Gene: FUT8

2530
-
fucosyltransferase 8
protein-coding
14q23.3
Ensembl:ENSG00000033170 MIM:602589 Vega:OTTHUMG00000142818 UniprotKB:Q9BYC5
NC_000014.9
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.784e-1 (AD)  4.471e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSEN10.885
CCDC88A0.847
ZFYVE160.842
RNF130.84
KLHL320.84
LRRC8D0.839
STRN0.839
PTK20.838
DYNC1I20.833
ABHD17B0.832

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.557
OR4F5-0.557
FCER2-0.305
SPRR4-0.299
ERVV-2-0.288
MTRNR2L3-0.286
FER1L6-0.28
KRT73-0.279
C8orf74-0.279
DPPA4-0.278

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of FUT8 mRNA"23829299
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FUT8 mRNA"19114083
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of FUT8 mRNA"20713471
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FUT8 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FUT8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FUT8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FUT8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FUT8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FUT8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FUT8 mRNA"27188386
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of FUT8 mRNA]21233418
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of FUT8 mRNA28522335
D001151ArsenicArsenic affects the methylation of FUT8 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FUT8 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FUT8 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FUT8 mRNA"20382639|2623829
D004958EstradiolEstradiol affects the expression of FUT8 mRNA22574217
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FUT8 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of FUT8 mRNA25047013
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FUT8 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of FUT8 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FUT8 mRNA28628672
D002330CarmustineFUT8 mRNA affects the susceptibility to Carmustine16365179
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of FUT8 mRNA23650126
D020245p-Chloromercuribenzoic AcidFucose analog inhibits the reaction [p-Chloromercuribenzoic Acid results in decreased activity of FUT8 protein]12770769
D020245p-Chloromercuribenzoic AcidGuanosine Diphosphate inhibits the reaction [p-Chloromercuribenzoic Acid results in decreased activity of FUT8 protein]12770769
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FUT8 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased activity of FUT8 protein12770769
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of FUT8 mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FUT8 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of FUT8 mRNA19320972
D003042CocaineCocaine affects the expression of FUT8 mRNA20187946
D019327Copper SulfateCopper Sulfate results in decreased expression of FUT8 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of FUT8 mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FUT8 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FUT8 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FUT8 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of FUT8 mRNA19561079
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in increased expression of FUT8 mRNA21858171
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of FUT8 mRNA26924002
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of FUT8 mRNA20524982
D004047Diethyl PyrocarbonateDiethyl Pyrocarbonate results in decreased activity of FUT8 protein12770769
D002117CalcitriolCalcitriol results in decreased expression of FUT8 mRNA26485663
D004147DioxinsDioxins affects the expression of FUT8 mRNA20463971
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FUT8 mRNA22079256
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of FUT8 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of FUT8 mRNA21233418
D005047EtoposideFUT8 protein affects the susceptibility to Etoposide16217747
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FUT8 gene20938992
D005643FucoseFucose analog inhibits the reaction [Mersalyl results in decreased activity of FUT8 protein]12770769
D005643FucoseFucose analog inhibits the reaction [p-Chloromercuribenzoic Acid results in decreased activity of FUT8 protein]12770769
D005643FucoseFucose analog inhibits the reaction [Phenylglyoxal results in decreased activity of FUT8 protein]12770769
D005643FucoseFucose analog inhibits the reaction [Pyridoxal Phosphate results in decreased activity of FUT8 protein]12770769
D005897GlafenineGlafenine results in increased expression of FUT8 mRNA24136188
D006153Guanosine DiphosphateGuanosine Diphosphate inhibits the reaction [Mersalyl results in decreased activity of FUT8 protein]12770769
D006153Guanosine DiphosphateGuanosine Diphosphate inhibits the reaction [p-Chloromercuribenzoic Acid results in decreased activity of FUT8 protein]12770769
D006153Guanosine DiphosphateGuanosine Diphosphate inhibits the reaction [Phenylglyoxal results in decreased activity of FUT8 protein]12770769
D006153Guanosine DiphosphateGuanosine Diphosphate results in decreased activity of FUT8 protein12770769
D006160Guanosine TriphosphateGuanosine Triphosphate results in decreased activity of FUT8 protein12770769
D006157Guanosine MonophosphateGuanosine Monophosphate results in decreased activity of FUT8 protein12770769
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FUT8 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FUT8 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FUT8 mRNA28628672
D007460IodoacetamideIodoacetamide results in decreased activity of FUT8 protein12770769
D007461IodoacetatesIodoacetates results in decreased activity of FUT8 protein12770769
