Gene: NR5A1

2516
AD4BP|ELP|FTZ1|FTZF1|POF7|SF-1|SF1|SPGF8|SRXX4|SRXY3|hSF-1
nuclear receptor subfamily 5 group A member 1
protein-coding
9q33.3
Ensembl:ENSG00000136931 MIM:184757 Vega:OTTHUMG00000020655 UniprotKB:Q13285
NG_008176.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.154e-1 (AD)  6.053e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DLK10.537
FAM183A0.507
TRH0.484
HCRT0.481
CFC10.479
OTX20.476
CCDC1400.476
SFRP50.47
BCL2L100.468
IL13RA20.467

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIAA0754-0.305
TNS1-0.268
ENPEP-0.259
SERINC5-0.248
ANXA9-0.237
SMYD1-0.231
LPAR3-0.23
FCN1-0.229
ZFP57-0.228
KDR-0.227

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04683(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATESmall MoleculeExperimentalTarget
DB04752Phosphatidyl ethanolSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C02581320-hydroxycholesterol[20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] promotes the reaction [NR5A1 protein binds to MC2R promoter]21610156
C02581320-hydroxycholesterol[NR5A1 protein co-treated with 20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased abundance of Progesterone21610156
C02581320-hydroxycholesterol[NR5A1 protein co-treated with 20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP11A1 mRNA21610156
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of NR5A1 mRNA]"19414516
C00358522-hydroxycholesterol22-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]9804848
C5532312-(4-hydroxyphenyl)-3-phenylpent-2-enoic acid (4-(2-dimethylaminoethoxy)phenyl)amide2-(4-hydroxyphenyl)-3-phenylpent-2-enoic acid (4-(2-dimethylaminoethoxy)phenyl)amide results in increased activity of NR5A1 protein19549922
C5532312-(4-hydroxyphenyl)-3-phenylpent-2-enoic acid (4-(2-dimethylaminoethoxy)phenyl)amide2-(4-hydroxyphenyl)-3-phenylpent-2-enoic acid (4-(2-dimethylaminoethoxy)phenyl)amide results in increased phosphorylation of NR5A1 protein19549922
C00799725-hydroxycholesterol25-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]9804848
C00799725-hydroxycholesterol25-hydroxycholesterol results in increased activity of NR5A1 protein9144161
C07699627-hydroxycholesterol27-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]9804848
C07699627-hydroxycholesterol27-hydroxycholesterol results in increased activity of NR5A1 protein9144161
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of NR5A1 mRNA16788091
C5278334-(heptyloxy)phenol4-(heptyloxy)phenol results in increased activity of NR5A1 protein23481593
C5278334-(heptyloxy)phenol[4-(heptyloxy)phenol results in increased activity of NR5A1 protein] which results in increased abundance of Estradiol23481593
C5278334-(heptyloxy)phenol[4-(heptyloxy)phenol results in increased activity of NR5A1 protein] which results in increased abundance of Progesterone23481593
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NR5A1 mRNA16483693
D000735AndrostenedioneFSHB protein promotes the reaction [[[NR5A1 protein binds to CYP17A1 promoter] which results in increased expression of CYP17A1 mRNA] which results in increased abundance of Androstenedione]22155568
D000735AndrostenedioneFSHB protein promotes the reaction [[[NR5A1 protein binds to STAR promoter] which results in increased expression of STAR mRNA] which results in increased abundance of Androstenedione]22155568
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of NR5A1 mRNA]18602937
D001280AtrazineAtrazine binds to and results in increased activity of NR5A1 protein17331471
D001280AtrazineAtrazine binds to NR5A1 protein17520059
D001280AtrazineAtrazine promotes the reaction [[NR5A1 protein binds to CYP19A1 gene] which results in increased expression of CYP19A1 mRNA]17520059
D001280AtrazineAtrazine results in increased expression of NR5A1 mRNA17520059|2237831
D001280AtrazineAtrazine results in increased expression of NR5A1 protein17520059
D001280AtrazineAtrazine results in increased phosphorylation of NR5A1 protein18461179
D001280AtrazineNR5A1 protein affects the reaction [Atrazine results in increased expression of CYP19A1 mRNA]18461179
D001280AtrazineNR5A1 protein affects the reaction [Atrazine results in increased expression of LHB mRNA]18461179
D001280AtrazineNR5A1 protein promotes the reaction [Atrazine results in increased expression of CYP11A1 mRNA]18461179
D001280AtrazineNR5A1 protein promotes the reaction [Atrazine results in increased expression of CYP19A1 mRNA]17331471
D001280AtrazineNR5A1 protein promotes the reaction [Atrazine results in increased expression of HSD11B2 mRNA]18461179
D001280AtrazineNR5A1 protein promotes the reaction [Atrazine results in increased expression of INHA mRNA]18461179
D001280AtrazineNR5A1 protein promotes the reaction [Atrazine results in increased expression of STAR mRNA]18461179
D001280AtrazineAtrazine results in increased activity of NR5A1 protein18461179
D001280AtrazineAtrazine results in decreased expression of NR5A1 mRNA19541795
D001280AtrazineAtrazine results in increased expression of NR5A1 mRNA20667998
