Gene: FTL

2512
LFTD|NBIA3
ferritin light chain
protein-coding
19q13.33
Ensembl:ENSG00000087086 MIM:134790 Vega:OTTHUMG00000183332 UniprotKB:P02792
NG_008152.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.301e-1 (AD)  2.147e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPL180.943
RPL13A0.939
RPS110.935
RPS160.931
RPLP10.927
RPS270.926
RPL100.926
RPS250.924
RPS20.921
RPL350.92

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.802
OR4F5-0.764
CDH7-0.331
ZNF860-0.33
NXPH2-0.322
TRPC5-0.32
GABRG3-0.317
KCNH1-0.314
IL12RB2-0.313
PCDHAC1-0.313

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06784Gallium citrate Ga 67Small Molecule41183-64-6ApprovedTransporter
DB00893Iron DextranSmall Molecule9004-66-4ApprovedTarget
DB02285ProtoporphyrinSmall Molecule553-12-8ExperimentalTarget
DB09147Ferric pyrophosphateSmall Molecule10058-44-3ExperimentalTarget
DB09517Sodium ferric gluconate complexSmall Molecule34089-81-1ApprovedTarget
DB13995Ferric pyrophosphate citrateSmall Molecule1802359-96-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0152621,6-hexamethylene diisocyanate"1,6-hexamethylene diisocyanate results in increased expression of FTL mRNA"24211530
C0552381-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene"1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene results in increased expression of FTL mRNA"23333615
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of FTL mRNA"20453058
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of FTL protein"25686467
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of FTL mRNA"20406850
C4041922-pyridylcarboxaldehyde isonicotinoylhydrazone2-pyridylcarboxaldehyde isonicotinoylhydrazone inhibits the reaction [Doxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]]12644586
C4041922-pyridylcarboxaldehyde isonicotinoylhydrazone2-pyridylcarboxaldehyde isonicotinoylhydrazone inhibits the reaction [Iron binds to [FTL protein binds to FTMT protein]]12644586
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FTL protein"25686467
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FTL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FTL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FTL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FTL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FTL mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of FTL mRNA"19561079
C0118655-hydroxymethylcytosine[Chloranil results in increased abundance of 5-hydroxymethylcytosine] which results in increased expression of FTL mRNA24214992
C5444715-hydroxythalidomide5-hydroxythalidomide binds to FTL protein27464947
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FTL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FTL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FTL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FTL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FTL mRNA"27188386
C0307357-aminocephalosporanic acid7-aminocephalosporanic acid results in increased expression of FTL mRNA24211530
D000171AcroleinAcrolein results in increased expression of FTL mRNA24211530
D000438AlcoholsAlcohols results in increased expression of FTL mRNA24025710
D000438AlcoholsAlcohols results in increased localization of FTL protein24025710
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FTL mRNA16483693
C018453ammonium hexachloroplatinateammonium hexachloroplatinate results in increased expression of FTL mRNA24211530
D000861AnserineAnserine results in decreased susceptibility to [salsolinol co-treated with [FTH1 protein binds to FTL protein]]19433265
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in increased expression of FTL mRNA28713220
D001151ArsenicArsenic affects the methylation of FTL gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of FTL mRNA20458559|2670570
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of FTL mRNA15894607
D001205Ascorbic AcidAscorbic Acid affects the expression of FTL protein19224539
D001280AtrazineAtrazine results in increased expression of FTL mRNA22378314
C051597Bandrowski's baseBandrowski's base results in increased expression of FTL mRNA20566472
D019817Benzoic AcidBenzoic Acid results in increased expression of FTL mRNA20566472
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [diallyl trisulfide results in increased degradation of and results in decreased expression of FTL protein]16707465
D004958EstradiolEstradiol affects the expression of FTL mRNA22574217
C044887beta-methylcholinebeta-methylcholine affects the expression of FTL mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of FTL mRNA25047013|2927551
C006780bisphenol Abisphenol A results in increased expression of FTL mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of FTL mRNA12414654|1596398
D002104CadmiumCadmium binds to FTL protein16790936
C028031cadmium acetatecadmium acetate results in increased expression of FTL mRNA12965115
C037123cadmium sulfatecadmium sulfate results in increased expression of FTL mRNA12064557|1467641
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FTL mRNA20360939
C005563captaxcaptax results in increased expression of FTL mRNA24211530
D002330CarmustineCarmustine results in decreased expression of FTL mRNA15980968
D002336CarnosineCarnosine results in decreased susceptibility to [salsolinol co-treated with [FTH1 protein binds to FTL protein]]19433265
D002635Chenodeoxycholic Acid[Chenodeoxycholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of FTL mRNA17724089
D002703Chloranil[Chloranil results in increased abundance of 5-hydroxymethylcytosine] which results in increased expression of FTL mRNA24214992
D002703ChloranilChloranil results in increased expression of FTL mRNA24214992
D002703ChloranilChloranil results in increased expression of FTL protein24214992
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FTL mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of FTL mRNA26272509
C100187chloropicrinchloropicrin results in increased expression of FTL mRNA24211530
D002784CholesterolCholesterol results in decreased expression of FTL protein17029598
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of FTL mRNA24211530
C020722cinnamyl alcoholcinnamyl alcohol results in increased expression of FTL mRNA20566472
C073341citraconic acidcitraconic acid promotes the reaction [NFE2L2 protein results in increased expression of FTL protein]28289076
C073341citraconic acidcitraconic acid results in increased expression of FTL protein28289076
C073341citraconic acidNFE2L2 protein affects the reaction [citraconic acid results in increased expression of FTL protein]28289076
C018021cobaltous chloridecobaltous chloride results in increased expression of FTL mRNA19320972
D003060Cod Liver OilCod Liver Oil results in increased expression of FTL mRNA26055946
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of FTL mRNA20971185
D003300CopperCopper affects the expression of FTL protein17192175
D003300CopperCopper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of FTL mRNA]20302851
D0150842,4-Dichlorophenoxyacetic Acid"2,4-Dichlorophenoxyacetic Acid results in increased expression of FTL mRNA"15878651
D003630DaunorubicinDaunorubicin results in increased expression of FTL mRNA23831762
D003630DaunorubicinDexrazoxane inhibits the reaction [Daunorubicin results in increased expression of FTL mRNA]23831762
D003676DeferoxamineDeferoxamine inhibits the reaction [Doxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]]12644586
D003676DeferoxamineDeferoxamine inhibits the reaction [Iron binds to [FTL protein binds to FTMT protein]]12644586
D003676Deferoxamine[Deferoxamine results in decreased abundance of Iron] which results in decreased expression of FTL mRNA12393473
D003676Deferoxamine[Deferoxamine results in decreased abundance of Iron] which results in decreased expression of FTL mRNA15893546
D064730DexrazoxaneDexrazoxane inhibits the reaction [Daunorubicin results in increased expression of FTL mRNA]23831762
C042577diallyl trisulfidebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [diallyl trisulfide results in increased degradation of and results in decreased expression of FTL protein]16707465
C042577diallyl trisulfidediallyl trisulfide results in increased degradation of and results in decreased expression of FTL protein16707465
C042577diallyl trisulfideMAP2K4 protein affects the reaction [diallyl trisulfide results in increased degradation of FTL protein]16707465
C042577diallyl trisulfideMAP2K7 protein affects the reaction [diallyl trisulfide results in increased degradation of FTL protein]16707465
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of FTL mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of FTL mRNA28302478
D004052DiethylnitrosamineCopper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of FTL mRNA]20302851
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FTL mRNA20360939
D004052Diethylnitrosamine[Iron co-treated with Diethylnitrosamine] results in increased expression of FTL mRNA20302851
C472511dimethylarsinous aciddimethylarsinous acid results in increased expression of FTL mRNA20886546
D000069462Dimethyl FumarateDimethyl Fumarate results in increased expression of FTL mRNA28289076
D000069462Dimethyl FumarateDimethyl Fumarate results in increased expression of FTL protein28289076
D000069462Dimethyl FumarateNFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL mRNA]28289076
D000069462Dimethyl FumarateNFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL protein]28289076
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of FTL mRNA20566472
D004221DisulfiramDisulfiram results in increased expression of FTL mRNA20566472
D004317Doxorubicin2-pyridylcarboxaldehyde isonicotinoylhydrazone inhibits the reaction [Doxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]]12644586
D004317DoxorubicinDeferoxamine inhibits the reaction [Doxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]]12644586
D004317DoxorubicinDoxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]12644586
D004317DoxorubicinDoxorubicin results in increased expression of FTL protein16770644
C512195elesclomolelesclomol results in increased expression of FTL mRNA18723479
D004811EpichlorohydrinEpichlorohydrin results in increased expression of FTL mRNA24211530
D000431EthanolEthanol results in increased expression of FTL mRNA15963989
D005054EugenolEugenol results in increased expression of FTL mRNA20566472
C013531ferric ammonium citrate[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of FTL mRNA12393473
C020748ferrous sulfateferrous sulfate results in increased expression of FTL protein16039939
C020748ferrous sulfate[nickel chloride results in increased activity of ACO1 protein] inhibits the reaction [ferrous sulfate results in increased expression of FTL protein]16039939
D005297FerrozineFerrozine results in decreased susceptibility to [salsolinol co-treated with [FTH1 protein binds to FTL protein]]19433265
D005492Folic AcidFolic Acid affects the expression of FTL mRNA17868486
D005561FormatesFormates results in decreased susceptibility to [salsolinol co-treated with [FTH1 protein binds to FTL protein]]19433265
D008299Maleic AnhydridesMaleic Anhydrides results in increased expression of FTL mRNA24211530
C027235gallium nitrategallium nitrate results in increased expression of FTL mRNA18586083
C077458ginkgetinginkgetin results in decreased expression of FTL protein25968939
D006427Hemin[Hemin results in increased abundance of Iron] which results in increased expression of FTL mRNA12393473
D006427HeminHemin results in increased expression of FTL mRNA15893546
C080043hexyl cinnamic aldehydehexyl cinnamic aldehyde results in increased expression of FTL mRNA20566472
C005038homocarnosinehomocarnosine results in decreased susceptibility to [salsolinol co-treated with [FTH1 protein binds to FTL protein]]19433265
D006861Hydrogen PeroxideHydrogen Peroxide results in increased degradation of FTL protein16707465
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of FTL mRNA12414654
D006861Hydrogen PeroxideMAP2K4 protein affects the reaction [Hydrogen Peroxide results in increased degradation of FTL protein]16707465
D017665Hydroxyl Radical[salsolinol co-treated with [FTH1 protein binds to FTL protein]] results in increased abundance of Hydroxyl Radical19433265
C492448ICG 001ICG 001 results in increased expression of FTL mRNA26191083
D007220Industrial WasteIndustrial Waste results in increased expression of FTL mRNA26055946
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FTL mRNA25613284
D007501Ironsalsolinol inhibits the reaction [Iron binds to [FTH1 protein binds to FTL protein]]19433265
D007501Iron2-pyridylcarboxaldehyde isonicotinoylhydrazone inhibits the reaction [Doxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]]12644586
D007501Iron2-pyridylcarboxaldehyde isonicotinoylhydrazone inhibits the reaction [Iron binds to [FTL protein binds to FTMT protein]]12644586
D007501IronDeferoxamine inhibits the reaction [Doxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]]12644586
D007501IronDeferoxamine inhibits the reaction [Iron binds to [FTL protein binds to FTMT protein]]12644586
D007501Iron[Deferoxamine results in decreased abundance of Iron] which results in decreased expression of FTL mRNA12393473
D007501IronDoxorubicin promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]12644586
D007501Iron[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of FTL mRNA12393473
D007501IronFTL protein mutant form results in decreased uptake of Iron16822677
D007501Iron[Hemin results in increased abundance of Iron] which results in increased expression of FTL mRNA12393473
D007501IronIron binds to [FTL protein binds to FTMT protein]12644586
D007501IronParaquat promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]12644586
D007501IronRazoxane inhibits the reaction [Iron binds to [FTL protein binds to FTMT protein]]12644586
D007501IronVitamin K 3 promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]12644586
D007501Iron[CP gene mutant form results in increased abundance of Iron] which results in increased expression of FTL mRNA16988052
D007501IronCopper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of FTL mRNA]20302851
D007501Iron[Deferoxamine results in decreased abundance of Iron] which results in decreased expression of FTL mRNA15893546
D007501Iron[Iron co-treated with Diethylnitrosamine] results in increased expression of FTL mRNA20302851
C448299iron protoporphyrin IXFTL protein binds to and affects the metabolism of iron protoporphyrin IX16781777
C036643isoeugenolisoeugenol results in increased expression of FTL mRNA20566472
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of FTL mRNA27392435
C544151jinfukangjinfukang results in increased expression of FTL mRNA27392435
D019344Lactic AcidLactic Acid results in increased expression of FTL mRNA20566472
C008261lead acetatelead acetate results in increased expression of FTL mRNA27562236
C008261lead acetatelead acetate results in increased expression of FTL mRNA11578147
C017461lead nitratelead nitrate results in increased expression of FTL protein19332663
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of FTL mRNA25613284
D008094LithiumLithium results in increased expression of FTL protein18296634
D008095Lithocholic Acid[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of FTL mRNA17724089
C025340manganese chloridemanganese chloride results in decreased expression of FTL mRNA15893546
D008353MannitolMannitol results in decreased susceptibility to [salsolinol co-treated with [FTH1 protein binds to FTL protein]]19433265
D015122MercaptopurineMercaptopurine results in increased expression of FTL mRNA27435855
C042720mercuric bromidemercuric bromide results in increased expression of FTL mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FTL mRNA"27188386
D008701MethapyrileneMethapyrilene results in decreased expression of FTL mRNA28935588
D008701MethapyrileneMethapyrilene results in increased expression of FTL protein28935588
D008701MethapyrileneMethapyrilene results in increased expression of FTL mRNA28935588
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FTL mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FTL mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of FTL mRNA23649840
C033069methyl salicylatemethyl salicylate results in increased expression of FTL mRNA20566472
D019810Sodium AzideSodium Azide results in decreased susceptibility to [salsolinol co-treated with [FTH1 protein binds to FTL protein]]19433265
C026385n-hexanen-hexane results in increased expression of FTL mRNA20566472
C022838nickel chloride[nickel chloride results in increased activity of ACO1 protein] inhibits the reaction [ferrous sulfate results in increased expression of FTL protein]16039939
C028007nickel monoxidenickel monoxide results in increased expression of FTL mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of FTL mRNA20566472
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of FTL mRNA20971185
D017239PaclitaxelFTL mRNA results in decreased susceptibility to Paclitaxel16322897
D010269ParaquatParaquat promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]12644586
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of FTL mRNA26678675
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FTL mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FTL mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in increased expression of FTL protein18563748
C023844potassium nitratepotassium nitrate results in increased expression of FTL mRNA15878651
D0198402-Propanol2-Propanol results in increased expression of FTL mRNA20566472
D011441PropylthiouracilPropylthiouracil results in increased expression of FTL mRNA24780913
C502851quinocetonequinocetone results in decreased expression of FTL mRNA27046791
D011929RazoxaneRazoxane inhibits the reaction [Iron binds to [FTL protein binds to FTMT protein]]12644586
C089730rosiglitazonerosiglitazone affects the expression of FTL protein19556978
C010327salinomycinsalinomycin results in decreased expression of FTL mRNA19682730
C036617salsolinolAnserine results in decreased susceptibility to [salsolinol co-treated with [FTH1 protein binds to FTL protein]]19433265
C036617salsolinolCarnosine results in decreased susceptibility to [salsolinol co-treated with [FTH1 protein binds to FTL protein]]19433265
C036617salsolinolCAT protein results in decreased susceptibility to [salsolinol co-treated with [FTH1 protein binds to FTL protein]]19433265
C036617salsolinolFerrozine results in decreased susceptibility to [salsolinol co-treated with [FTH1 protein binds to FTL protein]]19433265
C036617salsolinolFormates results in decreased susceptibility to [salsolinol co-treated with [FTH1 protein binds to FTL protein]]19433265
C036617salsolinol[FTH1 protein binds to FTL protein] which results in increased susceptibility to salsolinol19433265
C036617salsolinolhomocarnosine results in decreased susceptibility to [salsolinol co-treated with [FTH1 protein binds to FTL protein]]19433265
C036617salsolinolMannitol results in decreased susceptibility to [salsolinol co-treated with [FTH1 protein binds to FTL protein]]19433265
C036617salsolinol[salsolinol co-treated with [FTH1 protein binds to FTL protein]] results in increased abundance of Hydroxyl Radical19433265
C036617salsolinolsalsolinol inhibits the reaction [Iron binds to [FTH1 protein binds to FTL protein]]19433265
