Gene: FUCA1

2517
FUCA
alpha-L-fucosidase 1
protein-coding
1p36.11
Ensembl:ENSG00000179163 MIM:612280 Vega:OTTHUMG00000002965 UniprotKB:P04066
NG_013346.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.007e-1 (AD)  5.032e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPP1R20.878
HACL10.875
HMG20A0.873
VMP10.871
SCFD10.863
ADPGK0.862
CDC420.862
C5orf150.86
HEXB0.859
TSNAX0.858

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.517
OR4F29-0.473
FOXJ1-0.335
WDR38-0.324
FAM151A-0.316
C7orf61-0.312
ZBTB20-0.309
MIA-0.305
MTRNR2L6-0.304
MTRNR2L9-0.297

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C52473317-ethynyl-5-androstene-3, 7, 17-triol"17-ethynyl-5-androstene-3, 7, 17-triol binds to FUCA1 protein"22384159
C0319031-UFT protocolFUCA1 protein results in increased susceptibility to 1-UFT protocol16734730
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FUCA1 mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of FUCA1 mRNA"23146750
D000082AcetaminophenAcetaminophen affects the expression of FUCA1 mRNA25458485
D000082AcetaminophenAcetaminophen results in increased expression of FUCA1 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FUCA1 mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of FUCA1 mRNA"23195993
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of FUCA1 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FUCA1 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of FUCA1 mRNA20458559
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FUCA1 mRNA26001963
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene results in increased expression of FUCA1 mRNA]20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FUCA1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to FUCA1 promoter]19654925
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of FUCA1 mRNA"20382639
C006780bisphenol Abisphenol A affects the expression of FUCA1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of FUCA1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of FUCA1 mRNA26496021
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of FUCA1 mRNA18804290
D000069287CapecitabineFUCA1 protein results in increased susceptibility to Capecitabine16734730
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of FUCA1 mRNA17484886
D002994ClofibrateClofibrate results in decreased expression of FUCA1 mRNA17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of FUCA1 mRNA19549813
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of FUCA1 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of FUCA1 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of FUCA1 mRNA20106945|2556210
C014347decitabinedecitabine affects the expression of FUCA1 mRNA23300844
D003703DemecolcineDemecolcine results in increased expression of FUCA1 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FUCA1 mRNA21266533
D002945CisplatinCisplatin affects the expression of FUCA1 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of FUCA1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of FUCA1 mRNA19561079|2739243
D004147DioxinsDioxins affects the expression of FUCA1 mRNA20463971
C025034doxifluridineFUCA1 protein results in increased susceptibility to doxifluridine16734730
D000431EthanolEthanol results in increased expression of FUCA1 mRNA24355176
D000431EthanolEthanol results in increased expression of FUCA1 mRNA28069986
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FUCA1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FUCA1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FUCA1 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of FUCA1 mRNA23649840
D005485FlutamideFlutamide results in decreased expression of FUCA1 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of FUCA1 mRNA23649840
C546771gardiquimodgardiquimod results in decreased expression of FUCA1 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of FUCA1 mRNA]28003376
D017313FenretinideFenretinide results in increased expression of FUCA1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FUCA1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of FUCA1 mRNA27392435
C410337K 7174K 7174 results in increased expression of FUCA1 mRNA24086573
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of FUCA1 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of FUCA1 mRNA25613284
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of FUCA1 mRNA16966085
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of FUCA1 mRNA23649840
D009532NickelNickel results in decreased expression of FUCA1 mRNA23195993
C029938nickel sulfatenickel sulfate results in decreased expression of FUCA1 mRNA16780908
C012655nimesulidenimesulide results in decreased expression of FUCA1 mRNA24136188
D011374ProgesteroneProgesterone results in increased expression of FUCA1 mRNA23018184
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of FUCA1 mRNA]28003376
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of FUCA1 mRNA19167446
C079198S 1 (combination)FUCA1 protein results in increased susceptibility to S 1 (combination)16734730
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FUCA1 mRNA25895662
C061133tamibarotenetamibarotene results in increased expression of FUCA1 mRNA15498508
D013629TamoxifenTamoxifen affects the expression of FUCA1 mRNA17555576
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of FUCA1 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FUCA1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FUCA1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FUCA1 mRNA17942748|1946511
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FUCA1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FUCA1 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FUCA1 mRNA28065790
D019772TopotecanFUCA1 protein affects the susceptibility to Topotecan16217747
D014212TretinoinTretinoin results in increased expression of FUCA1 mRNA15498508|2383079
D014635Valproic AcidValproic Acid affects the expression of FUCA1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of FUCA1 mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FUCA1 gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of FUCA1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004560alpha-L-fucosidase activity-IBA21873635  
GO:0004560alpha-L-fucosidase activity-IDA19666478  
GO:0004560alpha-L-fucosidase activity-TAS11698403  
GO ID GO Term Qualifier Evidence PubMed
GO:0006004fucose metabolic process-IBA21873635  
GO:0006004fucose metabolic process-IDA19666478  
GO:0006027glycosaminoglycan catabolic process-NAS11698403  
GO:0016139glycoside catabolic process-IBA21873635  
GO:0016139glycoside catabolic process-IDA19666478  
GO:0019377glycolipid catabolic process-ISS-  
GO:0043312neutrophil degranulation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005737cytoplasm-TAS4074382  
GO:0005764lysosome-IBA21873635  
GO:0035578azurophil granule lumen-TAS-  
GO:0043202lysosomal lumen-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa00511Other glycan degradation
hsa04142Lysosome
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS
R-HSA-975576N-glycan antennae elongation in the medial/trans-GolgiTAS
R-HSA-975578Reactions specific to the complex N-glycan synthesis pathwayTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26614807Identification of gene expression signature for cigarette smoke exposure response--from man to mouse. (2015 Dec)Martin FHum Exp Toxicol
27154971The Effect of Different Case Definitions of Current Smoking on the Discovery of Smoking-Related Blood Gene Expression Signatures in Chronic Obstructive Pulmonary Disease. (2016 Sep)Obeidat MNicotine Tob Res