrol[[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of EIF4EBP1 protein21321189
C059514resveratrol[[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6KB1 protein21321189
C059514resveratrolresveratrol results in increased phosphorylation of MTOR protein22363816
C059514resveratrol[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol affects the susceptibility to Lipopolysaccharides]22363816
C059514resveratrol[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]22363816
C059514resveratrol[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]22363816
C059514resveratrol[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]22363816
C059514resveratrol[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]22363816
C059514resveratrol[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]22363816
C059514resveratrol[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]22363816
C059514resveratrol[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]22363816
C059514resveratrol[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]22363816
C059514resveratrol[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA mRNA]]22363816
C059514resveratrol[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]]22363816
C059514resveratrol[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]22363816
C059514resveratrol[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]22363816
C059514resveratrol[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CREB1 protein]]22363816
C059514resveratrol[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]22363816
C059514resveratrol[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]22363816
C059514resveratrol[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]22363816
C059514resveratrol[Sirolimus results in decreased activity of MTOR protein] which results in decreased susceptibility to resveratrol22363816
C059514resveratrolTSC1 protein affects the reaction [resveratrol promotes the reaction [temozolomide results in decreased phosphorylation of MTOR protein]]22530672
C059514resveratrolresveratrol results in decreased activity of and results in decreased phosphorylation of MTOR protein19108833
C059514resveratrol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of MTOR protein]]"23211629
C059514resveratrol"resveratrol inhibits the reaction [Amino Acids, Peptides, and Proteins results in increased activity of MTOR protein]"24599349
C059514resveratrolresveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of MTOR protein]23211629
C059514resveratrolresveratrol inhibits the reaction [Streptozocin results in decreased expression of MTOR mRNA]26071184
C059514resveratrolresveratrol results in decreased phosphorylation of MTOR protein24534837|2459934
C059514resveratrolresveratrol results in increased expression of MTOR mRNA26071184
C059514resveratrolresveratrol results in increased expression of MTOR protein21739664
C059514resveratrol[resveratrol co-treated with Quercetin co-treated with Catechin co-treated with gefitinib] results in decreased activity of MTOR protein23061908
C059514resveratrol[resveratrol co-treated with Quercetin co-treated with Catechin] results in decreased activity of MTOR protein23061908
C059514resveratrolresveratrol inhibits the reaction [INS protein results in increased activity of MTOR protein]20851890
C009172rhodiolosideEverolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of MTOR protein]]24989011
C009172rhodiolosiderhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of MTOR protein]24989011
C089730rosiglitazonerosiglitazone results in increased phosphorylation of MTOR protein19397913
D012402RotenoneRotenone results in decreased expression of MTOR mRNA23186747
D012402RotenoneCAT protein inhibits the reaction [[Rotenone results in increased abundance of Hydrogen Peroxide] inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]]25304210
D012402RotenoneCAT protein inhibits the reaction [[Rotenone results in increased abundance of Hydrogen Peroxide] inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6KB1 protein]]25304210
D012402RotenoneMTOR protein inhibits the reaction [Rotenone results in increased abundance of Hydrogen Peroxide]25304210
D012402Rotenone[Rotenone results in increased abundance of Hydrogen Peroxide] inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]25304210
D012402Rotenone[Rotenone results in increased abundance of Hydrogen Peroxide] inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6KB1 protein]25304210
C085746rottlerinrottlerin inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]19771169
C085746rottlerinrottlerin results in decreased phosphorylation of MTOR protein22902833
C018381salvinsalvin results in decreased phosphorylation of MTOR protein28918123
D012503SaponinsSaponins results in decreased phosphorylation of MTOR protein28088315
D012503SaponinsSaponins results in decreased expression of MTOR mRNA27369806
C064294sarpogrelatesarpogrelate inhibits the reaction [Palmitic Acid results in increased activity of MTOR protein]27133527
C064294sarpogrelatesarpogrelate inhibits the reaction [Serotonin results in increased activity of MTOR protein]27133527
C410958sauchinonesauchinone results in decreased phosphorylation of MTOR protein27871897
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased phosphorylation of MTOR protein"24735948
