Gene: ABL1

25
ABL|CHDSKM|JTK7|bcr/abl|c-ABL|c-ABL1|p150|v-abl
ABL proto-oncogene 1, non-receptor tyrosine kinase
protein-coding
9q34.12
Ensembl:ENSG00000097007 MIM:189980 Vega:OTTHUMG00000020813 UniprotKB:P00519
NG_012034.1
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.520e-1 (AD)  9.429e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PHF20.901
CTDSP20.878
PREX10.852
CRTC30.848
SGPL10.843
HNRNPUL10.84
EHMT10.838
CHD40.838
LLGL10.838
TCF30.833

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.672
OR4F29-0.647
CRH-0.21
LRRC38-0.195
EGFL6-0.191
HAPLN1-0.187
OSTN-0.186
NMU-0.185
FREM3-0.183
SULT2B1-0.181

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00171ATPSmall Molecule56-65-5Investigational|NutraceuticalTarget
DB00619ImatinibSmall Molecule152459-95-5ApprovedTarget
DB01254DasatinibSmall Molecule302962-49-8Approved|InvestigationalTarget
DB03878N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-PyridinecarboxamideSmall MoleculeExperimentalTarget
DB04868NilotinibSmall Molecule641571-10-0Approved|InvestigationalTarget
DB05184XL228Small Molecule-InvestigationalTarget
DB06616BosutinibSmall Molecule380843-75-4ApprovedTarget
DB078312-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDESmall MoleculeExperimentalTarget
DB080431-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREASmall MoleculeExperimentalTarget
DB08231Myristic acidSmall Molecule544-63-8ExperimentalTarget
DB083396-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONESmall MoleculeExperimentalTarget
DB083505-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDESmall MoleculeExperimentalTarget
DB085832-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamideSmall MoleculeExperimentalTarget
DB08896RegorafenibSmall Molecule755037-03-7ApprovedTarget
DB08901PonatinibSmall Molecule943319-70-8Approved|InvestigationalTarget
DB12267BrigatinibSmall Molecule1197953-54-0Approved|InvestigationalTarget
DB12323RadotinibSmall Molecule926037-48-1InvestigationalTarget
ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of ABL1 protein22527513
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[ABL1 protein results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein]17030193
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]16849647
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA]16849647
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in decreased expression of BCL2 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of BAX protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of FAS protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of PMAIP1 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of TNFRSF10B protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in decreased expression of BCL2 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of BAX protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of FAS protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of PMAIP1 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of TNFRSF10B protein"21214929
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ABL1 mRNA16788091
C575425(4-(4'-chloro-2'-fluoro)phenylamino)-6,7-dimethylquinazoline"(4-(4'-chloro-2'-fluoro)phenylamino)-6,7-dimethylquinazoline results in decreased activity of ABL1 protein"22573732
C4988264-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide[4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide co-treated with arsenic trioxide] results in decreased phosphorylation of ABL1 protein23883479
C4988264-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of CRKL protein]19878872
C4988264-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide inhibits the reaction [ABL1 protein results in increased phosphorylation of ABL1 protein]19878872
C4988264-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]16849647
C4988264-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA]16849647
C4988264-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in decreased phosphorylation of ABL1 protein23883479
C4988264-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in decreased phosphorylation of ABL1 protein mutant form19878872
C4988264-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in decreased activity of ABL1 protein18632630|2190843
C0944114-phenylcoumarin4-phenylcoumarin analog results in increased expression of ABL1 mRNA27773722
D000079AcetaldehydeABL1 protein promotes the reaction [Acetaldehyde results in increased phosphorylation of and results in decreased activity of PPARG protein]17030193
D000079AcetaldehydeAcetaldehyde results in increased activity of ABL1 protein17030193
D000079AcetaldehydeImatinib Mesylate inhibits the reaction [Acetaldehyde results in increased activity of ABL1 protein]17030193
D000082AcetaminophenAcetaminophen results in increased expression of ABL1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ABL1 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [NSC 680410 results in decreased phosphorylation of ABL1 protein]16481037
D000255Adenosine Triphosphate[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein19366808
D000255Adenosine Triphosphatesorafenib inhibits the reaction [[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein]19366808
D000447AldehydesAldehydes results in decreased expression of ABL1 mRNA25014914
C077990alvocidib[alvocidib co-treated with Bortezomib co-treated with ABL1 protein] results in decreased phosphorylation of LYN protein15039284
C077990alvocidib[alvocidib co-treated with Bortezomib co-treated with ABL1] results in decreased phosphorylation of CRKL protein15039284
C077990alvocidib[alvocidib co-treated with Bortezomib] results in decreased expression of ABL1 protein15039284
D000638AmiodaroneAmiodarone results in increased expression of ABL1 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of ABL1 protein16483693
C058317arsenic disulfidearsenic disulfide results in decreased activity of ABL1 protein12421474
C058317arsenic disulfidearsenic disulfide results in decreased expression of and results in decreased activity of ABL1 protein mutant form12421474
C006632arsenic trioxide[4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide co-treated with arsenic trioxide] results in decreased phosphorylation of ABL1 protein23883479
C006632arsenic trioxideABL1 protein affects the susceptibility to arsenic trioxide10648417
C006632arsenic trioxide[arsenic trioxide co-treated with Bortezomib] results in decreased expression of ABL1 protein17495969
C006632arsenic trioxidearsenic trioxide results in decreased expression of ABL1 mRNA20458559
C006632arsenic trioxidearsenic trioxide results in decreased expression of ABL1 protein10648417
C006632arsenic trioxidearsenic trioxide results in decreased expression of ABL1 protein mutant form14633726
C006632arsenic trioxidearsenic trioxide results in decreased expression of [BCR protein mutant form binds to ABL1 protein mutant form]24129092
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of ABL1 mRNA15894607
D001285Atropine[Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA17390078
C487081belinostatbelinostat results in decreased expression of ABL1 mRNA19606018
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ABL1 mRNA"19150397
C044887beta-methylcholinebeta-methylcholine affects the expression of ABL1 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of ABL1 mRNA23704952
C006780bisphenol Abisphenol A affects the expression of ABL1 mRNA25181051
D000069286Bortezomib[alvocidib co-treated with Bortezomib co-treated with ABL1 protein] results in decreased phosphorylation of LYN protein15039284
D000069286Bortezomib[alvocidib co-treated with Bortezomib co-treated with ABL1] results in decreased phosphorylation of CRKL protein15039284
D000069286Bortezomib[alvocidib co-treated with Bortezomib] results in decreased expression of ABL1 protein15039284
D000069286Bortezomib[arsenic trioxide co-treated with Bortezomib] results in decreased expression of ABL1 protein17495969
D000069286Bortezomib"[Bortezomib co-treated with N,N-dimethylsphingosine] results in decreased expression of ABL1 protein"21195056
D000069286BortezomibBortezomib promotes the reaction [Dichlororibofuranosylbenzimidazole results in decreased expression of ABL1 protein]15039284
C471992bosutinibbosutinib results in decreased activity of ABL1 protein17114238
C018475butyraldehydebutyraldehyde results in decreased expression of ABL1 mRNA26079696
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of ABL1 mRNA19840844
D002211CapsaicinCapsaicin results in increased expression of ABL1 mRNA19502594
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased phosphorylation of ABL1 protein17030193
D002251Carbon TetrachlorideImatinib Mesylate inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of ABL1 protein]17030193
D060729Coal AshCoal Ash results in increased expression of ABL1 mRNA19000753
D003042CocaineCocaine affects the expression of ABL1 mRNA15681117
D003300Copper[Thiosemicarbazones binds to Copper] which results in increased expression of ABL1 protein20931265
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of ABL1 mRNA21878529
C551994crizotinibcrizotinib results in decreased activity of ABL1 protein21812414
D003471CuprizoneCuprizone results in decreased expression of ABL1 mRNA27523638
