Gene: LCLAT1

253558
1AGPAT8|AGPAT8|ALCAT1|HSRG1849|LYCAT|UNQ1849
lysocardiolipin acyltransferase 1
protein-coding
2p23.1
Ensembl:ENSG00000172954 MIM:614241 Vega:OTTHUMG00000099349 UniprotKB:Q6UWP7
NC_000002.12
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.520e-1 (AD)  8.635e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4952147chr2:30553404 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs829646chr2:30496460 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs829642chr2:30477104 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NDC10.884
PPP2R5E0.883
VTA10.882
GFPT10.882
SLC25A460.879
CDC270.875
RNGTT0.874
EXOC60.873
MTMR90.87
BLOC1S60.87

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.443
OR4F5-0.437
OR4F29-0.379
FXYD3-0.374
ANPEP-0.345
OLAH-0.333
ROM1-0.328
PLIN4-0.328
MAGEA12-0.327
RHOD-0.322

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of LCLAT1 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LCLAT1 mRNA27153756
D001280AtrazineAtrazine results in decreased expression of LCLAT1 mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of LCLAT1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LCLAT1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LCLAT1 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LCLAT1 mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of LCLAT1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of LCLAT1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of LCLAT1 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of LCLAT1 mRNA17484886
D016572CyclosporineCyclosporine results in decreased expression of LCLAT1 mRNA25562108
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of LCLAT1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of LCLAT1 mRNA27392435
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of LCLAT1 mRNA27638505
C492448ICG 001ICG 001 results in decreased expression of LCLAT1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LCLAT1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of LCLAT1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of LCLAT1 mRNA27392435
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of LCLAT1 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of LCLAT1 mRNA25613284
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LCLAT1 mRNA"25554681
D010100OxygenOxygen deficiency affects the methylation of LCLAT1 promoter24205000
D010100OxygenOxygen deficiency results in increased expression of LCLAT1 mRNA24205000
D052638Particulate MatterParticulate Matter results in increased expression of LCLAT1 mRNA24769257
C006253pirinixic acidpirinixic acid results in increased expression of LCLAT1 mRNA20813756|2381119
C059514resveratrolresveratrol results in increased expression of LCLAT1 protein25505154
D012969Sodium FluorideSodium Fluoride results in decreased expression of LCLAT1 protein28918527
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LCLAT1 mRNA25613284
C012589trichostatin Atrichostatin A affects the expression of LCLAT1 mRNA28542535

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity-TAS-  
GO:0005515protein binding-IPI25416956  
GO:0008374O-acyltransferase activity-TAS-  
GO:0016746transferase activity, transferring acyl groups-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006644phospholipid metabolic process-IBA21873635  
GO:0006654phosphatidic acid biosynthetic process-TAS-  
GO:0007275multicellular organism development-IEA-  
GO:0016024CDP-diacylglycerol biosynthetic process-IEA-  
GO:0035965cardiolipin acyl-chain remodeling-TAS-  
GO:0036149phosphatidylinositol acyl-chain remodeling-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005829cytosol-IDA-  
GO:0012505endomembrane system-IBA21873635  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00561Glycerolipid metabolism
hsa00564Glycerophospholipid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1482798Acyl chain remodeling of CLTAS
R-HSA-1483166Synthesis of PATAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal