Gene: NR5A2

2494
B1F|B1F2|CPF|FTF|FTZ-F1|FTZ-F1beta|LRH-1|LRH1|hB1F-2
nuclear receptor subfamily 5 group A member 2
protein-coding
1q32.1
Ensembl:ENSG00000116833 MIM:604453 Vega:OTTHUMG00000035635 UniprotKB:O00482
NG_050913.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.950e-1 (AD)  1.668e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1060061chr1:200174314 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TDRD150.743
POM121L120.713
PABPC4L0.699
PRAMEF20.698
FOXD20.697
OR10K20.689
OR6K20.686
C20orf1870.684
OR4K20.671
BMX0.67

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YBX2-0.414
TMEM221-0.413
MMP15-0.412
OGDHL-0.41
BDH1-0.409
MARCH11-0.406
TMEM191C-0.404
EFNA5-0.401
CHST1-0.399
CYP46A1-0.398

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of NR5A2 mRNA"26377693
C0151531,2-dilauroylphosphatidylcholine"1,2-dilauroylphosphatidylcholine results in increased expression of NR5A2"24459144
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of NR5A2 mRNA]"19414516
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NR5A2 mRNA"19114083
C5471242,3-dibromopropyl-2,4,6-tribromophenyl ether"2,3-dibromopropyl-2,4,6-tribromophenyl ether analog results in decreased expression of NR5A2 mRNA"25818047
C5471242,3-dibromopropyl-2,4,6-tribromophenyl ether"2,3-dibromopropyl-2,4,6-tribromophenyl ether results in decreased expression of NR5A2 mRNA"25818047
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of NR5A2 mRNA"18648102
C0293704-toluidine4-toluidine results in increased expression of NR5A2 mRNA27638505
C5084707-(2-(2,2-difluoroethoxy)-3,5-di-tert-butylbenzene)-3-methylocta-2,4,6-trienoic acid"7-(2-(2,2-difluoroethoxy)-3,5-di-tert-butylbenzene)-3-methylocta-2,4,6-trienoic acid results in decreased expression of NR5A2 mRNA"16357189
C496492abrineabrine results in increased expression of NR5A2 mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of NR5A2 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of NR5A2 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of NR5A2 mRNA17585979
D019342Acetic AcidAcetic Acid results in decreased expression of NR5A2 protein21296659
D016604Aflatoxin B1Aflatoxin B1 affects the expression of NR5A2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NR5A2 gene27153756
D016604Aflatoxin B1[sulforafan co-treated with Aflatoxin B1] affects the expression of NR5A2 mRNA25450479
D000393Air PollutantsAir Pollutants analog results in decreased expression of NR5A2 mRNA21757418
C103303alitretinoinalitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]]16357189
C103303alitretinoinalitretinoin inhibits the reaction [NR5A2 protein results in increased expression of CYP19A1 mRNA]16357189
C103303alitretinoinalitretinoin results in decreased expression of NR5A2 mRNA16357189
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of NR5A2 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NR5A2 mRNA16483693
D000735AndrostenedioneAndrostenedione results in increased expression of NR5A2 mRNA21273442
D000735AndrostenedioneAR mutant form inhibits the reaction [Androstenedione results in increased expression of NR5A2 mRNA]21273442
D001151ArsenicArsenic affects the methylation of NR5A2 gene25304211
C015001arsenitearsenite results in increased methylation of NR5A2 promoter23974009
D001280AtrazineAtrazine results in increased activity of NR5A2 protein18461179
D001398AztreonamAztreonam results in increased expression of NR5A2 mRNA24657338
D004958EstradiolEstradiol results in decreased expression of NR5A2 mRNA20106945
D004958EstradiolEstradiol results in increased expression of NR5A2 mRNA20607599
D004958EstradiolEstradiol results in decreased expression of NR5A2 mRNA21632026
D004958EstradiolNR5A2 protein results in decreased abundance of Estradiol18628394
D004958Estradiol[[NR5A2 protein results in increased phosphorylation of and results in increased activity of NOS3 protein] which results in decreased activity of CYP19A1 protein] which results in decreased chemical synthesis of Estradiol18628394
D004958Estradiol[NR5A2 results in increased expression of NOS3 mRNA] which results in decreased abundance of Estradiol18628394
C477843bicyclolbicyclol inhibits the reaction [Diethylnitrosamine results in increased expression of NR5A2 mRNA]17106253
C006780bisphenol Abisphenol A results in decreased expression of NR5A2 mRNA21632026
C006780bisphenol Abisphenol A affects the methylation of NR5A2 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of NR5A2 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of NR5A2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NR5A2 gene28505145
C099813bromochloroacetic acidbromochloroacetic acid results in increased expression of NR5A2 protein21296659
D001971BromocriptineBromocriptine affects the reaction [methyl cellosolve results in increased expression of NR5A2 mRNA]21427058
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of NR5A2 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of NR5A2 mRNA18804290
D002512Cephalothin[Cephalothin co-treated with Neomycin] results in increased expression of NR5A2 mRNA24657338
