Gene: METAP1D

254042
MAP 1D|MAP1D|MetAP 1D|Metap1l
methionyl aminopeptidase type 1D, mitochondrial
protein-coding
2q31.1
Ensembl:ENSG00000172878 MIM:610267 Vega:OTTHUMG00000132283 UniprotKB:Q6UB28
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
5.660e-1 (AD)  1.473e-1 (ND)   (Frontal_Cortex)
5.666e-1 (AD)  8.068e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs788160chr2:172081587 (GRCh38.p7)T>A / T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POGZ0.817
PGAP20.815
RBM190.815
TCHP0.814
CSAD0.812
AAAS0.811
INTS30.81
MAU20.807
NUP2100.805
NUMA10.802

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.504
OR4F29-0.476
OR4F3-0.28
OPN1MW-0.276
KRTAP4-3-0.255
MTRNR2L9-0.251
ALPI-0.247
MTRNR2L6-0.244
PPBP-0.239
SPRR4-0.237

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of METAP1D mRNA19191707
D000082AcetaminophenAcetaminophen results in decreased expression of METAP1D mRNA25704631|2906747
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of METAP1D mRNA24449571
C006780bisphenol Abisphenol A affects the expression of METAP1D mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of METAP1D mRNA25181051
D019327Copper SulfateCopper Sulfate results in decreased expression of METAP1D mRNA19549813
C089595cylindrospermopsincylindrospermopsin results in increased expression of METAP1D mRNA24921660
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of METAP1D mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of METAP1D mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of METAP1D mRNA23649840
D005485FlutamideFlutamide results in increased expression of METAP1D mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of METAP1D mRNA26846883
C016517indole-3-carbinolindole-3-carbinol affects the expression of METAP1D mRNA21396975
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of METAP1D mRNA21889194|2479639
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of METAP1D mRNA23649840
D009966OrphenadrineOrphenadrine affects the expression of METAP1D mRNA23665939
D010936Plant ExtractsPlant Extracts results in increased expression of METAP1D mRNA23557933
C009277sodium arsenatesodium arsenate results in decreased expression of METAP1D mRNA23922661
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of METAP1D mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of METAP1D mRNA17942748
D014520UrethaneUrethane results in decreased expression of METAP1D mRNA28818685
D001335Vehicle EmissionsVehicle Emissions affects the methylation of METAP1D gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004177aminopeptidase activity-TAS14532271  
GO:0008235metalloexopeptidase activity-TAS14532271  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0018206peptidyl-methionine modification-TAS14532271  
GO:0031365N-terminal protein amino acid modification-TAS14532271  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA14532271  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal