Gene: XRCC6

2547
CTC75|CTCBF|G22P1|KU70|ML8|TLAA
X-ray repair cross complementing 6
protein-coding
22q13.2
Ensembl:ENSG00000196419 MIM:152690 Vega:OTTHUMG00000151190 UniprotKB:P12956
NC_000022.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.742e-1 (AD)  3.302e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VCP0.975
ILF20.966
SLC25A30.966
APEX10.964
PA2G40.964
VDAC20.963
CDC1230.963
PSMD60.962
PSMC10.96
PSMC20.959

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.796
OR4F29-0.768
MTRNR2L6-0.297
MTRNR2L9-0.289
MTRNR2L10-0.266
KLRB1-0.235
TTLL10-0.219
P2RY14-0.212
C8orf74-0.209
MTRNR2L3-0.208

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0313192-hydroxyethyl disulfide[2-hydroxyethyl disulfide co-treated with Glucose deficiency] results in decreased activity of [XRCC5 protein binds to XRCC6 protein]22926048
C0163923,3'-diindolylmethane"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of XRCC6 mRNA]"11179685
D000082AcetaminophenAcetaminophen affects the expression of XRCC6 mRNA17562736
D000111AcetylcysteineAcetylcysteine promotes the reaction [Acrylonitrile results in increased expression of XRCC6 mRNA]26332274
D000181AcrylonitrileAcetylcysteine promotes the reaction [Acrylonitrile results in increased expression of XRCC6 mRNA]26332274
D000181AcrylonitrileAcrylonitrile results in increased expression of XRCC6 mRNA26332274
D000181Acrylonitrilealpha-Tocopherol promotes the reaction [Acrylonitrile results in increased expression of XRCC6 mRNA]26332274
D000181AcrylonitrilePlant Extracts promotes the reaction [Acrylonitrile results in increased expression of XRCC6 mRNA]26332274
D000393Air PollutantsAir Pollutants results in increased expression of XRCC6 protein28389379
D024502alpha-Tocopherolalpha-Tocopherol promotes the reaction [Acrylonitrile results in increased expression of XRCC6 mRNA]26332274
D000643Ammonium ChlorideAmmonium Chloride affects the expression of XRCC6 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of XRCC6 mRNA15761015
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of XRCC6 mRNA"17331233
D001554BenzeneBenzene affects the expression of XRCC6 mRNA16188086
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of XRCC6 mRNA22228805
D004958Estradiol"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of XRCC6 mRNA]"11179685
D004958EstradiolEstradiol results in increased expression of XRCC6 mRNA11179685
D004958EstradiolTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of XRCC6 mRNA]11179685
C006780bisphenol Abisphenol A affects the expression of XRCC6 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of XRCC6 promoter27334623
C006780bisphenol Abisphenol A inhibits the reaction [[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] which results in increased expression of H2AFX protein]25693136
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of CAR6 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of CCL20 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of CXCL3 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of DSC1 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of EGR4 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of FRY mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of HCAR2 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of HPGD mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of LCN2 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of LGALS12 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of MYH1 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of MYH2 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of NEBL mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of NPR3 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of OSTN mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of PLCH2 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of SAA3 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of SLC26A7 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of WFDC17 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of AGTR2 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of AKR1B10 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of AREG mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of ATF3 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of CAR6 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of CYP2D22 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of DIO3 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of FZD2 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of GSTA5 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of HP mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of IL18R1 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of KAT2B mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of MMP15 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of PRG4 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of PTGS2 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of ROBO3 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of SLCO2B1 mRNA]27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of TNS1 mRNA]27082013
C006780bisphenol Abisphenol A affects the expression of XRCC6 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of XRCC6 mRNA25181051|2720808
C524865carfilzomib[carfilzomib co-treated with vorinostat] results in increased acetylation of XRCC6 protein20233973
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of XRCC6 mRNA23650126
D019327Copper SulfateCopper Sulfate results in decreased expression of XRCC6 mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of XRCC6 mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of XRCC6 mRNA21878529
D003474CurcuminCurcumin results in decreased expression of XRCC6 mRNA17596214
D003520CyclophosphamideCyclophosphamide results in decreased expression of XRCC6 mRNA21041162
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of XRCC6 mRNA24317228
C014347decitabinedecitabine affects the methylation of XRCC6 gene17630775
D015255Idarubicin[Dexrazoxane co-treated with Idarubicin] results in increased expression of XRCC6 mRNA28973540
D003907DexamethasoneDexamethasone results in decreased expression of XRCC6 mRNA21041162
D064730Dexrazoxane[Dexrazoxane co-treated with Idarubicin] results in increased expression of XRCC6 mRNA28973540
D002945CisplatinXRCC6 mRNA results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]18546291
D002945CisplatinXRCC6 protein results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]18546291
D002945CisplatinCisplatin results in decreased expression of XRCC6 mRNA21151649
C000944dicrotophosdicrotophos results in decreased expression of XRCC6 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of XRCC6 mRNA26924002
D004052DiethylnitrosamineMG 262 inhibits the reaction [XRCC6 protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 protein]]18506893
D004052DiethylnitrosamineXRCC6 protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 protein]18506893
D004052DiethylnitrosamineXRCC6 protein inhibits the reaction [Diethylnitrosamine results in increased expression of AURKA mRNA]18506893
D004052DiethylnitrosamineXRCC6 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein]18506893
D004052DiethylnitrosamineXRCC6 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PCNA protein]18506893
D004052DiethylnitrosamineXRCC6 protein inhibits the reaction [Diethylnitrosamine results in increased expression of UBA1 mRNA]18506893
D004052DiethylnitrosamineXRCC6 protein inhibits the reaction [Diethylnitrosamine results in increased expression of UBD mRNA]18506893
D004052DiethylnitrosamineXRCC6 protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of ATM protein]18506893
D004052DiethylnitrosamineXRCC6 protein results in decreased susceptibility to Diethylnitrosamine18506893
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of XRCC6 mRNA21041162
D002117CalcitriolCalcitriol results in decreased expression of XRCC6 mRNA15951637|1684735
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of XRCC6 mRNA"25448685
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of XRCC6 protein"25448685
D0151279,10-Dimethyl-1,2-benzanthracene"A gene mutant form inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of XRCC6 protein]"25448685
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of XRCC6 mRNA"23969067
C024629dimethyl phthalatedimethyl phthalate affects the expression of XRCC6 mRNA26924002
D004147DioxinsDioxins affects the expression of XRCC6 mRNA20463971
C067311docetaxel[wortmannin co-treated with docetaxel] results in decreased expression of XRCC6 protein20878124
D004317DoxorubicinDoxorubicin results in increased expression of XRCC6 protein24812279
D004317DoxorubicinSTAT3 gene mutant form promotes the reaction [Doxorubicin results in increased expression of XRCC6 protein]24812279
D004317Doxorubicin[STAT3 gene mutant form results in increased susceptibility to Doxorubicin] which results in increased expression of XRCC6 protein24812279
D004317DoxorubicinTRP53 protein mutant form promotes the reaction [Doxorubicin results in increased expression of XRCC6 protein]24812279
D004317DoxorubicinDoxorubicin results in decreased expression of XRCC6 mRNA27181935
D004317DoxorubicinFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of XRCC6 mRNA]27181935
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of XRCC6 protein23301498
C024352fludarabinefludarabine results in decreased activity of XRCC6 protein18852132
C024352fludarabine[LAQ824 co-treated with fludarabine] results in decreased activity of XRCC6 protein18852132
C024352fludarabine[LAQ824 co-treated with fludarabine] results in increased acetylation of XRCC6 protein18852132
D005472FluorouracilXRCC6 mRNA results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]18546291
D005472FluorouracilXRCC6 protein results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]18546291
D062610Fungal PolysaccharidesFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of XRCC6 mRNA]27181935
D005947Glucose[2-hydroxyethyl disulfide co-treated with Glucose deficiency] results in decreased activity of [XRCC5 protein binds to XRCC6 protein]22926048
C492448ICG 001ICG 001 results in increased expression of XRCC6 mRNA26191083
C477361LAQ824[LAQ824 co-treated with fludarabine] results in decreased activity of XRCC6 protein18852132
C477361LAQ824[LAQ824 co-treated with fludarabine] results in increased acetylation of XRCC6 protein18852132
C477361LAQ824LAQ824 results in decreased activity of XRCC6 protein18852132
D007854LeadLead results in decreased expression of XRCC6 mRNA19921347
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of XRCC6 mRNA12057914
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of XRCC6 mRNA25613284
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of XRCC6 mRNA23458150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of XRCC6 mRNA23649840
D015741MetriboloneMetribolone promotes the reaction [NDRG1 protein binds to XRCC6 protein]17220478
C423917MG 262MG 262 inhibits the reaction [XRCC6 protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 protein]]18506893
C517284monomethyl phthalatemonomethyl phthalate affects the expression of XRCC6 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of XRCC6 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of XRCC6 mRNA25729387
C030090phosphoramide mustardphosphoramide mustard affects the expression of XRCC6 mRNA25497287
C030090phosphoramide mustardphosphoramide mustard affects the expression of XRCC6 protein25497287
C030090phosphoramide mustardphosphoramide mustard results in increased expression of XRCC6 mRNA26708502
D010936Plant ExtractsPlant Extracts results in increased expression of XRCC6 mRNA23557933
D010936Plant ExtractsPlant Extracts promotes the reaction [Acrylonitrile results in increased expression of XRCC6 mRNA]26332274
C019536potassium bromatebisphenol A inhibits the reaction [[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] which results in increased expression of H2AFX protein]25693136
C019536potassium bromateXRCC6 gene mutant form results in increased susceptibility to potassium bromate25693136|2708201
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of CAR6 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of CCL20 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of CXCL3 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of DSC1 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of EGR4 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of FRY mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of HCAR2 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of HPGD mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of LCN2 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of LGALS12 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of MYH1 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of MYH2 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of NEBL mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of NPR3 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of OSTN mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of PLCH2 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of SAA3 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of SLC26A7 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of WFDC17 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of AKR1B10 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of AREG mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of BLNK mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of BMF mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of CYP2D22 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of DUSP2 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of EGR4 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of FGL2 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of GSTA5 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of HP mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of IKZF2 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of IL18R1 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of KLF15 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of PRG4 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of PTPN22 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of ROBO3 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of SLCO2B1 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of VIT mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of AGTR2 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of AKR1B10 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of AREG mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of ATF3 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of CAR6 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of CYP2D22 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of DIO3 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of FZD2 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of GSTA5 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of HP mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of IL18R1 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of KAT2B mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of MMP15 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of PRG4 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of PTGS2 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of ROBO3 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of SLCO2B1 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of TNS1 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] which results in increased expression of H2AFX protein25693136
C547185riccardin Driccardin D results in decreased expression of XRCC6 mRNA24069304
D012402RotenoneRotenone results in decreased expression of XRCC6 mRNA27900601
C009277sodium arsenatesodium arsenate results in increased expression of XRCC6 mRNA16882884
C017947sodium arsenitesodium arsenite results in increased expression of XRCC6 mRNA12016162
C017947sodium arsenitesodium arsenite results in decreased expression of XRCC6 mRNA16014739
C025462sulindac sulfidesulindac sulfide results in increased expression of XRCC6 mRNA12734198
D013629TamoxifenTamoxifen results in decreased expression of XRCC6 protein17219426
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of XRCC6 mRNA]11179685
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHRR protein binds to XRCC6 gene]28681081
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of XRCC6 mRNA21570461
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of XRCC6 mRNA25729387
C012589trichostatin Atrichostatin A results in increased acetylation of XRCC6 protein27064363
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of XRCC6 mRNA19042947
D017974Uranium CompoundsUranium Compounds results in decreased expression of XRCC6 mRNA19654044
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of XRCC6 gene25560391
D014810Vitamin EVitamin E results in increased expression of XRCC6 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of XRCC6 protein16928817
C111237vorinostat[carfilzomib co-treated with vorinostat] results in increased acetylation of XRCC6 protein20233973
C009687wortmannin[wortmannin co-treated with docetaxel] results in decreased expression of XRCC6 protein20878124

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-NAS1537839  
GO:0003684damaged DNA binding-IEA-  
GO:0003690double-stranded DNA bindingCONTRIBUTES_TOIBA21873635  
GO:0003690double-stranded DNA binding-TAS7957065  
GO:0003691double-stranded telomeric DNA bindingcontributes_toIDA10409678  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0004003ATP-dependent DNA helicase activity-IEA-  
GO:0005515protein binding-IPI8621488  10783163  10984620  11328876  11493912  12145306  
12377759  14734561  15075319  15205477  15383276  15383534  
15782130  16169070  17124166  17159921  17220478  17283121  
17308091  17334224  19303849  20711232  21044950  21070772  
21146485  21575865  21679440  22442688  22451927  22504299  
23685356  24095731  24610814  24965446  25574025  25749521  
25852083  26175416  26359349  26496610  28330616  28959974  
GO:0005524ATP binding-IEA-  
GO:0008022protein C-terminus binding-IPI10783163  
GO:0030332cyclin binding-IPI15159402  
GO:0042162telomeric DNA binding-IBA21873635  
GO:0044212transcription regulatory region DNA binding-IDA18809223  
GO:0044877protein-containing complex binding-IPI12377759  
GO:00515755'-deoxyribose-5-phosphate lyase activity-IMP20383123  
GO ID GO Term Qualifier Evidence PubMed
GO:0000723telomere maintenance-IBA21873635  
GO:0000723telomere maintenance-TAS15824061  18710952  24095731  
GO:0002218activation of innate immune response-IDA28712728  
GO:0006266DNA ligation-TAS9826654  
GO:0006303double-strand break repair via nonhomologous end joining-IBA21873635  
GO:0006303double-strand break repair via nonhomologous end joining-IMP20383123  26359349  
GO:0006303double-strand break repair via nonhomologous end joining-TAS15824061  
GO:0006310DNA recombination-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007420brain development-IEA-  
GO:0032481positive regulation of type I interferon production-TAS-  
GO:0032508DNA duplex unwinding-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO:0045087innate immune response-IEA-  
GO:0045860positive regulation of protein kinase activity-IDA22504299  
GO:0045892negative regulation of transcription, DNA-templated-IMP8621488  
GO:0045893positive regulation of transcription, DNA-templated-IDA12145306  
GO:0045893positive regulation of transcription, DNA-templated-IMP18809223  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP18809223  
GO:0048660regulation of smooth muscle cell proliferation-IMP25852083  
GO:0051290protein heterotetramerization-IDA24095731  
GO:0071475cellular hyperosmotic salinity response-IEA-  
GO:0071480cellular response to gamma radiation-IBA21873635  
GO:0071480cellular response to gamma radiation-IDA26359349  
GO:0071481cellular response to X-ray-IBA21873635  
GO:0071481cellular response to X-ray-IEA-  
GO:0075713establishment of integrated proviral latency-TAS-  
GO:0097680double-strand break repair via classical nonhomologous end joining-IDA24095731  
GO ID GO Term Qualifier Evidence PubMed
GO:0000783nuclear telomere cap complex-TAS15100233  
GO:0000784nuclear chromosome, telomeric region-HDA19135898  
GO:0000784nuclear chromosome, telomeric region-IBA21873635  
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-TAS10508516  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IDA12145306  
GO:0005730nucleolus-IDA27829214  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0032991protein-containing complex-IDA22504299  
GO:0032993protein-DNA complex-IDA22504299  
GO:0034774secretory granule lumen-TAS-  
GO:0043564Ku70:Ku80 complex-IBA21873635  
GO:0043564Ku70:Ku80 complex-IDA20383123  24095731  26359349  
GO:0070419nonhomologous end joining complex-IDA20383123  25941166  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
hsa03450Non-homologous end-joining
Reactome ID Reactome Term Evidence
R-HSA-162587HIV Life CycleTAS
R-HSA-162592Integration of provirusTAS
R-HSA-162594Early Phase of HIV Life CycleTAS
R-HSA-162906HIV InfectionTAS
R-HSA-1643685DiseaseTAS
R-HSA-1648432-LTR circle formationTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-1834941STING mediated induction of host immune responsesTAS
R-HSA-1834949Cytosolic sensors of pathogen-associated DNA TAS
R-HSA-3270619IRF3-mediated induction of type I IFNTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693571Nonhomologous End-Joining (NHEJ)TAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25702660Association of the genetic polymorphisms in XRCC6 and XRCC5 with the risk of ESCC in a high-incidence region of North China. (2015 Jan-Feb)Li KTumori
24382701Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai. (2014 Jul 15)Corral RInt J Cancer