Gene: ALPL

249
AP-TNAP|APTNAP|HOPS|TNALP|TNAP|TNSALP
alkaline phosphatase, liver/bone/kidney
protein-coding
1p36.12
Ensembl:ENSG00000162551 MIM:171760 Vega:OTTHUMG00000002949 UniprotKB:P05186
NG_008940.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.229e-1 (AD)  1.267e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEMA3G0.676
ENG0.641
NOTCH30.639
CCM2L0.625
SMAD60.623
ESAM0.622
LIMS20.618
MYO1C0.613
EPAS10.612
EGFL80.612

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.418
OR4F5-0.407
NOX3-0.268
GSTM1-0.246
BRS3-0.207
SIX3-0.207
TACR3-0.204
SAMD13-0.204
C6orf118-0.199
CA12-0.198

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09338MersalylSmall Molecule486-67-9ApprovedTarget
DB01143AmifostineSmall Molecule20537-88-6Approved|InvestigationalEnzyme
DB06716FospropofolSmall Molecule258516-89-1Approved|Illicit|InvestigationalEnzyme
DB09498Strontium chloride Sr-89Small Molecule38270-90-5Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of ALPL mRNA"26377693
C0979491,25-dihydroxyvitamin D"[Dexamethasone co-treated with 1,25-dihydroxyvitamin D] inhibits the reaction [WNT3A protein results in increased expression of ALPL protein]"15270777
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ALPL mRNA"28903501
C5598531-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid inhibits the reaction [LIF protein affects the reaction ALPL mRNA]26723917
C11912918alpha-glycyrrhetinic acid18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]21910061
C11912918alpha-glycyrrhetinic acid18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]21910061
C11912918alpha-glycyrrhetinic acid18alpha-glycyrrhetinic acid inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA]21910061
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ALPL mRNA"23146750
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of ALPL mRNA"21920950
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in decreased expression of ALPL mRNA]22019892
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of ALPL protein]26053266
C4086042-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of ALPL mRNA]]25789987
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of ALPL mRNA"25795401
C04048826,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3"26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3 results in increased expression of ALPL mRNA"12016462
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA]25194622
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ALPL mRNA"23196670
C0179063-dinitrobenzene3-dinitrobenzene affects the expression of ALPL mRNA24140754
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ALPL protein"11289319
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of ALPL mRNA]]25789987
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin results in increased expression of ALPL protein]26053266
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Glucosamine analog results in increased activity of ALPL protein]"20458730
C000603489(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone results in increased expression of ALPL mRNA25789987
C000603489(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of ALPL mRNA]]25789987
C000603489(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of ALPL mRNA]]25789987
C000603489(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of ALPL mRNA]25789987
C000603489(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of and results in increased activity of ALPL protein]25789987
C000603489(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanoneNOG protein inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of and results in increased activity of ALPL protein]]25789987
C000603489(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanoneSB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of ALPL mRNA]]25789987
C4620316-(1,1-dimethylallyl)naringenin"[6-(1,1-dimethylallyl)naringenin binds to ESR1 protein] which results in increased activity of ALPL protein"12650720
C4620316-(1,1-dimethylallyl)naringenin"fulvestrant inhibits the reaction [[6-(1,1-dimethylallyl)naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]"12650720
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Bezafibrate results in increased expression of ALPL mRNA]"21499286
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [1-Naphthylisothiocyanate results in increased secretion of ALPL protein]"27702592
C1197378-prenylnaringenin[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein12650720
C1197378-prenylnaringenin8-prenylnaringenin results in increased activity of ALPL protein16019205
C1197378-prenylnaringenin8-prenylnaringenin results in increased expression of ALPL mRNA16019205
C1197378-prenylnaringeninfulvestrant inhibits the reaction [[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein]12650720
C001969acephateacephate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D000082AcetaminophenAcetaminophen results in decreased expression of ALPL mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of ALPL mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of ALPL mRNA19784758
C056165acetovanilloneacetovanillone inhibits the reaction [Palmitic Acid results in increased expression of ALPL mRNA]24080574
D020106AcrylamideAcrylamide results in decreased expression of ALPL mRNA28959563
D000255Adenosine TriphosphateALPL gene mutant form promotes the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]27466191
D000255Adenosine TriphosphateALPL gene mutant form results in increased susceptibility to Adenosine Triphosphate27466191
D000305Adrenal Cortex HormonesAdrenal Cortex Hormones results in decreased expression of ALPL protein1790624
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ALPL protein20106945
C096920AGN 193109AGN 193109 inhibits the reaction [Indinavir promotes the reaction [Tretinoin results in increased expression of ALPL protein]]10704935
C000188alachloralachlor inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D000450Aldosteroneacephate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D000450Aldosteronealachlor inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D000450AldosteroneAldosterone results in increased expression of ALPL mRNA29149346
D000450AldosteroneAtrazine metabolite inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D000450Aldosteronebifenthrin inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D000450Aldosteronecypermethrin inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D000450AldosteroneDDT inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D000450AldosteroneDichlorodiphenyl Dichloroethylene inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D000450AldosteroneDimethoate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D000450Aldosteronefenvalerate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D000450Aldosteronefipronil inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D000450AldosteroneMethoxychlor inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D000450Aldosterone"o,p'-DDT inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]"29149346
D000450AldosteronePermethrin inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D000450AldosteroneSpironolactone inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D000450Aldosteroneterbutylazine inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D000450AldosteroneZineb inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D000493AllopurinolAllopurinol results in increased expression of ALPL mRNA26968635
D000498Allyl CompoundsAllyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein]15554553
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of ALPL mRNA17898587
C010845aluminum chloridealuminum chloride results in decreased activity of ALPL protein27720690
C010845aluminum chloridealuminum chloride results in decreased expression of ALPL mRNA26658030|2772069
C010845aluminum chloridealuminum chloride results in decreased expression of ALPL protein23065425
C010845aluminum chlorideTGFB1 protein inhibits the reaction [aluminum chloride results in decreased expression of ALPL mRNA]27720690
D000537Aluminum OxideAluminum Oxide results in increased expression of ALPL mRNA19464052
D005680gamma-Aminobutyric AcidALPL gene mutant form results in decreased abundance of gamma-Aminobutyric Acid7550313
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ALPL mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of ALPL mRNA22465848
D001205Ascorbic Acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of ALPL mRNA26424790
D001205Ascorbic AcidAscorbic Acid results in increased expression of ALPL mRNA28105418
D001205Ascorbic AcidEZH2 protein inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of ALPL mRNA]26424790
C040896AST 120AST 120 results in increased expression of ALPL mRNA16820376
D001280AtrazineAtrazine metabolite inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
C060988baohuoside Ibaohuoside I results in increased expression of ALPL mRNA17764702
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of ALPL mRNA26377693
D001554BenzeneBenzene results in decreased activity of ALPL protein19457444
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALPL mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ALPL mRNA21567390|2156981
D004958Estradiol[Estradiol binds to ESR1 protein] which results in increased activity of ALPL protein12650720
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of ALPL mRNA20660070
D004958Estradiolfulvestrant inhibits the reaction [[Estradiol binds to ESR1 protein] which results in increased activity of ALPL protein]12650720
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of ALPL mRNA17404688
D004958EstradiolEstradiol results in increased expression of ALPL mRNA15289156|1948475
C031463beta-glycerophosphoric acidALPL protein results in increased hydrolysis of beta-glycerophosphoric acid18500657
C031463beta-glycerophosphoric acid[ALPL protein results in increased hydrolysis of beta-glycerophosphoric acid] which results in increased abundance of Phosphates18500657
C031463beta-glycerophosphoric acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of ALPL mRNA26424790
C031463beta-glycerophosphoric acidbeta-glycerophosphoric acid results in increased activity of ALPL protein18500657
C031463beta-glycerophosphoric acidbeta-glycerophosphoric acid results in increased expression of ALPL mRNA18500657
C031463beta-glycerophosphoric acidEZH2 protein inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of ALPL mRNA]26424790
C031463beta-glycerophosphoric acidLevamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ALPL protein]18500657
C031463beta-glycerophosphoric acidLevamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of ALPL mRNA]18500657
C031463beta-glycerophosphoric acidALPL protein results in increased degradation of beta-glycerophosphoric acid17383965
C031463beta-glycerophosphoric acid[ALPL protein results in increased degradation of beta-glycerophosphoric acid] which results in increased abundance of Phosphates17383965
C031463beta-glycerophosphoric acidDiphosphates inhibits the reaction [ALPL protein results in increased degradation of beta-glycerophosphoric acid]17383965
C031463beta-glycerophosphoric acidDiphosphates inhibits the reaction [[ALPL protein results in increased degradation of beta-glycerophosphoric acid] which results in increased abundance of Phosphates]17383965
C095105bexarotenebexarotene results in increased expression of ALPL mRNA16648578
D001629BezafibrateBezafibrate results in decreased activity of ALPL protein8102192
D001629Bezafibrate"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Bezafibrate results in increased expression of ALPL mRNA]"21499286
D001629BezafibrateBezafibrate results in increased expression of ALPL mRNA21499286
D001629BezafibrateGSK0660 inhibits the reaction [Bezafibrate results in increased expression of ALPL mRNA]21499286
C099952bifenthrinbifenthrin inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ALPL mRNA28628672
C070515bisindolylmaleimide Ibisindolylmaleimide I results in decreased activity of ALPL protein11171635
C006780bisphenol A[bisphenol A binds to ESR1 protein] which results in increased activity of ALPL protein12650720
C006780bisphenol Abisphenol A results in decreased expression of ALPL mRNA23146750
C006780bisphenol Abisphenol A results in decreased activity of ALPL protein23900028
C006780bisphenol Abisphenol A results in increased expression of ALPL mRNA25181051
C038091butylparabenbutylparaben results in decreased expression of ALPL mRNA28527915
C038091butylparabenNR3C1 protein promotes the reaction [butylparaben results in decreased expression of ALPL mRNA]28527915
C038091butylparabenPPARG protein promotes the reaction [butylparaben results in decreased expression of ALPL mRNA]28527915
D002104CadmiumCadmium results in decreased expression of ALPL mRNA20570719
D002104CadmiumCadmium inhibits the reaction [zinc chloride results in increased activity of ALPL protein]26214600
D002104CadmiumCadmium results in decreased activity of ALPL protein26214600
D002104Cadmiumzinc chloride inhibits the reaction [Cadmium results in decreased activity of ALPL protein]26214600
D019256Cadmium Chloride2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in decreased expression of ALPL mRNA]22019892
D019256Cadmium ChlorideCadmium Chloride results in decreased activity of ALPL protein27558804
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ALPL mRNA22019892
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ALPL mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ALPL mRNA22209727
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester inhibits the reaction [Carbon Tetrachloride results in increased activity of ALPL protein]18436364
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester inhibits the reaction [Dexamethasone results in decreased expression of ALPL protein]28363435
D002122Calcium ChlorideCalcium Chloride results in increased expression of ALPL mRNA25824407
D002126Calcium HydroxideCalcium Hydroxide results in increased expression of ALPL mRNA22083529
C031293calcium silicate[Zinc binds to calcium silicate] which results in increased expression of ALPL mRNA23483914
D002251Carbon Tetrachloridecaffeic acid phenethyl ester inhibits the reaction [Carbon Tetrachloride results in increased activity of ALPL protein]18436364
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ALPL mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased activity of ALPL protein18436364
C010063carbonyl sulfidecarbonyl sulfide results in decreased expression of ALPL mRNA19395590
D048271ChitosanChitosan results in increased expression of ALPL mRNA25246786
D048271ChitosanChitosan results in increased expression of ALPL protein25246786
D002701ChloramphenicolChloramphenicol results in increased expression of ALPL mRNA22083529
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ALPL mRNA25795401
D004390Chlorpyrifos[cypermethrin co-treated with Chlorpyrifos] results in increased expression of ALPL protein15991261
D004390ChlorpyrifosPlant Extracts inhibits the reaction [[cypermethrin co-treated with Chlorpyrifos] results in increased expression of ALPL protein]15991261
D002791Cholesterol, Dietary"[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased secretion of ALPL protein"27394961
D002791Cholesterol, Dietary"MET gene mutant form promotes the reaction [[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased secretion of ALPL protein]"27394961
C022990chromic chloridechromic chloride results in decreased expression of ALPL protein25966675
C022990chromic chloride[cobaltous chloride co-treated with chromic chloride] results in decreased expression of ALPL protein25966675
D002857ChromiumChromium results in decreased activity of ALPL protein16866188
D002858Chromium AlloysChromium Alloys results in decreased expression of ALPL protein25966675
D002994ClofibrateClofibrate results in increased expression of ALPL mRNA23811191
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ALPL mRNA17602206
C018021cobaltous chloridecobaltous chloride affects the reaction [BMP2 protein results in increased expression of ALPL mRNA]26054564
C018021cobaltous chloridecobaltous chloride results in decreased expression of ALPL protein21882223
C018021cobaltous chlorideIndomethacin promotes the reaction [cobaltous chloride results in decreased expression of ALPL protein]21882223
C018021cobaltous chlorideSulindac promotes the reaction [cobaltous chloride results in decreased expression of ALPL protein]21882223
C018021cobaltous chloride[cobaltous chloride co-treated with chromic chloride] results in decreased expression of ALPL protein25966675
C018021cobaltous chloridecobaltous chloride promotes the reaction [GDF2 protein results in increased activity of ALPL protein]23203800
C018021cobaltous chloridecobaltous chloride results in decreased expression of ALPL mRNA16772336
C018021cobaltous chloridecobaltous chloride results in decreased expression of ALPL protein25966675
C018021cobaltous chlorideHIF1A protein promotes the reaction [cobaltous chloride promotes the reaction [GDF2 protein results in increased activity of ALPL protein]]23203800
C004692coomassie Brilliant Bluecoomassie Brilliant Blue inhibits the reaction [ALPL gene mutant form results in increased expression of SLC17A7 protein]27466191
D003375Coumestrol[Coumestrol binds to ESR1 protein] which results in increased activity of ALPL protein12650720
D003375Coumestrolfulvestrant inhibits the reaction [[Coumestrol binds to ESR1 protein] which results in increased activity of ALPL protein]12650720
C506365CyclohexaneCyclohexane results in decreased activity of ALPL protein19457444
D016572CyclosporineCyclosporine results in decreased expression of ALPL mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of ALPL protein1790624
C017160cypermethrincypermethrin inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
C017160cypermethrin[cypermethrin co-treated with Chlorpyrifos] results in increased expression of ALPL protein15991261
C017160cypermethrinPlant Extracts inhibits the reaction [[cypermethrin co-treated with Chlorpyrifos] results in increased expression of ALPL protein]15991261
C017160cypermethrincypermethrin results in increased activity of ALPL protein15365239
C004742daidzein[daidzein binds to ESR1 protein] which results in increased activity of ALPL protein12650720
C004742daidzeinfulvestrant inhibits the reaction [[daidzein binds to ESR1 protein] which results in increased activity of ALPL protein]12650720
D003634DDTDDT inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of ALPL mRNA23640034
D003676DeferoxamineDeferoxamine results in decreased expression of ALPL protein21882223
