Gene info: ID 250

Gene: ALPP

GENE ID: 250

Synonyms: ALP|PALP|PLAP|PLAP-1

Description: alkaline phosphatase, placental

Gene type: protein-coding

Location: 2q37.1

dbXrefs: Ensembl:ENSG00000163283 MIM:171800 Vega:OTTHUMG00000133255 UniprotKB:P05187

RefSeq: NG_012189.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.333e-1 (AD) 3.803e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg03188382	chr2:233245886	ALPP		1.200e-16	Smoking	27651444
cg19713851	chr2:233246594	ALPP		1.200e-9	Smoking	27651444
cg22403782	chr2:233246136	ALPP		1.300e-8	Smoking	27651444
cg23667432	chr2:233244439	ALPP		3.000e-8	Smoking	27651444
cg19713851	chr2:233246594	ALPP		5.440e-9	Tobacco smoking	28225026
cg03188382	chr2:233245886	ALPP		7.610e-8	Tobacco smoking	28225026
cg19713851	chr2:233246594	ALPP		5.390e-13	Smoking	28686328
cg03188382	chr2:233245886	ALPP		4.100e-10	Smoking	28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR7C2	0.637
OTOR	0.565
PLA2G2E	0.559
FAM83C	0.523
CAPN6	0.51
ODF4	0.51
SPATA32	0.509
DEFB115	0.487
TAAR1	0.463
OPN1MW2	0.457

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OTC	-0.265
RFTN2	-0.251
DIAPH3	-0.226
CASC10	-0.224
CDH20	-0.222
RAB41	-0.222
FAM151A	-0.22
YIPF7	-0.22
NDP	-0.219
C21orf58	-0.213

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01373	Calcium	Small Molecule	7440-70-2	Approved\|Nutraceutical	Target
DB08413	METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C043104	3-(hydroxymethyl)phenytoin	ALPP protein results in increased chemical synthesis of 3-(hydroxymethyl)phenytoin	1495895
C038699	acetophenone	ALPP protein results in increased chemical synthesis of acetophenone	1495895
D000242	Cyclic AMP	[Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of ALPP mRNA	16036225
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of ALPP mRNA	21298039
D000661	Amphetamine	Amphetamine promotes the reaction [Isoproterenol results in increased expression of ALPP mRNA]	16036225
D001280	Atrazine	Atrazine results in decreased expression of ALPP mRNA	22378314
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ALPP mRNA"	20018196
D004958	Estradiol	Estradiol results in increased expression of ALPP mRNA	23019147
D004958	Estradiol	Estradiol results in increased expression of ALPP protein	16053526
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of ALPP mRNA	17404688
C006780	bisphenol A	bisphenol A results in increased expression of ALPP mRNA	23019147
C584509	C646 compound	C646 compound results in increased expression of ALPP mRNA	26191083
D002118	Calcium	Calcium binds to ALPP protein	16815919
C100187	chloropicrin	chloropicrin results in increased expression of ALPP mRNA	26352163\|2847649
D002746	Chlorpromazine	Chlorpromazine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]	16036225
D002746	Chlorpromazine	Chlorpromazine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]	16036225
D003024	Clozapine	Clozapine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]	16036225
D003024	Clozapine	Clozapine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]	16036225
D005576	Colforsin	Chlorpromazine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]	16036225
D005576	Colforsin	Clozapine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]	16036225
D005576	Colforsin	[Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of ALPP mRNA	16036225
D005576	Colforsin	Colforsin results in increased expression of ALPP mRNA	16036225
D005576	Colforsin	Desipramine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]	16036225
C014347	decitabine	decitabine affects the methylation of ALPP gene	17630775
C014347	decitabine	decitabine inhibits the reaction [Smoke results in decreased expression of ALPP mRNA]	21095227
D013759	Dronabinol	Dronabinol results in decreased expression of ALPP protein	26070387
D003891	Desipramine	Desipramine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]	16036225
D003891	Desipramine	Desipramine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]	16036225
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased activity of ALPP protein	15563447
D004052	Diethylnitrosamine	Plant Extracts inhibits the reaction [Diethylnitrosamine results in increased activity of ALPP protein]	15563447
D004726	Endosulfan	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALPP mRNA	26159488
D004845	Epitestosterone	ALPP protein results in increased chemical synthesis of Epitestosterone	1495895
D004970	Estrone	ALPP protein results in increased chemical synthesis of Estrone	1495895
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ALPP mRNA	18936297
D005047	Etoposide	ALPP protein affects the susceptibility to Etoposide	16217747
D005557	Formaldehyde	Formaldehyde results in increased expression of ALPP mRNA	28937961
D019833	Genistein	Genistein results in increased expression of ALPP mRNA	23019147\|2686566
D006108	Graphite	Graphite results in increased expression of ALPP protein	22157353
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of ALPP mRNA	21179406
C492448	ICG 001	ICG 001 results in increased expression of ALPP mRNA	26191083
C026777	ICI 118551	ICI 118551 inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]	16036225
D007545	Isoproterenol	Amphetamine promotes the reaction [Isoproterenol results in increased expression of ALPP mRNA]	16036225
D007545	Isoproterenol	Chlorpromazine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]	16036225
D007545	Isoproterenol	Clozapine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]	16036225
D007545	Isoproterenol	Desipramine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]	16036225
D007545	Isoproterenol	ICI 118551 inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]	16036225
D007545	Isoproterenol	Isoproterenol results in increased expression of ALPP mRNA	16036225
D007545	Isoproterenol	norfluoxetine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]	16036225
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of ALPP mRNA	12057914
D018021	Lithium Chloride	Lithium Chloride results in increased activity of ALPP protein	16053526
D008727	Methotrexate	ALPP protein affects the susceptibility to Methotrexate	16217747
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of ALPP mRNA"	15585362
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of ALPP protein"	22157353
C008644	nitrophenylphosphate	ALPP protein results in increased chemical synthesis of nitrophenylphosphate	1495895
C036139	norfluoxetine	norfluoxetine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]	16036225
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of ALPP mRNA	23978341
D010634	Phenobarbital	Phenobarbital affects the expression of ALPP mRNA	19159669
D010936	Plant Extracts	Plant Extracts results in decreased expression of ALPP mRNA	23557933
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Diethylnitrosamine results in increased activity of ALPP protein]	15563447
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of ALPP mRNA	22714537
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of ALPP mRNA	17404688
D011374	Progesterone	Progesterone results in increased expression of ALPP mRNA	17404688
D012834	Silver	Silver results in increased expression of ALPP mRNA	28959546
D012906	Smoke	decitabine inhibits the reaction [Smoke results in decreased expression of ALPP mRNA]	21095227
D012906	Smoke	Smoke results in decreased expression of ALPP mRNA	21095227
C025700	strontium chloride	strontium chloride binds to ALPP protein	16815919
C016766	sulforafan	sulforafan results in increased expression of ALPP mRNA	26833863
D013739	Testosterone	ALPP protein results in increased chemical synthesis of Testosterone	1495895
D013749	Tetrachlorodibenzodioxin	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALPP mRNA	26159488
D014212	Tretinoin	Tretinoin results in decreased expression of ALPP mRNA	23830798
D014635	Valproic Acid	Valproic Acid results in increased methylation of ALPP gene	29154799

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000287	magnesium ion binding	-	ISS	-
GO:0004035	alkaline phosphatase activity	-	IDA	1939159 2017684 2133555
GO:0004035	alkaline phosphatase activity	-	NAS	3042787
GO:0005515	protein binding	-	IPI	25416956
GO:0008270	zinc ion binding	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0016311	dephosphorylation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	IDA	-
GO:0009986	cell surface	-	IDA	15907827
GO:0016021	integral component of membrane	-	IEA	-
GO:0031225	anchored component of membrane	-	IEA	-

KEGG ID	KEGG Term
hsa00790	Folate biosynthesis
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-6811438	Intra-Golgi traffic	TAS
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25424692	Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation. (2014 Oct)	Tsaprouni LG	Epigenetics