C016101shikoninshikonin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MTOR protein]28684144
D012822Silicon DioxideSilicon Dioxide analog results in decreased phosphorylation of MTOR protein27613482
D019821Simvastatingeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of MTOR protein]22144680
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of MTOR protein]22144680
D019821SimvastatinSimvastatin results in decreased phosphorylation of MTOR protein22144680
D019821SimvastatinSimvastatin results in decreased phosphorylation of MTOR protein22144680
D019821SimvastatinPhosphatidic Acids inhibits the reaction [Simvastatin results in increased activity of MTOR protein]23817226
D019821SimvastatinSimvastatin results in increased activity of MTOR protein23817226
D020123SirolimusSirolimus results in decreased activity of and results in decreased phosphorylation of MTOR protein16825603
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6 protein17908691
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] which results in increased phosphorylation of GSK3B protein17908691
D020123SirolimusSirolimus results in increased activity of MTOR protein19151764
D020123SirolimusMTOR protein inhibits the reaction [Sirolimus results in decreased activity of RPS6KB2 protein]12087098
D020123Sirolimus[Oxygen deficiency co-treated with Sirolimus] results in decreased expression of MTOR protein17968710
D020123Sirolimus[Sirolimus co-treated with Photosensitizing Agents] affects the phosphorylation of MTOR protein19125612
D020123SirolimusSirolimus inhibits the reaction [Daunorubicin results in increased phosphorylation of MTOR protein]21898527
D020123SirolimusSirolimus inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein]21187475
D020123SirolimusSirolimus inhibits the reaction [[MTOR protein binds to RAPTOR protein] which binds to LARP1 protein]25940091
D020123Sirolimus[Sirolimus inhibits the reaction [MTOR protein binds to RPTOR protein]] which results in increased expression of MAP1LC3A protein alternative form21742779
D020123SirolimusSirolimus inhibits the reaction [Oxygen deficiency results in increased expression of MTOR mRNA]17968710
D020123SirolimusSirolimus inhibits the reaction [Palmitic Acid results in increased activity of MTOR protein]27133527
D020123SirolimusSirolimus inhibits the reaction [puerarin results in increased phosphorylation of MTOR protein]27796870
D020123SirolimusSirolimus inhibits the reaction [Serotonin results in increased activity of MTOR protein]27133527
D020123SirolimusSirolimus promotes the reaction [Cisplatin results in decreased phosphorylation of MTOR protein]18058806
D020123SirolimusSirolimus results in decreased activity of MTOR protein11602639|1505041
D020123SirolimusSirolimus results in decreased activity of [MTOR protein binds to RPTOR protein]18776922
D020123SirolimusSirolimus results in decreased activity of [MTOR protein binds to RPTOR protein binds to MLST8 protein]19505958
D020123Sirolimus[Sirolimus results in decreased activity of [MTOR protein binds to RPTOR protein]] which results in increased activity of AR protein18776922
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]15919668
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] which results in decreased activity of RPS6KB1 protein14673156
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] which results in decreased expression of DDIT3 protein21321189
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] which results in decreased expression of PKM protein22574221
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] which results in decreased phosphorylation of EIF4EBP1 protein14673156|2016916
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6KB1 protein20169165|2257422
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6 protein17908691|2016916
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] which results in decreased phosphorylation of TP53 protein11602639
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] which results in increased phosphorylation of GSK3B protein17908691
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] which results in increased susceptibility to afimoxifene19016759
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] which results in increased susceptibility to fulvestrant19016759
D020123SirolimusSirolimus results in decreased expression of MTOR mRNA19698219
D020123SirolimusSirolimus results in decreased expression of MTOR protein26201060|2710778
D020123SirolimusSirolimus results in decreased expression of MTOR protein modified form25576684
D020123SirolimusSirolimus results in decreased phosphorylation of and results in increased expression of MTOR protein23363784
D020123SirolimusSirolimus results in decreased phosphorylation of MTOR protein19125612|1981570
D020123Sirolimus[Sirolimus results in decreased phosphorylation of MTOR protein] which results in decreased chemical synthesis of Reactive Oxygen Species20680277
D020123SirolimusSirolimus results in increased activity of MTOR protein19151764
D020123SirolimusSirolimus results in increased phosphorylation of MTOR protein23958494
D020123Sirolimussodium arsenite promotes the reaction [Sirolimus results in decreased expression of MTOR protein]28888487
D020123SirolimusSirolimus inhibits the reaction [[Cadmium Chloride co-treated with TGFB1 protein] results in increased phosphorylation of MTOR protein]28342888
D020123SirolimusSirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6KB1 protein]19567381
D020123SirolimusSirolimus inhibits the reaction [TNF protein results in increased phosphorylation of MTOR protein]22069489
D020123SirolimusSirolimus results in decreased activity of MTOR protein19567381|2036830
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol affects the susceptibility to Lipopolysaccharides]22363816
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]22363816
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]22363816
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]22363816
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]22363816
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]22363816
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]22363816
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]22363816
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]22363816
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA mRNA]]22363816
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]]22363816
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]22363816
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]22363816
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CREB1 protein]]22363816
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]22363816
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]22363816
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]22363816
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] which results in decreased susceptibility to resveratrol22363816
D020123SirolimusSirolimus results in decreased phosphorylation of MTOR protein18640276
D020123SirolimusSirolimus results in increased activity of MTOR protein19151764
D020123SirolimusSirolimus results in decreased activity of MTOR protein19108833
D020123SirolimusSirolimus results in decreased phosphorylation of MTOR protein19108833
D020123SirolimusSirolimus inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MTOR protein]26648565
D020123SirolimusSirolimus inhibits the reaction [Isoproterenol results in increased phosphorylation of MTOR protein]17623046|2504521
D020123SirolimusSirolimus inhibits the reaction [Paraquat results in increased phosphorylation of MTOR protein]27324791
D020123SirolimusSirolimus results in decreased expression of MTOR protein22561310
D020123SirolimusSirolimus results in decreased expression of MTOR protein modified form22561310
D020123SirolimusSirolimus results in decreased phosphorylation of MTOR protein18640276|2732479
D020123SirolimusSirolimus results in increased expression of MTOR mRNA24971338
D020123SirolimusTNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased phosphorylation of MTOR protein]]25045214
D020123SirolimusSirolimus inhibits the reaction [MTOR protein binds to RPTOR protein]21742779
D020123SirolimusSirolimus results in decreased activity of MTOR16316336|1863186
D020123SirolimusSirolimus results in decreased activity of MTOR protein15806154|1628351
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [[Glucose co-treated with INS protein] results in increased expression of PTEN protein]18303120
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]18303120
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] promotes the reaction [INS protein results in increased transport of Glucose]18303120
D020123SirolimusSirolimus results in increased activity of MTOR protein20574048
D020123SirolimusSirolimus results in increased expression of MTOR mRNA23978538
D012906Smoke[Smoke results in decreased expression of MTOR] which affects the expression of MMP121742783
D012906Smoke[Smoke results in decreased expression of MTOR] which affects the expression of TIMP321742783
C017947sodium arseniteMIR21 mRNA affects the reaction [sodium arsenite results in decreased expression of MTOR protein]27107786
C017947sodium arsenitePTEN protein affects the reaction [MIR21 mRNA affects the reaction [sodium arsenite results in decreased expression of MTOR protein]]27107786
C017947sodium arsenitePTEN protein affects the reaction [sodium arsenite results in decreased expression of MTOR protein]27107786
C017947sodium arsenitesodium arsenite affects the expression of MTOR mRNA29319823
C017947sodium arsenitesodium arsenite promotes the reaction [Sirolimus results in decreased expression of MTOR protein]28888487
C017947sodium arsenitesodium arsenite results in decreased expression of MTOR protein27107786
C017947sodium arseniteU 0126 inhibits the reaction [sodium arsenite results in decreased expression of MTOR protein]27107786
C017947sodium arsenitesodium arsenite results in decreased activity of MTOR protein23143138
C017947sodium arsenitesodium arsenite results in decreased expression of MTOR protein modified form23143138
D012969Sodium FluorideSodium Fluoride results in decreased expression of MTOR protein28918527
C471405sorafenib"[2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with sorafenib] results in decreased activity of MTOR protein"23036488
C471405sorafenibarsenic trioxide inhibits the reaction [sorafenib results in increased expression of MTOR protein]25416439
C471405sorafenib[sorafenib co-treated with PI103] inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein]21187475
C471405sorafenibsorafenib results in decreased activity of MTOR protein21601561|2303648
C471405sorafenibsorafenib results in decreased expression of MTOR mRNA26409325