C036617salsolinolSodium Azide results in decreased susceptibility to [salsolinol co-treated with [FTH1 protein binds to FTL protein]]19433265
D012643SeleniumSelenium results in increased expression of FTL mRNA19244175
C040115shogaolshogaol metabolite results in increased expression of FTL protein25148906
C040115shogaolshogaol results in increased expression of FTL mRNA25148906
C040115shogaolshogaol results in increased expression of FTL protein25148906
D012834SilverSilver results in increased expression of FTL mRNA26551752
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of FTL mRNA]21245298
C009277sodium arsenatesodium arsenate results in increased expression of FTL mRNA12727804
C017947sodium arseniteNFE2L2 mutant form inhibits the reaction [sodium arsenite results in increased expression of FTL mRNA]23699174
C017947sodium arsenitePRMT1 mutant form inhibits the reaction [sodium arsenite results in increased expression of FTL mRNA]23699174
C017947sodium arsenitePRMT1 mutant form inhibits the reaction [sodium arsenite results in increased expression of FTL protein]23699174
C017947sodium arsenitesodium arsenite results in decreased expression of FTL mRNA22692362
C017947sodium arsenitesodium arsenite results in increased expression of FTL mRNA20371982|2128196
C017947sodium arsenitesodium arsenite results in increased expression of FTL protein23699174
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in increased expression of FTL mRNA20566472
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FTL mRNA18465118
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FTL mRNA25613284
D013893ThiramThiram results in increased expression of FTL mRNA24211530
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of FTL mRNA27404394|2786577
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of FTL mRNA15894607
D014212TretinoinTretinoin results in increased expression of FTL mRNA15894607|1721838
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FTL mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of FTL mRNA24935251|2497364
D014635Valproic AcidValproic Acid results in increased expression of FTL mRNA23179753|2718838
D024483Vitamin K 3Vitamin K 3 affects the expression of FTL mRNA20044591
D024483Vitamin K 3Vitamin K 3 promotes the reaction [Iron binds to [FTL protein binds to FTMT protein]]12644586
D024483Vitamin K 3Vitamin K 3 results in increased expression of FTL mRNA12414654
D015032ZincZinc deficiency results in increased expression of FTL mRNA12888634
D015032ZincZinc results in increased expression of FTL mRNA15984569
D015032ZincZinc deficiency results in increased expression of FTL protein18073202
D015054ZymosanZymosan analog results in increased expression of FTL mRNA16239567
D015054ZymosanZymosan analog results in increased expression of FTL protein16239567

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004322ferroxidase activity-IBA21873635  
GO:0004322ferroxidase activityNOTIBA21873635  
GO:0005506iron ion binding-IBA21873635  
GO:0005506iron ion binding-IDA19923220  20159981  
GO:0005515protein binding-IPI16169070  16189514  18486613  21516116  23275563  23685131  
25416956  25910212  27107014  
GO:0008198ferrous iron binding-IBA21873635  
GO:0008199ferric iron binding-IBA21873635  
GO:0008199ferric iron binding-IEA-  
GO:0042802identical protein binding-IBA21873635  
GO:0042802identical protein binding-IPI16169070  16189514  16790936  25416956  25910212  
GO ID GO Term Qualifier Evidence PubMed
GO:0006826iron ion transport-IEA-  
GO:0006879cellular iron ion homeostasis-TAS7492760  
GO:0006880intracellular sequestering of iron ion-IBA21873635  
GO:0043312neutrophil degranulation-TAS-  
GO:0055072iron ion homeostasis-TAS19923220  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0008043intracellular ferritin complex-IBA21873635  
GO:0008043intracellular ferritin complex-IDA19923220  20159981  
GO:0016020membrane-HDA19946888  
GO:0035578azurophil granule lumen-TAS-  
GO:0044754autolysosome-IBA21873635  
GO:0044754autolysosome-IDA25327288  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa00860Porphyrin and chlorophyll metabolism
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-199992trans-Golgi Network Vesicle BuddingTAS
R-HSA-2173782Binding and Uptake of Ligands by Scavenger ReceptorsIEA
R-HSA-3000480Scavenging by Class A ReceptorsIEA
R-HSA-382551Transport of small moleculesTAS
R-HSA-421837Clathrin derived vesicle buddingTAS
R-HSA-432722Golgi Associated Vesicle BiogenesisTAS
R-HSA-5653656Vesicle-mediated transportIEA
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-917937Iron uptake and transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10534137Low free-thyroxine levels are a risk factor for subclinical atherosclerosis in euthyroid hyperlipidemic patients. (1999 Oct)Bruckert EJ Cardiovasc Risk