Gene: G6PC

2538
G6PC1|G6PT|G6Pase|GSD1|GSD1a
glucose-6-phosphatase catalytic subunit
protein-coding
17q21.31
Ensembl:ENSG00000131482 MIM:613742 Vega:OTTHUMG00000180657 UniprotKB:P35575
NG_011808.1
PubMed
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.595e-1 (AD)  4.329e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR8K10.704
SPATA31D10.676
FSCB0.675
POTEH0.674
OR8H10.671
OR10G30.668
CRISP10.668
OR9G40.665
OR10X10.664
PRAMEF180.66

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C16orf95-0.29
ANKRD55-0.287
HUNK-0.275
HYOU1-0.273
HSPA4L-0.273
DTX4-0.266
SCN2B-0.264
ADRA1B-0.263
SLC32A1-0.261
GDF10-0.261

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [FOXO1 protein binds to G6PC promoter]"24769335
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [[Progesterone co-treated with Estradiol] results in increased expression of G6PC mRNA]"21768169
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of G6PC mRNA"24769335|2487833
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of G6PC protein"24769335
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of G6PC mRNA"21354444
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"Testosterone metabolite inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [FOXO1 protein binds to G6PC promoter]]"24769335
C4901661-(4-methoxyphenyl)piperazine1-(4-methoxyphenyl)piperazine results in decreased expression of G6PC mRNA26821219
C0780921-piperonylpiperazine1-piperonylpiperazine results in decreased expression of G6PC mRNA26821219
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of G6PC mRNA"24559133
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of G6PC mRNA"20056577
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of G6PC mRNA"25768209
C0545892,4,6-triphenyl-1,3-dioxane"2,4,6-triphenyl-1,3-dioxane inhibits the reaction [FOXO1 protein binds to G6PC promoter]"23231652
C0545892,4,6-triphenyl-1,3-dioxane"2,4,6-triphenyl-1,3-dioxane inhibits the reaction [HNF4A protein binds to G6PC promoter]"23231652
C0545892,4,6-triphenyl-1,3-dioxane"2,4,6-triphenyl-1,3-dioxane promotes the reaction [NR1I3 protein binds to G6PC promoter]"23231652
C0545892,4,6-triphenyl-1,3-dioxane"2,4,6-triphenyl-1,3-dioxane results in decreased expression of G6PC mRNA"23231652
C0545892,4,6-triphenyl-1,3-dioxane"2,4,6-triphenyl-1,3-dioxane results in decreased expression of G6PC protein"23231652
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of G6PC mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of G6PC mRNA"21346803
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of G6PC mRNA25088246
C0065932-anthramine2-anthramine results in increased expression of G6PC mRNA23038007
C0230353,4,5,3',4'-pentachlorobiphenyl"[Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in decreased expression of G6PC mRNA"28163111
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of G6PC mRNA"27509375
C5464123-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide results in decreased expression of G6PC mRNA19694723
C0005923534-(4,6-diphenyl-1,3-dioxan-2-yl)-N,N-dimethylaniline"4-(4,6-diphenyl-1,3-dioxan-2-yl)-N,N-dimethylaniline inhibits the reaction [FOXO1 protein binds to G6PC promoter]"23231652
C0005923534-(4,6-diphenyl-1,3-dioxan-2-yl)-N,N-dimethylaniline"4-(4,6-diphenyl-1,3-dioxan-2-yl)-N,N-dimethylaniline inhibits the reaction [HNF4A protein binds to G6PC promoter]"23231652
C0005923534-(4,6-diphenyl-1,3-dioxan-2-yl)-N,N-dimethylaniline"4-(4,6-diphenyl-1,3-dioxan-2-yl)-N,N-dimethylaniline promotes the reaction [NR1I3 protein binds to G6PC promoter]"23231652
C0005923534-(4,6-diphenyl-1,3-dioxan-2-yl)-N,N-dimethylaniline"4-(4,6-diphenyl-1,3-dioxan-2-yl)-N,N-dimethylaniline results in decreased expression of G6PC mRNA"23231652
C0005923534-(4,6-diphenyl-1,3-dioxan-2-yl)-N,N-dimethylaniline"4-(4,6-diphenyl-1,3-dioxan-2-yl)-N,N-dimethylaniline results in decreased expression of G6PC protein"23231652
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of G6PC mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of G6PC mRNA"18289764|2538013
C461658(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid"(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of G6PC mRNA]"21815645
C0118674-hydroxyphenylethanol4-hydroxyphenylethanol inhibits the reaction [Streptozocin results in increased activity of G6PC protein]25641191
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [FOXO1 protein binds to G6PC promoter]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of G6PC mRNA"21768169|2487833
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of G6PC protein"24878338
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [FOXO1 protein binds to G6PC promoter]]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of G6PC mRNA]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"NR1I3 mutant form inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of G6PC mRNA]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"NR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of G6PC mRNA]]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of G6PC mRNA]]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of G6PC mRNA]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [FOXO1 protein binds to G6PC promoter]]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of G6PC mRNA]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Progesterone promotes the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [FOXO1 protein binds to G6PC promoter]]]"21768169
C001969acephateacephate results in increased activity of G6PC protein22778074
C001969acephatediphenyldiselenide inhibits the reaction [acephate results in increased activity of G6PC protein]22778074
D000082AcetaminophenAcetaminophen results in decreased expression of G6PC mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of G6PC mRNA15606129|1756273
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of G6PC mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of G6PC mRNA]17585979
D000082AcetaminophenAcetaminophen results in decreased expression of G6PC mRNA15084756
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of G6PC mRNA22129741
D000242Cyclic AMP[Dexamethasone co-treated with Cyclic AMP] results in increased expression of G6PC mRNA22676303
D000242Cyclic AMPFatty Acids analog inhibits the reaction [[Dexamethasone co-treated with Cyclic AMP] results in increased expression of G6PC mRNA]22676303
D000242Cyclic AMPFatty Acids analog inhibits the reaction [[Glucagon co-treated with Cyclic AMP] results in increased expression of G6PC mRNA]22676303
D000242Cyclic AMP[Glucagon co-treated with Cyclic AMP] results in increased expression of G6PC mRNA22676303
D016604Aflatoxin B1Aflatoxin B1 affects the expression of G6PC protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of G6PC gene27153756
C031143AICA ribonucleotideAICA ribonucleotide results in decreased expression of G6PC mRNA19664596
D000496AlloxanAlloxan results in increased activity of G6PC protein25779343
D000496AlloxanSodium Selenite inhibits the reaction [Alloxan results in increased activity of G6PC protein]25779343
D000498Allyl CompoundsAllyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC protein]15554553
C001864aluminum phosphidealuminum phosphide results in increased activity of G6PC protein20929055
D000643Ammonium ChlorideAmmonium Chloride affects the expression of G6PC mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of G6PC mRNA"22863853
C026987aroclor 1260[Methionine deficiency co-treated with Choline deficiency co-treated with aroclor 1260] results in decreased expression of G6PC mRNA28163111
D000069059Atorvastatin Calcium[Atorvastatin Calcium co-treated with NR1I2 protein] results in increased expression of G6PC mRNA24204015
C547126AZM551248AZM551248 results in decreased expression of G6PC mRNA22323515
D001414BacitracinBacitracin results in decreased expression of G6PC mRNA18289764
D001554BenzeneBenzene results in decreased expression of G6PC mRNA15878777
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of G6PC mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of G6PC mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of G6PC mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of G6PC mRNA19770486
D004958Estradiol"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [FOXO1 protein binds to G6PC promoter]]"21768169
D004958Estradiol"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of G6PC mRNA]"21768169
D004958EstradiolEstradiol inhibits the reaction [Phenobarbital results in decreased expression of G6PC mRNA]21768169
D004958EstradiolEstradiol results in decreased expression of G6PC mRNA20106945|2163298
D004958Estradiol"NR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of G6PC mRNA]]"21768169
D004958EstradiolNR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [Phenobarbital results in decreased expression of G6PC mRNA]]21768169
D004958Estradiol"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of G6PC mRNA]"21768169
D004958Estradiol[Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in decreased expression of G6PC mRNA]21768169
D004958Estradiol"Progesterone promotes the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [FOXO1 protein binds to G6PC promoter]]]"21768169
D004958Estradiol"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [[Progesterone co-treated with Estradiol] results in increased expression of G6PC mRNA]"21768169
D004958Estradiolbisphenol A inhibits the reaction [Estradiol results in increased expression of G6PC mRNA]28476547
D004958Estradiolbisphenol A inhibits the reaction [Estradiol results in increased expression of G6PC protein]28476547
D004958EstradiolEstradiol results in increased expression of G6PC mRNA28476547
D004958EstradiolEstradiol results in increased expression of G6PC protein28476547
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of G6PC mRNA21768169
D001623BetamethasoneBetamethasone results in increased activity of G6PC protein15928026
C452139BIRB 796BIRB 796 results in decreased expression of G6PC mRNA21328587
C511635bis(allixinato)oxovanadium(IV)[bis(allixinato)oxovanadium(IV) results in increased phosphorylation of FOXO1 protein] inhibits the reaction [[FOXO1 protein binds to G6PC promoter] which results in increased expression of G6PC mRNA]17805585|1780558
C074212bis(maltolato)oxovanadium(IV)bis(maltolato)oxovanadium(IV) inhibits the reaction [Streptozocin results in increased expression of G6PC mRNA]12446591
C006780bisphenol Abisphenol A inhibits the reaction [Estradiol results in increased expression of G6PC mRNA]28476547
C006780bisphenol Abisphenol A inhibits the reaction [Estradiol results in increased expression of G6PC protein]28476547
C006780bisphenol Abisphenol A results in increased expression of G6PC mRNA21932408|2847654
C006780bisphenol Abisphenol A results in increased expression of G6PC protein21932408|2847654
C006780bisphenol A[bisphenol A co-treated with Dietary Fats] results in increased expression of G6PC protein25112833
C006780bisphenol Abisphenol A promotes the reaction [Dietary Fats results in increased expression of G6PC mRNA]25112833
C006780bisphenol Abisphenol A results in decreased expression of G6PC mRNA25181051
C517295bis(quercetinato)oxovanadium(IV)bis(quercetinato)oxovanadium(IV) results in decreased expression of G6PC mRNA17565414
D002104CadmiumCadmium results in increased expression of G6PC mRNA17327699
D019256Cadmium ChlorideCadmium Chloride results in increased expression of G6PC mRNA18409656
D019256Cadmium Chloride[Cadmium Chloride co-treated with methylmercuric chloride] results in increased expression of G6PC mRNA27814245
D019256Cadmium ChlorideCadmium Chloride affects the expression of G6PC mRNA22110744
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of G6PC mRNA25993096
D019256Cadmium ChlorideCadmium Chloride results in increased expression of G6PC mRNA17327699
C037123cadmium sulfatecadmium sulfate results in decreased expression of G6PC mRNA16221973
D002118CalciumCalcium affects the expression of G6PC mRNA15913539
D002220CarbamazepineCarbamazepine results in decreased expression of G6PC mRNA17381134
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of G6PC mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of G6PC mRNA15963342|1623916
D002392Catechin[Catechin co-treated with Dietary Fats] affects the expression of G6PC mRNA25861419
D002509CephaloridineCephaloridine results in decreased expression of G6PC mRNA18500788
C006972chloroacetic acidchloroacetic acid results in decreased expression of G6PC mRNA28189721
C006972chloroacetic acidchloroacetic acid results in decreased expression of G6PC protein28189721
D002794Choline"[Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in decreased expression of G6PC mRNA"28163111
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with aroclor 1260] results in decreased expression of G6PC mRNA28163111
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of G6PC mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of G6PC mRNA28472532
D002922CiguatoxinsCiguatoxins affects the expression of G6PC mRNA18353800
C007078citronellolcitronellol inhibits the reaction [Streptozocin results in increased activity of G6PC protein]26944432
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of G6PC mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of G6PC mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of G6PC mRNA]17585979
D002994ClofibrateClofibrate results in decreased expression of G6PC mRNA12851107
C018021cobaltous chloridecobaltous chloride results in decreased expression of G6PC mRNA24386269
D005576Colforsin[Dexamethasone co-treated with Colforsin] results in increased expression of G6PC mRNA18972406
D003300CopperCopper results in decreased expression of G6PC mRNA20875833
D003300CopperCopper results in decreased expression of G6PC mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of G6PC mRNA19549813
D003474CurcuminCurcumin affects the expression of G6PC mRNA27208389
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of G6PC mRNA17654400|2549711
D016572CyclosporineCyclosporine results in decreased expression of G6PC mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of G6PC mRNA19770486
D003687DehydroepiandrosteroneDehydroepiandrosterone results in decreased expression of G6PC mRNA11228057
D0174851-Deoxynojirimycin[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of G6PC protein]25446853
D003907DexamethasoneDexamethasone results in increased expression of G6PC protein26616219
D003907Dexamethasone[Dexamethasone co-treated with Colforsin] results in increased expression of G6PC mRNA18972406
D003907Dexamethasone[Dexamethasone co-treated with Cyclic AMP] results in increased expression of G6PC mRNA22676303
D003907DexamethasoneDexamethasone results in increased expression of G6PC mRNA18972406|2316683
D003907DexamethasoneDexamethasone results in increased expression of G6PC protein15965953|2316683
D003907DexamethasoneFatty Acids analog inhibits the reaction [[Dexamethasone co-treated with Cyclic AMP] results in increased expression of G6PC mRNA]22676303
D003907DexamethasoneINS protein inhibits the reaction [Dexamethasone results in increased expression of G6PC mRNA]18972406
D003994BucladesineBucladesine results in increased expression of G6PC mRNA22859313
D003994BucladesineBucladesine results in increased expression of G6PC protein26064446
D003994BucladesineIL22 protein inhibits the reaction [Bucladesine results in increased expression of G6PC protein]26064446
D003994BucladesineNFE2L2 gene mutant form promotes the reaction [Bucladesine results in increased expression of G6PC mRNA]22859313
D003994BucladesineSTAT3 gene mutant form affects the reaction [IL22 protein inhibits the reaction [Bucladesine results in increased expression of G6PC protein]]26064446
D002945CisplatinCisplatin results in decreased expression of G6PC mRNA18289764
C121718dicyclanildicyclanil results in increased expression of G6PC mRNA15664270
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of G6PC mRNA16931933
D004041Dietary Fats[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of G6PC protein]25446853
D004041Dietary FatsANGPTL4 protein modified form affects the reaction [Dietary Fats affects the expression of G6PC mRNA]28842503
D004041Dietary Fats[Catechin co-treated with Dietary Fats] affects the expression of G6PC mRNA25861419
D004041Dietary FatsDietary Fats affects the expression of G6PC mRNA26064446|2884250
D004041Dietary Fats[Dietary Fats co-treated with Streptozocin] results in decreased activity of G6PC protein27769711
D004041Dietary Fats[Dietary Fats co-treated with Streptozocin] results in increased expression of G6PC protein25446853
D004041Dietary Fats[Dietary Fats co-treated with Tetrachlorodibenzodioxin] results in decreased expression of G6PC mRNA27713108
D004041Dietary FatsDietary Fats results in increased expression of G6PC mRNA22198281|2296772
D004041Dietary Fatsesculetin promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of G6PC protein]27769711
D004041Dietary FatsIL22 protein affects the reaction [Dietary Fats affects the expression of G6PC mRNA]26064446
D004041Dietary Fatsnaringin inhibits the reaction [Dietary Fats results in increased expression of G6PC mRNA]22198281
D004041Dietary FatsPlant Extracts inhibits the reaction [Dietary Fats results in increased expression of G6PC mRNA]22967722
D004041Dietary Fats[Plant Preparations co-treated with Dietary Fats] affects the expression of G6PC mRNA25861419
D004041Dietary FatsSodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of G6PC mRNA]26522834
D004041Dietary Fats[Streptozocin co-treated with Dietary Fats] results in increased expression of G6PC mRNA26522834
D004041Dietary Fats[bisphenol A co-treated with Dietary Fats] results in increased expression of G6PC protein25112833
D004041Dietary Fatsbisphenol A promotes the reaction [Dietary Fats results in increased expression of G6PC mRNA]25112833
D004041Dietary Fats[Dietary Fats co-treated with Ethanol] results in increased expression of G6PC mRNA24275070
D004041Dietary FatsDietary Fats results in increased expression of G6PC mRNA24275070|2511283
D004042Dietary Fats, Unsaturated"Dietary Fats, Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of G6PC mRNA]"23626681
D004042Dietary Fats, Unsaturated"Dietary Fats, Unsaturated results in increased expression of G6PC mRNA"23626681
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of G6PC mRNA19245819
C014476diethyl maleatediethyl maleate results in decreased expression of G6PC mRNA25270620
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of G6PC mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of G6PC mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of G6PC mRNA]17942915
D004052DiethylnitrosamineAllyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC protein]15554553
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC protein15554553
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of G6PC mRNA28943392
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of G6PC mRNA22129741
D004052DiethylnitrosamineSulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC protein]15554553
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of G6PC mRNA"27840820
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of G6PC mRNA25380136
D004147DioxinsDioxins affects the expression of G6PC mRNA20463971
C061132diphenyldiselenidediphenyldiselenide inhibits the reaction [acephate results in increased activity of G6PC protein]22778074
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of G6PC mRNA26159488
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of G6PC protein26159488
D004726EndosulfanEndosulfan promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of G6PC protein]26159488
D004726EndosulfanEndosulfan results in decreased expression of G6PC mRNA26159488
D004726EndosulfanEndosulfan affects the activity of G6PC protein6281947
D004726EndosulfanVitamin A inhibits the reaction [Endosulfan affects the activity of G6PC protein]6281947
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of G6PC mRNA24534155
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of G6PC mRNA15549673
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of G6PC mRNA16988119
D004918Erythromycin EstolateErythromycin Estolate results in decreased expression of G6PC mRNA24412560
C007628esculetinesculetin promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of G6PC protein]27769711
D000431EthanolEthanol results in decreased expression of G6PC mRNA19167417
D000431Ethanol[Dietary Fats co-treated with Ethanol] results in increased expression of G6PC mRNA24275070
D000431EthanolEthanol results in increased expression of G6PC mRNA15353170|1792074
D000431EthanolEthanol results in increased expression of G6PC protein23544086
D000431Ethanoltauroursodeoxycholic acid inhibits the reaction [Ethanol results in increased expression of G6PC mRNA]23544086
D000431Ethanoltauroursodeoxycholic acid inhibits the reaction [Ethanol results in increased expression of G6PC protein]23544086
C024565ethylene dichlorideethylene dichloride results in decreased expression of G6PC mRNA28189721
C024565ethylene dichlorideethylene dichloride results in decreased expression of G6PC protein28189721
D005227Fatty AcidsFatty Acids analog inhibits the reaction [[Dexamethasone co-treated with Cyclic AMP] results in increased expression of G6PC mRNA]22676303
D005227Fatty AcidsFatty Acids analog inhibits the reaction [[Glucagon co-treated with Cyclic AMP] results in increased expression of G6PC mRNA]22676303
C047360felbamatefelbamate results in decreased expression of G6PC mRNA17381134
D011345FenofibrateFenofibrate results in decreased expression of G6PC mRNA25572481
D0150732-AcetylaminofluoreneAllyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC protein]15554553
D0150732-Acetylaminofluorene[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC protein15554553
D0150732-AcetylaminofluoreneSulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC protein]15554553
D005485FlutamideFlutamide results in decreased expression of G6PC mRNA24136188
C065180fluvastatin[fluvastatin co-treated with NR1I2 protein] results in increased expression of G6PC mRNA24204015
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of G6PC mRNA20938992
C058728fosbretabulinfosbretabulin results in decreased expression of G6PC mRNA18434188
D005632FructoseFructose results in increased expression of G6PC mRNA14988444|1515037
D005632FructoseFructose results in increased expression of G6PC protein19196556
D005632Fructoserosiglitazone inhibits the reaction [Fructose results in increased expression of G6PC mRNA]19196556
D005632Fructoserosiglitazone inhibits the reaction [Fructose results in increased expression of G6PC protein]19196556
C056933fumonisin B1fumonisin B1 results in decreased expression of G6PC mRNA16221962
C039281furanfuran results in decreased expression of G6PC mRNA26194646
C040029gabapentingabapentin results in decreased expression of G6PC mRNA17381134
D005839GentamicinsGentamicins results in decreased expression of G6PC mRNA18289764|2206182
C049864ginsenoside Reginsenoside Re results in decreased expression of G6PC mRNA21971952
D005897GlafenineGlafenine results in decreased expression of G6PC mRNA24136188
D005934GlucagonFatty Acids analog inhibits the reaction [[Glucagon co-treated with Cyclic AMP] results in increased expression of G6PC mRNA]22676303
D005934Glucagon[Glucagon co-treated with Cyclic AMP] results in increased expression of G6PC mRNA22676303
D005947GlucoseGlucose promotes the reaction [[ARNT protein binds to G6PC promoter] which results in increased expression of G6PC mRNA]15767253|1576725
D005947GlucoseGlucose results in increased stability of and results in increased expression of G6PC mRNA15767253
D005947GlucoseGlucose results in decreased expression of G6PC mRNA14988444
D005947GlucoseGlucose results in increased activity of G6PC protein16920846
D005947GlucoseGlucose results in increased expression of G6PC mRNA19576170
D005947GlucoseMetformin inhibits the reaction [Glucose results in increased expression of G6PC mRNA]19576170
D005947Glucosetungstate inhibits the reaction [Glucose results in increased activity of G6PC protein]16920846
D005947GlucoseVanadates inhibits the reaction [Glucose results in increased activity of G6PC protein]16920846
D005905GlyburideGlyburide inhibits the reaction [Streptozocin results in increased activity of G6PC protein]25641191
C412815GW 4064GW 4064 results in decreased expression of G6PC mRNA23371517
C412815GW 4064GW 4064 results in increased expression of G6PC mRNA26655953
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of G6PC mRNA22129741
D007501IronIron deficiency results in decreased expression of G6PC mRNA16629162
D007654KetoconazoleKetoconazole affects the expression of G6PC mRNA18289764
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of G6PC mRNA"18930950
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of G6PC mRNA27339419
D008627Mercuric ChlorideMercuric Chloride results in decreased activity of G6PC protein22413763|2241665
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of G6PC mRNA16507785
D008627Mercuric ChlorideMercuric Chloride results in increased activity of G6PC protein22413763
D008627Mercuric Chloridezinc chloride inhibits the reaction [Mercuric Chloride results in increased activity of G6PC protein]22413763
D008687MetforminMetformin results in decreased expression of G6PC mRNA19664596|2442882
D008687MetforminMetformin inhibits the reaction [Glucose results in increased expression of G6PC mRNA]19576170
D008687MetforminMetformin results in decreased expression of G6PC mRNA19664596
D008715Methionine"[Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in decreased expression of G6PC mRNA"28163111
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with aroclor 1260] results in decreased expression of G6PC mRNA28163111
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of G6PC mRNA20938992
C013598methoxyacetic acidmethoxyacetic acid affects the expression of G6PC mRNA20864626
C004925methylmercuric chloride[Cadmium Chloride co-treated with methylmercuric chloride] results in increased expression of G6PC mRNA27814245
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of G6PC mRNA24128854
C500085muraglitazarmuraglitazar results in increased expression of G6PC mRNA21515302
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of G6PC mRNA"29244179
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of G6PC mRNA25380136
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of G6PC mRNA18289764
C005274naringinnaringin affects the reaction [LEPR protein affects the expression of G6PC mRNA]16427799
C005274naringinnaringin inhibits the reaction [Dietary Fats results in increased expression of G6PC mRNA]22198281
C461488N-benzylpiperazineN-benzylpiperazine results in decreased expression of G6PC mRNA26821219
C051752nefazodonenefazodone results in decreased expression of G6PC mRNA24136188
C022838nickel chloridenickel chloride affects the expression of G6PC mRNA22110744
C007350nitrofennitrofen results in decreased expression of G6PC mRNA20638522
C025589ochratoxin Aochratoxin A results in decreased expression of G6PC mRNA26341324
C572462octaphlorethol Aoctaphlorethol A inhibits the reaction [LEPR gene mutant form results in increased expression of G6PC mRNA]26939912
D010126OzoneOzone results in decreased expression of G6PC mRNA16183385
D010126OzoneOzone results in increased expression of G6PC mRNA25838073
D017239PaclitaxelPaclitaxel results in increased expression of G6PC mRNA15585946
D052638Particulate MatterParticulate Matter results in decreased expression of G6PC24149114
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in increased expression of G6PC mRNA22387981
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of G6PC mRNA19162173
C023036perfluorooctanoic acid"Dietary Fats, Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of G6PC mRNA]"23626681
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of G6PC mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of G6PC mRNA28511854
D010578PetroleumPetroleum affects the expression of G6PC mRNA25208076
D010634PhenobarbitalEstradiol inhibits the reaction [Phenobarbital results in decreased expression of G6PC mRNA]21768169
D010634PhenobarbitalNR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [Phenobarbital results in decreased expression of G6PC mRNA]]21768169
D010634PhenobarbitalNR1I3 mutant form inhibits the reaction [Phenobarbital results in decreased expression of G6PC mRNA]21768169
D010634PhenobarbitalNR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [Phenobarbital results in decreased expression of G6PC mRNA]]21768169
D010634PhenobarbitalPhenobarbital affects the expression of G6PC mRNA19084549
D010634PhenobarbitalPhenobarbital results in decreased expression of G6PC mRNA21768169
D010634Phenobarbital[Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in decreased expression of G6PC mRNA]21768169
D010634PhenobarbitalProgesterone inhibits the reaction [Phenobarbital results in decreased expression of G6PC mRNA]21768169
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of G6PC mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of G6PC mRNA19270015|1948288
D010634PhenobarbitalPhenobarbital affects the expression of G6PC mRNA19162173
D010634PhenobarbitalPhenobarbital results in decreased expression of G6PC mRNA17381134
D010672PhenytoinPhenytoin results in decreased expression of G6PC mRNA17381134
D010695PhlorhizinPhlorhizin inhibits the reaction [Streptozocin results in increased expression of G6PC mRNA]12446591
C014153pirimiphos methylpirimiphos methyl results in decreased expression of G6PC mRNA27845199
C006253pirinixic acidpirinixic acid results in increased expression of G6PC mRNA17426115|1844570
D010936Plant ExtractsPlant Extracts inhibits the reaction [Dietary Fats results in increased expression of G6PC mRNA]22967722
D010936Plant ExtractsPlant Extracts inhibits the reaction [Streptozocin results in decreased activity of G6PC protein]26616445
D010936Plant ExtractsPlant Extracts inhibits the reaction [Streptozocin results in increased expression of G6PC mRNA]27038876
D028321Plant Preparations[Plant Preparations co-treated with Dietary Fats] affects the expression of G6PC mRNA25861419
C014758plumbaginplumbagin inhibits the reaction [Streptozocin results in increased activity of G6PC protein]22960630
D011134Polysaccharides[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of G6PC protein]25446853
D011134PolysaccharidesPolysaccharides inhibits the reaction [Streptozocin results in decreased activity of G6PC protein]26616445
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile affects the expression of G6PC mRNA19162173
D011374Progesterone"NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of G6PC mRNA]]"21768169
D011374ProgesteroneNR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [Phenobarbital results in decreased expression of G6PC mRNA]]21768169
D011374Progesterone"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of G6PC mRNA]"21768169
D011374Progesterone[Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in decreased expression of G6PC mRNA]21768169
D011374Progesterone"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [FOXO1 protein binds to G6PC promoter]]"21768169
D011374Progesterone"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of G6PC mRNA]"21768169
D011374ProgesteroneProgesterone inhibits the reaction [Phenobarbital results in decreased expression of G6PC mRNA]21768169
D011374Progesterone"Progesterone promotes the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [FOXO1 protein binds to G6PC promoter]]]"21768169
D011374Progesterone"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [[Progesterone co-treated with Estradiol] results in increased expression of G6PC mRNA]"21768169
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of G6PC mRNA21768169
C031280pyrazolepyrazole results in decreased expression of G6PC mRNA17945193
D011794QuercetinQuercetin results in decreased expression of G6PC mRNA21632981
D015125OxyquinolineOxyquinoline results in increased expression of G6PC mRNA21632981
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC mRNA]25554529
C059514resveratrolresveratrol promotes the reaction [FOXO1 protein results in increased expression of G6PC mRNA]16917544
C059514resveratrol[TO-901317 co-treated with resveratrol] results in decreased expression of G6PC mRNA23591747
C059514resveratrolFOXO1 protein affects the reaction [resveratrol results in increased expression of G6PC mRNA]15788402
D012293RifampinINS protein inhibits the reaction [[Rifampin co-treated with NR1I2 protein] results in increased expression of G6PC mRNA]24204015
D012293RifampinRifampin affects the expression of G6PC mRNA24204015
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in increased expression of G6PC mRNA24204015
D012293RifampinSGK2 mutant form affects the reaction [Rifampin affects the expression of G6PC mRNA]24204015
D012293RifampinSGK2 mutant form inhibits the reaction [[Rifampin co-treated with NR1I2 protein] results in increased expression of G6PC mRNA]24204015
C089730rosiglitazonerosiglitazone results in decreased expression of G6PC mRNA25572481
C089730rosiglitazonerosiglitazone inhibits the reaction [Fructose results in increased expression of G6PC mRNA]19196556
C089730rosiglitazonerosiglitazone inhibits the reaction [Fructose results in increased expression of G6PC protein]19196556
D012402RotenoneRotenone results in decreased expression of G6PC mRNA19664596
D012822Silicon DioxideSilicon Dioxide results in decreased expression of G6PC mRNA23221170
D019821Simvastatin[Simvastatin co-treated with NR1I2 protein] results in increased expression of G6PC mRNA24204015
C570013SJ 000311413SJ 000311413 inhibits the reaction [Triiodothyronine results in increased expression of G6PC mRNA]21815645
C017947sodium arsenitesodium arsenite results in decreased expression of G6PC mRNA24535192
C017947sodium arsenitesodium arsenite results in decreased expression of G6PC protein24866292
C017947sodium arsenitesodium arsenite results in decreased expression of G6PC protein24866292
C017947sodium arsenitesodium arsenite results in decreased expression of G6PC mRNA25610880
C016104sodium bichromatesodium bichromate affects the expression of G6PC mRNA22110744
C016104sodium bichromatesodium bichromate results in decreased expression of G6PC mRNA25993096
D018038Sodium SeleniteSodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of G6PC mRNA]26522834
D018038Sodium SeleniteSodium Selenite inhibits the reaction [Alloxan results in increased activity of G6PC protein]25779343
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC mRNA]25554529
D013311Streptozocin[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of G6PC protein]25446853
D013311Streptozocin[Dietary Fats co-treated with Streptozocin] results in decreased activity of G6PC protein27769711
D013311Streptozocin[Dietary Fats co-treated with Streptozocin] results in increased expression of G6PC protein25446853
D013311Streptozocinesculetin promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of G6PC protein]27769711
D013311StreptozocinSodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of G6PC mRNA]26522834
D013311Streptozocin[Streptozocin co-treated with Dietary Fats] results in increased expression of G6PC mRNA26522834
D013311Streptozocin4-hydroxyphenylethanol inhibits the reaction [Streptozocin results in increased activity of G6PC protein]25641191
D013311Streptozocinbis(maltolato)oxovanadium(IV) inhibits the reaction [Streptozocin results in increased expression of G6PC mRNA]12446591
D013311Streptozocincitronellol inhibits the reaction [Streptozocin results in increased activity of G6PC protein]26944432
D013311StreptozocinGlyburide inhibits the reaction [Streptozocin results in increased activity of G6PC protein]25641191
D013311StreptozocinPhlorhizin inhibits the reaction [Streptozocin results in increased expression of G6PC mRNA]12446591
D013311StreptozocinPlant Extracts inhibits the reaction [Streptozocin results in decreased activity of G6PC protein]26616445
D013311StreptozocinPlant Extracts inhibits the reaction [Streptozocin results in increased expression of G6PC mRNA]27038876
D013311Streptozocinplumbagin inhibits the reaction [Streptozocin results in increased activity of G6PC protein]22960630
D013311StreptozocinPolysaccharides inhibits the reaction [Streptozocin results in decreased activity of G6PC protein]26616445
D013311StreptozocinStreptozocin results in decreased activity of G6PC protein26616445
D013311StreptozocinStreptozocin results in decreased expression of G6PC mRNA25905778
D013311StreptozocinStreptozocin results in increased activity of G6PC protein22960630|2564119
D013311StreptozocinStreptozocin results in increased expression of G6PC mRNA12446591|2703887
D013311StreptozocinStreptozocin results in increased expression of G6PC protein19634143
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in increased expression of G6PC protein]19634143
D013395SucroseSucrose results in increased expression of G6PC mRNA12514263
D013440SulfidesSulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC protein]15554553
D014284Triiodothyronine"(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of G6PC mRNA]"21815645
D014284TriiodothyronineSJ 000311413 inhibits the reaction [Triiodothyronine results in increased expression of G6PC mRNA]21815645
D014284TriiodothyronineTriiodothyronine results in increased expression of G6PC mRNA21815645
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [Ethanol results in increased expression of G6PC mRNA]23544086
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [Ethanol results in increased expression of G6PC protein]23544086
D013739Testosterone"Testosterone metabolite inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [FOXO1 protein binds to G6PC promoter]]"24769335
D013739TestosteroneTestosterone results in increased expression of G6PC mRNA20843997
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of G6PC mRNA26159488
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of G6PC protein26159488
D013749TetrachlorodibenzodioxinEndosulfan promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of G6PC protein]26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of G6PC mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of G6PC mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of G6PC protein26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of G6PC mRNA21632981
D013749Tetrachlorodibenzodioxin[Dietary Fats co-treated with Tetrachlorodibenzodioxin] results in decreased expression of G6PC mRNA27713108
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of G6PC mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of G6PC mRNA17949056|1816354
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of G6PC mRNA18172886
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of G6PC mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of G6PC mRNA18178546
D013752TetracyclineTetracycline results in decreased expression of G6PC mRNA24489787
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of G6PC mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of G6PC mRNA23411599
C423915TO-901317[TO-901317 co-treated with resveratrol] results in decreased expression of G6PC mRNA23591747
D014266TrientineTrientine inhibits the reaction [Streptozocin results in increased expression of G6PC protein]19634143
C001899triptolidetriptolide results in decreased expression of G6PC mRNA23639586
C057693troglitazonetroglitazone results in decreased expression of G6PC mRNA25572481
C057693troglitazonetroglitazone results in decreased expression of G6PC mRNA11228057
C057693troglitazonetroglitazone results in decreased expression of G6PC mRNA10446394
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of G6PC mRNA"18930950
C045951tungstatetungstate inhibits the reaction [Glucose results in increased activity of G6PC protein]16920846
D014415TunicamycinTunicamycin results in decreased expression of G6PC mRNA17127020
D017974Uranium CompoundsUranium Compounds results in increased expression of G6PC mRNA19654044
D014520UrethaneUrethane results in increased expression of G6PC mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of G6PC mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of G6PC mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of G6PC mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of G6PC mRNA24489787
D014635Valproic AcidValproic Acid results in decreased expression of G6PC mRNA17381134
D014638VanadatesVanadates inhibits the reaction [Glucose results in increased activity of G6PC protein]16920846
D014640VancomycinVancomycin results in increased expression of G6PC mRNA18930951
D014640VancomycinVancomycin results in decreased expression of G6PC mRNA18289764
C029297vinylidene chloridevinylidene chloride results in decreased expression of G6PC mRNA26682919
D014801Vitamin AVitamin A inhibits the reaction [Endosulfan affects the activity of G6PC protein]6281947
D009536NiacinamideNiacinamide inhibits the reaction [FOXO1 protein results in increased expression of G6PC mRNA]16917544
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of G6PC mRNA"25208076
C009687wortmanninwortmannin inhibits the reaction [INS protein results in decreased expression of G6PC mRNA]24535192
C009687wortmanninwortmannin results in increased expression of G6PC mRNA24535192
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of G6PC mRNA16931933
C016837zinc chloridezinc chloride inhibits the reaction [Mercuric Chloride results in increased activity of G6PC protein]22413763

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004346glucose-6-phosphatase activity-EXP12093795  
GO:0004346glucose-6-phosphatase activity-IBA21873635  
GO:0004346glucose-6-phosphatase activity-IDA8211187  10318794  15661744  
GO:0016773phosphotransferase activity, alcohol group as acceptor-IEA-  
GO:0042301phosphate ion binding-IMP12093795  
GO ID GO Term Qualifier Evidence PubMed
GO:0005977glycogen metabolic process-TAS8211187  
GO:0005980glycogen catabolic process-IEA-  
GO:0006094gluconeogenesis-IBA21873635  
GO:0006094gluconeogenesis-IEA-  
GO:0006094gluconeogenesis-IMP8211187  
GO:0006094gluconeogenesis-TAS-  
GO:0006641triglyceride metabolic process-IEA-  
GO:0008202steroid metabolic process-IEA-  
GO:0010468regulation of gene expression-IEA-  
GO:0015760glucose-6-phosphate transport-IEA-  
GO:0032094response to food-IEA-  
GO:0035264multicellular organism growth-IEA-  
GO:0042593glucose homeostasis-IMP8211187  
GO:0042632cholesterol homeostasis-IEA-  
GO:0046415urate metabolic process-IEA-  
GO:0046838phosphorylated carbohydrate dephosphorylation-IEA-  
GO:0051156glucose 6-phosphate metabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IDA10318794  
GO:0030176integral component of endoplasmic reticulum membrane-TAS10318794  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00052Galactose metabolism
hsa00500Starch and sucrose metabolism
hsa01100Metabolic pathways
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04973Carbohydrate digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-3229121Glycogen storage diseasesTAS
R-HSA-3274531Glycogen storage disease type Ia (G6PC)TAS
R-HSA-5663084Diseases of carbohydrate metabolismTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-70263GluconeogenesisTAS
R-HSA-70326Glucose metabolismTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26321514Upregulated hepatic expression of mitochondrial PEPCK triggers initial gluconeogenic reactions in the HCV-3 patients. (2015 Aug)Sheikh TIAsian Pac J Trop Med