Gene: FUT2

2524
B12QTL1|SE|SEC2|Se2|sej
fucosyltransferase 2
protein-coding
19q13.33
Ensembl:ENSG00000176920 MIM:182100 Vega:OTTHUMG00000164427 UniprotKB:Q10981
NG_007511.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.405e-1 (AD)  8.489e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACOT110.633
LRP10.604
SPDYE10.597
MAMDC40.592
RYR10.589
COL5A30.586
C9orf1310.577
ERVH48-10.565
ADAM330.563
ADAMTS170.562

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ITGB6-0.332
LACC1-0.316
C9orf135-0.312
STARD6-0.311
HMSD-0.294
TRPM8-0.291
OR4F5-0.277
LCE2A-0.271
KLHL4-0.267
C11orf88-0.262

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of FUT2 mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FUT2 mRNA"19114083
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of FUT2 mRNA21983209
D000082AcetaminophenAcetaminophen affects the expression of FUT2 mRNA17562736
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of FUT2 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FUT2 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of FUT2 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FUT2 mRNA22228805
D004958EstradiolEstradiol results in increased expression of FUT2 mRNA15289156|1948475
C006780bisphenol Abisphenol A results in decreased expression of FUT2 mRNA25181051
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FUT2 mRNA20360939
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of FUT2 mRNA28472532
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of FUT2 mRNA23640034
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of FUT2 mRNA23640034|2391405
D004041Dietary FatsDietary Fats results in decreased expression of FUT2 mRNA28031460
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FUT2 mRNA20360939
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of FUT2 mRNA15289156
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of FUT2 mRNA21658437
C039281furanfuran results in increased expression of FUT2 mRNA27387713
D019833GenisteinGenistein results in increased expression of FUT2 mRNA15289156
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FUT2 mRNA26752646
D007840LatexLatex analog results in increased expression of FUT2 mRNA24768652
D009532NickelNickel results in increased expression of FUT2 mRNA25583101
C028007nickel monoxidenickel monoxide results in decreased expression of FUT2 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of FUT2 mRNA25729387
D010269ParaquatParaquat results in increased expression of FUT2 mRNA17077588
D010634PhenobarbitalPhenobarbital affects the expression of FUT2 mRNA19136022
C006253pirinixic acidpirinixic acid affects the expression of FUT2 mRNA19136022
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FUT2 mRNA16704738
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FUT2 mRNA21570461
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of FUT2 mRNA25729387
D014805Vitamin B 12FUT2 gene polymorphism affects the abundance of Vitamin B 1218776911

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008107galactoside 2-alpha-L-fucosyltransferase activity-IBA21873635  
GO:0008107galactoside 2-alpha-L-fucosyltransferase activity-TAS11698403  
GO:0008417fucosyltransferase activity-TAS7876235  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-TAS7876235  
GO:0006486protein glycosylation-IBA21873635  
GO:0006486protein glycosylation-IEA-  
GO:0006486protein glycosylation-TAS11698403  
GO:0036065fucosylation-IBA21873635  
GO:0036065fucosylation-IEA-  
GO:0042355L-fucose catabolic process-NAS11698403  
GO ID GO Term Qualifier Evidence PubMed
GO:0005794Golgi apparatus-TAS11698403  
GO:0016021integral component of membrane-IEA-  
GO:0032580Golgi cisterna membrane-IEA-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
hsa00601Glycosphingolipid biosynthesis - lacto and neolacto series
hsa00603Glycosphingolipid biosynthesis - globo series
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26646561Combinations of FUT2 gene polymorphisms and environmental factors are associated with oral cancer risk. (2016 May)Su KJTumour Biol