Gene: IPMK

253430
-
inositol polyphosphate multikinase
protein-coding
10q21.1
Ensembl:ENSG00000151151 MIM:609851 Vega:OTTHUMG00000018268 UniprotKB:Q8NFU5
NC_000010.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.849e-1 (AD)  6.314e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12261547chr10:58209350 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEC24A0.855
LYSMD30.849
TNPO10.846
MARCH50.838
MYNN0.838
TMF10.833
CPEB40.832
MIER30.829
SCYL20.821
TMED70.82

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.511
OR4F29-0.457
SPRR2D-0.219
RSPO1-0.202
TCL1A-0.198
PTGDR2-0.197
FAM25A-0.188
KRT6C-0.187
MUSTN1-0.185
KRT6A-0.185

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of IPMK mRNA"19114083
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of IPMK mRNA]"19467301
D000082AcetaminophenAcetaminophen affects the expression of IPMK mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of IPMK gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IPMK mRNA16483693
D001554BenzeneBenzene affects the expression of IPMK mRNA15878777
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IPMK mRNA22228805
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of IPMK mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of IPMK mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of IPMK mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of IPMK mRNA18353800
D019327Copper SulfateCopper Sulfate results in increased expression of IPMK mRNA19549813
D002945CisplatinCisplatin results in increased expression of IPMK mRNA27594783
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of IPMK mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of IPMK mRNA19467301
D018120FinasterideFinasteride results in increased expression of IPMK mRNA24136188
D005419FlavonoidsFlavonoids results in decreased expression of IPMK mRNA18035473
D005485FlutamideFlutamide results in decreased expression of IPMK mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of IPMK mRNA20938992
D005839GentamicinsGentamicins results in increased expression of IPMK mRNA22061828
D006046GoldGold results in decreased expression of IPMK mRNA25523186
D017313FenretinideFenretinide results in increased expression of IPMK mRNA28973697
C544151jinfukangjinfukang results in decreased expression of IPMK mRNA27392435
C045463leflunomideleflunomide results in increased expression of IPMK mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of IPMK mRNA20938992
D008777MethyltestosteroneMethyltestosterone results in decreased expression of IPMK mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IPMK mRNA"25620056
C051752nefazodonenefazodone results in decreased expression of IPMK mRNA24136188
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of IPMK mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of IPMK mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IPMK mRNA19710929
D012715Sesame OilSesame Oil results in increased expression of IPMK mRNA29191790
D013467SulindacSulindac results in decreased expression of IPMK mRNA24136188
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of IPMK mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IPMK mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of IPMK mRNA19465110
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of IPMK mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IPMK mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of IPMK mRNA28973375
C009495titanium dioxidetitanium dioxide affects the expression of IPMK mRNA17656681
D014212TretinoinTretinoin results in increased expression of IPMK mRNA21934132
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of IPMK mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of IPMK mRNA28973697
D014520UrethaneUrethane results in increased expression of IPMK mRNA28818685
C025643vinclozolinvinclozolin results in decreased expression of IPMK mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000823inositol-1,4,5-trisphosphate 6-kinase activity-IEA-  
GO:0000824inositol tetrakisphosphate 3-kinase activity-TAS-  
GO:0000825inositol tetrakisphosphate 6-kinase activity-TAS-  
GO:0005524ATP binding-IEA-  
GO:0008440inositol-1,4,5-trisphosphate 3-kinase activity-TAS-  
GO:0047326inositol tetrakisphosphate 5-kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016310phosphorylation-IEA-  
GO:0032958inositol phosphate biosynthetic process-IEA-  
GO:0043647inositol phosphate metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA-  
KEGG ID KEGG Term
hsa00562Inositol phosphate metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483249Inositol phosphate metabolismTAS
R-HSA-1855191Synthesis of IPs in the nucleusTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal