Gene: FYB1

2533
ADAP|FYB|PRO0823|SLAP-130|SLAP130|THC3
FYN binding protein 1
protein-coding
5p13.1
Ensembl:ENSG00000082074 MIM:602731 Vega:OTTHUMG00000162071 UniprotKB:O15117
NG_029596.1
SNP Mapped
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.030e-1 (AD)  2.451e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7700754chr5:39252920 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs696748chr5:39213594 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of FYB1 mRNA"24172598
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FYB1 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of FYB1 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of FYB1 mRNA24449571
D001151ArsenicArsenic affects the methylation of FYB1 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of FYB1 mRNA15761015
C028559bathocuproine sulfonate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FYB1 mRNA]15477007
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FYB1 mRNA20064835
C018475butyraldehydebutyraldehyde results in decreased expression of FYB1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FYB1 mRNA26472689
C018021cobaltous chloridecobaltous chloride results in increased expression of FYB1 mRNA19376846
D004237DiuronDiuron metabolite results in increased expression of FYB1 mRNA24172598
D004397FonofosFonofos results in decreased methylation of FYB1 promoter22847954
D015759Ionomycin[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FYB1 mRNA]15477007
D015759Ionomycinpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FYB1 mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FYB1 mRNA15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FYB1 mRNA25613284
C051890irinotecanirinotecan analog results in decreased expression of FYB1 mRNA18927307
D008727MethotrexateMethotrexate results in decreased expression of FYB1 mRNA17400583
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of FYB1 mRNA22108045
D009532NickelNickel results in increased expression of FYB1 mRNA24768652
D010278ParathionParathion results in decreased methylation of FYB1 promoter22847954
C020972pyrrolidine dithiocarbamic acid[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FYB1 mRNA]15477007
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FYB1 mRNA]15477007
D015474IsotretinoinIsotretinoin results in increased expression of FYB1 mRNA18769122
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FYB1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of FYB1 mRNA25351596
D012834SilverSilver results in increased expression of FYB1 mRNA28959546
C017947sodium arsenitesodium arsenite results in decreased expression of FYB1 mRNA24516582
C061133tamibarotenetamibarotene affects the expression of FYB1 mRNA15498508
C012568terbufosterbufos results in decreased methylation of FYB1 promoter22847954
D013755Tetradecanoylphorbol Acetate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FYB1 mRNA]15477007
D013755Tetradecanoylphorbol Acetatepyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FYB1 mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FYB1 mRNA15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FYB1 mRNA25613284
D014212TretinoinTretinoin affects the expression of FYB1 mRNA15498508
D014212TretinoinTretinoin results in increased expression of FYB1 mRNA16129123|1624948
C034028vanadyl sulfatevanadyl sulfate results in decreased expression of FYB1 mRNA16330358
C088658zoledronic acidzoledronic acid results in decreased expression of FYB1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-TAS10747096  
GO:0005515protein binding-IPI9207119  10409671  10570256  10671560  15096483  16461356  
17474147  19798671  20534575  22074159  25814554  27335501  
GO:0008289lipid binding-IEA-  
GO:0044877protein-containing complex binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-TAS9207119  
GO:0006607NLS-bearing protein import into nucleus-TAS9207119  
GO:0006955immune response-IEA-  
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-TAS9207119  
GO:0008150biological_process-ND-  
GO:0035556intracellular signal transduction-TAS9207119  
GO:0050852T cell receptor signaling pathway-TAS-  
GO:0072659protein localization to plasma membrane-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0015629actin cytoskeleton-TAS10747096  
GO:0030054cell junction-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-202403TCR signalingTAS
R-HSA-202403TCR signalingIEA
R-HSA-202433Generation of second messenger moleculesTAS
R-HSA-202433Generation of second messenger moleculesIEA
R-HSA-391160Signal regulatory protein family interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal