Gene: FUS

2521
ALS6|ETM4|FUS1|HNRNPP2|POMP75|TLS
FUS RNA binding protein
protein-coding
16p11.2
Ensembl:ENSG00000089280 MIM:137070 Vega:OTTHUMG00000132395 UniprotKB:P35637
NG_012889.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.122e-1 (AD)  2.369e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EWSR10.93
TAF150.92
PDAP10.915
APEX10.915
THRAP30.913
CAPZB0.913
ILF30.908
EIF4H0.907
DBNL0.907
IK0.907

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.805
OR4F29-0.786
MTRNR2L6-0.289
MTRNR2L9-0.276
MTRNR2L10-0.218
MOGAT2-0.216
PPBP-0.211
MICB-0.199
PRAMEF8-0.197
CLEC2B-0.194

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of FUS mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FUS mRNA"21354444
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of FUS mRNA"22101062
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of FUS mRNA"25565004
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of FUS mRNA"19095052
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FUS mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of FUS mRNA"28973690
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of FUS mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FUS mRNA"27188386
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of FUS mRNA20829426
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FUS mRNA"27188386
C496492abrineabrine results in decreased expression of FUS mRNA22595364
D000082AcetaminophenAcetaminophen results in increased expression of FUS mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of FUS mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of FUS mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FUS mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FUS mRNA19770486
D001151ArsenicArsenic results in decreased expression of FUS mRNA19654921
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of FUS mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FUS mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FUS mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of FUS mRNA"20018196
C006780bisphenol Abisphenol A affects the expression of FUS mRNA21786754
C006780bisphenol Abisphenol A affects the expression of FUS mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of FUS mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of FUS mRNA26063408
C006780bisphenol Abisphenol A affects the expression of FUS mRNA21786754
C006780bisphenol Abisphenol A affects the expression of FUS mRNA25181051
D002065BuspironeBuspirone results in decreased expression of FUS mRNA24136188
C026105butylidenephthalidebutylidenephthalide results in increased expression of FUS protein23770345
D002104CadmiumCadmium results in increased expression of FUS mRNA21120746
C026690cerous chloridecerous chloride results in increased expression of FUS mRNA23573234
D002737ChloropreneChloroprene results in decreased expression of FUS mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FUS mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of FUS mRNA28472532
D002922CiguatoxinsCiguatoxins affects the expression of FUS mRNA18353800
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of FUS mRNA20971185
D003300Copper[Thiosemicarbazones binds to Copper] which results in increased expression of FUS protein20931265
D003474CurcuminCurcumin results in decreased expression of FUS mRNA17999991
D003474CurcuminCurcumin results in increased expression of FUS mRNA17198877
D016572CyclosporineCyclosporine results in decreased expression of FUS mRNA21632981|2556210
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of FUS mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of FUS mRNA22733784
D003976DiazinonDiazinon results in increased methylation of FUS gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FUS mRNA17361019|2126653
D002945CisplatinCisplatin results in decreased expression of FUS mRNA27594783
D004041Dietary FatsDietary Fats results in increased expression of FUS mRNA25016146
D002117CalcitriolCalcitriol results in decreased expression of FUS mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of FUS mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene affects the expression of FUS mRNA"21785161
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of FUS mRNA"19480007
D004391DustDust results in decreased expression of FUS mRNA17805423
C118739entinostatentinostat results in decreased expression of FUS mRNA27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of FUS protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FUS mRNA20170705
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of FUS mRNA23649840
C000499ferric oxideferric oxide analog results in decreased expression of FUS mRNA25086211
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FUS mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of FUS mRNA20655997
D005897GlafenineGlafenine results in increased expression of FUS mRNA24136188
D017313FenretinideFenretinide results in increased expression of FUS mRNA28973697
C492448ICG 001ICG 001 results in increased expression of FUS mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FUS mRNA25613284
D007545IsoproterenolIsoproterenol results in decreased expression of FUS mRNA20003209
D007854LeadLead results in increased expression of FUS mRNA19921347
C045463leflunomideleflunomide results in decreased expression of FUS mRNA28988120
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of FUS mRNA26378955
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of FUS mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of FUS mRNA26378955
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FUS mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of FUS mRNA24449571
D008731MethoxychlorMethoxychlor affects the expression of FUS mRNA20829426
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FUS mRNA20375079
C031721naphthalenenaphthalene results in decreased expression of FUS mRNA14595851
C051752nefazodonenefazodone results in decreased expression of FUS mRNA24136188
C029938nickel sulfatenickel sulfate results in increased expression of FUS mRNA18651567
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of FUS mRNA20971185
C005290oxybenzoneoxybenzone results in increased expression of FUS mRNA22721600
C008776pelargonic acidpelargonic acid results in increased expression of FUS mRNA11379042
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of FUS mRNA19095052
D010634PhenobarbitalPhenobarbital results in decreased expression of FUS mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of FUS mRNA16985257|1844570
C045950propiconazolepropiconazole results in decreased expression of FUS mRNA21278054
D012643SeleniumSelenium results in increased expression of FUS mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FUS mRNA23806026|2589566
D012822Silicon DioxideSilicon Dioxide results in decreased expression of FUS mRNA19073995
C009277sodium arsenatesodium arsenate results in increased expression of FUS mRNA21795629
C017947sodium arsenitesodium arsenite affects the expression of FUS mRNA29319823
D012969Sodium FluorideSodium Fluoride results in decreased expression of FUS protein28918527
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of FUS mRNA26378955
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of FUS mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of FUS mRNA26378955
D013629TamoxifenTamoxifen results in decreased expression of FUS mRNA16202921
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of FUS mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of FUS mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FUS mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FUS mRNA25613284
D013882Thiosemicarbazones[Thiosemicarbazones binds to Copper] which results in increased expression of FUS protein20931265
C009495titanium dioxidetitanium dioxide results in decreased expression of FUS mRNA23557971
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in decreased expression of FUS mRNA"11379042
D014212TretinoinTretinoin results in decreased expression of FUS mRNA16249480
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FUS mRNA"27188386
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of FUS mRNA"23306105
C031324tris(chloroethyl)phosphatetris(chloroethyl)phosphate results in increased expression of FUS mRNA27776230
C057693troglitazonetroglitazone results in decreased expression of FUS mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of FUS mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of FUS gene25560391
D014810Vitamin EVitamin E results in increased expression of FUS mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003712transcription coregulator activity-IBA21873635  
GO:0003713transcription coactivator activity-IDA21909421  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI9774382  15975576  18509338  18954305  20085233  21988832  
22240165  22778397  23232809  23975937  
GO:0030331estrogen receptor binding-IEA-  
GO:0031489myosin V binding-IEA-  
GO:0035255ionotropic glutamate receptor binding-IEA-  
GO:0042802identical protein binding-IPI18509338  23975937  
GO:0046872metal ion binding-IEA-  
GO:0046965retinoid X receptor binding-IEA-  
GO:0046966thyroid hormone receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0071277cellular response to calcium ion-IEA-  
GO:1903508positive regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA16365397  21909421  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005844polysome-IEA-  
GO:0043204perikaryon-IEA-  
GO:0044327dendritic spine head-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20472259[Research in amyotrophic lateral sclerosis: what is new in 2009?]. (2010 Aug-Sep)Pradat PFRev Neurol (Paris)