C471405sorafenibsorafenib results in decreased phosphorylation of MTOR protein20054642
C471405sorafenib[[sorafenib results in increased expression of ATF4 protein] which results in increased expression of DDIT4 protein] which results in decreased activity of MTOR protein21601561
C471405sorafenib[[[sorafenib results in increased expression of ATF4 protein] which results in increased expression of DDIT4 protein] which results in decreased activity of MTOR protein] which results in decreased expression of BIRC5 protein21601561
C471405sorafenib[sorafenib results in increased expression of DDIT4 protein] which results in decreased activity of MTOR protein21601561
C471405sorafenib[[sorafenib results in increased expression of DDIT4 protein] which results in decreased activity of MTOR protein] which results in decreased expression of BIRC5 protein21601561
C471405sorafenib[[sorafenib results in increased expression of DDIT4 protein] which results in decreased activity of MTOR protein] which results in increased susceptibility to TNFSF10 protein21601561
C471405sorafenibsorafenib results in increased expression of MTOR protein25416439
C471405sorafenibsorafenib results in increased phosphorylation of MTOR protein21187475
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]25554529
D013267StilbenesStilbenes results in decreased phosphorylation of and results in decreased activity of MTOR protein23059970
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin results in decreased expression of MTOR mRNA]26071184
D013311StreptozocinStreptozocin results in decreased expression of MTOR mRNA26071184
C473643sulphoraphenesulphoraphene results in decreased expression of MTOR protein29247643
C473643sulphoraphenesulphoraphene results in decreased phosphorylation of MTOR protein29247643
D013629TamoxifenTamoxifen results in decreased activity of MTOR protein19931998
D013629Tamoxifen[Tamoxifen results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6KB1 protein19931998
D013629TamoxifenTamoxifen affects the expression of MTOR mRNA17555576
D013654TaurineTaurine inhibits the reaction [Methamphetamine results in decreased phosphorylation of MTOR protein]23041169
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [ursolic acid results in decreased phosphorylation of MTOR protein]24802810
C047246temozolomideresveratrol promotes the reaction [temozolomide results in decreased phosphorylation of MTOR protein]22530672
C047246temozolomidetemozolomide results in decreased phosphorylation of MTOR protein22530672
C047246temozolomideresveratrol promotes the reaction [temozolomide results in decreased phosphorylation of MTOR protein]22530672
C047246temozolomidetemozolomide results in decreased phosphorylation of MTOR protein22530672
C047246temozolomideTSC1 protein affects the reaction [resveratrol promotes the reaction [temozolomide results in decreased phosphorylation of MTOR protein]]22530672
C047246temozolomideTSC1 protein affects the reaction [temozolomide results in decreased phosphorylation of MTOR protein]22530672
C401859temsirolimusCisplatin promotes the reaction [temsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]]21358348
C401859temsirolimusCisplatin promotes the reaction [temsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6 protein]]21358348
C401859temsirolimustemsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]21358348
C401859temsirolimustemsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6 protein]21358348
C401859temsirolimustemsirolimus results in decreased activity of MTOR protein16033649
C401859temsirolimus[perifosine co-treated with temsirolimus] results in decreased activity of MTOR protein21267448
C401859temsirolimustemsirolimus results in decreased activity of MTOR16012795
C401859temsirolimustemsirolimus results in decreased activity of MTOR protein16954435
D013739TestosteroneTestosterone affects the expression of MTOR mRNA20843997
D013739Testosterone[Methylnitrosourea co-treated with Testosterone] results in increased expression of MTOR protein25164625
D013739TestosteroneQuercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of MTOR protein]25164625
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide promotes the reaction [Imatinib Mesylate results in decreased expression of MTOR protein]19208803
D013749Tetrachlorodibenzodioxinalpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of MTOR protein]22266097
D013749TetrachlorodibenzodioxinMifepristone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of MTOR protein]22266097
D013749TetrachlorodibenzodioxinPGR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of MTOR protein]22266097
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased phosphorylation of MTOR protein22266097
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MTOR mRNA17942748
D013755Tetradecanoylphorbol AcetateRAF1 protein affects the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MTOR protein]17976640
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of MTOR protein17976640
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of MTOR protein20109541
C009438tetrandrinetetrandrine results in decreased expression of and results in decreased phosphorylation of MTOR protein26822499
C009438tetrandrinetetrandrine results in decreased expression of MTOR protein modified form25266202
D013853Thioacetamidecucurbitacin E inhibits the reaction [Thioacetamide results in increased phosphorylation of MTOR protein]27363783
D013853ThioacetamideCurcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of MTOR protein]27363783
D013853ThioacetamideThioacetamide results in increased phosphorylation of MTOR protein27363783
C009495titanium dioxidetitanium dioxide results in increased expression of MTOR mRNA27760801
D019772TopotecanTopotecan inhibits the reaction [Cisplatin results in increased phosphorylation of MTOR protein]20935474
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MTOR mRNA25729387
C099150trabectedinEverolimus inhibits the reaction [MTOR results in decreased susceptibility to trabectedin]21622721
C099150trabectedinMTOR results in decreased susceptibility to trabectedin21622721
C011559tributyltintributyltin results in decreased expression of MTOR26961604
C011559tributyltintributyltin results in decreased phosphorylation of MTOR protein20371977
D014241TrichloroethyleneTrichloroethylene results in increased expression of MTOR mRNA19448997
D014268TrifluoperazineTrifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]21544200
D014268TrifluoperazineTrifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]21544200
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of MTOR mRNA19042947
C001899triptolidetriptolide results in increased expression of and results in increased phosphorylation of MTOR protein26990902
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MTOR mRNA"26179874
C031324tris(chloroethyl)phosphatetris(chloroethyl)phosphate results in decreased expression of and results in decreased phosphorylation of MTOR protein26378621
D014415Tunicamycin[resveratrol results in decreased activity of MTOR protein] inhibits the reaction [Tunicamycin results in increased expression of DDIT3 mRNA]21321189
D014415Tunicamycin[resveratrol results in decreased activity of MTOR protein] inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]21321189
D014415Tunicamycin[resveratrol results in decreased activity of MTOR protein] inhibits the reaction [Tunicamycin results in increased expression of XBP1 mRNA alternative form]21321189
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [7-ketocholesterol results in increased phosphorylation of MTOR protein]20466046
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MTOR protein]20466046
C113580U 0126U 0126 inhibits the reaction [sodium arsenite results in decreased expression of MTOR protein]27107786
C005466ursolic acidtauroursodeoxycholic acid inhibits the reaction [ursolic acid results in decreased phosphorylation of MTOR protein]24802810
C005466ursolic acidursolic acid results in decreased phosphorylation of MTOR protein24802810
C073339usnic acidusnic acid results in decreased phosphorylation of and results in decreased expression of MTOR protein25078063
D014640VancomycinVancomycin results in increased expression of MTOR mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MTOR gene25560391
D014752Vinyl ChlorideVinyl Chloride metabolite results in increased phosphorylation of MTOR protein26962056
C029297vinylidene chloridevinylidene chloride results in decreased expression of MTOR mRNA26682919
D009536NiacinamideNiacinamide inhibits the reaction [resveratrol results in decreased phosphorylation of MTOR protein]19928762
D009536NiacinamideNiacinamide results in increased phosphorylation of MTOR protein19928762
D002762CholecalciferolCholecalciferol results in decreased expression of MTOR18628207
D002762CholecalciferolMTOR mutant form promotes the reaction [Cholecalciferol results in increased expression of BECN1 protein]18628207
D002762CholecalciferolMTOR results in decreased susceptibility to Cholecalciferol18628207
C111237vorinostatvorinostat results in decreased expression of MTOR protein18850582
C111237vorinostatvorinostat results in decreased expression of MTOR protein modified form18850582
C111237vorinostatvorinostat results in decreased phosphorylation of and results in decreased activity of MTOR protein17881280
C111237vorinostatvorinostat results in decreased phosphorylation of MTOR protein20543569|2096257
C009687wortmanninwortmannin inhibits the reaction [Phenylephrine results in increased phosphorylation of MTOR protein]17976640
C009687wortmanninwortmannin inhibits the reaction [Capsaicin results in increased phosphorylation of MTOR protein]19139269
C547581WYE 125132WYE 125132 results in decreased activity of MTOR protein21322566
C576808XL765XL765 results in decreased activity of MTOR protein29031482
C066632yessotoxinPDE4A protein promotes the reaction [yessotoxin results in decreased expression of MTOR protein modified form]25576684
C066632yessotoxinyessotoxin results in decreased expression of MTOR protein modified form25576684
D015034Zinc OxideZinc Oxide analog results in decreased phosphorylation of MTOR protein24614525
C510150ZSTK474ZSTK474 affects the activity of MTOR protein20129775

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001030RNA polymerase III type 1 promoter DNA binding-IDA20233713  
GO:0001031RNA polymerase III type 2 promoter DNA binding-IDA20233713  
GO:0001032RNA polymerase III type 3 promoter DNA binding-IDA20233713  
GO:0001156TFIIIC-class transcription factor binding-IDA20543138  
GO:0004672protein kinase activity-IDA12150926  
GO:0004674protein serine/threonine kinase activity-EXP22768106  
