Gene: LCORL

254251
MLR1
ligand dependent nuclear receptor corepressor like
protein-coding
4p15.31
Ensembl:ENSG00000178177 MIM:611799 Vega:OTTHUMG00000128538 UniprotKB:Q8N3X6
NG_015822.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.402e-1 (AD)  9.971e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ESCO10.831
ZNF920.817
CTDSPL20.803
MIER10.795
FNDC3A0.794
FAM172A0.794
MRPL420.792
CEP57L10.786
RAB8B0.784
RAB33B0.782

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.421
OR4F29-0.385
PTGDR2-0.35
PLA2G5-0.271
MUC6-0.265
HES5-0.252
MUSTN1-0.223
JSRP1-0.222
ARSF-0.221
ADAMTSL5-0.217

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of LCORL mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of LCORL mRNA"19095052
D020106AcrylamideAcrylamide results in decreased expression of LCORL mRNA28959563
D001280AtrazineAtrazine results in decreased expression of LCORL mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of LCORL mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of LCORL mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of LCORL mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of LCORL mRNA27858113
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of LCORL mRNA26496021
C018475butyraldehydebutyraldehyde results in decreased expression of LCORL mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of LCORL mRNA27339419
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of LCORL mRNA27858113
D019327Copper SulfateCopper Sulfate results in decreased expression of LCORL mRNA19549813
D003471CuprizoneCuprizone results in increased expression of LCORL mRNA27523638
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of LCORL mRNA27392435
D002945CisplatinCisplatin results in decreased expression of LCORL mRNA27392435
D002945Cisplatin[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of LCORL mRNA23625948
D002117CalcitriolCalcitriol results in decreased expression of LCORL mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of LCORL mRNA21592394
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of LCORL mRNA"27840820
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of LCORL mRNA"23811387
C118739entinostatentinostat results in decreased expression of LCORL mRNA27188386
D005557FormaldehydeFormaldehyde results in decreased expression of LCORL mRNA23649840
D017313FenretinideFenretinide results in increased expression of LCORL mRNA28973697
D007213IndomethacinIndomethacin results in increased expression of LCORL mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LCORL mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of LCORL mRNA27392435
C544151jinfukangjinfukang results in decreased expression of LCORL mRNA27392435
D007854LeadLead affects the splicing of LCORL mRNA28903495
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LCORL mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of LCORL mRNA23649840
D009285NaphthoquinonesNaphthoquinones results in increased expression of LCORL mRNA23811387
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of LCORL mRNA19095052
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of LCORL mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of LCORL mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of LCORL mRNA19482888
D010936Plant ExtractsPlant Extracts results in increased expression of LCORL mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of LCORL mRNA23608068
D012834SilverSilver affects the expression of LCORL mRNA27131904
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of LCORL mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of LCORL mRNA21592394
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of LCORL mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LCORL mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LCORL mRNA19933214
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LCORL mRNA25613284
D013849ThimerosalThimerosal results in increased expression of LCORL mRNA27188386
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of LCORL mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of LCORL mRNA23179753|2519280
D014750VincristineVincristine results in decreased expression of LCORL mRNA23649840
C111237vorinostatvorinostat results in decreased expression of LCORL mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23202124New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. (2013 Jan)Horikoshi MNat Genet