Gene info: ID 2534

Gene: FYN

GENE ID: 2534

Synonyms: SLK|SYN|p59-FYN

Description: FYN proto-oncogene, Src family tyrosine kinase

Gene type: protein-coding

Location: 6q21

dbXrefs: Ensembl:ENSG00000010810 MIM:137025 Vega:OTTHUMG00000016305 UniprotKB:P06241

RefSeq: NC_000006.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 13

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.263e-1 (AD) 6.718e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg08130572	chr6:112081102	FYN		4.600e-9	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TMBIM6	0.93
CLU	0.922
CD81	0.908
HDGF	0.896
HADHA	0.894
ITM2C	0.892
PRDX1	0.889
HNRNPUL1	0.889
SCD5	0.886
ZFAND3	0.883

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.832
OR4F29	-0.818
GADL1	-0.208
CETP	-0.195
SCARA5	-0.194
FER1L6	-0.191
IFNG	-0.186
BMP5	-0.173
OR6C74	-0.172
OR52E4	-0.171

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01254	Dasatinib	Small Molecule	302962-49-8	Approved\|Investigational	Target
DB02078	Triglyme	Small Molecule	112-49-2	Experimental	Target

ID	Drug Name	Action	PubMed
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased phosphorylation of FYN protein]	20850416
C104750	3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole	FYN gene mutant form inhibits the reaction [3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole results in increased phosphorylation of GRIN2B protein]	16407246
C027309	3,4,5,3',4',5'-hexachlorobiphenyl	"3,4,5,3',4',5'-hexachlorobiphenyl results in increased expression of FYN mRNA"	16050139
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [CAV1 mutant form results in decreased expression of FYN protein]"	24709675
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FYN protein"	24709675
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of FYN mRNA"	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FYN mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FYN mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FYN mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FYN mRNA"	27188386
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [cobaltous chloride results in increased phosphorylation of FYN protein]"	20850416
D000082	Acetaminophen	Acetaminophen results in decreased expression of FYN mRNA	29067470
D000082	Acetaminophen	Acetaminophen results in increased expression of FYN mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of FYN mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased activity of FYN protein]	12902192
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of FYN protein]	20850416
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of FYN protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of FYN mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of FYN mRNA	19770486
C412373	AG 1879	AG 1879 inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein]	14572611
C412373	AG 1879	AG 1879 inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein]	14572611
C412373	AG 1879	AG 1879 inhibits the reaction [cobaltous chloride results in increased phosphorylation of FYN protein]	20850416
C412373	AG 1879	AG 1879 results in decreased activity of FYN protein	19174152
C430898	AGN 194204	AGN 194204 affects the expression of FYN mRNA	11970994
C000188	alachlor	alachlor results in increased expression of FYN mRNA	12419858
D000447	Aldehydes	Aldehydes results in increased expression of FYN mRNA	25014914
D024502	alpha-Tocopherol	alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein]	14572611
D024502	alpha-Tocopherol	alpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein]	14572611
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of FYN mRNA	16483693
D000941	Antigens	Antigens results in increased activity of FYN protein	21958720
D000941	Antigens	Quinoxalines analog inhibits the reaction [Antigens results in increased activity of FYN protein]	21958720
D047310	Apigenin	Apigenin results in decreased activity of FYN protein	19814731
D001151	Arsenic	Arsenic affects the methylation of FYN gene	25304211
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein]	14572611
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein]	14572611
D001280	Atrazine	Atrazine results in decreased expression of FYN mRNA	25929836
D001374	Azacitidine	Azacitidine results in increased expression of FYN mRNA	21245298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FYN mRNA	20064835\|2010694
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FYN mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of FYN mRNA	16050139
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FYN mRNA"	19150397\|2001819
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of and results in increased activity of FYN protein"	21501596
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"cyanidin 3-O-glucoside inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased activity of FYN protein]"	21501596
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FYN mRNA	19619570
D004958	Estradiol	Estradiol results in decreased expression of FYN mRNA	20106945
D004958	Estradiol	Estradiol results in increased expression of FYN mRNA	19619570
C044887	beta-methylcholine	beta-methylcholine affects the expression of FYN mRNA	21179406
C083520	bis(2-hydroxy-2-ethylbutanoato)oxochromate(V)	AG 1879 inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein]	14572611
C083520	bis(2-hydroxy-2-ethylbutanoato)oxochromate(V)	alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein]	14572611
C083520	bis(2-hydroxy-2-ethylbutanoato)oxochromate(V)	Ascorbic Acid inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein]	14572611
C083520	bis(2-hydroxy-2-ethylbutanoato)oxochromate(V)	bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein	14572611
C083520	bis(2-hydroxy-2-ethylbutanoato)oxochromate(V)	CAT protein inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein]	14572611
C083520	bis(2-hydroxy-2-ethylbutanoato)oxochromate(V)	Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein]	14572611
C006780	bisphenol A	bisphenol A results in decreased expression of FYN mRNA	26063408
C006780	bisphenol A	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] affects the expression of FYN mRNA	25607892
C006780	bisphenol A	bisphenol A results in increased expression of FYN mRNA	25181051
C038091	butylparaben	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] affects the expression of FYN mRNA	25607892
C018475	butyraldehyde	butyraldehyde results in increased expression of FYN mRNA	26079696
D002110	Caffeine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of FYN mRNA"	20230807
D002110	Caffeine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FYN mRNA]"	20230807
D002122	Calcium Chloride	Calcium Chloride results in increased expression of FYN protein	25824407
D002217	Carbachol	Carbachol results in increased phosphorylation of FYN protein	16439036
D002330	Carmustine	Carmustine results in decreased expression of FYN mRNA	15980968
C074702	chromium hexavalent ion	Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased activity of FYN protein]	12902192
C074702	chromium hexavalent ion	CAT protein inhibits the reaction [chromium hexavalent ion results in increased activity of FYN protein]	12902192
C074702	chromium hexavalent ion	chromium hexavalent ion results in increased activity of FYN protein	12902192\|1999490
C074702	chromium hexavalent ion	[chromium hexavalent ion results in increased activity of FYN protein] which results in increased activity of STAT1 protein	19994902
C074702	chromium hexavalent ion	FYN protein promotes the reaction [chromium hexavalent ion results in increased expression of IRF7 mRNA]	19994902
C074702	chromium hexavalent ion	FYN protein promotes the reaction [chromium hexavalent ion results in increased phosphorylation of STAT1 protein]	19994902
C018021	cobaltous chloride	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased phosphorylation of FYN protein]	20850416
C018021	cobaltous chloride	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [cobaltous chloride results in increased phosphorylation of FYN protein]"	20850416
C018021	cobaltous chloride	Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of FYN protein]	20850416
C018021	cobaltous chloride	AG 1879 inhibits the reaction [cobaltous chloride results in increased phosphorylation of FYN protein]	20850416
C018021	cobaltous chloride	cobaltous chloride results in increased phosphorylation of FYN protein	20850416
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of FYN mRNA	24386269
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of FYN mRNA	20971185
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of FYN mRNA	15467011
D003300	Copper	Copper results in increased phosphorylation of FYN protein	21172064
D019327	Copper Sulfate	Copper Sulfate results in increased expression of FYN mRNA	19549813
C114438	cyanidin 3-O-glucoside	cyanidin 3-O-glucoside binds to FYN protein	21501596
C114438	cyanidin 3-O-glucoside	[cyanidin 3-O-glucoside binds to FYN protein] which results in decreased activity of FYN protein	21501596
C114438	cyanidin 3-O-glucoside	"cyanidin 3-O-glucoside inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased activity of FYN protein]"	21501596
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of FYN mRNA	17403535
D016572	Cyclosporine	Cyclosporine results in decreased expression of FYN mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in increased expression of FYN mRNA	19770486
D003561	Cytarabine	Cytarabine results in increased expression of FYN mRNA	21198554
D000069439	Dasatinib	Dasatinib binds to FYN protein	18180381
C014347	decitabine	decitabine affects the expression of FYN mRNA	18337055
C014347	decitabine	decitabine affects the expression of FYN protein	18337055
C014347	decitabine	decitabine results in increased expression of FYN mRNA	16367923\|1915171
C017185	delphinidin	delphinidin results in decreased activity of FYN protein	19174152
C017185	delphinidin	[delphinidin results in decreased activity of FYN protein] inhibits the reaction [TNF protein results in increased expression of PTGS2]	19174152
D013759	Dronabinol	FYN results in increased susceptibility to Dronabinol	12657697
D003907	Dexamethasone	Dexamethasone results in increased phosphorylation of FYN protein	15187100
D003976	Diazinon	Diazinon results in increased methylation of FYN gene	22964155
D003976	Diazinon	Diazinon affects the expression of FYN mRNA	22546817
D003993	Dibutyl Phthalate	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of FYN mRNA	25607892
D002945	Cisplatin	Cisplatin promotes the reaction [jinfukang results in decreased expression of FYN mRNA]	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of FYN mRNA	19561079
D002945	Cisplatin	jinfukang promotes the reaction [Cisplatin results in decreased expression of FYN mRNA]	27392435
D003633	Dichlorodiphenyl Dichloroethylene	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of FYN mRNA	25607892
D004026	Dieldrin	Dieldrin affects the expression of FYN mRNA	22546817
D004026	Dieldrin	Dieldrin results in increased activity of FYN protein	21801747
D004026	Dieldrin	FYN protein promotes the reaction [Dieldrin promotes the reaction [CASP3 protein results in increased cleavage of and results in increased activity of PRKCD protein]]	21801747
D004026	Dieldrin	FYN protein promotes the reaction [Dieldrin results in increased phosphorylation of PRKCD protein]	21801747
D004051	Diethylhexyl Phthalate	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of FYN mRNA	25607892
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of FYN mRNA	25380136
D004237	Diuron	Diuron results in decreased expression of FYN mRNA	25152437
C038939	enzacamene	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] affects the expression of FYN mRNA	25607892
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FYN mRNA	22079256
C109476	epoxiconazole	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of FYN mRNA	25607892
D000431	Ethanol	Ethanol results in increased phosphorylation of FYN protein	18182400
D000431	Ethanol	sodium arsenite promotes the reaction [Ethanol results in increased phosphorylation of FYN protein]	18182400
D005047	Etoposide	FYN protein affects the susceptibility to Etoposide	16217747
D005047	Etoposide	Etoposide results in decreased expression of FYN mRNA	25270620
D005472	Fluorouracil	FYN protein affects the susceptibility to Fluorouracil	16217747
D005609	Free Radicals	Free Radicals results in increased activity of FYN protein	20850416
D005609	Free Radicals	[Free Radicals results in increased activity of FYN protein] which results in increased secretion of VEGFA protein	20850416
D005839	Gentamicins	Gentamicins results in increased expression of FYN mRNA	22061828
C030691	gluconic acid	gluconic acid results in decreased expression of FYN mRNA	16556975
D005978	Glutathione	Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein]	14572611
D005978	Glutathione	Glutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein]	14572611
C094503	glyceryl 2-arachidonate	FYN gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein]	12657697
C094503	glyceryl 2-arachidonate	FYN gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein]	12657697
D006220	Haloperidol	FYN gene mutant form inhibits the reaction [Haloperidol results in increased phosphorylation of GRIN2B protein]	16407246
D006220	Haloperidol	FYN protein affects the susceptibility to Haloperidol	16407246
D006220	Haloperidol	Haloperidol results in increased phosphorylation of FYN protein	16407246
D017313	Fenretinide	Fenretinide results in increased expression of FYN mRNA	28973697
C544151	jinfukang	Cisplatin promotes the reaction [jinfukang results in decreased expression of FYN mRNA]	27392435
C544151	jinfukang	jinfukang promotes the reaction [Cisplatin results in decreased expression of FYN mRNA]	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of FYN mRNA	23086925
D007854	Lead	FYN protein affects the reaction [Lead results in decreased expression of PDGFRA protein]	17298174
D007854	Lead	Lead results in increased activity of FYN protein	17298174
C008261	lead acetate	FYN protein affects the reaction [lead acetate results in decreased expression of PDGFRA protein]	17298174
C008261	lead acetate	lead acetate results in increased activity of FYN protein	17298174
D008044	Linuron	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of FYN mRNA	25607892
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of FYN mRNA	26378955
D008694	Methamphetamine	Methamphetamine results in increased expression of FYN mRNA	26307267
D008731	Methoxychlor	Methoxychlor results in decreased expression of FYN mRNA	21782745
D008748	Methylcholanthrene	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of FYN mRNA	23519560
C004925	methylmercuric chloride	methylmercuric chloride affects the localization of FYN protein	28736149
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of FYN mRNA	28736149
D008767	Methylmercury Compounds	FYN protein affects the reaction [Methylmercury Compounds results in increased ubiquitination of and results in increased degradation of PDGFRA protein]	17298174
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased activity of FYN protein	17298174
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in increased expression of FYN mRNA	12634122
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FYN mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of FYN mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FYN mRNA]"	20230807
C008493	methylselenic acid	methylselenic acid results in increased expression of FYN mRNA	18548127
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of FYN mRNA	29191790
D016685	Mitomycin	FYN protein affects the susceptibility to Mitomycin	16217747
D008942	Mitoxantrone	FYN protein affects the susceptibility to Mitoxantrone	16217747
D009151	Mustard Gas	Mustard Gas results in decreased expression of FYN mRNA	15674843
C568507	N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide	"N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide results in decreased activity of FYN protein"	21888390
D009532	Nickel	Nickel results in increased expression of FYN mRNA	24768652\|2558310
C029938	nickel sulfate	nickel sulfate results in increased expression of FYN mRNA	16780908
D009538	Nicotine	LCK protein promotes the reaction [Nicotine results in increased phosphorylation of and results in increased activity of FYN protein]	17709503
D009538	Nicotine	Nicotine results in increased phosphorylation of and results in increased activity of FYN protein	17709503
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of FYN mRNA	20971185
C118580	octylmethoxycinnamate	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] affects the expression of FYN mRNA	25607892
C507134	ON 01910	ON 01910 results in increased phosphorylation of FYN protein	25472472
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of FYN mRNA	25729387
C029341	oxophenylarsine	oxophenylarsine affects the localization of FYN protein	9546377
D010269	Paraquat	FYN protein affects the reaction [Paraquat results in decreased expression of PDGFRA protein]	17298174
D010269	Paraquat	Paraquat affects the expression of FYN mRNA	15206577
D010269	Paraquat	Paraquat results in increased activity of FYN protein	17298174
C046012	pentanal	pentanal results in increased expression of FYN mRNA	26079696
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of FYN mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of FYN mRNA	19482888
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FYN mRNA	19710929
D010894	Piroxicam	Piroxicam results in decreased expression of FYN mRNA	21858171
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons results in increased activity of FYN protein	10706243
C545373	ponatinib	ponatinib results in decreased activity of FYN protein	19878872
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FYN mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of FYN mRNA	22079256
D011192	Potassium Dichromate	AG 1879 inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein]	14572611
D011192	Potassium Dichromate	alpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein]	14572611
D011192	Potassium Dichromate	Ascorbic Acid inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein]	14572611
D011192	Potassium Dichromate	CAT protein inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein]	14572611
D011192	Potassium Dichromate	Glutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein]	14572611
D011192	Potassium Dichromate	Potassium Dichromate results in increased phosphorylation of FYN protein	14572611
C045362	prochloraz	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of FYN mRNA	25607892
C035988	procymidone	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of FYN mRNA	25607892
C005556	propionaldehyde	propionaldehyde results in increased expression of FYN mRNA	26079696
D011794	Quercetin	Quercetin results in decreased activity of FYN protein	19814731
D011810	Quinoxalines	Quinoxalines analog inhibits the reaction [Antigens results in increased activity of FYN protein]	21958720
C059514	resveratrol	resveratrol affects the localization of FYN protein	21467134
C059514	resveratrol	resveratrol promotes the reaction [[ITGAV protein binds to ITGB3 protein] which affects the localization of FYN protein]	21467134
C089730	rosiglitazone	rosiglitazone results in decreased expression of FYN mRNA	25572481
C010327	salinomycin	salinomycin results in decreased expression of FYN mRNA	19682730
D012834	Silver	Silver inhibits the reaction [GDNF protein results in increased activity of FYN protein]	20488942
C017947	sodium arsenite	sodium arsenite promotes the reaction [Ethanol results in increased phosphorylation of FYN protein]	18182400
C017947	sodium arsenite	sodium arsenite results in increased expression of FYN mRNA	12016162
C017947	sodium arsenite	sodium arsenite results in increased expression of FYN mRNA	16014739
C017947	sodium arsenite	sodium arsenite results in increased phosphorylation of FYN protein	18407307
D012999	Soman	Soman results in increased expression of FYN mRNA	19281266
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of FYN mRNA	26378955
C061133	tamibarotene	tamibarotene results in decreased expression of FYN mRNA	15498508
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FYN mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FYN mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FYN mRNA	24680724
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FYN mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FYN mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of FYN mRNA	23519560
C024746	tobacco tar	tobacco tar results in decreased expression of FYN mRNA	19559774
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of FYN mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of FYN mRNA	15498508\|2193413
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FYN mRNA"	27188386
C012589	trichostatin A	trichostatin A affects the expression of FYN mRNA	28542535
C012589	trichostatin A	trichostatin A results in increased expression of FYN mRNA	24935251\|2627250
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of FYN mRNA"	26179874
D014520	Urethane	Urethane results in increased expression of FYN mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FYN mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of FYN mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased methylation of FYN gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of FYN mRNA	17292431
D014635	Valproic Acid	Valproic Acid results in decreased palmitoylation of FYN protein	26348896
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of FYN gene	25560391
C025643	vinclozolin	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of FYN mRNA	25607892
C025643	vinclozolin	vinclozolin affects the expression of FYN mRNA	19015723\|2303416

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004713	protein tyrosine kinase activity	-	EXP	1381360 9799234 10861086 11110698 11448999 12923167 16921024 17462920 18697750 27692963
GO:0004713	protein tyrosine kinase activity	-	IMP	16979591
GO:0004713	protein tyrosine kinase activity	-	ISS	17526495
GO:0004713	protein tyrosine kinase activity	-	TAS	17526495 28386764
GO:0004715	non-membrane spanning protein tyrosine kinase activity	-	IBA	21873635
GO:0004715	non-membrane spanning protein tyrosine kinase activity	-	NAS	7822789
GO:0005088	Ras guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005102	signaling receptor binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	1661130 1715582 7516469 7565724 7642581 7685273 7687537 8621719 9045636 9195899 9207119 9360983 9677430 9763511 10209036 10383400 10409671 10790433 11741929 12721299 12788081 14707117 14757743 14993658 15491611 15556646 15784897 16374509 16479011 16636290 16777849 16831868 16899217 16964398 17094785 17130124 17189269 17474147 17925405 18056706 19151721 19807924 19940238 20100835 22641034 22939624 23535298 23866081 24012003 24815698 25241761 25416956 25814554 27335501
GO:0005524	ATP binding	-	IEA	-
GO:0019899	enzyme binding	-	IPI	27525436
GO:0031802	type 5 metabotropic glutamate receptor binding	-	ISS	-
GO:0042608	T cell receptor binding	-	IEA	-
GO:0042609	CD4 receptor binding	-	IEA	-
GO:0042610	CD8 receptor binding	-	IEA	-
GO:0042802	identical protein binding	-	IPI	14993658 27001024
GO:0043014	alpha-tubulin binding	-	ISS	-
GO:0043548	phosphatidylinositol 3-kinase binding	-	IEA	-
GO:0044325	ion channel binding	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-
GO:0046875	ephrin receptor binding	-	IPI	10498895
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	-	TAS	-
GO:0048156	tau protein binding	-	ISS	-
GO:0048156	tau protein binding	-	TAS	25707991
GO:0051428	peptide hormone receptor binding	-	IEA	-
GO:0070851	growth factor receptor binding	-	IPI	16479011
GO:0097718	disordered domain specific binding	-	IPI	9351809

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000165	MAPK cascade	-	TAS	-
GO:0000304	response to singlet oxygen	-	ISS	27525436
GO:0001764	neuron migration	-	IEA	-
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	-
GO:0002250	adaptive immune response	-	IEA	-
GO:0003015	heart process	-	IGI	27525436
GO:0006468	protein phosphorylation	-	NAS	7822789
GO:0006468	protein phosphorylation	-	TAS	25707991
GO:0006816	calcium ion transport	-	NAS	7822789
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	-	IBA	21873635
GO:0007411	axon guidance	-	TAS	-
GO:0007596	blood coagulation	-	TAS	-
GO:0007612	learning	-	TAS	1361685
GO:0007631	feeding behavior	-	TAS	8264796
GO:0008360	regulation of cell shape	-	ISS	-
GO:0010629	negative regulation of gene expression	-	IEA	-
GO:0010730	negative regulation of hydrogen peroxide biosynthetic process	-	ISS	27525436
GO:0010976	positive regulation of neuron projection development	-	IEA	-
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	-	IEA	-
GO:0018108	peptidyl-tyrosine phosphorylation	-	IMP	16979591
GO:0018108	peptidyl-tyrosine phosphorylation	-	ISS	27525436
GO:0018108	peptidyl-tyrosine phosphorylation	-	TAS	25707991
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0030154	cell differentiation	-	IBA	21873635
GO:0030168	platelet activation	-	TAS	-
GO:0030900	forebrain development	-	IEA	-
GO:0031295	T cell costimulation	-	TAS	-
GO:0031397	negative regulation of protein ubiquitination	-	IEA	-
GO:0035556	intracellular signal transduction	-	TAS	1361685
GO:0036120	cellular response to platelet-derived growth factor stimulus	-	IEA	-
GO:0038083	peptidyl-tyrosine autophosphorylation	-	IBA	21873635
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	-	TAS	-
GO:0042110	T cell activation	-	IBA	21873635
GO:0042127	regulation of cell proliferation	-	IBA	21873635
GO:0042177	negative regulation of protein catabolic process	-	IEA	-
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	-	IEA	-
GO:0042542	response to hydrogen peroxide	-	ISS	27525436
GO:0042981	regulation of apoptotic process	-	IBA	21873635
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	IEA	-
GO:0043524	negative regulation of neuron apoptotic process	-	IEA	-
GO:0045087	innate immune response	-	IBA	21873635
GO:0045471	response to ethanol	-	IEA	-
GO:0046854	phosphatidylinositol phosphorylation	-	IEA	-
GO:0048010	vascular endothelial growth factor receptor signaling pathway	-	TAS	-
GO:0048013	ephrin receptor signaling pathway	-	TAS	-
GO:0048813	dendrite morphogenesis	-	IEA	-
GO:0050690	regulation of defense response to virus by virus	-	TAS	-
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	-	ISS	-
GO:0050798	activated T cell proliferation	-	IEA	-
GO:0050852	T cell receptor signaling pathway	-	IBA	21873635
GO:0050852	T cell receptor signaling pathway	-	IDA	7722293
GO:0050900	leukocyte migration	-	TAS	-
GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	-	IEA	-
GO:0051897	positive regulation of protein kinase B signaling	-	TAS	-
GO:0071375	cellular response to peptide hormone stimulus	-	IEA	-
GO:0071560	cellular response to transforming growth factor beta stimulus	-	IEA	-
GO:0090314	positive regulation of protein targeting to membrane	-	ISS	-
GO:0097062	dendritic spine maintenance	-	TAS	25707991
GO:1900182	positive regulation of protein localization to nucleus	-	IEA	-
GO:1900449	regulation of glutamate receptor signaling pathway	-	ISS	-
GO:1901216	positive regulation of neuron death	-	ISS	-
GO:1902951	negative regulation of dendritic spine maintenance	-	ISS	-
GO:1903202	negative regulation of oxidative stress-induced cell death	-	ISS	27525436
GO:1903997	positive regulation of non-membrane spanning protein tyrosine kinase activity	-	TAS	-
GO:1904645	response to amyloid-beta	-	ISS	-
GO:1905232	cellular response to L-glutamate	-	ISS	17526495
GO:1905430	cellular response to glycine	-	ISS	17526495
GO:1905477	positive regulation of protein localization to membrane	-	TAS	28386764
GO:1905664	regulation of calcium ion import across plasma membrane	-	ISS	-
GO:2001056	positive regulation of cysteine-type endopeptidase activity	-	ISS	17526495
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	ISS	27525436
GO:0005739	mitochondrion	-	ISS	27525436
GO:0005768	endosome	-	IDA	15611048
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0005884	actin filament	-	IEA	-
GO:0005886	plasma membrane	-	IDA	12150984 15611048
GO:0005886	plasma membrane	-	TAS	-
GO:0014069	postsynaptic density	-	ISS	-
GO:0030425	dendrite	-	ISS	-
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	-	IBA	21873635
GO:0044297	cell body	-	ISS	-
GO:0045121	membrane raft	colocalizes_with	IDA	12150984
GO:0045121	membrane raft	-	IMP	23386614
GO:0045121	membrane raft	-	ISS	-
GO:0045121	membrane raft	-	TAS	28386764
GO:0048471	perinuclear region of cytoplasm	-	ISS	27525436
GO:0097038	perinuclear endoplasmic reticulum	-	ISS	27525436
GO:0097386	glial cell projection	-	ISS	-

KEGG ID	KEGG Term
hsa04360	Axon guidance
hsa04380	Osteoclast differentiation
hsa04510	Focal adhesion
hsa04520	Adherens junction
hsa04650	Natural killer cell mediated cytotoxicity
hsa04660	T cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa05020	Prion diseases
hsa05130	Pathogenic Escherichia coli infection
hsa05416	Viral myocarditis

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-114604	GPVI-mediated activation cascade	TAS
R-HSA-1227986	Signaling by ERBB2	TAS
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1280215	Cytokine Signaling in Immune system	IEA
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1280218	Adaptive Immune System	IEA
R-HSA-1433557	Signaling by SCF-KIT	TAS
R-HSA-1433557	Signaling by SCF-KIT	IEA
R-HSA-1433559	Regulation of KIT signaling	TAS
R-HSA-1500931	Cell-Cell communication	TAS
R-HSA-1500931	Cell-Cell communication	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-162906	HIV Infection	TAS
R-HSA-162909	Host Interactions of HIV factors	TAS
R-HSA-1643685	Disease	TAS
R-HSA-164944	Nef and signal transduction	TAS
R-HSA-164952	The role of Nef in HIV-1 replication and disease pathogenesis	TAS
R-HSA-166520	Signaling by NTRKs	TAS
R-HSA-166520	Signaling by NTRKs	IEA
R-HSA-168249	Innate Immune System	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-194138	Signaling by VEGF	TAS
R-HSA-199418	Negative regulation of the PI3K/AKT network	TAS
R-HSA-202733	Cell surface interactions at the vascular wall	TAS
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	TAS
R-HSA-2029481	FCGR activation	TAS
R-HSA-210990	PECAM1 interactions	TAS
R-HSA-2172127	DAP12 interactions	TAS
R-HSA-2172127	DAP12 interactions	IEA
R-HSA-2219528	PI3K/AKT Signaling in Cancer	TAS
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	TAS
R-HSA-2424491	DAP12 signaling	TAS
R-HSA-2424491	DAP12 signaling	IEA
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	IEA
R-HSA-2682334	EPH-Ephrin signaling	TAS
R-HSA-2682334	EPH-Ephrin signaling	IEA
R-HSA-2730905	Role of LAT2/NTAL/LAB on calcium mobilization	IEA
R-HSA-373752	Netrin-1 signaling	TAS
R-HSA-373752	Netrin-1 signaling	IEA
R-HSA-373753	Nephrin family interactions	TAS
R-HSA-373753	Nephrin family interactions	IEA
R-HSA-373755	Semaphorin interactions	TAS
R-HSA-373755	Semaphorin interactions	IEA
R-HSA-375165	NCAM signaling for neurite out-growth	IEA
R-HSA-375165	NCAM signaling for neurite out-growth	TAS
R-HSA-388841	Costimulation by the CD28 family	TAS
R-HSA-389356	CD28 co-stimulation	TAS
R-HSA-389357	CD28 dependent PI3K/Akt signaling	TAS
R-HSA-389359	CD28 dependent Vav1 pathway	TAS
R-HSA-389513	CTLA4 inhibitory signaling	TAS
R-HSA-3928662	EPHB-mediated forward signaling	TAS
R-HSA-3928662	EPHB-mediated forward signaling	IEA
R-HSA-3928663	EPHA-mediated growth cone collapse	TAS
R-HSA-3928663	EPHA-mediated growth cone collapse	IEA
R-HSA-3928664	Ephrin signaling	TAS
R-HSA-3928664	Ephrin signaling	IEA
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	TAS
R-HSA-399954	Sema3A PAK dependent Axon repulsion	TAS
R-HSA-399955	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	IEA
R-HSA-399955	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	TAS
R-HSA-399956	CRMPs in Sema3A signaling	TAS
R-HSA-399956	CRMPs in Sema3A signaling	IEA
R-HSA-418885	DCC mediated attractive signaling	TAS
R-HSA-418885	DCC mediated attractive signaling	IEA
R-HSA-418886	Netrin mediated repulsion signals	IEA
R-HSA-422475	Axon guidance	TAS
R-HSA-422475	Axon guidance	IEA
R-HSA-4420097	VEGFA-VEGFR2 Pathway	TAS
R-HSA-449147	Signaling by Interleukins	IEA
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling	IEA
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling	TAS
R-HSA-5621480	Dectin-2 family	TAS
R-HSA-5621481	C-type lectin receptors (CLRs)	TAS
R-HSA-5621575	CD209 (DC-SIGN) signaling	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5663205	Infectious disease	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	TAS
R-HSA-75892	Platelet Adhesion to exposed collagen	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-8866376	Reelin signalling pathway	TAS
R-HSA-9006115	Signaling by NTRK2 (TRKB)	TAS
R-HSA-9006115	Signaling by NTRK2 (TRKB)	IEA
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	IEA
R-HSA-9032500	Activated NTRK2 signals through FYN	TAS
R-HSA-9032500	Activated NTRK2 signals through FYN	IEA
R-HSA-9032759	NTRK2 activates RAC1	TAS
R-HSA-9032759	NTRK2 activates RAC1	IEA
R-HSA-912631	Regulation of signaling by CBL	IEA
R-HSA-912631	Regulation of signaling by CBL	TAS
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	IEA
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22906118	Associations between diabetic retinopathy and plasma levels of high-sensitive C-reactive protein or von Willebrand factor in long-term type 1 diabetic patients. (2013 Jan)	Laursen JV	Curr Eye Res
27784625	Nicotine-induced neuroplasticity counteracts the effect of schizophrenia-linked neuregulin 1 signaling on NMDAR function in the rat hippocampus. (2017 Feb)	Yamazaki Y	Neuropharmacology
29520592	Decrease of cocaine, but not heroin, self-administration and relapse by the tyrosine kinase inhibitor masitinib in male Sprague Dawley rats. (2018 May)	Belin-Rauscent A	Psychopharmacology (Berl)
11121167	Mutation and association analysis of the Fyn kinase gene with alcoholism and schizophrenia. (2000 Dec 4)	Ishiguro H	Am J Med Genet
16441285	From blue states to up states: a regional view of NMDA-ethanol interactions. (2006 Feb)	Woodward JJ	Alcohol Clin Exp Res
25516494	Antioxidant effects of hydrogen sulfide on left ventricular remodeling in smoking rats are mediated via PI3K/Akt-dependent activation of Nrf2. (2015 Mar)	Zhou X	Toxicol Sci
14675807	Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts. (2003 Dec 15)	Schumann G	Biol Psychiatry
9839441	Fyn, a Src family tyrosine kinase. (1998 Nov)	Resh MD	Int J Biochem Cell Biol
23908141	Interaction of polymorphisms in mitotic regulator genes with cigarette smoking and pancreatic cancer risk. (2013 Nov)	Jang JH	Mol Carcinog
28818835	Src-dependent phosphorylation of mu-opioid receptor at Tyr(336) modulates opiate withdrawal. (2017 Nov)	Zhang L	EMBO Mol Med
21688016	Proliferative retinopathy predicts nephropathy: a 25-year follow-up study of type 1 diabetic patients. (2012 Aug)	Karlberg C	Acta Diabetol
18849153	Genetic association between -93A/G polymorphism in the Fyn kinase gene and alcohol dependence in Spanish men. (2009 Apr)	Pastor IJ	Eur Psychiatry
11838419	[Lung cancer: survival rate differences in Danish counties. Survival analysis of 33.838 patients during the period 1984-1998]. (2002 Jan 21)	Madsen FF	Ugeskr Laeger