D003676DeferoxamineIndomethacin promotes the reaction [Deferoxamine results in decreased expression of ALPL protein]21882223
D003676DeferoxamineSulindac promotes the reaction [Deferoxamine results in decreased expression of ALPL protein]21882223
D003676DeferoxamineDeferoxamine results in decreased expression of ALPL mRNA16772336
D003907Dexamethasone[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of ALPL mRNA26424790
D003907DexamethasoneDexamethasone results in increased expression of ALPL mRNA27608943
D003907DexamethasoneEZH2 protein inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of ALPL mRNA]26424790
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ALPL mRNA28628672
D003907Dexamethasone"[Dexamethasone co-treated with 1,25-dihydroxyvitamin D] inhibits the reaction [WNT3A protein results in increased expression of ALPL protein]"15270777
D003907Dexamethasonecaffeic acid phenethyl ester inhibits the reaction [Dexamethasone results in decreased expression of ALPL protein]28363435
D003907DexamethasoneDexamethasone results in decreased expression of ALPL protein28363435
C042577diallyl trisulfidediallyl trisulfide results in increased expression of ALPL protein19550292
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of ALPL mRNA28962523
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ALPL mRNA22985736
D004052Diethylnitrosamine[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein15548946
D004052DiethylnitrosamineAllyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein]15554553
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein15554553
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALPL mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ALPL mRNA17602206
D004052DiethylnitrosamineSulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein]15554553
D004052DiethylnitrosamineTocotrienols affects the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein]15548946
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ALPL mRNA15289156|1559153
D002117CalcitriolCalcitriol results in increased expression of ALPL mRNA12016462|2154201
D002117CalcitriolCalcitriol results in increased expression of ALPL protein21542014
D004117DimethoateDimethoate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of ALPL mRNA"22485181
D011756DiphosphatesALPL protein inhibits the reaction [Diphosphates results in increased expression of ANK mRNA]17383965
D011756DiphosphatesDiphosphates inhibits the reaction [ALPL protein results in increased degradation of beta-glycerophosphoric acid]17383965
D011756DiphosphatesDiphosphates inhibits the reaction [[ALPL protein results in increased degradation of beta-glycerophosphoric acid] which results in increased abundance of Phosphates]17383965
D011756DiphosphatesDiphosphates results in increased activity of ALPL protein17383965
D011756DiphosphatesDiphosphates results in increased expression of ALPL mRNA17383965
D011756DiphosphatesALPL protein results in increased degradation of Diphosphates17383965|1850065
D004237DiuronDiuron results in decreased expression of ALPL mRNA25152437
D004237DiuronDiuron results in increased expression of ALPL mRNA21551480
D015118Eicosapentaenoic AcidEicosapentaenoic Acid results in decreased expression of ALPL mRNA21193197
C028044epoxy resin AH-26epoxy resin AH-26 results in decreased expression of ALPL mRNA20630305
D004997Ethinyl EstradiolVDR gene polymorphism affects the reaction [[Ethinyl Estradiol co-treated with Levonorgestrel] affects the expression of ALPL protein]12521655
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ALPL protein17240242
D005054EugenolEugenol results in increased expression of ALPL mRNA22083529
D015025Zearalenonefulvestrant inhibits the reaction [[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein]12650720
D015025Zearalenone[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein12650720
D011345FenofibrateFenofibrate results in decreased expression of ALPL mRNA25572481
C017690fenvaleratefenvalerate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
C017690fenvaleratefenvalerate inhibits the reaction [Progesterone results in increased activity of ALPL protein]16326432
C017690fenvaleratefenvalerate results in increased activity of ALPL protein15696646
C082360fipronilfipronil inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D0150732-Acetylaminofluorene[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein15548946
D0150732-AcetylaminofluoreneAllyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein]15554553
D0150732-Acetylaminofluorene[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein15554553
D0150732-AcetylaminofluoreneSulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein]15554553
D0150732-AcetylaminofluoreneTocotrienols affects the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein]15548946
D005459FluoridesFluorides analog results in increased activity of ALPL protein20634111
D005557FormaldehydeFormaldehyde results in increased expression of ALPL mRNA22083529
C070081fulvestrant"fulvestrant inhibits the reaction [[6-(1,1-dimethylallyl)naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]"12650720
C070081fulvestrantfulvestrant inhibits the reaction [[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein]12650720
C070081fulvestrantfulvestrant inhibits the reaction [[Coumestrol binds to ESR1 protein] which results in increased activity of ALPL protein]12650720
C070081fulvestrantfulvestrant inhibits the reaction [[daidzein binds to ESR1 protein] which results in increased activity of ALPL protein]12650720
C070081fulvestrantfulvestrant inhibits the reaction [[Estradiol binds to ESR1 protein] which results in increased activity of ALPL protein]12650720
C070081fulvestrantfulvestrant inhibits the reaction [[Genistein binds to ESR1 protein] which results in increased activity of ALPL protein]12650720
C070081fulvestrantfulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]12650720
C070081fulvestrantfulvestrant inhibits the reaction [[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein]12650720
C039281furanfuran results in increased expression of ALPL mRNA25539665|2619464
C057580gallocatecholgallocatechol results in increased expression of ALPL mRNA21877759
