Gene info: ID 2539

Gene: G6PD

GENE ID: 2539

Synonyms: G6PD1

Description: glucose-6-phosphate dehydrogenase

Gene type: protein-coding

Location: Xq28

dbXrefs: Ensembl:ENSG00000160211 MIM:305900 Vega:OTTHUMG00000024237 UniprotKB:P11413

RefSeq: NG_009015.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 7

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
AP1B1	0.934
OGDH	0.918
AP3D1	0.912
GRINA	0.909
CSNK1D	0.906
YIPF3	0.904
CARM1	0.903
WBP2	0.903
PACS1	0.901
CAPN1	0.901

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.735
OR4F29	-0.69
OR6C74	-0.305
KCNJ15	-0.3
CTNNA3	-0.295
CPA3	-0.291
MTRNR2L6	-0.291
CNTF	-0.289
OR52B4	-0.289
DNASE1L3	-0.288

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB03085	Glycolic acid	Small Molecule	79-14-1	Approved\|Investigational	Target
DB03461	2'-Monophosphoadenosine 5'-Diphosphoribose	Small Molecule		Experimental	Target
DB05107	16-Bromoepiandrosterone	Small Molecule	28507-02-0	Investigational	Target
DB11638	Artenimol	Small Molecule	71939-50-9	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of G6PD mRNA"	17690111
C041507	1-methylphenanthrene	[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of G6PD mRNA	17690111
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of G6PD mRNA]	12717738
C046728	2,2'-azobis(2-amidinopropane)	"2,2'-azobis(2-amidinopropane) results in decreased activity of G6PD protein"	12628296
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of G6PD mRNA"	19114083
C010925	2,5-dihydroxybenzoic acid	"2,5-dihydroxybenzoic acid results in decreased activity of G6PD protein mutant form"	5432368
C010925	2,5-dihydroxybenzoic acid	"2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of G6PD protein]"	15454305
C572491	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of G6PD protein	26194647
C000623021	3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one	3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one results in increased expression of G6PD mRNA	28790194
C000623021	3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one	NFE2L2 protein affects the reaction [3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one results in increased expression of G6PD mRNA]	28790194
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of G6PD mRNA"	27188386
C032642	4-aminophenylarsenoxide	4-aminophenylarsenoxide binds to G6PD protein	26598702
C032642	4-aminophenylarsenoxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to G6PD protein]	26598702
C006983	4-chlorobiphenyl	4-chlorobiphenyl metabolite results in increased expression of G6PD mRNA	25417049
C011867	4-hydroxyphenylethanol	4-hydroxyphenylethanol inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]	25641191
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in increased expression of G6PD mRNA	15982314
C029370	4-toluidine	4-toluidine results in increased expression of G6PD mRNA	27638505
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of G6PD mRNA"	27188386
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cadmium Chloride results in increased expression of G6PD mRNA]"	12717738
D000079	Acetaldehyde	Acetaldehyde results in increased activity of G6PD protein	8123704
D000079	Acetaldehyde	Acetaldehyde results in increased expression of G6PD mRNA	8123704
D000082	Acetaminophen	Acetaminophen affects the expression of G6PD mRNA	25064622
D000082	Acetaminophen	Acetaminophen results in increased expression of G6PD mRNA	22230336\|2539940
D000082	Acetaminophen	Acetaminophen results in increased expression of G6PD protein	22230336
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of G6PD mRNA]	12717738
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of G6PD mRNA]	15225644
D000111	Acetylcysteine	Acetylcysteine results in increased activity of G6PD protein	3099627
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of G6PD gene	27153756
D000420	Albuterol	Albuterol results in increased activity of G6PD protein	1978808
C103303	alitretinoin	alitretinoin results in increased expression of G6PD mRNA	15982314
C038491	allyl sulfide	allyl sulfide inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein]	18972399
D000535	Aluminum	Aluminum results in increased activity of G6PD protein	16979867
D000535	Aluminum	Aluminum results in increased activity of G6PD protein	16572710
D017607	Aluminum Compounds	Aluminum Compounds results in decreased activity of G6PD protein	28665548
C001864	aluminum phosphide	aluminum phosphide results in decreased activity of G6PD protein	20929055
D000638	Amiodarone	Amiodarone affects the expression of G6PD mRNA	25064622
D000638	Amiodarone	Amiodarone results in increased expression of G6PD mRNA	19774075
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of G6PD mRNA	16483693
D000738	Androsterone	Androsterone results in decreased activity of G6PD protein	7752092
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in increased expression of G6PD mRNA	28713220
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in increased expression of G6PD protein	28713220
C061640	arjunolic acid	arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]	19133311\|1968244
D001151	Arsenic	Arsenic results in decreased activity of G6PD protein	21864513\|2222986
D001151	Arsenic	silybin inhibits the reaction [Arsenic results in decreased activity of G6PD protein]	22229868
C025657	arsenic acid	arsenic acid results in increased expression of G6PD protein	19632019
C042120	arsenic pentoxide	arsenic pentoxide results in decreased activity of G6PD protein	23363574
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to G6PD protein]	26598702
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of G6PD protein	25419056
C006632	arsenic trioxide	G6PD protein results in decreased susceptibility to arsenic trioxide	20707922
D017639	Asbestos, Amosite	"Asbestos, Amosite results in decreased activity of G6PD protein"	14613721\|1837041
D017639	Asbestos, Amosite	"Glutathione inhibits the reaction [Asbestos, Amosite results in decreased activity of G6PD protein]"	14613721
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite binds to and results in decreased activity of G6PD protein"	11978496
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in decreased activity of G6PD protein"	18370412
C011669	ascorbate-2-phosphate	ascorbate-2-phosphate results in increased activity of G6PD protein	19746226
C011669	ascorbate-2-phosphate	ascorbate-2-phosphate results in increased expression of G6PD mRNA	19746226
C011669	ascorbate-2-phosphate	Dehydroepiandrosterone inhibits the reaction [ascorbate-2-phosphate results in increased activity of G6PD protein]	19746226
D001241	Aspirin	Aspirin results in decreased activity of G6PD protein mutant form	5432368
D001241	Aspirin	G6PD results in decreased susceptibility to Aspirin	5432368
C005948	astaxanthine	astaxanthine results in increased activity of G6PD protein	28665548
D001262	Atenolol	Atenolol inhibits the reaction [Dopamine results in increased activity of G6PD protein]	1978808
D001262	Atenolol	Atenolol inhibits the reaction [Isoproterenol results in increased activity of G6PD protein]	1978808
D001280	Atrazine	Atrazine results in increased expression of G6PD mRNA	22982499
C051597	Bandrowski's base	Bandrowski's base results in increased expression of G6PD mRNA	20566472
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of G6PD mRNA	17690111
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of G6PD protein	28903497
D019817	Benzoic Acid	Benzoic Acid results in increased expression of G6PD mRNA	20566472
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of G6PD mRNA"	17690111
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of G6PD mRNA	17690111
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of G6PD mRNA	17690111
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of G6PD mRNA"	17690111
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of G6PD mRNA	17690111
D001564	Benzo(a)pyrene	[Soot co-treated with Benzo(a)pyrene] results in increased expression of G6PD protein	24464499
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased activity of G6PD protein	11856576
D001585	Benzoyl Peroxide	"2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of G6PD protein]"	15454305
D001585	Benzoyl Peroxide	Benzoyl Peroxide results in decreased activity of G6PD protein	12804013\|1522590
D001585	Benzoyl Peroxide	cycloartenol inhibits the reaction [Benzoyl Peroxide results in decreased activity of G6PD protein]	12804013
D001585	Benzoyl Peroxide	Isotretinoin inhibits the reaction [Benzoyl Peroxide results in decreased activity of G6PD protein]	15225900
D001585	Benzoyl Peroxide	Plant Extracts inhibits the reaction [Benzoyl Peroxide results in decreased activity of G6PD protein]	15629248
D004958	Estradiol	Estradiol results in decreased activity of G6PD protein	11856576
C023888	beta-hexachlorocyclohexane	beta-hexachlorocyclohexane results in increased activity of G6PD protein	2461408
D001629	Bezafibrate	Bezafibrate inhibits the reaction [etomoxir results in increased activity of G6PD protein]	3421940
C551172	bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)	"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in decreased expression of G6PD mRNA"	20162321
C006780	bisphenol A	bisphenol A results in increased expression of G6PD mRNA	28159858
C006780	bisphenol A	bisphenol A results in increased expression of G6PD mRNA	27474941
C006780	bisphenol A	bisphenol A results in increased expression of G6PD protein	27474941
C006780	bisphenol A	bisphenol A results in increased expression of G6PD mRNA	29275510
C006780	bisphenol A	bisphenol A affects the expression of G6PD mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of G6PD protein	22649256
D000069286	Bortezomib	Bortezomib results in decreased expression of G6PD mRNA	20977926
D002065	Buspirone	Buspirone results in decreased expression of G6PD mRNA	24136188
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased expression of G6PD mRNA	12717738
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased activity of G6PD protein	12628296
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased activity of G6PD protein	15336504
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased activity of G6PD protein	15336504
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased activity of G6PD protein	16928893
D002104	Cadmium	Cadmium results in decreased activity of G6PD protein	16752219
D002104	Cadmium	Cadmium results in increased activity of G6PD protein	16752219
D002104	Cadmium	Cadmium results in increased expression of G6PD mRNA	18394669
D002104	Cadmium	[Cadmium co-treated with Zinc] results in increased activity of G6PD protein	20143450
D002104	Cadmium	Cadmium results in increased activity of G6PD protein	20143450
D002104	Cadmium	Cadmium results in decreased activity of G6PD protein	17698948
D002104	Cadmium	Cadmium results in decreased expression of G6PD	17125799
D002104	Cadmium	Cadmium results in decreased expression of G6PD protein	19615871
D002104	Cadmium	diallyl tetrasulfide inhibits the reaction [Cadmium results in decreased activity of G6PD protein]	17698948
D002104	Cadmium	diallyl tetrasulfide inhibits the reaction [Cadmium results in decreased expression of G6PD]	17125799
D002104	Cadmium	myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased activity of G6PD protein]	24923654
D002104	Cadmium	Quercetin inhibits the reaction [Cadmium results in decreased expression of G6PD protein]	19615871
D002104	Cadmium	[Streptozocin co-treated with Cadmium] results in decreased activity of G6PD protein	24923654
D002104	Cadmium	Cadmium results in increased expression of G6PD mRNA	24095957
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of G6PD protein	24874008
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of G6PD mRNA	26525392
D019256	Cadmium Chloride	Cadmium Chloride results in decreased activity of G6PD protein	18414974\|1856190
D019256	Cadmium Chloride	Taurine inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein]	18414974\|1856190
D019256	Cadmium Chloride	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of G6PD mRNA]	12717738
D019256	Cadmium Chloride	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cadmium Chloride results in increased expression of G6PD mRNA]"	12717738
D019256	Cadmium Chloride	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of G6PD mRNA]	12717738
D019256	Cadmium Chloride	allyl sulfide inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein]	18972399
D019256	Cadmium Chloride	Cadmium Chloride results in decreased activity of G6PD protein	15454312\|1897239
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of G6PD protein	19063931
D019256	Cadmium Chloride	Cadmium Chloride results in increased activity of G6PD protein	12717738
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of G6PD mRNA	12717738\|1525286
D019256	Cadmium Chloride	hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein]	21134734
D019256	Cadmium Chloride	naringenin inhibits the reaction [Cadmium Chloride results in decreased expression of G6PD protein]	19063931
D019256	Cadmium Chloride	Plant Extracts inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein]	23961183
D019256	Cadmium Chloride	S-ethyl glutathione inhibits the reaction [Cadmium Chloride results in increased expression of G6PD mRNA]	12717738
D019256	Cadmium Chloride	zinc chloride inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein]	18972399
C035196	cadmium nitrate	cadmium nitrate results in decreased activity of G6PD protein	28557068
C040048	caffeic acid	caffeic acid results in decreased activity of G6PD protein	25130191
D002119	Calcium Carbonate	Calcium Carbonate results in decreased activity of G6PD protein	16735067
C058819	calphostin C	calphostin C results in decreased activity of G6PD protein	19429815
D012721	Carbaryl	Carbaryl results in increased activity of G6PD protein	27214522
D012721	Carbaryl	[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein	27214522
D012721	Carbaryl	Plant Extracts inhibits the reaction [[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein]	27214522
D002244	Carbon	Carbon inhibits the reaction [lead nitrate results in increased expression of G6PD mRNA]	18346799
D002509	Cephaloridine	Cephaloridine results in increased expression of G6PD mRNA	18500788
C016299	chelerythrine	chelerythrine results in decreased activity of G6PD protein	19429815
C001599	chlorite	chlorite results in decreased activity of G6PD protein	27478981
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased activity of G6PD protein	3099627\|4005852
D002746	Chlorpromazine	Chlorpromazine affects the expression of G6PD mRNA	25064622
D002746	Chlorpromazine	Chlorpromazine analog results in decreased expression of G6PD mRNA	15924885
D002791	Cholesterol, Dietary	"Cholesterol, Dietary results in increased expression of G6PD mRNA"	19509184
D002791	Cholesterol, Dietary	"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of G6PD mRNA"	19509184
D002791	Cholesterol, Dietary	"[CCL7 protein results in increased susceptibility to [Dietary Fats co-treated with Cholesterol, Dietary]] which results in increased activity of G6PD protein"	23462015
C023600	chromic oxide	chromic oxide affects the expression of G6PD mRNA	15003702
C074702	chromium hexavalent ion	chromium hexavalent ion results in decreased activity of G6PD protein	15980013
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of G6PD mRNA	15003702
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased expression of G6PD mRNA	19524605
C020722	cinnamyl alcohol	cinnamyl alcohol results in increased expression of G6PD mRNA	20566472
D002939	Ciprofloxacin	G6PD protein mutant form results in increased susceptibility to Ciprofloxacin	20127091
C007078	citronellol	citronellol inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]	26944432
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of G6PD mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in increased activity of G6PD protein	15225644
C018021	cobaltous chloride	cobaltous chloride results in increased expression of G6PD mRNA	15225644
C025913	cobaltous nitrate	cobaltous nitrate results in decreased activity of G6PD protein	23363574
D003042	Cocaine	Cocaine results in increased expression of G6PD protein	25100957
D009243	NAD	[G6PD protein co-treated with Glucose-6-Phosphate] results in increased chemical synthesis of NAD	23295224
D009249	NADP	G6PD protein results in increased reduction of NADP	5432368
D009249	NADP	NADP results in increased expression of G6PD protein	1922005
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of G6PD mRNA	20971185
D003300	Copper	Copper affects the expression of G6PD mRNA	23825565
D003300	Copper	Copper results in increased expression of G6PD mRNA	18394669
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of G6PD mRNA	23660017
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of G6PD protein	23660017
C007164	cumene hydroperoxide	cumene hydroperoxide results in increased activity of G6PD protein	16928893
D003474	Curcumin	Curcumin results in increased expression of G6PD mRNA	18299980
C100089	cycloartenol	cycloartenol inhibits the reaction [Benzoyl Peroxide results in decreased activity of G6PD protein]	12804013
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Isoproterenol results in increased activity of G6PD protein]	1978808
D016572	Cyclosporine	Cyclosporine affects the expression of G6PD mRNA	25064622
D016572	Cyclosporine	Cyclosporine results in decreased expression of G6PD mRNA	27989131
D016572	Cyclosporine	Cyclosporine results in increased expression of G6PD mRNA	25562108
C017160	cypermethrin	[cypermethrin co-treated with propetamphos] results in decreased activity of G6PD protein	25926273
C017160	cypermethrin	cypermethrin results in decreased activity of G6PD protein	25926273
D003609	Dactinomycin	Dactinomycin promotes the reaction [Endosulfan results in decreased activity of G6PD protein]	15202864
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Isoproterenol results in increased activity of G6PD protein]	1978808
D003622	Dapsone	G6PD protein mutant form results in increased susceptibility to Dapsone	7752092
D003634	DDT	[DDT co-treated with Methylmercury Compounds] results in increased activity of G6PD protein	18675336
D003634	DDT	DDT results in increased activity of G6PD protein	12667599
D003634	DDT	Inositol inhibits the reaction [DDT results in increased activity of G6PD protein]	12667599
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone inhibits the reaction [ascorbate-2-phosphate results in increased activity of G6PD protein]	19746226
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of G6PD mRNA]	27941970
D003907	Dexamethasone	Dexamethasone results in decreased activity of G6PD protein	15895680
C431585	diallyl tetrasulfide	diallyl tetrasulfide inhibits the reaction [Cadmium results in decreased activity of G6PD protein]	17698948
C431585	diallyl tetrasulfide	diallyl tetrasulfide inhibits the reaction [Cadmium results in decreased expression of G6PD]	17125799
D003976	Diazinon	Diazinon affects the expression of G6PD mRNA	22546817
C041517	dibenzo(a,l)pyrene	"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of G6PD mRNA"	17690111
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of G6PD mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of G6PD mRNA	21151649
D004026	Dieldrin	Dieldrin affects the expression of G6PD mRNA	22546817
D004041	Dietary Fats	"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of G6PD mRNA"	19509184
D004041	Dietary Fats	"[CCL7 protein results in increased susceptibility to [Dietary Fats co-treated with Cholesterol, Dietary]] which results in increased activity of G6PD protein"	23462015
D004041	Dietary Fats	Dietary Fats analog results in decreased expression of G6PD mRNA	12669817
C014476	diethyl maleate	diethyl maleate results in increased activity of G6PD protein	3099627
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of G6PD protein	28903497
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Methapyrilene] results in increased expression of G6PD protein	28903497
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased activity of G6PD protein	16188247
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of G6PD protein	28903497
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of G6PD protein	28903497
D004052	Diethylnitrosamine	Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in decreased activity of G6PD protein]	16188247
D004077	Digoxin	Digoxin results in decreased activity of G6PD protein	26820767
C039060	dihydroartemisinin	dihydroartemisinin analog binds to G6PD protein	26340163
D002117	Calcitriol	Calcitriol results in increased activity of G6PD protein	8910257
D002117	Calcitriol	Calcitriol results in increased expression of G6PD mRNA	12040012\|1600243
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of G6PD mRNA	21592394
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in increased expression of G6PD mRNA	27638505
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of G6PD mRNA	20566472
D004178	Diquat	Diquat results in increased activity of G6PD protein	28108222
D004178	Diquat	Diquat results in increased activity of G6PD protein	8934631
D004178	Diquat	Diquat results in increased expression of G6PD mRNA	8934631
D004178	Diquat	Diquat results in increased expression of G6PD protein	8934631
D004221	Disulfiram	Disulfiram results in increased expression of G6PD mRNA	20566472
D004237	Diuron	Diuron results in increased expression of G6PD mRNA	21551480
D004280	Dobutamine	Dobutamine results in increased activity of G6PD protein	1978808
D004298	Dopamine	Atenolol inhibits the reaction [Dopamine results in increased activity of G6PD protein]	1978808
D004298	Dopamine	Dopamine results in decreased activity of G6PD protein	26820767
D004298	Dopamine	Dopamine results in increased activity of G6PD protein	1978808
D004317	Doxorubicin	Doxorubicin results in increased expression of G6PD mRNA	16404146
D004317	Doxorubicin	Doxorubicin affects the expression of G6PD protein	15909818
D004610	Ellagic Acid	Ellagic Acid results in decreased activity of G6PD protein	25130191
D004726	Endosulfan	Dactinomycin promotes the reaction [Endosulfan results in decreased activity of G6PD protein]	15202864
D004726	Endosulfan	Endosulfan results in decreased activity of G6PD protein	15202864
D004726	Endosulfan	Endosulfan results in decreased expression of G6PD mRNA	15202864
D004726	Endosulfan	Endosulfan results in decreased expression of G6PD protein	15202864
D004726	Endosulfan	Endosulfan results in increased activity of G6PD protein	7900959\|8588293
D004785	Environmental Pollutants	Environmental Pollutants affects the expression of G6PD protein	16998633
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of G6PD protein	23301498
C062669	epicatechin gallate	epicatechin gallate results in increased activity of G6PD protein	26187476
C011246	essential 303 forte	[essential 303 forte co-treated with Silymarin] affects the activity of G6PD protein	25903262
C011246	essential 303 forte	[essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of G6PD protein	25903262
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of G6PD mRNA	25064622
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of G6PD mRNA	17288598
C054207	etomoxir	Bezafibrate inhibits the reaction [etomoxir results in increased activity of G6PD protein]	3421940
C054207	etomoxir	etomoxir results in increased activity of G6PD protein	3421940
D005054	Eugenol	Eugenol results in increased expression of G6PD mRNA	20566472
D005280	Fenoterol	Fenoterol results in increased activity of G6PD protein	1978808
C017690	fenvalerate	fenvalerate results in decreased activity of G6PD protein	15313449
C024555	ferric chloride	ferric chloride results in decreased activity of G6PD protein	24599681
C024555	ferric chloride	ferric chloride results in decreased expression of G6PD mRNA	24599681
C020326	ferric nitrilotriacetate	ferric nitrilotriacetate results in decreased activity of G6PD protein	9667754
C020748	ferrous sulfate	ferrous sulfate results in decreased activity of G6PD protein	16735067
C004999	ferulic acid	ferulic acid results in decreased activity of G6PD protein	25130191
C007738	fluoranthene	[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of G6PD mRNA	17690111
D005459	Fluorides	Fluorides results in decreased activity of G6PD protein	19945446
D005485	Flutamide	Flutamide results in decreased expression of G6PD mRNA	24793618
D005485	Flutamide	Flutamide results in increased expression of G6PD mRNA	19299419\|2413618
D002955	Leucovorin	Leucovorin inhibits the reaction [Methotrexate results in decreased activity of G6PD protein]	21213337
D005632	Fructose	"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of G6PD mRNA"	19509184
D005632	Fructose	Fructose results in increased activity of G6PD protein	18346472
C039281	furan	furan results in increased expression of G6PD mRNA	25539665\|2619464
D005665	Furosemide	Furosemide results in decreased activity of G6PD protein	26820767
D005711	Gallopamil	Gallopamil inhibits the reaction [Isoproterenol results in increased activity of G6PD protein]	1978808
C040641	genistin	genistin analog results in increased expression of G6PD mRNA	16719502
D005839	Gentamicins	Gentamicins results in increased expression of G6PD protein	22061828
D005897	Glafenine	Glafenine results in increased expression of G6PD mRNA	24136188
D019298	Glucose-6-Phosphate	[G6PD protein co-treated with Glucose-6-Phosphate] results in increased chemical synthesis of NAD	23295224
D005976	Glutaral	Glutaral results in decreased activity of G6PD protein	19490936
D005978	Glutathione	"Glutathione inhibits the reaction [Asbestos, Amosite results in decreased activity of G6PD protein]"	14613721
D005978	Glutathione	Glutathione inhibits the reaction [Oxygen deficiency results in increased expression of G6PD mRNA]	15225644
D005905	Glyburide	Glyburide inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]	25641191
C071834	glycidamide	glycidamide results in increased expression of G6PD mRNA	17822822
C031150	glyoxylic acid	glyoxylic acid results in decreased activity of G6PD protein	15144222
C010974	glyphosate	glyphosate results in decreased activity of G6PD protein	24636977\|2862740
C010974	glyphosate	glyphosate results in increased activity of G6PD protein	23820267
D006540	Herbicides	Herbicides results in decreased activity of G6PD protein	24636977
C013015	hesperetin	hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein]	21134734
D006569	Hesperidin	Hesperidin results in decreased activity of G6PD protein	25130191
D006569	Hesperidin	Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein]	16427799
C080043	hexyl cinnamic aldehyde	hexyl cinnamic aldehyde results in increased expression of G6PD mRNA	20566472
D017313	Fenretinide	Fenretinide results in increased expression of G6PD protein	25246272
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased activity of G6PD protein	15336504
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased activity of G6PD protein	15336504
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of G6PD mRNA	15922008
D006861	Hydrogen Peroxide	[Zinc Sulfate co-treated with Hydrogen Peroxide] results in increased expression of G6PD mRNA	15922008
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased activity of G6PD protein	11856576
D007213	Indomethacin	Indomethacin results in increased expression of G6PD mRNA	18299717
D007294	Inositol	Inositol inhibits the reaction [DDT results in increased activity of G6PD protein]	12667599
D007294	Inositol	[Phytic Acid co-treated with Inositol] inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]	28757134
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of G6PD mRNA	25613284
D007501	Iron	Iron results in decreased activity of G6PD protein	16735067
C036643	isoeugenol	isoeugenol results in increased expression of G6PD mRNA	20566472
D007529	Isoflavones	Isoflavones results in increased expression of G6PD mRNA	17374662
D007545	Isoproterenol	Atenolol inhibits the reaction [Isoproterenol results in increased activity of G6PD protein]	1978808
D007545	Isoproterenol	Cycloheximide inhibits the reaction [Isoproterenol results in increased activity of G6PD protein]	1978808
D007545	Isoproterenol	Dactinomycin inhibits the reaction [Isoproterenol results in increased activity of G6PD protein]	1978808
D007545	Isoproterenol	Gallopamil inhibits the reaction [Isoproterenol results in increased activity of G6PD protein]	1978808
D007545	Isoproterenol	Isoproterenol results in increased activity of G6PD protein	1978808
D007548	Isosorbide Dinitrate	G6PD protein results in decreased susceptibility to Isosorbide Dinitrate	6401899
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of G6PD mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of G6PD mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of G6PD mRNA	24796395
C410337	K 7174	K 7174 results in increased expression of G6PD mRNA	24086573
D007648	Kerosene	"[Kerosene co-treated with Asbestos, Serpentine] results in increased activity of G6PD protein"	9177657
D007654	Ketoconazole	Ketoconazole results in increased expression of G6PD mRNA	25399406
D019344	Lactic Acid	Lactic Acid results in increased expression of G6PD mRNA	20566472
C008261	lead acetate	lead acetate results in decreased activity of G6PD protein	25228019
C008261	lead acetate	[naringenin co-treated with lead acetate] results in decreased activity of G6PD protein	25228019
C017461	lead nitrate	Carbon inhibits the reaction [lead nitrate results in increased expression of G6PD mRNA]	18346799
C017461	lead nitrate	lead nitrate results in increased expression of G6PD mRNA	18346799
C017461	lead nitrate	lead nitrate results in decreased activity of G6PD protein	28557068
C533894	LG 100815	LG 100815 results in decreased expression of G6PD mRNA	16951191
D001556	Lindane	Lindane results in increased activity of G6PD protein	11222031
D001556	Lindane	Lindane affects the activity of G6PD protein	7535533\|8519523
D001556	Lindane	Lindane results in increased activity of G6PD protein	2461408
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of G6PD mRNA"	24972896
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of G6PD mRNA	25613284
D008294	Malathion	[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein	27214522
D008294	Malathion	Malathion results in increased activity of G6PD protein	27214522
D008294	Malathion	Plant Extracts inhibits the reaction [[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein]	27214522
C520506	manganese tetrakis-(N-ethyl-2 pyridyl) porphyrin	manganese tetrakis-(N-ethyl-2 pyridyl) porphyrin results in decreased expression of G6PD protein	23682840
D008550	Melatonin	[essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of G6PD protein	25903262
D008550	Melatonin	Melatonin results in increased activity of G6PD protein	16224550
D008627	Mercuric Chloride	Mercuric Chloride results in increased activity of G6PD protein	11222031
D008627	Mercuric Chloride	Mercuric Chloride results in increased activity of G6PD protein	15977196
D008628	Mercury	Mercury results in decreased activity of G6PD protein	16752219
D008628	Mercury	Mercury results in increased activity of G6PD protein	16752219
D008628	Mercury	Mercury results in decreased activity of G6PD protein	10798623
D008701	Methapyrilene	[Diethylnitrosamine co-treated with Methapyrilene] results in increased expression of G6PD protein	28903497
D008701	Methapyrilene	Methapyrilene results in increased expression of G6PD mRNA	28903497
D008727	Methotrexate	Leucovorin inhibits the reaction [Methotrexate results in decreased activity of G6PD protein]	21213337
D008727	Methotrexate	Methotrexate results in decreased activity of G6PD protein	21213337
D008751	Methylene Blue	Methylene Blue results in increased activity of G6PD protein	1901343
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of G6PD mRNA	23103053
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of G6PD mRNA	28001369
D008767	Methylmercury Compounds	[DDT co-treated with Methylmercury Compounds] results in increased activity of G6PD protein	18675336
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased activity of G6PD protein	18675336
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of G6PD mRNA	16966085
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased activity of G6PD protein	24941299
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of G6PD mRNA	26011545
D008773	Methylphenazonium Methosulfate	Methylphenazonium Methosulfate results in increased activity of G6PD protein	1901343
C033069	methyl salicylate	methyl salicylate results in increased expression of G6PD mRNA	20566472
D008790	Metoprolol	Metoprolol inhibits the reaction [Norepinephrine results in increased activity of G6PD protein]	1378361
D015741	Metribolone	Metribolone results in decreased expression of G6PD protein	17152098
D008920	Misonidazole	G6PD protein affects the susceptibility to Misonidazole	3053537
D008999	Monocrotophos	Monocrotophos affects the activity of G6PD protein	24248738
D008999	Monocrotophos	[Monocrotophos co-treated with quinalphos] affects the activity of G6PD protein	24248738
D009151	Mustard Gas	Mustard Gas analog results in increased activity of G6PD protein	15147793
C040015	myricetin	myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased activity of G6PD protein]	24923654
C005273	naringenin	naringenin results in decreased activity of G6PD protein	25130191
C005273	naringenin	[naringenin co-treated with lead acetate] results in decreased activity of G6PD protein	25228019
C005273	naringenin	naringenin inhibits the reaction [Cadmium Chloride results in decreased expression of G6PD protein]	19063931
C005273	naringenin	naringenin results in decreased activity of G6PD protein	25228019
C005274	naringin	naringin affects the reaction [LEPR protein affects the activity of G6PD protein]	16427799
C005274	naringin	naringin inhibits the reaction [nickel sulfate results in decreased activity of G6PD protein]	20950607
C026385	n-hexane	n-hexane results in increased expression of G6PD mRNA	20566472
D009532	Nickel	Nickel results in decreased activity of G6PD protein	22534063
D009532	Nickel	Nickel results in increased activity of G6PD protein	22444726\|2253406
C022838	nickel chloride	nickel chloride affects the expression of G6PD mRNA	22546817
C028007	nickel monoxide	nickel monoxide results in increased expression of G6PD mRNA	19167457
C029938	nickel sulfate	nickel sulfate results in increased expression of G6PD mRNA	20566472
C029938	nickel sulfate	naringin inhibits the reaction [nickel sulfate results in decreased activity of G6PD protein]	20950607
C029938	nickel sulfate	nickel sulfate results in decreased activity of G6PD protein	20950607
D009538	Nicotine	Nicotine results in decreased activity of G6PD protein	20498001
D009582	Nitrofurantoin	Nitrofurantoin results in decreased activity of G6PD protein	11856576
D009599	Nitroprusside	Zinc Sulfate promotes the reaction [Nitroprusside results in increased expression of G6PD mRNA]	17018880
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of G6PD mRNA"	12888634\|1701888
C025256	nonylphenol	nonylphenol results in decreased expression of G6PD mRNA	22982499
C025256	nonylphenol	nonylphenol results in decreased expression of G6PD protein	19260726
D009638	Norepinephrine	Metoprolol inhibits the reaction [Norepinephrine results in increased activity of G6PD protein]	1378361
D009638	Norepinephrine	Norepinephrine results in increased activity of G6PD mRNA	1378361
D009638	Norepinephrine	Norepinephrine results in increased activity of G6PD protein	7605896
D009638	Norepinephrine	Norepinephrine results in increased expression of G6PD mRNA	7605896
D009638	Norepinephrine	Prazosin inhibits the reaction [Norepinephrine results in increased activity of G6PD protein]	1378361
C005310	norfenefrine	norfenefrine results in increased activity of G6PD protein	1378361
C005310	norfenefrine	Prazosin inhibits the reaction [norfenefrine results in increased activity of G6PD protein]	1378361
C423264	(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate	(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate results in increased expression of G6PD mRNA	18598687
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of G6PD mRNA	20971185
C062198	octa-2,4,6-trienoic acid	"octa-2,4,6-trienoic acid results in decreased expression of G6PD mRNA"	16951191
C108709	oleoyl-estrone	oleoyl-estrone results in decreased expression of G6PD mRNA	17725831
C009897	O,O-diisopropyl-S-benzylthiophosphate	"O,O-diisopropyl-S-benzylthiophosphate results in decreased expression of G6PD mRNA"	18983944
C009897	O,O-diisopropyl-S-benzylthiophosphate	"O,O-diisopropyl-S-benzylthiophosphate results in increased expression of G6PD mRNA"	18983944
D010100	Oxygen	Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of G6PD mRNA]	15225644
D010100	Oxygen	Glutathione inhibits the reaction [Oxygen deficiency results in increased expression of G6PD mRNA]	15225644
D010100	Oxygen	Oxygen deficiency results in increased activity of G6PD protein	15225644
D010100	Oxygen	Oxygen deficiency results in increased expression of G6PD mRNA	15225644
D010100	Oxygen	S-ethyl glutathione inhibits the reaction [Oxygen deficiency results in increased expression of G6PD mRNA]	15225644
D010269	Paraquat	Paraquat affects the expression of G6PD mRNA	25064622
D010269	Paraquat	Paraquat results in increased activity of G6PD protein	12453665
D010269	Paraquat	Paraquat results in increased activity of G6PD protein	10036331
D010269	Paraquat	Paraquat affects the activity of G6PD protein	11814328
D010269	Paraquat	Paraquat results in increased activity of G6PD protein	7522492
D010575	Pesticides	Pesticides results in increased activity of G6PD protein	23820267
C031181	phenanthrene	phenanthrene results in increased expression of G6PD mRNA	19457238
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased activity of G6PD protein	16188247
D010634	Phenobarbital	Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in decreased activity of G6PD protein]	16188247
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of G6PD mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of G6PD mRNA	26272509
D010833	Phytic Acid	[Phytic Acid co-treated with Inositol] inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]	28757134
D010882	Piperonyl Butoxide	[Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of G6PD protein	28903497
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Benzoyl Peroxide results in decreased activity of G6PD protein]	15629248
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein]	23961183
D010936	Plant Extracts	Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in decreased activity of G6PD protein]	16188247
D010936	Plant Extracts	Plant Extracts inhibits the reaction [[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein]	27214522
D010936	Plant Extracts	Plant Extracts results in increased activity of G6PD protein	16188247
C058229	polydatin	polydatin results in decreased activity of G6PD protein	25130191
C019536	potassium bromate	potassium bromate results in decreased activity of G6PD protein	25213677
C019536	potassium bromate	Taurine inhibits the reaction [potassium bromate results in decreased activity of G6PD protein]	25213677
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased activity of G6PD protein	7753043
D011192	Potassium Dichromate	Potassium Dichromate results in decreased activity of G6PD protein	21681464
D011192	Potassium Dichromate	Potassium Dichromate results in decreased activity of G6PD protein	1512015
D011224	Prazosin	Prazosin inhibits the reaction [Norepinephrine results in increased activity of G6PD protein]	1378361
D011224	Prazosin	Prazosin inhibits the reaction [norfenefrine results in increased activity of G6PD protein]	1378361
D011319	Primaquine	G6PD protein affects the susceptibility to Primaquine	19616568
D011319	Primaquine	G6PD protein results in decreased susceptibility to Primaquine	22330256
D011374	Progesterone	Progesterone results in increased expression of G6PD mRNA	23012394
D011398	Promethazine	Promethazine results in increased expression of G6PD mRNA	28903497
D019840	2-Propanol	2-Propanol results in increased expression of G6PD mRNA	20566472
C035967	propetamphos	[cypermethrin co-treated with propetamphos] results in decreased activity of G6PD protein	25926273
C035967	propetamphos	propetamphos results in decreased activity of G6PD protein	25926273
D011758	Pyrroles	Pyrroles results in increased activity of G6PD protein	1901343
D011794	Quercetin	Quercetin results in increased expression of G6PD mRNA	21632981
D011794	Quercetin	Quercetin analog inhibits the reaction [sodium arsenite results in decreased activity of G6PD protein]	20371363
D011794	Quercetin	Quercetin inhibits the reaction [Cadmium results in decreased expression of G6PD protein]	19615871
C009145	quinalphos	[Monocrotophos co-treated with quinalphos] affects the activity of G6PD protein	24248738
C009145	quinalphos	quinalphos affects the activity of G6PD protein	24248738
C502851	quinocetone	quinocetone results in decreased expression of G6PD mRNA	27046791
C502851	quinocetone	quinocetone results in decreased expression of G6PD protein	27046791
C502851	quinocetone	quinocetone results in increased expression of G6PD protein	27046791
C052785	rebamipide	rebamipide results in increased expression of G6PD mRNA	18299717
C059514	resveratrol	resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] affects the activity of G6PD protein]	19059388
C059514	resveratrol	resveratrol results in decreased activity of G6PD protein	24012391
D015474	Isotretinoin	Isotretinoin results in decreased expression of G6PD mRNA	20436886
D015474	Isotretinoin	Isotretinoin results in increased expression of G6PD mRNA	15982314
D015474	Isotretinoin	Isotretinoin inhibits the reaction [Benzoyl Peroxide results in decreased activity of G6PD protein]	15225900
C089730	rosiglitazone	rosiglitazone results in increased expression of G6PD mRNA	19201733
C078903	seocalcitol	seocalcitol results in increased expression of G6PD mRNA	12040012
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased activity of G6PD protein"	16039947\|1837041
D017632	Asbestos, Serpentine	"[Kerosene co-treated with Asbestos, Serpentine] results in increased activity of G6PD protein"	9177657
D017632	Asbestos, Serpentine	"[Soot co-treated with Asbestos, Serpentine] results in increased activity of G6PD protein"	9177657
C042431	S-ethyl glutathione	S-ethyl glutathione inhibits the reaction [Cadmium Chloride results in increased expression of G6PD mRNA]	12717738
C042431	S-ethyl glutathione	S-ethyl glutathione inhibits the reaction [Oxygen deficiency results in increased expression of G6PD mRNA]	15225644
D012822	Silicon Dioxide	Silicon Dioxide analog affects the secretion of G6PD protein	25895662
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of G6PD mRNA	25895662
D012834	Silver	Silver results in increased expression of G6PD mRNA	18394669
D012835	Silver Nitrate	Silver Nitrate results in decreased activity of G6PD protein	23363574
D012835	Silver Nitrate	Silver Nitrate results in decreased activity of G6PD protein	28557068
C440975	silybin	silybin inhibits the reaction [Arsenic results in decreased activity of G6PD protein]	22229868
D012838	Silymarin	[essential 303 forte co-treated with Silymarin] affects the activity of G6PD protein	25903262
D012838	Silymarin	[essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of G6PD protein	25903262
C073734	sinapinic acid	sinapinic acid results in decreased activity of G6PD protein	25130191
C017947	sodium arsenite	sodium arsenite affects the methylation of G6PD gene	28589171
C017947	sodium arsenite	sodium arsenite results in increased expression of G6PD mRNA	25493608\|2728725
C017947	sodium arsenite	sodium arsenite results in increased expression of G6PD protein	24866292\|2871322
C017947	sodium arsenite	sodium arsenite results in increased expression of G6PD protein	24866292
C017947	sodium arsenite	sodium arsenite inhibits the reaction [Sodium Fluoride results in decreased activity of G6PD protein]	19635623
C017947	sodium arsenite	sodium arsenite results in decreased activity of G6PD protein	19635623
C017947	sodium arsenite	Sodium Fluoride inhibits the reaction [sodium arsenite results in decreased activity of G6PD protein]	19635623
C017947	sodium arsenite	Vitamin E inhibits the reaction [sodium arsenite results in decreased activity of G6PD protein]	19635623
C017947	sodium arsenite	Quercetin analog inhibits the reaction [sodium arsenite results in decreased activity of G6PD protein]	20371363
C017947	sodium arsenite	sodium arsenite results in decreased activity of G6PD protein	20371363
C017947	sodium arsenite	sodium arsenite results in increased activity of G6PD protein	10996542
C032706	sodium chlorate	sodium chlorate results in decreased activity of G6PD protein	28084674
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in increased expression of G6PD mRNA	20566472
D012969	Sodium Fluoride	sodium arsenite inhibits the reaction [Sodium Fluoride results in decreased activity of G6PD protein]	19635623
D012969	Sodium Fluoride	Sodium Fluoride inhibits the reaction [sodium arsenite results in decreased activity of G6PD protein]	19635623
D012969	Sodium Fluoride	Sodium Fluoride results in decreased activity of G6PD protein	19635623
C031618	sodium nitrate	sodium nitrate results in decreased activity of G6PD protein	19922758
D012977	Sodium Nitrite	Sodium Nitrite results in decreased activity of G6PD protein	26231821
D012989	Soil Pollutants	Soil Pollutants results in decreased activity of G6PD protein	10706032
D053260	Soot	[Soot co-treated with Benzo(a)pyrene] results in increased expression of G6PD protein	24464499
D053260	Soot	"[Soot co-treated with Asbestos, Serpentine] results in increased activity of G6PD protein"	9177657
C539817	S-sulindac	S-sulindac results in increased expression of G6PD mRNA	19276279
D013311	Streptozocin	4-hydroxyphenylethanol inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]	25641191
D013311	Streptozocin	arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]	19133311\|1968244
D013311	Streptozocin	citronellol inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]	26944432
D013311	Streptozocin	Glyburide inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]	25641191
D013311	Streptozocin	myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased activity of G6PD protein]	24923654
D013311	Streptozocin	[Phytic Acid co-treated with Inositol] inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]	28757134
D013311	Streptozocin	resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] affects the activity of G6PD protein]	19059388
D013311	Streptozocin	[Streptozocin co-treated with Cadmium] results in decreased activity of G6PD protein	24923654
D013311	Streptozocin	[Streptozocin co-treated with Niacinamide] affects the activity of G6PD protein	19059388
D013311	Streptozocin	Streptozocin results in decreased activity of G6PD protein	19133311\|1968244
C016766	sulforafan	sulforafan results in increased expression of G6PD mRNA	26833863
D013605	T-2 Toxin	T-2 Toxin affects the expression of G6PD protein	26141394
D013605	T-2 Toxin	T-2 Toxin results in decreased expression of G6PD mRNA	26141394
D000068581	Tadalafil	Tadalafil results in increased activity of G6PD protein	24911673
D013629	Tamoxifen	Tamoxifen affects the expression of G6PD mRNA	14699072
D013654	Taurine	Taurine inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein]	18414974\|1856190
D013654	Taurine	Taurine inhibits the reaction [potassium bromate results in decreased activity of G6PD protein]	25213677
D013726	Terbutaline	Terbutaline results in increased activity of G6PD protein	1978808
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of G6PD mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of G6PD mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of G6PD mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of G6PD mRNA	16054898\|2121527
D013752	Tetracycline	Tetracycline affects the expression of G6PD mRNA	25064622
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of G6PD mRNA	25613284
D013849	Thimerosal	Thimerosal results in decreased expression of G6PD mRNA	27188386
D013853	Thioacetamide	Thioacetamide affects the expression of G6PD mRNA	25064622
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of G6PD protein	28903497
D013853	Thioacetamide	Thioacetamide results in increased expression of G6PD mRNA	23411599\|2890349
D013890	Thiourea	Thiourea results in increased activity of G6PD protein	12658717
D013890	Thiourea	Thyroxine inhibits the reaction [Thiourea results in increased activity of G6PD protein]	12658717
D013974	Thyroxine	Thyroxine inhibits the reaction [Thiourea results in increased activity of G6PD protein]	12658717
C009495	titanium dioxide	[Vitallium analog binds to titanium dioxide] which results in increased expression of G6PD mRNA	23825117
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of G6PD mRNA	28065790
D014212	Tretinoin	Tretinoin metabolite results in increased expression of G6PD mRNA	15982314
D014212	Tretinoin	Tretinoin results in increased expression of G6PD mRNA	15982314
C057693	troglitazone	troglitazone results in increased expression of G6PD mRNA	28973697
C080163	trovafloxacin	trovafloxacin results in decreased expression of G6PD mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of G6PD mRNA	25064622
D014635	Valproic Acid	Valproic Acid affects the expression of G6PD mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of G6PD mRNA	25399406\|2915479
D014635	Valproic Acid	Valproic Acid results in increased methylation of G6PD gene	29154799
C025643	vinclozolin	vinclozolin results in decreased expression of G6PD mRNA	23034163
D014800	Vitallium	[Vitallium analog binds to titanium dioxide] which results in increased expression of G6PD mRNA	23825117
D014800	Vitallium	Vitallium analog results in increased expression of G6PD mRNA	23825117
D009536	Niacinamide	resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] affects the activity of G6PD protein]	19059388
D009536	Niacinamide	[Streptozocin co-treated with Niacinamide] affects the activity of G6PD protein	19059388
D014810	Vitamin E	Vitamin E inhibits the reaction [sodium arsenite results in decreased activity of G6PD protein]	19635623
C111237	vorinostat	vorinostat results in decreased expression of G6PD mRNA	27188386
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased activity of G6PD protein"	25179371
D015032	Zinc	Zinc results in decreased activity of G6PD protein	26602879
D015032	Zinc	Zinc results in decreased expression of G6PD mRNA	26602879
D015032	Zinc	Zinc results in increased expression of G6PD mRNA	17948801\|1839466
D015032	Zinc	[Cadmium co-treated with Zinc] results in increased activity of G6PD protein	20143450
D015032	Zinc	Zinc results in increased activity of G6PD protein	20143450
D015032	Zinc	Zinc affects the activity of G6PD protein	17181878
C016837	zinc chloride	zinc chloride results in increased expression of G6PD mRNA	19683351
C016837	zinc chloride	zinc chloride inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein]	18972399
C042103	zinc nitrate	zinc nitrate results in decreased activity of G6PD protein	28557068
D019287	Zinc Sulfate	Zinc Sulfate promotes the reaction [Nitroprusside results in increased expression of G6PD mRNA]	17018880
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of G6PD mRNA	17018880
D019287	Zinc Sulfate	[Zinc Sulfate co-treated with Hydrogen Peroxide] results in increased expression of G6PD mRNA	15922008
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of G6PD mRNA	15922008

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004345	glucose-6-phosphate dehydrogenase activity	-	EXP	10745013
GO:0004345	glucose-6-phosphate dehydrogenase activity	-	IDA	15858258
GO:0004345	glucose-6-phosphate dehydrogenase activity	-	IMP	743300 2420826 5643703
GO:0005515	protein binding	-	IPI	21157431 24769394
GO:0005536	glucose binding	-	IDA	15858258
GO:0005536	glucose binding	-	IMP	5643703
GO:0042802	identical protein binding	-	IPI	24769394 25416956
GO:0042803	protein homodimerization activity	-	IPI	15858258
GO:0050661	NADP binding	-	IDA	15858258

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006006	glucose metabolic process	-	IEA	-
GO:0006098	pentose-phosphate shunt	-	IDA	2297768
GO:0006098	pentose-phosphate shunt	-	TAS	-
GO:0006629	lipid metabolic process	-	TAS	17361089
GO:0006695	cholesterol biosynthetic process	-	IMP	12027950
GO:0006739	NADP metabolic process	-	IDA	15858258
GO:0006740	NADPH regeneration	-	IMP	17516514
GO:0006749	glutathione metabolic process	-	IMP	2420826 17516514
GO:0009051	pentose-phosphate shunt, oxidative branch	-	IMP	2420826
GO:0010041	response to iron(III) ion	-	IEA	-
GO:0010734	negative regulation of protein glutathionylation	-	IMP	17516514
GO:0014070	response to organic cyclic compound	-	IEA	-
GO:0019322	pentose biosynthetic process	-	IDA	5643703
GO:0021762	substantia nigra development	-	HEP	22926577
GO:0032094	response to food	-	IEA	-
GO:0034599	cellular response to oxidative stress	-	IMP	17516514
GO:0043249	erythrocyte maturation	-	IMP	5643703
GO:0043523	regulation of neuron apoptotic process	-	IEA	-
GO:0045471	response to ethanol	-	IEA	-
GO:0046390	ribose phosphate biosynthetic process	-	IMP	2420826
GO:0051156	glucose 6-phosphate metabolic process	-	IDA	15858258
GO:0051156	glucose 6-phosphate metabolic process	-	IMP	5643703
GO:0055114	oxidation-reduction process	-	IMP	2420826
GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	-	IEA	-
GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	-	IEA	-
GO:2000378	negative regulation of reactive oxygen species metabolic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-
GO:0005737	cytoplasm	-	IDA	-
GO:0005829	cytosol	-	IDA	743300
GO:0005829	cytosol	-	TAS	-
GO:0009898	cytoplasmic side of plasma membrane	-	IDA	743300
GO:0016020	membrane	-	HDA	19946888
GO:0070062	extracellular exosome	-	HDA	19056867 23533145

KEGG ID	KEGG Term
hsa00030	Pentose phosphate pathway
hsa00480	Glutathione metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-5628897	TP53 Regulates Metabolic Genes	TAS
R-HSA-71336	Pentose phosphate pathway (hexose monophosphate shunt)	TAS
R-HSA-71387	Metabolism of carbohydrates	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
18671841	PSMB2 and RPL32 are suitable denominators to normalize gene expression profiles in bronchoalveolar cells. (2008 Jul 31)	Kriegova E	BMC Mol Biol
25392263	Epidemiology and Associated Morbidity of Pterygium: A Large, Community-Based Case-Control Study. (2016)	Nemet AY	Semin Ophthalmol
26988295	The influence of chronic nicotine treatment on proteins expressed in the mouse hippocampus and cortex. (2016 Jun 5)	Matsuura K	Eur J Pharmacol
17784549	[Red cell system and selected red cell enzymes in men occupationally exposed to mercury vapours]. (2006)	Zabinski Z	Przegl Lek
11355791	The epidemiology of recurrent pregnancy loss. (2000)	Cramer DW	Semin Reprod Med
27858887	Glucose-6-phosphate dehydrogenase deficiency and risk of colorectal cancer in Northern Sardinia: A retrospective observational study. (2016 Nov)	Dore MP	Medicine (Baltimore)
8935483	Liver involvement in murine typhus. (1996 Aug)	Silpapojakul K	QJM