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of NR5A2 mRNA15629111
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of NR5A220938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NR5A2 gene20938992
D002994ClofibrateClofibrate results in increased expression of NR5A2 mRNA28973556
C018021cobaltous chloridecobaltous chloride results in decreased expression of NR5A2 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of NR5A2 mRNA24386269
D005576Colforsinalitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]]16357189
D005576ColforsinColforsin results in increased expression of NR5A2 mRNA16357189
D005576ColforsinNR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]16357189
D019327Copper SulfateCopper Sulfate results in decreased expression of NR5A2 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of NR5A2 mRNA19789285
D016572CyclosporineCyclosporine results in decreased expression of NR5A2 mRNA20106945|2798913
D003703DemecolcineDemecolcine results in increased expression of NR5A2 mRNA23649840
D003907DexamethasoneDexamethasone results in decreased expression of NR5A2 mRNA20888898
D002945CisplatinCisplatin results in decreased expression of NR5A2 mRNA27392435
D004026DieldrinDieldrin results in decreased expression of NR5A2 mRNA28385952
D004041Dietary FatsDietary Fats results in decreased expression of NR5A2 mRNA25016146
D004041Dietary Fats[Oligosaccharides co-treated with Dietary Fats] results in decreased expression of NR5A2 mRNA28549616
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of NR5A2 mRNA25975992
D004052Diethylnitrosaminebicyclol inhibits the reaction [Diethylnitrosamine results in increased expression of NR5A2 mRNA]17106253
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of NR5A2 mRNA17106253
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of NR5A2 mRNA22100434
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NR5A2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR5A2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of NR5A2 mRNA15834898
D005472FluorouracilFluorouracil affects the expression of NR5A2 protein21296659
D005485FlutamideFlutamide results in decreased expression of NR5A2 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of NR5A220938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NR5A2 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of NR5A2 mRNA23649840
D015378Imipenem[Vancomycin co-treated with Imipenem] results in increased expression of NR5A2 mRNA24657338
C069837fullerene C60fullerene C60 results in decreased expression of NR5A2 mRNA19167457
D019833GenisteinGenistein results in increased expression of NR5A2 mRNA22553218
C516216GSK 8470GSK 8470 binds to and results in increased activity of NR5A2 protein17154495
C516216GSK 8470GSK 8470 promotes the reaction [NR5A2 protein results in increased expression of NR0B2 mRNA]17154495
C544151jinfukangjinfukang results in decreased expression of NR5A2 mRNA27392435
C017461lead nitratelead nitrate results in increased expression of NR5A2 mRNA16049268
C052901lemongrass oillemongrass oil affects the expression of NR5A2 mRNA25976427
C095104LG 100268LG 100268 results in decreased expression of NR5A2 mRNA16357189
D008095Lithocholic AcidLithocholic Acid results in decreased expression of NR5A2 mRNA20888898
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NR5A2 mRNA26378955
D008627Mercuric ChlorideMercuric Chloride affects the expression of NR5A2 mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of NR5A220938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NR5A2 gene20938992
C005219methyl cellosolveBromocriptine affects the reaction [methyl cellosolve results in increased expression of NR5A2 mRNA]21427058
C005219methyl cellosolvemethyl cellosolve results in increased expression of NR5A2 mRNA21427058
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NR5A2 mRNA23903816
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of NR5A2 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NR5A2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NR5A2 mRNA"25620056
D009355Neomycin[Cephalothin co-treated with Neomycin] results in increased expression of NR5A2 mRNA24657338
C464660obeticholic acidobeticholic acid results in decreased expression of NR5A2 mRNA27939613
D009844Oligosaccharides[Oligosaccharides co-treated with Dietary Fats] results in decreased expression of NR5A2 mRNA28549616
D010126OzoneOzone results in decreased expression of NR5A2 mRNA16183385
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of NR5A2 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of NR5A2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of NR5A2 mRNA19482888
C006253pirinixic acidpirinixic acid results in decreased expression of NR5A2 mRNA18445702
D011192Potassium DichromatePotassium Dichromate results in decreased expression of NR5A2 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of NR5A2 mRNA20888898
D011374ProgesteroneNR5A2 gene mutant form results in decreased abundance of Progesterone17409375
D011374ProgesteroneNR5A2 protein results in increased abundance of Progesterone18628394
D012906SmokeSmoke affects the expression of NR5A2 mRNA23693141
D053260SootSoot results in decreased expression of NR5A2 mRNA26551751
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NR5A2 mRNA26378955
C016766sulforafan[sulforafan co-treated with Aflatoxin B1] affects the expression of NR5A2 mRNA25450479
D013469SulpirideSulpiride results in increased expression of NR5A2 mRNA21427058
D013739TestosteroneAR mutant form inhibits the reaction [Testosterone results in increased expression of NR5A2 mRNA]21273442
D013739TestosteroneNR5A2 mutant form inhibits the reaction [Testosterone results in increased expression of CYP19A1 mRNA]21273442
D013739TestosteroneTestosterone promotes the reaction [NR5A2 protein binds to CYP19A1 promoter]21273442
D013739TestosteroneTestosterone results in increased expression of NR5A2 mRNA21273442
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NR5A2 mRNA20055451
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NR5A2 mRNA17517823
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NR5A2 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NR5A2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR5A2 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of NR5A2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NR5A2 mRNA24058054
D013755Tetradecanoylphorbol Acetatealitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]]16357189
D013755Tetradecanoylphorbol AcetateNR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]16357189
D014212TretinoinTretinoin results in increased expression of NR5A2 mRNA21934132
D014241TrichloroethylenePPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of NR5A2 mRNA]15363585
C012589trichostatin Atrichostatin A results in decreased expression of NR5A2 mRNA15901671
D014580Ursodeoxycholic AcidNFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of NR5A2 mRNA]18687751
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of NR5A2 mRNA18687751
D014635Valproic AcidValproic Acid results in increased expression of NR5A2 mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of NR5A2 mRNA15901671
D014640Vancomycin[Vancomycin co-treated with Imipenem] results in increased expression of NR5A2 mRNA24657338
D014750VincristineVincristine results in increased expression of NR5A2 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-ISS-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003677DNA binding-IDA16289203  
GO:0003682chromatin binding-IBA21873635  
GO:0003682chromatin binding-ISS-  
GO:0003700DNA-binding transcription factor activity-IDA15205472  15723037  16289203  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-TAS9786908  
GO:0003707steroid hormone receptor activity-IEA-  
GO:0004879nuclear receptor activity-IBA21873635  
GO:0004879nuclear receptor activity-TAS16271724  
GO:0005515protein binding-IPI12040021  14701856  15143342  15205472  17664281  19264593  
GO:0005543phospholipid binding-IDA15723037  
GO:0008270zinc ion binding-IEA-  
GO:0043565sequence-specific DNA binding-IDA16289203  
GO:0044212transcription regulatory region DNA binding-IDA15205472  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-IDA15723037  
GO:0006355regulation of transcription, DNA-templated-TAS16289203  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0008206bile acid metabolic process-IEA-  
GO:0009755hormone-mediated signaling pathway-IBA21873635  
GO:0009792embryo development ending in birth or egg hatching-TAS16289203  
GO:0009888tissue development-IBA21873635  
GO:0030522intracellular receptor signaling pathway-IEA-  
GO:0030855epithelial cell differentiation-IEA-  
GO:0042127regulation of cell proliferation-IEA-  
GO:0042592homeostatic process-NAS16289203  
GO:0042632cholesterol homeostasis-IEA-  
GO:0043401steroid hormone mediated signaling pathway-IEA-  
GO:0045070positive regulation of viral genome replication-IDA19264593  
GO:0045893positive regulation of transcription, DNA-templated-IDA15143342  
GO:0045893positive regulation of transcription, DNA-templated-TAS15205472  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0061113pancreas morphogenesis-IEA-  
GO:0097720calcineurin-mediated signaling-IEA-  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA15143342  15205472  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA15205472  
GO:0090575RNA polymerase II transcription factor complex-IBA21873635  
GO:0090575RNA polymerase II transcription factor complex-ISS-  
KEGG ID KEGG Term
hsa04950Maturity onset diabetes of the young
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-186712Regulation of beta-cell developmentIEA
R-HSA-210747Regulation of gene expression in early pancreatic precursor cellsIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-383280Nuclear Receptor transcription pathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21357378Body mass index and obesity- and diabetes-associated genotypes and risk for pancreatic cancer. (2011 May)Tang HCancer Epidemiol Biomarkers Prev
20647474New strategies in pancreatic cancer: emerging epidemiologic and therapeutic concepts. (2010 Sep 1)Li DClin Cancer Res