D019833Genisteinfulvestrant inhibits the reaction [[Genistein binds to ESR1 protein] which results in increased activity of ALPL protein]12650720
D019833Genistein[Genistein binds to ESR1 protein] which results in increased activity of ALPL protein12650720
D019833GenisteinGenistein results in increased expression of ALPL mRNA15289156
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of ALPL mRNA21782745
D005944Glucosamine"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Glucosamine analog results in increased activity of ALPL protein]"20458730
D005944GlucosamineGlucosamine analog results in increased activity of ALPL protein20458730
D005944GlucosamineGlucosamine analog results in increased expression of ALPL mRNA20458730
C529769GSK0660GSK0660 inhibits the reaction [Bezafibrate results in increased expression of ALPL mRNA]21499286
C577920GSK126BMP2 protein inhibits the reaction [GSK126 results in increased expression of ALPL mRNA]26424790
C577920GSK126GSK126 results in increased expression of ALPL mRNA26424790
C577920GSK126GSK126 results in increased expression of ALPL protein26424790
C412815GW 4064GW 4064 results in increased expression of ALPL mRNA26655953
D0193071-(5-Isoquinolinesulfonyl)-2-Methylpiperazine1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased activity of ALPL protein11171635
D017313FenretinideFenretinide results in increased expression of ALPL mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ALPL mRNA25130202
D006861Hydrogen Peroxidemyricitrin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ALPL mRNA]25130202
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ALPL mRNA25130202
D006861Hydrogen Peroxidemyricitrin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ALPL mRNA]25130202
D002112CalcifediolCalcifediol results in increased expression of ALPL mRNA21542014
D002112CalcifediolCalcifediol results in increased expression of ALPL protein21542014
D002112CalcifediolCYP27B1 protein promotes the reaction [Calcifediol results in increased expression of ALPL mRNA]21542014
D002112CalcifediolCYP27B1 protein promotes the reaction [Calcifediol results in increased expression of ALPL protein]21542014
D002112CalcifediolKetoconazole inhibits the reaction [Calcifediol results in increased expression of ALPL mRNA]21542014
C499403icaritinicaritin results in increased expression of ALPL mRNA17764702
D019469IndinavirAGN 193109 inhibits the reaction [Indinavir promotes the reaction [Tretinoin results in increased expression of ALPL protein]]10704935
D019469IndinavirIndinavir promotes the reaction [Tretinoin results in increased expression of ALPL protein]10704935
D007213IndomethacinIndomethacin promotes the reaction [cobaltous chloride results in decreased expression of ALPL protein]21882223
D007213IndomethacinIndomethacin promotes the reaction [Deferoxamine results in decreased expression of ALPL protein]21882223
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ALPL mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ALPL mRNA28628672
C028904isoproturon[Lindane co-treated with isoproturon] results in decreased activity of ALPL protein11180283
C028904isoproturon[Lindane co-treated with isoproturon] results in increased expression of ALPL protein11180283
D007654KetoconazoleKetoconazole inhibits the reaction [Calcifediol results in increased expression of ALPL mRNA]21542014
D064747LansoprazoleLansoprazole results in decreased expression of ALPL mRNA19543559
D007854LeadLead results in decreased expression of ALPL mRNA23086611
C008261lead acetatelead acetate results in decreased expression of ALPL protein21712424
D001556Lindane[Lindane co-treated with isoproturon] results in decreased activity of ALPL protein11180283
D001556Lindane[Lindane co-treated with isoproturon] results in increased expression of ALPL protein11180283
D001556LindaneLindane results in increased activity of ALPL protein11180283
D001556LindaneLindane results in increased expression of ALPL protein11180283
D008095Lithocholic AcidEGF protein promotes the reaction [Lithocholic Acid results in increased activity of ALPL protein]19646460
D008095Lithocholic Acid[Lithocholic Acid co-treated with lysophosphatidic acid] results in increased activity of ALPL protein19646460
C032881lysophosphatidic acid[Lithocholic Acid co-treated with lysophosphatidic acid] results in increased activity of ALPL protein19646460
D008550MelatoninMelatonin results in increased expression of ALPL mRNA20738756
C030814menatetrenonemenatetrenone results in increased activity of ALPL protein11113387
D008713MethimazoleMethimazole results in increased expression of ALPL mRNA22504374
D008731MethoxychlorMethoxychlor inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of ALPL mRNA21782745
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ALPL mRNA26011545
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of ALPL mRNA12634122
C015358methylparabenmethylparaben results in decreased expression of ALPL mRNA28527915
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ALPL protein26558463
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate analog results in decreased expression of ALPL protein25777084
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of ALPL protein25777084
C500085muraglitazarmuraglitazar results in increased expression of ALPL mRNA21515302
C008577myricitrinmyricitrin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ALPL mRNA]25130202
C008577myricitrinmyricitrin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ALPL mRNA]25130202
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ALPL mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ALPL mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of ALPL mRNA18978301
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ALPL protein28049044
D0150581-NaphthylisothiocyanateRAG1 gene mutant form inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ALPL protein]28049044
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased secretion of ALPL protein27702592
D0150581-Naphthylisothiocyanate"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [1-Naphthylisothiocyanate results in increased secretion of ALPL protein]"27702592
C005273naringeninfulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]12650720
C005273naringenin[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein12650720
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of ALPL mRNA19812364
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"[zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of ALPL mRNA"19913120
C025256nonylphenol[nonylphenol binds to ESR1 protein] which results in increased activity of ALPL protein12650720
D016912LevonorgestrelVDR gene polymorphism affects the reaction [[Ethinyl Estradiol co-treated with Levonorgestrel] affects the expression of ALPL protein]12521655
C474055octylphenol[octylphenol binds to ESR1 protein] which results in increased activity of ALPL protein12650720
C016340o,p'-DDT"o,p'-DDT inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]"29149346
D009966OrphenadrineOrphenadrine affects the expression of ALPL mRNA23665939
D010100OxygenOxygen deficiency results in increased expression of ALPL mRNA26516004
D010100OxygenOxygen deficiency inhibits the reaction [LIF protein affects the reaction ALPL mRNA]26723917
D010117OxypurinolOxypurinol results in increased expression of ALPL mRNA26968635
D019308Palmitic Acidacetovanillone inhibits the reaction [Palmitic Acid results in increased expression of ALPL mRNA]24080574
D019308Palmitic AcidCYBA mutant form inhibits the reaction [Palmitic Acid results in increased expression of ALPL mRNA]24080574
D019308Palmitic AcidPalmitic Acid results in increased expression of ALPL mRNA24080574
D019308Palmitic AcidU 0126 inhibits the reaction [Palmitic Acid results in increased expression of ALPL mRNA]24080574
C019248pamidronatepamidronate results in increased expression of ALPL protein11683535
C016030pantogabpantogab results in increased expression of ALPL mRNA17379144
C084656paricalcitol[Phosphorus co-treated with paricalcitol] results in increased expression of ALPL mRNA17715259
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ALPL protein26178269
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ALPL mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ALPL mRNA23146750
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ALPL mRNA19162173
D026023PermethrinPermethrin inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D026023PermethrinPermethrin inhibits the reaction [Progesterone results in increased activity of ALPL protein]16326432
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of ALPL mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of ALPL mRNA19482888
D019800PhenolPhenol results in increased expression of ALPL mRNA22083529
D010710Phosphates[ALPL protein results in increased hydrolysis of beta-glycerophosphoric acid] which results in increased abundance of Phosphates18500657
D010710Phosphates[ALPL protein results in increased degradation of beta-glycerophosphoric acid] which results in increased abundance of Phosphates17383965
D010710PhosphatesDiphosphates inhibits the reaction [[ALPL protein results in increased degradation of beta-glycerophosphoric acid] which results in increased abundance of Phosphates]17383965
D010710PhosphatesALPL protein results in increased chemical synthesis of Phosphates18500657
D010758Phosphorus[Phosphorus co-treated with paricalcitol] results in increased expression of ALPL mRNA17715259
D010795Phthalic AcidsPhthalic Acids results in decreased expression of ALPL mRNA21061450
D048789PhytoestrogensPhytoestrogens results in increased activity of ALPL protein16019205
D048789PhytoestrogensPhytoestrogens results in increased expression of ALPL mRNA16019205
C006253pirinixic acidpirinixic acid results in increased expression of ALPL mRNA20059764|2081375
C006253pirinixic acidpirinixic acid results in increased expression of ALPL protein19176532
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of ALPL mRNA]20059764
C006253pirinixic acidRXRA protein promotes the reaction [pirinixic acid results in increased expression of ALPL protein]19176532
C006253pirinixic acidpirinixic acid results in increased expression of ALPL mRNA19162173
D010936Plant Extracts[Plant Extracts binds to ESR1 protein] which results in increased activity of ALPL protein12650720
D010936Plant ExtractsPlant Extracts inhibits the reaction [[cypermethrin co-treated with Chlorpyrifos] results in increased expression of ALPL protein]15991261
D028321Plant PreparationsPlant Preparations results in increased expression of ALPL mRNA24973489
D011192Potassium DichromatePotassium Dichromate results in decreased activity of ALPL protein16866188
D011343ProcaineProcaine results in increased expression of ALPL mRNA22083529
D011374ProgesteroneProgesterone results in increased expression of ALPL mRNA23018184
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of ALPL mRNA20660070
D011374Progesteronefenvalerate inhibits the reaction [Progesterone results in increased activity of ALPL protein]16326432
D011374ProgesteronePermethrin inhibits the reaction [Progesterone results in increased activity of ALPL protein]16326432
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of ALPL mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of ALPL mRNA21540246
D011374ProgesteroneProgesterone results in increased activity of ALPL protein16326432
D011374ProgesteroneProgesterone results in increased expression of ALPL mRNA17404688
D011441PropylthiouracilPropylthiouracil results in increased expression of ALPL mRNA22504374
D011732Pyridoxal PhosphateALPL gene mutant form results in increased abundance of Pyridoxal Phosphate7550313
D011748PyrogallolPyrogallol results in increased expression of ALPL mRNA20362636
D011794Quercetin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of ALPL protein]26053266
D011794Quercetin4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin results in increased expression of ALPL protein]26053266
D011794QuercetinQuercetin results in increased expression of ALPL protein26053266
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA]11018766
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased activity of ALPL protein]11018766
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA]11018766
C009172rhodiolosiderhodioloside results in increased activity of ALPL protein24055767
C009172rhodiolosiderhodioloside results in increased expression of ALPL mRNA24055767
C089730rosiglitazonerosiglitazone results in decreased expression of ALPL mRNA25572481
C089730rosiglitazonerosiglitazone results in decreased expression of ALPL mRNA23086663|2332281
C089730rosiglitazonerosiglitazone results in decreased expression of ALPL protein25777084
C089730rosiglitazonerosiglitazone results in increased expression of ALPL mRNA21515302
C093642SB 203580SB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of ALPL mRNA]]25789987
C000625880SBI-425ALPL gene mutant form results in increased susceptibility to SBI-42527466191
C000625880SBI-425[ALPL gene mutant form results in increased susceptibility to SBI-425] which results in increased expression of FOS mRNA27466191
C000625880SBI-425SBI-425 results in decreased activity of ALPL protein27466191
D020845Selective Estrogen Receptor ModulatorsSelective Estrogen Receptor Modulators results in decreased expression of ALPL protein17240242
D019821SimvastatinSimvastatin results in increased expression of ALPL mRNA20417880
D012906SmokeSmoke results in decreased expression of ALPL protein18035141
C017947sodium arsenitesodium arsenite affects the methylation of ALPL gene28589171
D020358Sodium Cholate"[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased secretion of ALPL protein"27394961
D020358Sodium Cholate"MET gene mutant form promotes the reaction [[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased secretion of ALPL protein]"27394961
D012969Sodium FluorideDKK1 protein inhibits the reaction [Sodium Fluoride results in increased expression of ALPL mRNA]24300170
D012969Sodium FluorideSodium Fluoride affects the expression of ALPL mRNA25132241
D012969Sodium FluorideSodium Fluoride results in increased expression of ALPL mRNA24300170
D012973Sodium HypochloriteSodium Hypochlorite results in increased expression of ALPL mRNA22083529
D053260SootSoot results in increased expression of ALPL mRNA22461453
D013148SpironolactoneSpironolactone inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
D013440SulfidesSulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein]15554553
D013467SulindacSulindac promotes the reaction [cobaltous chloride results in decreased expression of ALPL protein]21882223
D013467SulindacSulindac promotes the reaction [Deferoxamine results in decreased expression of ALPL protein]21882223
D013629TamoxifenTamoxifen affects the expression of ALPL mRNA20937368
D013629TamoxifenTamoxifen results in decreased expression of ALPL mRNA25123088
C037565terbutylazineterbutylazine inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
C501413tesaglitazartesaglitazar results in increased expression of ALPL mRNA21515302
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of ALPL protein25777084
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA]11018766
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased activity of ALPL protein11018766
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ALPL mRNA11018766
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ALPL mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ALPL protein18724896
D013749Tetrachlorodibenzodioxin2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA]25194622
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ALPL mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ALPL mRNA22749964|2519462
D013749Tetrachlorodibenzodioxintributyltin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA]22749964
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased activity of ALPL protein]11018766
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA]11018766
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased activity of ALPL protein11018766
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of ALPL mRNA28973375
D007978LevamisoleLevamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ALPL protein]18500657
D007978LevamisoleLevamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of ALPL mRNA]18500657
D007978LevamisoleALPL gene mutant form results in increased susceptibility to Levamisole27466191
D007978Levamisole[ALPL gene mutant form results in increased susceptibility to Levamisole] which results in increased expression of FOS mRNA27466191
D007978LevamisoleLevamisole results in decreased activity of ALPL protein27466191
D007978LevamisoleLevamisole results in decreased activity of ALPL protein18500657
D013853ThioacetamideThioacetamide results in decreased expression of ALPL mRNA19784758
C009495titanium dioxidetitanium dioxide results in increased expression of ALPL mRNA19464052
C009495titanium dioxidetitanium dioxide results in increased expression of ALPL mRNA21259345|2355797
C009495titanium dioxidetitanium dioxide results in increased expression of ALPL protein27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ALPL mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of and results in increased secretion of ALPL protein27793746|2781834
D024508TocotrienolsTocotrienols affects the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein]15548946
D014108Tosylphenylalanyl Chloromethyl KetoneTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]10567916
D014108Tosylphenylalanyl Chloromethyl KetoneTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]10567916
D014108Tosylphenylalanyl Chloromethyl KetoneTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]10567916
D014212TretinoinTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]10567916
D014212TretinoinTretinoin inhibits the reaction [Tunicamycin results in increased degradation of ALPL protein]10567916
D014212TretinoinTretinoin results in decreased expression of ALPL mRNA21934132
D014212TretinoinTretinoin results in increased activity of ALPL protein10567916
D014212TretinoinTretinoin results in increased expression of and results in increased N-linked glycosylation of ALPL protein10567916
D014212TretinoinTunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]10567916
D014212TretinoinAGN 193109 inhibits the reaction [Indinavir promotes the reaction [Tretinoin results in increased expression of ALPL protein]]10704935
D014212TretinoinIndinavir promotes the reaction [Tretinoin results in increased expression of ALPL protein]10704935
D014212TretinoinTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]10567916
D014212TretinoinTretinoin results in increased activity of ALPL protein10567916
D014212TretinoinTretinoin results in increased expression of ALPL mRNA16604517
D014212TretinoinTretinoin results in increased expression of ALPL protein10704935
D014212TretinoinTretinoin results in increased expression of and results in increased N-linked glycosylation of ALPL protein10567916
D014212TretinoinTunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]10567916
D014212TretinoinEGF protein inhibits the reaction [Tretinoin results in increased activity of ALPL protein]11171635
D014212TretinoinIL1B protein promotes the reaction [Tretinoin results in increased expression of ALPL mRNA]11171635
D014212TretinoinIL1B protein promotes the reaction [Tretinoin results in increased expression of and results in increased activity of ALPL protein]11171635
D014212TretinoinIL2 protein inhibits the reaction [Tretinoin results in increased activity of ALPL protein]11171635
D014212TretinoinIL4 protein inhibits the reaction [Tretinoin results in increased activity of ALPL protein]11171635
D014212TretinoinIL5RA protein inhibits the reaction [Tretinoin results in increased activity of ALPL protein]11171635
D014212TretinoinTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]10567916
D014212TretinoinTretinoin results in increased activity of ALPL protein10567916|1117163
D014212TretinoinTretinoin results in increased expression of ALPL mRNA10022522|1056791
D014212TretinoinTretinoin results in increased expression of and results in increased N-linked glycosylation of ALPL protein10567916
D014212TretinoinTunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]10567916
C011559tributyltintributyltin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA]22749964
C011559tributyltintributyltin results in decreased expression of ALPL mRNA22749964|2332281
C011559tributyltintributyltin results in decreased expression of ALPL protein25777084
C053549triflumizoltriflumizol results in decreased expression of ALPL mRNA23086663
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ALPL mRNA19042947
C030665triphenyltintriphenyltin results in decreased expression of ALPL protein25777084
C057693troglitazonetroglitazone inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]19122273
D014415TunicamycinTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]10567916
D014415TunicamycinTretinoin inhibits the reaction [Tunicamycin results in increased degradation of ALPL protein]10567916
D014415TunicamycinTunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]10567916
D014415TunicamycinTunicamycin results in increased degradation of ALPL protein10567916
D014415TunicamycinTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]10567916
D014415TunicamycinTunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]10567916
D014415TunicamycinTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]10567916
D014415TunicamycinTunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]10567916
C113580U 0126U 0126 inhibits the reaction [Palmitic Acid results in increased expression of ALPL mRNA]24080574
D014635Valproic AcidValproic Acid results in decreased methylation of ALPL gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ALPL mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of ALPL mRNA17292431
D014640VancomycinVancomycin results in increased expression of ALPL mRNA18930951
D014859WarfarinWarfarin inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]21910061
D014859WarfarinWarfarin inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]21910061
D014859WarfarinWarfarin inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA]21910061
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased activity of ALPL protein"19457444
C104536xanthohumolxanthohumol results in increased activity of ALPL protein16019205
C104536xanthohumolxanthohumol results in increased expression of ALPL mRNA16019205
D015032Zinc[Zinc binds to calcium silicate] which results in increased expression of ALPL mRNA23483914
D015032ZincZinc deficiency results in decreased expression of ALPL mRNA21893222
D015032ZincZinc results in increased expression of ALPL mRNA16413754
C016837zinc chloride"[zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of ALPL mRNA"19913120
C016837zinc chlorideCadmium inhibits the reaction [zinc chloride results in increased activity of ALPL protein]26214600
C016837zinc chloridezinc chloride inhibits the reaction [Cadmium results in decreased activity of ALPL protein]26214600
C016837zinc chloridezinc chloride results in increased activity of ALPL protein26214600
D015038ZinebZineb inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]29149346
C028541zirconium oxidezirconium oxide results in increased expression of ALPL mRNA19464052
C088658zoledronic acidTNFRSF11B protein affects the reaction [zoledronic acid results in decreased activity of ALPL protein]18496637
C088658zoledronic acidzoledronic acid results in decreased activity of ALPL protein18496637

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004035alkaline phosphatase activity-IEA-  
GO:0005515protein binding-IPI15208311  
GO:0016462pyrophosphatase activity-IDA19874193  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-TAS9781036  
GO:0001649osteoblast differentiation-HDA16210410  
GO:0001958endochondral ossification-IEA-  
GO:0003006developmental process involved in reproduction-IEA-  
GO:0016311dephosphorylation-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0033280response to vitamin D-IEP17023519  
GO:0046677response to antibiotic-IEA-  
GO:0051384response to glucocorticoid-IEA-  
GO:0071407cellular response to organic cyclic compound-IEA-  
GO:0071529cementum mineralization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-HDA16210410  
GO:0016021integral component of membrane-IEA-  
GO:0031225anchored component of membrane-IEA-  
GO:0065010extracellular membrane-bounded organelle-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa00790Folate biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23030247Nicotine alters MicroRNA expression and hinders human adult stem cell regenerative potential. (2013 Mar 1)Ng TKStem Cells Dev