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FUT8 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FUT8 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FUT8 mRNA28628672
C544151jinfukangjinfukang results in increased expression of FUT8 mRNA27392435
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of FUT8 mRNA25613284
D008634MersalylFucose analog inhibits the reaction [Mersalyl results in decreased activity of FUT8 protein]12770769
D008634MersalylGuanosine Diphosphate inhibits the reaction [Mersalyl results in decreased activity of FUT8 protein]12770769
D008634MersalylMersalyl results in decreased activity of FUT8 protein12770769
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FUT8 gene20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of FUT8 mRNA20713471
C014055methyl iodidemethyl iodide results in decreased activity of FUT8 protein12770769
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FUT8 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FUT8 mRNA23649840
C517284monomethyl phthalatemonomethyl phthalate affects the expression of FUT8 mRNA26924002
D009151Mustard GasMustard Gas affects the expression of FUT8 mRNA15651846
C022838nickel chloridenickel chloride results in increased expression of FUT8 mRNA17312168
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of FUT8 mRNA25729387
D010634PhenobarbitalPhenobarbital affects the expression of FUT8 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of FUT8 mRNA19270015
D010658PhenylglyoxalFucose analog inhibits the reaction [Phenylglyoxal results in decreased activity of FUT8 protein]12770769
D010658PhenylglyoxalGuanosine Diphosphate inhibits the reaction [Phenylglyoxal results in decreased activity of FUT8 protein]12770769
D010658PhenylglyoxalPhenylglyoxal results in decreased activity of FUT8 protein12770769
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FUT8 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of FUT8 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of FUT8 mRNA17426115|1830175
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in increased expression of FUT8 mRNA21858171
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FUT8 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of FUT8 mRNA22079256
D011732Pyridoxal PhosphateFucose analog inhibits the reaction [Pyridoxal Phosphate results in decreased activity of FUT8 protein]12770769
D011732Pyridoxal PhosphatePyridoxal Phosphate results in decreased activity of FUT8 protein12770769
D011794QuercetinQuercetin results in decreased expression of FUT8 mRNA21632981
D015474IsotretinoinIsotretinoin results in increased expression of FUT8 mRNA20436886
D013629TamoxifenTamoxifen results in decreased expression of FUT8 mRNA25123088
C047246temozolomideFUT8 mRNA affects the susceptibility to temozolomide16365179
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FUT8 mRNA17555868
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FUT8 mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FUT8 mRNA22298810
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of FUT8 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of FUT8 mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of FUT8 gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FUT8 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of FUT8 mRNA26272509
D014501UraniumUranium affects the expression of FUT8 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of FUT8 mRNA15672453
D014635Valproic AcidValproic Acid affects the expression of FUT8 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions affects the methylation of FUT8 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of FUT8 mRNA20044591
C088658zoledronic acidzoledronic acid results in increased expression of FUT8 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008424glycoprotein 6-alpha-L-fucosyltransferase activity-IDA17172260  
GO:0008424glycoprotein 6-alpha-L-fucosyltransferase activity-TAS11698403  
GO:0017124SH3 domain binding-IEA-  
GO:0046921alpha-(1->6)-fucosyltransferase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001701in utero embryonic development-NAS11698403  
GO:0006487protein N-linked glycosylation-IBA21873635  
GO:0006487protein N-linked glycosylation-TAS9133635  
GO:0006491N-glycan processing-TAS11698403  
GO:0007179transforming growth factor beta receptor signaling pathway-IEA-  
GO:0007229integrin-mediated signaling pathway-IEA-  
GO:0007585respiratory gaseous exchange-IEA-  
GO:0009312oligosaccharide biosynthetic process-TAS9133635  
GO:0010468regulation of gene expression-IEA-  
GO:0016477cell migration-IEA-  
GO:0018279protein N-linked glycosylation via asparagine-IDA17172260  
GO:0033578protein glycosylation in Golgi-IEA-  
GO:0036071N-glycan fucosylation-IBA21873635  
GO:0036071N-glycan fucosylation-IEA-  
GO:0042355L-fucose catabolic process-NAS11698403  
GO:0043112receptor metabolic process-IEA-  
GO:0046368GDP-L-fucose metabolic process-IDA17172260  
GO:1900407regulation of cellular response to oxidative stress-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005794Golgi apparatus-NAS11698403  
GO:0005829cytosol-IDA-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
GO:0032580Golgi cisterna membrane-IEA-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
hsa00510N-Glycan biosynthesis
hsa00533Glycosaminoglycan biosynthesis - keratan sulfate
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS
R-HSA-975576N-glycan antennae elongation in the medial/trans-GolgiTAS
R-HSA-975578Reactions specific to the complex N-glycan synthesis pathwayTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26206179Fucosylated surfactant protein-D is a biomarker candidate for the development of chronic obstructive pulmonary disease. (2015 Sep 8)Ito EJ Proteomics