GO:0004674protein serine/threonine kinase activity-IDA12718876  15467718  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0005515protein binding-IPI10089303  11438723  12150925  12150926  12408816  14743216  
15467718  16098514  16915281  17148612  17461779  17565979  
18339839  18550814  18566587  18955708  19446321  19619545  
19875983  20080789  20543138  20562859  20864032  21045808  
21376236  21471201  21614075  22307628  22424946  22664266  
23027611  23263282  23394946  23524951  23636326  23953116  
24036451  24375676  24670654  25241761  25446900  25657994  
25686248  26593251  26678875  26787466  27043084  
GO:0005524ATP binding-IEA-  
GO:0016301kinase activity-IBA21873635  
GO:0016301kinase activity-IDA15467718  25327288  
GO:0016301kinase activity-TAS11853878  
GO:0019901protein kinase binding-IEA-  
GO:0019904protein domain specific binding-IEA-  
GO:0042802identical protein binding-IPI11438723  24670654  
GO:0043022ribosome binding-IEA-  
GO:0051219phosphoprotein binding-IPI11853878  
GO ID GO Term Qualifier Evidence PubMed
GO:0001558regulation of cell growth-IDA18762023  
GO:0001933negative regulation of protein phosphorylation-IEA-  
GO:0001934positive regulation of protein phosphorylation-IDA20233713  
GO:0001938positive regulation of endothelial cell proliferation-IEA-  
GO:0003007heart morphogenesis-IEA-  
GO:0003179heart valve morphogenesis-IEA-  
GO:0005979regulation of glycogen biosynthetic process-IEA-  
GO:0006112energy reserve metabolic process-IEA-  
GO:0006207'de novo' pyrimidine nucleobase biosynthetic process-IEA-  
GO:0006281DNA repair-IBA21873635  
GO:0006468protein phosphorylation-IDA12150926  15467718  18925875  
GO:0006468protein phosphorylation-IMP17028174  
GO:0007050cell cycle arrest-TAS-  
GO:0007281germ cell development-IEA-  
GO:0007420brain development-IEA-  
GO:0007569cell aging-IEA-  
GO:0007584response to nutrient-IMP17028174  
GO:0007616long-term memory-IEA-  
GO:0008361regulation of cell size-IMP22424946  
GO:0008542visual learning-IEA-  
GO:0009267cellular response to starvation-IDA28223137  
GO:0009791post-embryonic development-IEA-  
GO:0010507negative regulation of autophagy-IMP22424946  
GO:0010507negative regulation of autophagy-ISS-  
GO:0010592positive regulation of lamellipodium assembly-IEA-  
GO:0010628positive regulation of gene expression-IMP17028174  
GO:0010718positive regulation of epithelial to mesenchymal transition-IMP27919618  
GO:0010831positive regulation of myotube differentiation-IEA-  
GO:0014042positive regulation of neuron maturation-IEA-  
GO:0014736negative regulation of muscle atrophy-IEA-  
GO:0014823response to activity-IEA-  
GO:0016241regulation of macroautophagy-TAS-  
GO:0016242negative regulation of macroautophagy-IDA25327288  
GO:0016310phosphorylation-IDA11853878  25327288  
GO:0018105peptidyl-serine phosphorylation-IMP20537536  23728790  
GO:0018107peptidyl-threonine phosphorylation-IEA-  
GO:0021510spinal cord development-IEA-  
GO:0030163protein catabolic process-TAS11853878  
GO:0030838positive regulation of actin filament polymerization-IEA-  
GO:0031397negative regulation of protein ubiquitination-IEA-  
GO:0031529ruffle organization-IEA-  
GO:0031641regulation of myelination-IEA-  
GO:0031669cellular response to nutrient levels-ISS-  
GO:0031929TOR signaling-IMP15467718  17028174  18762023  26018084  
GO:0031929TOR signaling-NAS23778976  
GO:0031998regulation of fatty acid beta-oxidation-IEA-  
GO:0032095regulation of response to food-IEA-  
GO:0032148activation of protein kinase B activity-TAS-  
GO:0032516positive regulation of phosphoprotein phosphatase activity-TAS28386764  
GO:0032868response to insulin-IEA-  
GO:0032956regulation of actin cytoskeleton organization-IMP15467718  
GO:0034198cellular response to amino acid starvation-IDA22424946  
GO:0035176social behavior-IEA-  
GO:0035264multicellular organism growth-IEA-  
GO:0038202TORC1 signaling-IDA28223137  
GO:0038202TORC1 signaling-IMP12718876  22424946  
GO:0042060wound healing-IEA-  
GO:0042220response to cocaine-IEA-  
GO:0043087regulation of GTPase activity-IEA-  
GO:0043200response to amino acid-IDA18497260  
GO:0043276anoikis-NAS23778976  
GO:0043278response to morphine-IEA-  
GO:0043610regulation of carbohydrate utilization-IEA-  
GO:0045429positive regulation of nitric oxide biosynthetic process-IEA-  
GO:0045670regulation of osteoclast differentiation-ISS-  
GO:0045727positive regulation of translation-IDA18762023  
GO:0045792negative regulation of cell size-IEA-  
GO:0045945positive regulation of transcription by RNA polymerase III-IMP20233713  
GO:0046777protein autophosphorylation-IDA15467718  
GO:0046889positive regulation of lipid biosynthetic process-IMP18762023  
GO:0048255mRNA stabilization-IEA-  
GO:0048661positive regulation of smooth muscle cell proliferation-IEA-  
GO:0048714positive regulation of oligodendrocyte differentiation-IEA-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IEA-  
GO:0050882voluntary musculoskeletal movement-IEA-  
GO:0051496positive regulation of stress fiber assembly-IEA-  
GO:0051549positive regulation of keratinocyte migration-IMP27919618  
GO:0051897positive regulation of protein kinase B signaling-IEA-  
GO:0055013cardiac muscle cell development-IEA-  
GO:0060048cardiac muscle contraction-IEA-  
GO:0060135maternal process involved in female pregnancy-IEA-  
GO:0060252positive regulation of glial cell proliferation-IEA-  
GO:0060999positive regulation of dendritic spine development-IEA-  
GO:0061051positive regulation of cell growth involved in cardiac muscle cell development-IEA-  
GO:0070885negative regulation of calcineurin-NFAT signaling cascade-IEA-  
GO:0071230cellular response to amino acid stimulus-IDA22424946  
GO:0071233cellular response to leucine-IDA22424946  
GO:0071456cellular response to hypoxia-ISS-  
GO:0090335regulation of brown fat cell differentiation-IEA-  
GO:0090559regulation of membrane permeability-IEA-  
GO:1900034regulation of cellular response to heat-TAS-  
GO:1901216positive regulation of neuron death-IEA-  
GO:1901838positive regulation of transcription of nucleolar large rRNA by RNA polymerase I-IMP24036451  
GO:1903691positive regulation of wound healing, spreading of epidermal cells-IMP27919618  
GO:1904000positive regulation of eating behavior-IEA-  
GO:1904056positive regulation of cholangiocyte proliferation-IEA-  
GO:1904058positive regulation of sensory perception of pain-IEA-  
GO:1904193negative regulation of cholangiocyte apoptotic process-IEA-  
GO:1904197positive regulation of granulosa cell proliferation-IEA-  
GO:1904206positive regulation of skeletal muscle hypertrophy-IEA-  
GO:1904213negative regulation of iodide transmembrane transport-IEA-  
GO:1904690positive regulation of cytoplasmic translational initiation-TAS28386764  
GO:1990253cellular response to leucine starvation-IDA22424946  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA11853878  20381137  
GO:0005741mitochondrial outer membrane-IEA-  
GO:0005764lysosome-IDA20381137  25936802  
GO:0005764lysosome-IMP22424946  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005829cytosol-TAS-  
GO:0012505endomembrane system-IDA18497260  22424946  
GO:0016020membrane-HDA19946888  
GO:0016020membrane-IDA11853878  
GO:0016605PML bodycolocalizes_withISS-  
GO:0030425dendrite-IEA-  
GO:0031931TORC1 complex-IDA12150926  12718876  15467718  18925875  
GO:0031931TORC1 complex-IMP20537536  
GO:0031932TORC2 complex-IDA15467718  18925875  
GO:0043025neuronal cell body-IEA-  
KEGG ID KEGG Term
hsa04012ErbB signaling pathway
hsa04150mTOR signaling pathway
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04930Type II diabetes mellitus
hsa05200Pathways in cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05221Acute myeloid leukemia
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1632852MacroautophagyTAS
R-HSA-1643685DiseaseTAS
R-HSA-165159mTOR signallingTAS
R-HSA-166208mTORC1-mediated signallingTAS
R-HSA-168256Immune SystemTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3371556Cellular response to heat stressTAS
R-HSA-3371571HSF1-dependent transactivationTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-380972Energy dependent regulation of mTOR by LKB1-AMPKTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389356CD28 co-stimulationTAS
R-HSA-389357CD28 dependent PI3K/Akt signalingTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-5218920VEGFR2 mediated vascular permeabilityTAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5674400Constitutive Signaling by AKT1 E17K in CancerTAS
R-HSA-6804757Regulation of TP53 DegradationTAS
R-HSA-6806003Regulation of TP53 Expression and DegradationTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8943724Regulation of PTEN gene transcriptionTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18370695Immunosuppression and metabolic syndrome in renal transplant recipients. (2004 Fall)Lo AMetab Syndr Relat Disord
25058399Roles of PI3K/Akt and c-Jun signaling pathways in human papillomavirus type 16 oncoprotein-induced HIF-1alpha, VEGF, and IL-8 expression and in vitro angiogenesis in non-small cell lung cancer cells. (2014)Zhang EPLoS One
29463039The Significance of MMP-1 in EGFR-TKI-Resistant Lung Adenocarcinoma: Potential for Therapeutic Targeting. (2018 Feb 18)Saito RInt J Mol Sci
25484085Autophagy and ethanol neurotoxicity. (2014)Luo JAutophagy
17065372Role of lung maintenance program in the heterogeneity of lung destruction in emphysema. (2006 Nov)Tuder RMProc Am Thorac Soc
25769588Prevalence of hypertension after living-donor liver transplantation: a prospective study. (2015 Mar)Tong MSTransplant Proc
26043790Cocaine-mediated microglial activation involves the ER stress-autophagy axis. (2015)Guo MLAutophagy
22497103Early diagnosis improves survival in kidney cancer. (2012 Feb)Lewis GPractitioner
28612613[Recent Overview of Kidney Cancer Diagnostics and Treatment]. (Summer 2017)Marencak JKlin Onkol
20106877Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD. (2010 Mar-Apr)Wempe FDis Model Mech
29677422[Risk factors for cancer development in patients after kidney transplantation]. (2016)Laudanska EPrzegl Lek
27658472The Diagnosis, Treatment, and Follow-up of Renal Cell Carcinoma. (2016 Sep 5)Doehn CDtsch Arztebl Int
24267900Social disparities, health risk behaviors, and cancer. (2013)Rametta SBMC Surg
27921038The Clinical Manifestation and Management of Autosomal Dominant Polycystic Kidney Disease in China. (2016 Oct)Xue CKidney Dis (Basel)
17342327PTEN and phosphorylated AKT expression and prognosis in early- and late-stage non-small cell lung cancer. (2007 Apr)Lim WTOncol Rep
27899881Transcriptomics of Environmental Enrichment Reveals a Role for Retinoic Acid Signaling in Addiction. (2016)Zhang YFront Mol Neurosci
25535548Human umbilical endothelial cells (HUVECs) have a sex: characterisation of the phenotype of male and female cells. (2014)Addis RBiol Sex Differ
23566666A role for benzo[a]pyrene and Slug in invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis: a potential molecular link between smoking and radiographic progression. (2013 Dec)Lee JJoint Bone Spine
28674727Cellular and molecular mechanisms of alcohol-induced osteopenia. (2017 Dec)Luo ZCell Mol Life Sci
26667343KRAS-Mutant Lung Cancers in the Era of Targeted Therapy. (2016)Naidoo JAdv Exp Med Biol
28652248GLI1 Blockade Potentiates the Antitumor Activity of PI3K Antagonists in Lung Squamous Cell Carcinoma. (2017 Aug 15)Kasiri SCancer Res
27613305Decreased activation of placental mTOR family members is associated with the induction of intrauterine growth restriction by secondhand smoke in the mouse. (2017 Feb)Mejia CCell Tissue Res
20301399Tuberous Sclerosis Complex (1993)Northrup H-
25213146Hirsutenone in Alnus extract inhibits akt activity and suppresses prostate cancer cell proliferation. (2015 Nov)Kang SMol Carcinog
28789440TRIM59 is a novel potential prognostic biomarker in patients with non-small cell lung cancer: A research based on bioinformatics analysis. (2017 Aug)Hao LOncol Lett
21242979Akt1 deletion prevents lung tumorigenesis by mutant K-ras. (2011 Apr 14)Hollander MCOncogene
23466691mTOR activation is required for the anti-alcohol effect of ketamine, but not memantine, in alcohol-preferring rats. (2013 Jun 15)Sabino VBehav Brain Res
21742783Cigarette smoke components induce matrix metalloproteinase-1 in aortic endothelial cells through inhibition of mTOR signaling. (2011 Oct)Lemaitre VToxicol Sci
19097356Pathology of renal tumors in adults. Molecular biology, histopathological diagnosis and prognosis. (2008)Okon KPol J Pathol
25122428Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a comprehensive genomic analysis. (2014 Sep)Umemura SJ Thorac Oncol
22966072Novel and reversible mechanisms of smoking-induced insulin resistance in humans. (2012 Dec)Bergman BCDiabetes
23802852Lung adenocarcinoma biomarker incidence in Hispanic versus non-Hispanic white patients. (2014 Mar)McQuitty EArch Pathol Lab Med
17368733Targeting receptor tyrosine kinase signalling in small cell lung cancer (SCLC): what have we learned so far? (2007 Jun)Fischer BCancer Treat Rev
29281903Assessment of FGFR1 Over-Expression and Over-Activity in Lung Cancer Cells: A Toolkit for Anti-FGFR1 Drug Screening. (2018 Feb)Hu PHum Gene Ther Methods
23256715Can we delay the accelerated lung aging in COPD? Anti-aging molecules and interventions. (2013 Feb)Papaioannou AICurr Drug Targets
24658667Hydrogen sulfide improves left ventricular function in smoking rats via regulation of apoptosis and autophagy. (2014 Jun)Zhou XApoptosis
24641414Favorable outcome in elderly Asian patients with metastatic renal cell carcinoma treated with everolimus: the Osaka Urologic Oncology Group. (2014)Inamoto TAsian Pac J Cancer Prev
22347189An emerging role for the Mammalian target of rapamycin in "pathological" protein translation: relevance to cocaine addiction. (2012)Dayas CVFront Pharmacol
27363715The Effect of Nicotine and Tobacco on Aortic Matrix Metalloproteinases in the Production of Aortic Aneurysm. (2016)Rabkin SWCurr Vasc Pharmacol
27921039Clinical Manifestation and Management of ADPKD in Western Countries. (2016 Oct)Sommerer CKidney Dis (Basel)
29431650Protein Translation in the Nucleus Accumbens Is Dysregulated during Cocaine Withdrawal and Required for Expression of Incubation of Cocaine Craving. (2018 Mar 14)Werner CTJ Neurosci
27056740Pharmacological modulation of protein kinases as a new approach to treat addiction to cocaine and opiates. (2016 Jun 15)Garcia-Pardo MPEur J Pharmacol
21609394mTOR-STAT3-notch signalling contributes to ALDH2-induced protection against cardiac contractile dysfunction and autophagy under alcoholism. (2012 Mar)Ge WJ Cell Mol Med
25426078Diabetes, pancreatic cancer, and metformin therapy. (2014)Gong JFront Physiol
23727505Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents. (2013 Sep 5)Alvaro-Bartolome MNeuroscience
24595501Reactivation of cocaine reward memory engages the Akt/GSK3/mTOR signaling pathway and can be disrupted by GSK3 inhibition. (2014 Aug)Shi XPsychopharmacology (Berl)
28816646Chronic Cigarette Smoke Mediated Global Changes in Lung Mucoepidermoid Cells: A Phosphoproteomic Analysis. (2017 Aug)Solanki HSOMICS
26480622[THE CURRENT APPROACH TO METASTATIC RENAL CELL CARCINOMA]. (2015 Aug)Keizman DHarefuah
26184482Nicotine Induces Tumor Growth and Chemoresistance through Activation of the PI3K/Akt/mTOR Pathway in Bladder Cancer. (2015 Sep)Yuge KMol Cancer Ther
22905289Mechanisms mediating the effects of alcohol and HIV anti-retroviral agents on mTORC1, mTORC2 and protein synthesis in myocytes. (2012 Jun 26)Hong-Brown LQWorld J Biol Chem
27998433[Effects of mTOR-Cdc42 signaling pathway on phagocytosis of alveolar macrophages in chronic obstructive pulmonary disease mice]. (2016 Dec 13)Wang YJZhonghua Yi Xue Za Zhi
23452441Unexplained antepartum stillbirth: a consequence of placental aging? (2013 Apr)Smith RPlacenta
25936472Immunohistochemical characterization of the mTOR pathway in stage-I non-small-cell lung carcinoma. (2015 Jul)Shin ELung Cancer