Gene: RICTOR

253260
AVO3|PIA|hAVO3
RPTOR independent companion of MTOR complex 2
protein-coding
5p13.1
Ensembl:ENSG00000164327 MIM:609022 Vega:OTTHUMG00000162037 UniprotKB:Q6R327
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.867e-1 (AD)  9.749e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAR10.9
C3orf580.893
FNIP10.893
RIF10.887
ZNF4510.887
ZMYM20.885
MON20.884
RPS6KB10.883
UBA60.88
CREBRF0.879

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.532
OR4F29-0.489
PLA2G5-0.336
WNT7B-0.274
LYPD1-0.257
RNF223-0.254
AQP5-0.253
HES5-0.253
RASSF10-0.252
MTRNR2L8-0.244

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of RICTOR mRNA"20453058
C0297284-phenylenediamine4-phenylenediamine results in decreased expression of RICTOR protein26784575
D000082AcetaminophenAcetaminophen results in decreased expression of RICTOR mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RICTOR mRNA19770486
D001280AtrazineAtrazine results in decreased expression of RICTOR mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RICTOR mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RICTOR mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RICTOR mRNA"19150397
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of and results in increased ubiquitination of RICTOR protein25897075
D004958EstradiolRICTOR mutant form inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]23000059
D004958EstradiolRICTOR mutant form inhibits the reaction [Estradiol results in increased phosphorylation of PRKCA protein]23000059
C006780bisphenol Abisphenol A affects the expression of RICTOR mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of RICTOR mRNA27571134
D020122tert-Butylhydroperoxidepioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of RICTOR mRNA]20847119
D020122tert-Butylhydroperoxiderosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of RICTOR mRNA]20847119
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of RICTOR mRNA23410634
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of RICTOR mRNA20847119
D020122tert-Butylhydroperoxide[troglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of RICTOR mRNA20847119
D020122tert-Butylhydroperoxidetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of RICTOR mRNA]20847119
C018475butyraldehydebutyraldehyde results in decreased expression of RICTOR mRNA26079696
C473711Chir 99021Chir 99021 results in increased expression of RICTOR protein25897075
D003010ClorgylineClorgyline results in increased expression of RICTOR mRNA19691856
D003375CoumestrolCoumestrol results in decreased expression of RICTOR mRNA19167446
D003513CycloheximideCycloheximide promotes the reaction [FBXW7 protein binds to and results in decreased expression of RICTOR protein]25897075
D016572CyclosporineCyclosporine results in increased expression of RICTOR mRNA25562108
D002945CisplatinCisplatin results in decreased expression of RICTOR mRNA27594783
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of RICTOR mRNA"27840820
C118739entinostatentinostat results in decreased expression of RICTOR mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RICTOR mRNA29097150
D005557FormaldehydeFormaldehyde results in decreased expression of RICTOR mRNA23322811
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of RICTOR mRNA23410634
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RICTOR mRNA25613284
C544151jinfukangjinfukang results in decreased expression of RICTOR mRNA27392435
D018021Lithium ChlorideFBXW7 protein inhibits the reaction [Lithium Chloride results in increased expression of RICTOR protein]25897075
D018021Lithium ChlorideLithium Chloride results in increased expression of and results in decreased ubiquitination of RICTOR protein25897075
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RICTOR mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RICTOR mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RICTOR mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RICTOR mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of RICTOR mRNA22714537
D010100OxygenOxygen deficiency affects the methylation of RICTOR promoter24205000
D010100OxygenOxygen deficiency results in increased expression of RICTOR mRNA24205000
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of RICTOR protein28288859
C539933pevonedistatpevonedistat results in increased expression of RICTOR protein25897075
D010634PhenobarbitalPhenobarbital results in decreased expression of RICTOR mRNA23091169
C060836pioglitazonepioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of RICTOR mRNA]20847119
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RICTOR mRNA19710929
D011374ProgesteroneProgesterone results in decreased expression of RICTOR mRNA23541542
C089730rosiglitazonerosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of RICTOR mRNA]20847119
C417521SB 216763FBXW7 protein inhibits the reaction [SB 216763 results in increased expression of RICTOR protein]25897075
C417521SB 216763SB 216763 results in increased expression of RICTOR protein25897075
D020123SirolimusSirolimus results in decreased expression of RICTOR protein18776922
C009277sodium arsenatesodium arsenate results in increased expression of RICTOR mRNA21795629
D013739TestosteroneTestosterone results in increased expression of RICTOR mRNA20843997
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RICTOR mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RICTOR mRNA25613284
D014212TretinoinTretinoin results in increased expression of RICTOR mRNA21934132
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of RICTOR mRNA"26179874
C057693troglitazone[troglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of RICTOR mRNA20847119
C057693troglitazonetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of RICTOR mRNA]20847119
C057693troglitazonetroglitazone results in decreased expression of RICTOR mRNA28973697
D014520UrethaneUrethane results in increased expression of RICTOR mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of RICTOR mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of RICTOR mRNA23179753|2519280
D014635Valproic AcidValproic Acid results in decreased methylation of RICTOR gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of RICTOR gene25560391
C025643vinclozolinvinclozolin results in increased expression of RICTOR mRNA23034163
D024483Vitamin K 3Vitamin K 3 affects the expression of RICTOR mRNA23410634

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15467718  17461779  17565979  18339839  18566587  19446321  
19875983  21045808  21339740  21376236  21964062  22307628  
23263282  23953116  24036451  24375676  25897075  27043084  
GO:0008047enzyme activator activity-IBA21873635  
GO:0019901protein kinase binding-IPI21177249  25897075  
GO:0043022ribosome binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001938positive regulation of endothelial cell proliferation-IEA-  
GO:0009792embryo development ending in birth or egg hatching-ISS-  
GO:0010468regulation of gene expression-IEA-  
GO:0018105peptidyl-serine phosphorylation-IGI21177249  
GO:0030010establishment of cell polarity-IBA21873635  
GO:0030838positive regulation of actin filament polymerization-IEA-  
GO:0030950establishment or maintenance of actin cytoskeleton polarity-IBA21873635  
GO:0031532actin cytoskeleton reorganization-IBA21873635  
GO:0031532actin cytoskeleton reorganization-IMP15268862  
GO:0031929TOR signaling-IEA-  
GO:0032008positive regulation of TOR signaling-IMP15467718  
GO:0032148activation of protein kinase B activity-TAS-  
GO:0032956regulation of actin cytoskeleton organization-IBA21873635  
GO:0032956regulation of actin cytoskeleton organization-IMP15467718  
GO:0033135regulation of peptidyl-serine phosphorylation-IEA-  
GO:0042325regulation of phosphorylation-IBA21873635  
GO:0043087regulation of GTPase activity-IEA-  
GO:0050727regulation of inflammatory response-IEA-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IEA-  
GO:0051896regulation of protein kinase B signaling-IDA15718470  
GO:0051897positive regulation of protein kinase B signaling-IBA21873635  
GO:2000114regulation of establishment of cell polarity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0031932TORC2 complex-IBA21873635  
GO:0031932TORC2 complex-IDA15268862  15467718  24036451  
KEGG ID KEGG Term
hsa04150mTOR signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-168256Immune SystemTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389356CD28 co-stimulationTAS
R-HSA-389357CD28 dependent PI3K/Akt signalingTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-5218920VEGFR2 mediated vascular permeabilityTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5674400Constitutive Signaling by AKT1 E17K in CancerTAS
R-HSA-6804757Regulation of TP53 DegradationTAS
R-HSA-6806003Regulation of TP53 Expression and DegradationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25122428Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a comprehensive genomic analysis. (2014 Sep)Umemura SJ Thorac Oncol