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NR5A1 mRNA17520059
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to NR5A1 promoter]19654925
D004958Estradiol[4-(heptyloxy)phenol results in increased activity of NR5A1 protein] which results in increased abundance of Estradiol23481593
D004958EstradiolEstradiol results in increased expression of NR5A1 mRNA23747749
D004958EstradiolEstradiol results in increased activity of NR5A1 protein19549922
D004958EstradiolNR5A1 protein results in decreased susceptibility to Estradiol20045459
D004958EstradiolU 0126 inhibits the reaction [Estradiol results in increased activity of NR5A1 protein]19549922
D004958Estradiolwortmannin inhibits the reaction [Estradiol results in increased activity of NR5A1 protein]19549922
D004958EstradiolEstradiol affects the expression of NR5A1 mRNA29092056
D004958Estradiol[NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased abundance of Estradiol21610156
C006780bisphenol Abisphenol A results in decreased expression of NR5A1 mRNA20064783
C006780bisphenol Abisphenol A affects the methylation of NR5A1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of NR5A1 mRNA22875908|2909205
C006780bisphenol Abisphenol A results in increased expression of NR5A1 mRNA21123812
C006780bisphenol Abisphenol A affects the expression of NR5A1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NR5A1 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate[20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] promotes the reaction [NR5A1 protein binds to MC2R promoter]21610156
D0151248-Bromo Cyclic Adenosine Monophosphate[NR5A1 protein co-treated with 20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased abundance of Progesterone21610156
D0151248-Bromo Cyclic Adenosine Monophosphate[NR5A1 protein co-treated with 20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP11A1 mRNA21610156
D0151248-Bromo Cyclic Adenosine Monophosphate[NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] affects the expression of HSD17B2 mRNA21610156
D0151248-Bromo Cyclic Adenosine Monophosphate[NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased abundance of Estradiol21610156
D0151248-Bromo Cyclic Adenosine Monophosphate[NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased abundance of Progesterone21610156
D0151248-Bromo Cyclic Adenosine Monophosphate[NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased abundance of Testosterone21610156
D0151248-Bromo Cyclic Adenosine Monophosphate[NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP11A1 mRNA21610156
D0151248-Bromo Cyclic Adenosine Monophosphate[NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP11B1 mRNA21610156
D0151248-Bromo Cyclic Adenosine Monophosphate[NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP17A1 mRNA21610156
D0151248-Bromo Cyclic Adenosine Monophosphate[NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP19A1 mRNA21610156
D0151248-Bromo Cyclic Adenosine Monophosphate[NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP21A1 mRNA21610156
D0151248-Bromo Cyclic Adenosine Monophosphate[NR5A1 protein co-treated with LIF protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Tretinoin] results in increased abundance of Progesterone21610156
C038091butylparabenbutylparaben results in decreased expression of NR5A1 mRNA27122241
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [LHB protein results in increased expression of NR5A1 protein]23146792
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [NR5A1 protein binds to STAR promoter]25786521
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of NR5A1 protein25786521
D002110CaffeineCaffeine results in decreased expression of NR5A1 mRNA24717552
D002110CaffeineCaffeine results in decreased expression of NR5A1 protein24717552
D002110CaffeineCaffeine results in increased methylation of NR5A1 promoter24717552
C074702chromium hexavalent ionAscorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of NR5A1 mRNA]18602937
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of NR5A1 mRNA18602937
D005576ColforsinColforsin affects the expression of NR5A1 mRNA20726872
C004742daidzeindecitabine inhibits the reaction [[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA]28964809
C004742daidzein[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA28964809
C004742daidzein[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 protein28964809
C004742daidzein[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased methylation of NR5A1 promoter28964809
C013908daidzindecitabine inhibits the reaction [[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA]28964809
C013908daidzin[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA28964809
C013908daidzin[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 protein28964809
C013908daidzin[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased methylation of NR5A1 promoter28964809
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of NR5A1 mRNA26602377
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of NR5A1 protein26602377
C014347decitabinedecitabine affects the methylation of NR5A1 promoter17519303
C014347decitabinedecitabine inhibits the reaction [[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA]28964809
C014347decitabinedecitabine results in increased expression of NR5A1 mRNA28964809
C007262deoxynivalenoldeoxynivalenol results in decreased expression of NR5A1 mRNA22982764
D003976DiazinonDiazinon results in increased methylation of NR5A1 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate inhibits the reaction [NR5A1 binds to CYP11A1 promoter]17884934
D003993Dibutyl PhthalateDibutyl Phthalate inhibits the reaction [NR5A1 binds to CYP17A1 promoter]17884934
D003993Dibutyl PhthalateDibutyl Phthalate inhibits the reaction [NR5A1 binds to STAR promoter]17884934
D003993Dibutyl PhthalateDibutyl Phthalate inhibits the reaction [NR5A1 protein binds to CYP11A1 promoter]23358192
D003993Dibutyl PhthalateDibutyl Phthalate inhibits the reaction [NR5A1 protein binds to CYP17A1 promoter]23358192
D003993Dibutyl PhthalateDibutyl Phthalate inhibits the reaction [NR5A1 protein binds to STAR promoter]23358192
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NR5A1 mRNA17379624|2126653
D003994BucladesineBucladesine inhibits the reaction [CTBP1 protein binds to NR5A1 protein]18184656
D003994BucladesineNR0B1 protein inhibits the reaction [NR5A1 protein promotes the reaction [Bucladesine results in increased expression of STAR mRNA]]18787026
D003994BucladesineNR5A1 protein promotes the reaction [Bucladesine results in increased expression of STAR mRNA]18787026
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene affects the expression of NR5A1 mRNA16707152
D004026DieldrinDieldrin affects the expression of NR5A1 mRNA16707152
D019422Dietary SucroseDietary Sucrose results in increased expression of NR5A1 mRNA26033743
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of NR5A1 mRNA16690193
C007379diethyl phthalatediethyl phthalate inhibits the reaction [NR5A1 binds to CYP17A1 promoter]17884934
C007379diethyl phthalatediethyl phthalate inhibits the reaction [NR5A1 binds to STAR promoter]17884934
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of NR5A1 mRNA22100434
D004726EndosulfanEndosulfan results in increased expression of NR5A1 mRNA23747749
D004726Endosulfan[Endosulfan co-treated with Flutamide] results in increased expression of NR5A1 mRNA22227439
D004726EndosulfanEndosulfan results in decreased expression of NR5A1 mRNA22307005
D004726EndosulfanEndosulfan results in increased expression of NR5A1 mRNA22227439
D004726Endosulfan[Flutamide co-treated with Endosulfan] results in decreased expression of NR5A1 mRNA22307005
D000431EthanolEthanol affects the expression of NR5A1 mRNA26188107
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR5A1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NR5A1 mRNA23300682
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of NR5A1 mRNA17222921
D005278FenitrothionFenitrothion results in decreased expression of NR5A1 mRNA26264430
D005278FenitrothionQuercetin inhibits the reaction [Fenitrothion results in decreased expression of NR5A1 mRNA]26264430
D005411Flame RetardantsFlame Retardants results in decreased expression of NR5A1 mRNA23347875
D005485Flutamide[Endosulfan co-treated with Flutamide] results in increased expression of NR5A1 mRNA22227439
D005485Flutamide[Flutamide co-treated with Endosulfan] results in decreased expression of NR5A1 mRNA22307005
D005485FlutamideFlutamide results in decreased expression of NR5A1 mRNA22307005
D005485FlutamideFlutamide results in increased expression of NR5A1 mRNA22227439
D005485FlutamideFlutamide results in decreased expression of NR5A1 mRNA17222921
D019833Genistein[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of NR5A1 mRNA27181934
D019833Genisteindecitabine inhibits the reaction [[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA]28964809
D019833Genistein[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA28964809
D019833Genistein[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 protein28964809
D019833Genistein[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased methylation of NR5A1 promoter28964809
C040641genistindecitabine inhibits the reaction [[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA]28964809
C040641genistin[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA28964809
C040641genistin[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 protein28964809
C040641genistin[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased methylation of NR5A1 promoter28964809
C086566glyciteindecitabine inhibits the reaction [[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA]28964809
C086566glycitein[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA28964809
C086566glycitein[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 protein28964809
C086566glycitein[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased methylation of NR5A1 promoter28964809
C433283glycitindecitabine inhibits the reaction [[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA]28964809
C433283glycitin[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA28964809
C433283glycitin[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 protein28964809
C433283glycitin[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased methylation of NR5A1 promoter28964809
C010974glyphosateglyphosate results in increased expression of NR5A1 protein24617544
C516216GSK 8470GSK 8470 binds to and results in increased activity of NR5A1 protein17154495
C089796hexabromocyclododecane[hexabromocyclododecane co-treated with CGA protein] results in decreased expression of NR5A1 mRNA25447410
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of NR5A1 mRNA23347875|2544741
C082359imidaclopridimidacloprid results in decreased expression of NR5A1 mRNA27914857
C016599mono-(2-ethylhexyl)phthalate[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of NR5A1 mRNA27181934
D009538NicotineNicotine results in decreased expression of NR5A1 mRNA24709674
D009538NicotineNicotine results in decreased expression of NR5A1 protein24709674
D009538Nicotinetrichostatin A inhibits the reaction [Nicotine results in decreased expression of NR5A1 mRNA]24709674
D009538NicotineNicotine results in decreased expression of NR5A1 mRNA24709674|2898617
D009538NicotineNicotine results in decreased expression of NR5A1 protein24709674|2898617
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of NR5A1 mRNA23399300
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of NR5A1 protein23399300
D015232DinoprostoneDinoprostone promotes the reaction [NR5A1 protein binds to CYP19A1 promoter]19001523
D015232DinoprostoneDinoprostone promotes the reaction [NR5A1 protein binds to STAR promoter]19001523
D019800PhenolPhenol inhibits the reaction [LHB protein results in increased expression of NR5A1 protein]23423282
D010795Phthalic AcidsPhthalic Acids results in decreased expression of NR5A1 mRNA22112501
D010936Plant ExtractsPlant Extracts results in decreased expression of NR5A1 mRNA23557933
D044945ProanthocyanidinsProanthocyanidins inhibits the reaction [quinocetone metabolite affects the expression of NR5A1 mRNA]26802905
D011374Progesterone[4-(heptyloxy)phenol results in increased activity of NR5A1 protein] which results in increased abundance of Progesterone23481593
D011374ProgesteroneFSHB protein promotes the reaction [[[NR5A1 protein binds to CYP17A1 promoter] which results in increased expression of CYP17A1 mRNA] which results in increased abundance of Progesterone]22155568
D011374ProgesteroneFSHB protein promotes the reaction [[[NR5A1 protein binds to STAR promoter] which results in increased expression of STAR mRNA] which results in increased abundance of Progesterone]22155568
D011374ProgesteroneNR5A1 protein results in increased abundance of Progesterone20045459
D011374Progesterone[NR5A1 protein co-treated with 20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased abundance of Progesterone21610156
D011374Progesterone[NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased abundance of Progesterone21610156
D011374Progesterone[NR5A1 protein co-treated with LIF protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Tretinoin] results in increased abundance of Progesterone21610156
D011441PropylthiouracilPropylthiouracil promotes the reaction [NR5A1 protein binds to STAR promoter]20924043
D019289Pyruvic AcidPyruvic Acid inhibits the reaction [CTBP1 protein binds to NR5A1 protein]18184656
D019289Pyruvic AcidPyruvic Acid promotes the reaction [NR5A1 protein binds to CYP17A1 promoter]18184656
D011794QuercetinQuercetin inhibits the reaction [Fenitrothion results in decreased expression of NR5A1 mRNA]26264430
D011794QuercetinQuercetin inhibits the reaction [Zinc Oxide analog results in decreased expression of NR5A1 mRNA]27111109
D011794QuercetinQuercetin results in increased expression of NR5A1 mRNA27111109
C502851quinocetoneProanthocyanidins inhibits the reaction [quinocetone metabolite affects the expression of NR5A1 mRNA]26802905
C502851quinocetonequinocetone metabolite affects the expression of NR5A1 mRNA26802905
D012839SimazineSimazine results in increased expression of NR5A1 mRNA17520059
D014284TriiodothyronineTriiodothyronine affects the expression of NR5A1 mRNA17403546
D013605T-2 ToxinT-2 Toxin results in decreased expression of NR5A1 mRNA22982764
D013629TamoxifenTamoxifen analog results in increased activity of NR5A1 protein19549922
D013629TamoxifenTamoxifen analog results in increased phosphorylation of NR5A1 protein19549922
D013739Testosterone[NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased abundance of Testosterone21610156
D013739TestosteroneTestosterone deficiency results in increased expression of NR5A1 mRNA8940405
D013739TestosteroneTestosterone inhibits the reaction [Testosterone deficiency results in increased expression of NR5A1 mRNA]8940405
C004648testosterone enanthatetestosterone enanthate results in decreased expression of NR5A1 mRNA21427060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NR5A1 mRNA24058054
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR5A1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NR5A1 mRNA16254025
D013755Tetradecanoylphorbol AcetateNR0B1 protein inhibits the reaction [NR5A1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAR mRNA]]18787026
D013755Tetradecanoylphorbol AcetateNR5A1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAR mRNA]18787026
D014212Tretinoin[20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] promotes the reaction [NR5A1 protein binds to MC2R promoter]21610156
D014212Tretinoin[NR5A1 protein co-treated with 20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased abundance of Progesterone21610156
D014212Tretinoin[NR5A1 protein co-treated with 20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP11A1 mRNA21610156
D014212Tretinoin[NR5A1 protein co-treated with LIF protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Tretinoin] results in increased abundance of Progesterone21610156
D014212TretinoinTretinoin results in decreased expression of NR5A1 mRNA16604517|1678809
C012589trichostatin Atrichostatin A inhibits the reaction [Nicotine results in decreased expression of NR5A1 mRNA]24709674
C012589trichostatin Atrichostatin A results in increased expression of NR5A1 mRNA24709674
C113580U 0126U 0126 inhibits the reaction [Estradiol results in increased activity of NR5A1 protein]19549922
D014635Valproic AcidValproic Acid results in increased methylation of NR5A1 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the expression of NR5A1 mRNA23940539
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of NR5A1 mRNA16788563
C025643vinclozolinvinclozolin results in decreased expression of NR5A1 mRNA18042343
C009687wortmanninwortmannin inhibits the reaction [Estradiol results in increased activity of NR5A1 protein]19549922
D015034Zinc OxideQuercetin inhibits the reaction [Zinc Oxide analog results in decreased expression of NR5A1 mRNA]27111109
D015034Zinc OxideZinc Oxide analog results in decreased expression of NR5A1 mRNA27111109
D015039ZiramZiram results in decreased expression of NR5A1 mRNA28973382
D015039ZiramZiram results in decreased expression of NR5A1 protein28973382

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA23610160  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-ISS-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-IDA10567391  
GO:0003682chromatin binding-IBA21873635  
GO:0003682chromatin binding-ISS-  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IDA21412441  
GO:0003707steroid hormone receptor activity-IEA-  
GO:0003713transcription coactivator activity-TAS8205615  
GO:0004879nuclear receptor activity-IBA21873635  
GO:0004879nuclear receptor activity-IDA23610160  
GO:0005515protein binding-IPI10567391  14701856  16709599  17664281  21220346  23610160  
25416956  25910212  
GO:0005543phospholipid binding-IDA17664281  
GO:0008270zinc ion binding-IEA-  
GO:0019899enzyme binding-IPI17664281  
GO:0043565sequence-specific DNA binding-IDA27378692  
GO ID GO Term Qualifier Evidence PubMed
GO:0001553luteinization-IEA-  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0007267cell-cell signaling-TAS10369247  
GO:0007530sex determination-IMP24405868  27378692  27490115  27610946  27855412  
GO:0007538primary sex determination-TAS9590178  
GO:0008584male gonad development-IMP27378692  
GO:0008585female gonad development-IMP27378692  
GO:0009755hormone-mediated signaling pathway-IBA21873635  
GO:0009888tissue development-IBA21873635  
GO:0010259multicellular organism aging-IEA-  
GO:0010628positive regulation of gene expression-IDA27378692  
GO:0010628positive regulation of gene expression-IMP23610160  
GO:0030154cell differentiation-IEA-  
GO:0030325adrenal gland development-IEA-  
GO:0030522intracellular receptor signaling pathway-IEA-  
GO:0042445hormone metabolic process-IEA-  
GO:0043401steroid hormone mediated signaling pathway-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IGI23610160  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP17664281  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0050810regulation of steroid biosynthetic process-TAS10567391  
GO:0051457maintenance of protein location in nucleus-IEA-  
GO:0097210response to gonadotropin-releasing hormone-IEA-  
GO:0097720calcineurin-mediated signaling-IEA-  
GO:2000020positive regulation of male gonad development-IDA21412441  
GO:2000195negative regulation of female gonad development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10567391  10848616  17664281  
GO:0005654nucleoplasm-TAS-  
GO:0090575RNA polymerase II transcription factor complex-IBA21873635  
GO:0090575RNA polymerase II transcription factor complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-383280Nuclear Receptor transcription pathwayTAS
R-HSA-452723Transcriptional regulation of pluripotent stem cellsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29429410The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester. (2018 Feb 12)Johnston ZCBMC Med