Gene: FUT3

2525
CD174|FT3B|FucT-III|LE|Les
fucosyltransferase 3 (Lewis blood group)
protein-coding
19p13.3
Ensembl:ENSG00000171124 MIM:111100 Vega:OTTHUMG00000180614 UniprotKB:P21217
NG_007482.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.574e-2 (AD)  7.015e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DLX40.745
IGFL10.629
FUT50.608
CR20.608
PYY0.607
CDH30.582
PRSS550.581
OVOL10.58
CLEC4F0.572
DONSON0.558

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT7A-0.352
ARSE-0.327
ZNF469-0.303
GDF11-0.302
C1QTNF2-0.299
LRRN1-0.292
DUSP19-0.289
RERGL-0.285
VIT-0.277
ETV5-0.275

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C006632arsenic trioxideFUT3 protein results in decreased susceptibility to arsenic trioxide20707922
D004958EstradiolEstradiol results in increased expression of FUT3 mRNA23019147
D002104CadmiumCadmium results in increased expression of FUT3 mRNA21120746
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of FUT3 mRNA24763279
C014347decitabinedecitabine affects the expression of and affects the activity of FUT3 protein16427187
C014347decitabinedecitabine affects the expression of FUT3 mRNA16427187
D002117CalcitriolCalcitriol results in increased expression of FUT3 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of FUT3 mRNA21592394
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of FUT3 mRNA"23811387
D005557FormaldehydeFormaldehyde results in increased expression of FUT3 mRNA27664576
D019833GenisteinGenistein results in increased expression of FUT3 mRNA23019147
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of FUT3 mRNA24763279
C492448ICG 001ICG 001 results in decreased expression of FUT3 mRNA26191083
C045463leflunomideleflunomide results in increased expression of FUT3 mRNA28988120
D009151Mustard GasMustard Gas results in increased expression of FUT3 mRNA25102026
D009285NaphthoquinonesNaphthoquinones results in increased expression of FUT3 mRNA23811387
D009532NickelNickel results in increased expression of FUT3 mRNA25583101
D010936Plant ExtractsPlant Extracts results in decreased expression of FUT3 mRNA23557933
D010938Plant OilsPlant Oils results in decreased expression of FUT3 mRNA23370395
C005556propionaldehydepropionaldehyde results in increased expression of FUT3 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FUT3 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FUT3 mRNA23806026
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of FUT3 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of FUT3 mRNA21592394
D014635Valproic AcidValproic Acid results in increased methylation of FUT3 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008417fucosyltransferase activity-IDA7721776  12668675  
GO:00170603-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity-TAS-  
GO:0046920alpha-(1->3)-fucosyltransferase activity-IBA21873635  
GO:0046920alpha-(1->3)-fucosyltransferase activity-IDA1977660  
GO ID GO Term Qualifier Evidence PubMed
GO:0006486protein glycosylation-IEA-  
GO:0006672ceramide metabolic process-IDA7721776  12668675  
GO:0009312oligosaccharide biosynthetic process-IDA1977660  
GO:0009988cell-cell recognition-IC12668675  
GO:0036065fucosylation-IBA21873635  
GO:0036065fucosylation-IEA-  
GO:0043413macromolecule glycosylation-IDA1977660  12668675  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0016020membrane-IDA1977660  
GO:0016021integral component of membrane-IEA-  
GO:0032580Golgi cisterna membrane-IEA-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
hsa00601Glycosphingolipid biosynthesis - lacto and neolacto series
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS
R-HSA-975576N-glycan antennae elongation in the medial/trans-GolgiTAS
R-HSA-975578Reactions specific to the complex N-glycan synthesis pathwayTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17383304Fucosyltransferase 3 polymorphism and atherothrombotic disease in the Framingham Offspring Study. (2007 Apr)Djousse LAm Heart J