C093628cyproconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of ABL1 mRNA29038839
D015638Cytochalasin DCytochalasin D results in increased phosphorylation of ABL1 protein21900236
D015638Cytochalasin DEGF protein inhibits the reaction [Cytochalasin D results in increased phosphorylation of ABL1 protein]21900236
D000069439DasatinibDasatinib binds to ABL1 protein17684099|1818038
D000069439DasatinibDasatinib binds to ABL1 protein mutant form17684099|1818038
D000069439Dasatinib[Dasatinib co-treated with vorinostat] results in decreased expression of ABL1 protein mutant form17020995
D000069439Dasatinib[Dasatinib co-treated with vorinostat] results in decreased phosphorylation of ABL1 protein mutant form17020995
D000069439DasatinibDasatinib inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of CRKL protein]19100678|1987887
D000069439DasatinibDasatinib inhibits the reaction [ABL1 protein results in increased phosphorylation of ABL1 protein]19878872
D000069439DasatinibDasatinib results in decreased activity of ABL1 protein mutant form19100678
D000069439DasatinibDasatinib results in decreased phosphorylation of ABL1 protein mutant form17020995|1987887
D000069439DasatinibDasatinib binds to ABL1 protein17684099
D000069439DasatinibDasatinib results in decreased activity of ABL1 protein17114238|2112860
D003630DaunorubicinABL1 results in decreased susceptibility to Daunorubicin12410571
C560099DCC-2036DCC-2036 results in decreased activity of ABL1 protein21908430
D002945CisplatinABL1 protein results in increased susceptibility to Cisplatin21324906
D002945Cisplatin"[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein"21214929
D002945Cisplatin"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein"21214929
D002945Cisplatin"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in decreased expression of BCL2 protein"21214929
D002945Cisplatin"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of BAX protein"21214929
D002945Cisplatin"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of FAS protein"21214929
D002945Cisplatin"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of PMAIP1 protein"21214929
D002945Cisplatin"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of TNFRSF10B protein"21214929
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ABL1 mRNA27392435
D002945Cisplatin[Cisplatin co-treated with panobinostat] affects the expression of ABL1 mRNA21791302
D002945CisplatinCisplatin results in decreased expression of ABL1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ABL1 protein22023808
D004004DichlororibofuranosylbenzimidazoleBortezomib promotes the reaction [Dichlororibofuranosylbenzimidazole results in decreased expression of ABL1 protein]15039284
D004004DichlororibofuranosylbenzimidazoleDichlororibofuranosylbenzimidazole results in decreased expression of ABL1 protein15039284
C000944dicrotophosdicrotophos results in increased expression of ABL1 mRNA28302478
D002117CalcitriolCalcitriol results in increased expression of ABL1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of ABL1 mRNA21592394
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased expression of ABL1 mRNA"27840820
D004317Doxorubicin"[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein"21214929
D004317Doxorubicin"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein"21214929
D004317Doxorubicin"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in decreased expression of BCL2 protein"21214929
D004317Doxorubicin"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of BAX protein"21214929
D004317Doxorubicin"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of FAS protein"21214929
D004317Doxorubicin"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of PMAIP1 protein"21214929
D004317Doxorubicin"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of TNFRSF10B protein"21214929
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of ABL1 mRNA29038839
D004967EstrogensABL1 protein results in increased susceptibility to Estrogens20234815
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ABL1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ABL1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ABL1 mRNA17942748
C069837fullerene C60fullerene C60 results in increased expression of ABL1 mRNA19167457
D005707Gallic AcidGallic Acid promotes the reaction [Imatinib Mesylate results in decreased phosphorylation of [BCR protein mutant form binds to ABL1 protein mutant form]]22245431
D005707Gallic AcidGallic Acid results in decreased phosphorylation of [BCR protein mutant form binds to ABL1 protein mutant form]22245431
D005707Gallic AcidImatinib Mesylate promotes the reaction [Gallic Acid results in decreased phosphorylation of [BCR protein mutant form binds to ABL1 protein mutant form]]22245431
D006046Gold[Polyethyleneimine binds to Gold] which results in decreased expression of ABL1 mRNA28433809
D006632Histamine2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]16849647
D006632Histamine4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]16849647
D006632Histamine[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine16849647
D006632HistamineImatinib Mesylate inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]16849647
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ABL1 protein21179406
D006861Hydrogen PeroxideHydrogen Peroxide results in increased activity of ABL1 protein17030193
D006861Hydrogen PeroxideImatinib Mesylate inhibits the reaction [Hydrogen Peroxide results in increased activity of ABL1 protein]17030193
C492448ICG 001ICG 001 results in increased expression of ABL1 mRNA26191083
D000068877Imatinib MesylateImatinib Mesylate results in decreased phosphorylation of ABL1 protein12032135
D000068877Imatinib MesylateABL1 mutant form results in increased susceptibility to Imatinib Mesylate15107311
D000068877Imatinib MesylateABL1 protein results in decreased susceptibility to Imatinib Mesylate15039284
D000068877Imatinib MesylateGallic Acid promotes the reaction [Imatinib Mesylate results in decreased phosphorylation of [BCR protein mutant form binds to ABL1 protein mutant form]]22245431
D000068877Imatinib MesylateImatinib Mesylate inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of CRKL protein]19878872
D000068877Imatinib MesylateImatinib Mesylate inhibits the reaction [ABL1 protein results in increased phosphorylation of ABL1 protein]19878872
D000068877Imatinib MesylateImatinib Mesylate inhibits the reaction [Acetaldehyde results in increased activity of ABL1 protein]17030193
D000068877Imatinib MesylateImatinib Mesylate inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]16849647
D000068877Imatinib MesylateImatinib Mesylate inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA]16849647
D000068877Imatinib MesylateImatinib Mesylate inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of ABL1 protein]17030193
D000068877Imatinib MesylateImatinib Mesylate inhibits the reaction [Hydrogen Peroxide results in increased activity of ABL1 protein]17030193
D000068877Imatinib MesylateImatinib Mesylate promotes the reaction [Gallic Acid results in decreased phosphorylation of [BCR protein mutant form binds to ABL1 protein mutant form]]22245431
D000068877Imatinib MesylateImatinib Mesylate results in decreased activity of ABL1 protein mutant form15329907
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of [BCR protein mutant form binds to ABL1 protein mutant form]22397755
D000068877Imatinib MesylateImatinib Mesylate results in decreased phosphorylation of ABL1 protein mutant form19366808|1987887
D000068877Imatinib MesylateImatinib Mesylate results in decreased phosphorylation of [BCR protein mutant form binds to ABL1 protein mutant form]22245431
D000068877Imatinib Mesylate[vorinostat co-treated with Imatinib Mesylate] results in decreased expression of ABL1 protein mutant form12446442
D000068877Imatinib Mesylate[vorinostat co-treated with Imatinib Mesylate] results in decreased phosphorylation of ABL1 protein mutant form12446442
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of ABL1 mutant form16481037
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of ABL1 protein16481037
D000068877Imatinib MesylateImatinib Mesylate results in decreased phosphorylation of ABL1 protein12032135
D000068877Imatinib MesylateImatinib Mesylate analog results in decreased activity of ABL1 protein modified form15501042
D000068877Imatinib MesylateImatinib Mesylate results in decreased activity of ABL1 protein16940797|2190843
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ABL1 mRNA27392435
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ABL1 mRNA12057914
C013592mangiferinmangiferin results in decreased expression of ABL1 mRNA15498116
D008628MercuryMercury results in increased expression of ABL1 mRNA19937285
D008694MethamphetamineMethamphetamine results in increased expression of ABL1 mRNA26307267
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ABL1 mRNA20061341
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of ABL1 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of ABL1 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ABL1 mRNA19840844
C005246myristicinmyristicin results in decreased expression of ABL1 mRNA24792648
C455139myrtucommulone Amyrtucommulone A results in decreased expression of ABL1 mRNA26032814
C017558nickel sulfide[[[nickel sulfide results in increased methylation of MIR203A promoter] co-treated with [nickel sulfide results in increased methylation of MIR203A exon]] results in decreased expression of MIR203A mRNA] which affects the expression of ABL123968727
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in decreased expression of ABL1 mRNA22561872
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in increased expression of ABL1 mRNA22561872
C061800N,N-dimethylsphingosine"[Bortezomib co-treated with N,N-dimethylsphingosine] results in decreased expression of ABL1 protein"21195056
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ABL1 mRNA"12756304
C404397NSC 680410Acetylcysteine inhibits the reaction [NSC 680410 results in decreased phosphorylation of ABL1 protein]16481037
C404397NSC 680410NSC 680410 affects the phosphorylation of and affects the expression of ABL1 mutant form16481037
C404397NSC 680410NSC 680410 results in decreased phosphorylation of and affects the expression of ABL1 protein16481037
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of ABL1 mRNA19840844
C496932panobinostat[Cisplatin co-treated with panobinostat] affects the expression of ABL1 mRNA21791302
D010269ParaquatParaquat results in increased expression of ABL1 mRNA18836921
D010278Parathion[Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA17390078
D010278ParathionParathion results in increased expression of ABL1 mRNA17390078
C410127PCB 180PCB 180 affects the expression of ABL1 mRNA21703328
C011272perfosfamideperfosfamide results in increased expression of ABL1 mRNA19429390
D010634PhenobarbitalPhenobarbital results in decreased methylation of ABL1 gene19233941
D010634PhenobarbitalPhenobarbital results in decreased methylation of ABL1 promoter19482888
D010634PhenobarbitalPhenobarbital results in increased expression of ABL1 mRNA19482888
D010656PhenylephrineABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]17615370
D010656PhenylephrineABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]17615370
D010656PhenylephrineABL1 protein affects the reaction [Phenylephrine results in increased phosphorylation of BCAR1 protein]17615370
D010656PhenylephrineABL1 protein affects the susceptibility to Phenylephrine17615370
D010656PhenylephrinePhenylephrine results in increased phosphorylation of ABL1 protein17615370
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which results in decreased expression of ABL1 mRNA28433809
C545373ponatinibponatinib analog results in decreased activity of ABL1 protein21561767
C545373ponatinibponatinib analog results in decreased activity of ABL1 protein mutant form21561767
C545373ponatinibponatinib inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of ABL1 protein mutant form]19878872
C545373ponatinibponatinib inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of CRKL protein]19878872
C545373ponatinibponatinib inhibits the reaction [ABL1 protein results in increased phosphorylation of ABL1 protein]19878872
C545373ponatinibponatinib results in decreased activity of ABL1 protein19878872|2156176
C545373ponatinibponatinib results in decreased activity of ABL1 protein mutant form19878872|2051315
C545373ponatinibponatinib results in decreased phosphorylation of ABL1 protein25304212
C545373ponatinibponatinib results in decreased phosphorylation of ABL1 protein mutant form19878872
C545373ponatinibponatinib binds to and results in decreased activity of ABL1 protein mutant form21118377
C545373ponatinibponatinib results in decreased activity of ABL1 protein21482694|2190843
D011189Potassium ChlorideABL1 protein affects the reaction [Potassium Chloride results in increased phosphorylation of BCAR1 protein]17615370
D011189Potassium ChlorideABL1 protein affects the susceptibility to Potassium Chloride17615370
D011189Potassium ChloridePotassium Chloride results in increased phosphorylation of ABL1 protein17615370
C470893purmorphaminepurmorphamine inhibits the reaction [resveratrol results in decreased expression of [BCR protein mutant form binds to ABL1 protein mutant form]]22397755
D011794QuercetinQuercetin results in decreased expression of ABL1 protein19207037
C059514resveratrolpurmorphamine inhibits the reaction [resveratrol results in decreased expression of [BCR protein mutant form binds to ABL1 protein mutant form]]22397755
C059514resveratrolresveratrol results in decreased expression of [BCR protein mutant form binds to ABL1 protein mutant form]22397755
C085746rottlerinrottlerin inhibits the reaction [[ABL1 protein results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein]17030193
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of ABL1 mRNA21427059
C524947Scutellaria barbata extractScutellaria barbata extract results in decreased expression of ABL1 protein16218664
C017947sodium arsenitesodium arsenite results in increased expression of ABL1 mRNA12016162
C017947sodium arsenitesodium arsenite results in decreased expression of ABL1 mRNA16014739
C471405sorafenibsorafenib inhibits the reaction [[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein]19366808
C471405sorafenibsorafenib results in decreased activity of ABL1 protein mutant form19366808
C471405sorafenibsorafenib results in decreased phosphorylation of ABL1 protein mutant form19366808
D013629TamoxifenABL1 protein results in decreased susceptibility to Tamoxifen20234815
D013629TamoxifenTamoxifen affects the expression of ABL1 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of ABL1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of ABL1 mRNA21592394
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of ABL1 mRNA28970181
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ABL1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ABL1 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ABL1 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ABL1 mRNA19840844
D013882Thiosemicarbazones[Thiosemicarbazones binds to Copper] which results in increased expression of ABL1 protein20931265
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of ABL1 mRNA15894607
D014212TretinoinTretinoin results in increased expression of ABL1 mRNA16788091
C012589trichostatin Atrichostatin A results in decreased expression of ABL1 mRNA19606018|2377000
D014635Valproic AcidValproic Acid affects the expression of ABL1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ABL1 mRNA21427059
D014639VanadiumVanadium results in increased expression of ABL1 mRNA19000753
C111237vorinostat[Dasatinib co-treated with vorinostat] results in decreased expression of ABL1 protein mutant form17020995
C111237vorinostat[Dasatinib co-treated with vorinostat] results in decreased phosphorylation of ABL1 protein mutant form17020995
C111237vorinostat[vorinostat co-treated with Imatinib Mesylate] results in decreased expression of ABL1 protein mutant form12446442
C111237vorinostat[vorinostat co-treated with Imatinib Mesylate] results in decreased phosphorylation of ABL1 protein mutant form12446442
C111237vorinostatvorinostat results in decreased expression of ABL1 mRNA mutant form12446442
C111237vorinostatvorinostat results in decreased expression of ABL1 protein mutant form12446442
C111237vorinostat[VX680 co-treated with vorinostat] results in decreased activity of ABL1 protein mutant form18829489
C484810VX680[VX680 co-treated with vorinostat] results in decreased activity of ABL1 protein mutant form18829489
D015032ZincZinc affects the expression of ABL1 protein16636310

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA9144171  
GO:0001784phosphotyrosine residue binding-IPI20624904  
GO:0003677DNA binding-NAS8242749  
GO:0003785actin monomer binding-TAS20841568  
GO:0004515nicotinate-nucleotide adenylyltransferase activity-TAS20841568  
GO:0004672protein kinase activity-IDA11120811  
GO:0004672protein kinase activity-IMP24863063  
GO:0004713protein tyrosine kinase activity-EXP15657136  
GO:0004713protein tyrosine kinase activity-IDA7590236  9144171  11121037  12944467  15657060  17888034  
20823226  
GO:0004713protein tyrosine kinase activity-IMP24520051  
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IBA21873635  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IDA9461559  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IMP28428613  
GO:0005080protein kinase C binding-IPI10713049  
GO:0005102signaling receptor binding-IBA21873635  
GO:0005515protein binding-IPI7590236  9144171  9168117  9346925  9461559  9593709  
10849448  10970852  11374898  11375976  11418237  12384576  
12893824  15448168  15657060  15696159  15886098  16273093  
16397227  16443220  16831423  16888623  17101133  17112510  
17318191  17474147  17515907  17888034  18328268  19234221  
19442657  19470755  19914245  20598684  20697350  22286129  
22401567  24520051  24658140  24728074  24947832  25852190  
GO:0005524ATP binding-IDA9144171  
GO:0008022protein C-terminus binding-IPI11971963  
GO:0016301kinase activity-IMP28288113  
GO:0017124SH3 domain binding-IPI7590236  
GO:0019905syntaxin binding-IPI23006999  
GO:0030145manganese ion binding-IDA9144171  
GO:0038191neuropilin binding-IPI24863063  
GO:0042169SH2 domain binding-IPI12384576  
GO:0046875ephrin receptor binding-ISS-  
GO:0051015actin filament binding-IEA-  
GO:0051019mitogen-activated protein kinase binding-IPI11121037  
GO:0070064proline-rich region binding-IDA15657060  
GO:0070064proline-rich region binding-IPI7590236  
GO ID GO Term Qualifier Evidence PubMed
GO:0000278mitotic cell cycle-TAS24522549  
GO:0001843neural tube closure-IEA-  
GO:0001922B-1 B cell homeostasis-IEA-  
GO:0001934positive regulation of protein phosphorylation-IMP24700464  
GO:0002322B cell proliferation involved in immune response-IEA-  
GO:0002333transitional one stage B cell differentiation-IEA-  
GO:0006298mismatch repair-TAS10391249  
GO:0006355regulation of transcription, DNA-templated-TAS8242749  
GO:0006464cellular protein modification process-NAS8242749  
GO:0006468protein phosphorylation-IMP24863063  
GO:0006914autophagy-IEA-  
GO:0006974cellular response to DNA damage stimulus-IDA15657060  
GO:0006975DNA damage induced protein phosphorylation-IDA18280240  
GO:0006979response to oxidative stress-IGI17626041  
GO:0007050cell cycle arrest-TAS24522549  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IBA21873635  
GO:0007173epidermal growth factor receptor signaling pathway-IEA-  
GO:0007204positive regulation of cytosolic calcium ion concentration-IMP24367707  
GO:0007229integrin-mediated signaling pathway-IMP24863063  
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage-TAS20841568  
GO:0009791post-embryonic development-IEA-  
GO:0010506regulation of autophagy-TAS20841568  
GO:0010595positive regulation of endothelial cell migration-IMP24863063  
GO:0018108peptidyl-tyrosine phosphorylation-IDA7590236  9144171  10713049  11121037  
GO:0018108peptidyl-tyrosine phosphorylation-IMP24520051  28428613  
GO:0018108peptidyl-tyrosine phosphorylation-TAS23626584  24522549  
GO:0021587cerebellum morphogenesis-IEA-  
GO:0022408negative regulation of cell-cell adhesion-IEA-  
GO:0030035microspike assembly-IEA-  
GO:0030036actin cytoskeleton organization-ISS-  
GO:0030100regulation of endocytosis-TAS20841568  
GO:0030154cell differentiation-IBA21873635  
GO:0030155regulation of cell adhesion-TAS20841568  
GO:0030514negative regulation of BMP signaling pathway-IEA-  
GO:0030516regulation of axon extension-IMP24520051  
GO:0031113regulation of microtubule polymerization-IMP24520051  
GO:0032489regulation of Cdc42 protein signal transduction-IMP26051942  
GO:0032956regulation of actin cytoskeleton organization-IMP24520051  
GO:0033690positive regulation of osteoblast proliferation-IEA-  
GO:0034446substrate adhesion-dependent cell spreading-IEA-  
GO:0034599cellular response to oxidative stress-TAS24522549  
GO:0035791platelet-derived growth factor receptor-beta signaling pathway-IMP24520051  
GO:0038083peptidyl-tyrosine autophosphorylation-IBA21873635  
GO:0038083peptidyl-tyrosine autophosphorylation-IDA10518561  
GO:0038083peptidyl-tyrosine autophosphorylation-IMP24520051  
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis-TAS-  
GO:0038189neuropilin signaling pathway-IMP24863063  
GO:0042127regulation of cell proliferation-IBA21873635  
GO:0042770signal transduction in response to DNA damage-IDA9037071  15657060  
GO:0042981regulation of apoptotic process-IBA21873635  
GO:0043065positive regulation of apoptotic process-IDA9037071  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IEA-  
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling-IEA-  
GO:0043542endothelial cell migration-IMP24863063  
GO:0045087innate immune response-IBA21873635  
GO:0045184establishment of protein localization-IMP24520051  
GO:0045580regulation of T cell differentiation-ISS-  
GO:0045930negative regulation of mitotic cell cycle-IEA-  
GO:0045931positive regulation of mitotic cell cycle-IEA-  
GO:0046632alpha-beta T cell differentiation-IEA-  
GO:0046777protein autophosphorylation-IDA10713049  
GO:0048536spleen development-IEA-  
GO:0048538thymus development-IEA-  
GO:0048668collateral sprouting-IEA-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA15657060  
GO:0050798activated T cell proliferation-IEA-  
GO:0050853B cell receptor signaling pathway-IEA-  
GO:0050885neuromuscular process controlling balance-IEA-  
GO:0051149positive regulation of muscle cell differentiation-TAS-  
GO:0051281positive regulation of release of sequestered calcium ion into cytosol-IEA-  
GO:0051353positive regulation of oxidoreductase activity-IDA12893824  
GO:0051444negative regulation of ubiquitin-protein transferase activity-IDA20823226  
GO:0051444negative regulation of ubiquitin-protein transferase activity-TAS23626584  24522549  
GO:0051496positive regulation of stress fiber assembly-IMP24863063  
GO:0051882mitochondrial depolarization-TAS24522549  
GO:0051894positive regulation of focal adhesion assembly-IMP24863063  
GO:0060020Bergmann glial cell differentiation-IEA-  
GO:0060563neuroepithelial cell differentiation-IEA-  
GO:0070301cellular response to hydrogen peroxide-IDA10713049  
GO:0070373negative regulation of ERK1 and ERK2 cascade-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IEA-  
GO:0071222cellular response to lipopolysaccharide-IEA-  
GO:0071901negative regulation of protein serine/threonine kinase activity-IDA11121037  
GO:0072358cardiovascular system development-IEA-  
GO:0090050positive regulation of cell migration involved in sprouting angiogenesis-IEA-  
GO:0090135actin filament branching-IEA-  
GO:1900026positive regulation of substrate adhesion-dependent cell spreading-IMP24863063  
GO:1900042positive regulation of interleukin-2 secretion-IEA-  
GO:1900272negative regulation of long-term synaptic potentiation-ISS-  
GO:1900275negative regulation of phospholipase C activity-IMP24367707  
GO:1901216positive regulation of neuron death-IEA-  
GO:1902036regulation of hematopoietic stem cell differentiation-TAS-  
GO:1902715positive regulation of interferon-gamma secretion-IEA-  
GO:1903053regulation of extracellular matrix organization-IEA-  
GO:1903351cellular response to dopamine-TAS24522549  
GO:1904528positive regulation of microtubule binding-IMP24520051  
GO:1904531positive regulation of actin filament binding-IMP24520051  
GO:1905244regulation of modification of synaptic structure-ISS-  
GO:1905555positive regulation blood vessel branching-IEA-  
GO:1990051activation of protein kinase C activity-IDA10713049  
GO:2000096positive regulation of Wnt signaling pathway, planar cell polarity pathway-IEA-  
GO:2000145regulation of cell motility-TAS20841568  
GO:2000249regulation of actin cytoskeleton reorganization-TAS20841568  
GO:2000251positive regulation of actin cytoskeleton reorganization-IMP24863063  
GO:2000352negative regulation of endothelial cell apoptotic process-IEA-  
GO:2000773negative regulation of cellular senescence-IEA-  
GO:2001020regulation of response to DNA damage stimulus-IDA9461559  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA9168116  17626041  17888034  
GO:0005634nucleus-ISS-  
GO:0005634nucleus-NAS8242749  
GO:0005634nucleus-TAS20841568  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA12944467  17626041  
GO:0005737cytoplasm-IDA17515907  
GO:0005737cytoplasm-TAS20841568  
GO:0005739mitochondrion-NAS24522549  
GO:0005829cytosol-IDA11120811  
GO:0005829cytosol-TAS-  
GO:0015629actin cytoskeleton-TAS20841568  
GO:0016604nuclear body-IDA-  
GO:0030425dendrite-ISS-  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-IBA21873635  
GO:0031252cell leading edge-IEA-  
GO:0031965nuclear membrane-IEA-  
GO:0032991protein-containing complex-IPI12384576  
GO:0043025neuronal cell body-ISS-  
GO:0048471perinuclear region of cytoplasm-IDA17888034  
GO:0098794postsynapse-TAS24658113  
KEGG ID KEGG Term
hsa04012ErbB signaling pathway
hsa04110Cell cycle
hsa04360Axon guidance
hsa04722Neurotrophin signaling pathway
hsa05130Pathogenic Escherichia coli infection
hsa05131Shigellosis
hsa05200Pathways in cancer
hsa05220Chronic myeloid leukemia
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisTAS
R-HSA-2029482Regulation of actin dynamics for phagocytic cup formationTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-375170CDO in myogenesisTAS
R-HSA-375170CDO in myogenesisIEA
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-376176Signaling by ROBO receptorsTAS
R-HSA-422475Axon guidanceIEA
R-HSA-422475Axon guidanceTAS
R-HSA-428890Role of ABL in ROBO-SLIT signalingIEA
R-HSA-428890Role of ABL in ROBO-SLIT signalingTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-525793MyogenesisTAS
R-HSA-525793MyogenesisIEA
R-HSA-5663213RHO GTPases Activate WASPs and WAVEsTAS
R-HSA-5685938HDR through Single Strand Annealing (SSA)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693606DNA Double Strand Break ResponseTAS
R-HSA-69231Cyclin D associated events in G1TAS
R-HSA-69236G1 PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878166Transcriptional regulation by RUNX2IEA
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCsTAS
R-HSA-8940973RUNX2 regulates osteoblast differentiationIEA
R-HSA-8941326RUNX2 regulates bone developmentIEA
R-HSA-983231Factors involved in megakaryocyte development and platelet productionIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25807961Thrombosis in thrombocythemic Ph- myeloproliferations is associated with higher platelet count prior to the event: results of analyses of prothrombotic risk factors from a registry of patients treated with anagrelide. (2016 Jan)Schwarz JEur J Haematol
16945033Periodontal disease and coronary heart disease. (2006 Sep)Geismar KJ Periodontol