Gene: GAB1

2549
-
GRB2 associated binding protein 1
protein-coding
4q31.21
Ensembl:ENSG00000109458 MIM:604439 Vega:OTTHUMG00000161432 UniprotKB:Q13480
NC_000004.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.971e-1 (AD)  7.317e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BBX0.867
ZNF240.854
SLAIN10.853
LAMP20.842
SLC44A10.842
FRYL0.841
USP540.838
VEZF10.837
FOXN20.836
AMER20.834

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.386
PNOC-0.386
KAZALD1-0.369
OR4F5-0.368
VGF-0.363
CRH-0.36
SHISA8-0.344
WDR86-0.338
NAT16-0.326
PRSS56-0.323

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of GAB1 protein"21705713
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"CTNNB1 gene mutant form affects the susceptibility to [1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of GAB1 protein]"21705713
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"GAB1 protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of CTNNB1 protein modified form]"21705713
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of GAB1 mRNA19933214
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of GAB1 mRNA"20638727
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of GAB1 mRNA"20406850
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GAB1 mRNA"20816883
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GAB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GAB1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of GAB1 mRNA22230336|2669055
D000393Air PollutantsAir Pollutants analog results in decreased expression of GAB1 mRNA21757418
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of GAB1 mRNA24449571
D004958EstradiolEstradiol results in decreased expression of GAB1 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of GAB1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of GAB1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of GAB1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of GAB1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GAB1 gene28505145
C013418bromfenacoumbromfenacoum results in decreased expression of GAB1 protein28903499
D002220CarbamazepineCarbamazepine affects the expression of GAB1 mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GAB1 mRNA17484886
D019327Copper SulfateCopper Sulfate results in decreased expression of GAB1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of GAB1 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of GAB1 mRNA19770486
C089595cylindrospermopsincylindrospermopsin results in increased expression of GAB1 mRNA23726867
D002945Cisplatin[Cisplatin co-treated with Lutein] results in decreased expression of GAB1 mRNA24865317
D002945CisplatinCisplatin results in decreased expression of GAB1 mRNA24865317
D004008DiclofenacDiclofenac affects the expression of GAB1 mRNA24752500
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of GAB1 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of GAB1 mRNA18042831|1903023
C014476diethyl maleatediethyl maleate results in decreased expression of GAB1 mRNA25270620
D002117CalcitriolCalcitriol results in increased expression of GAB1 mRNA16002434
C118739entinostatentinostat results in decreased expression of GAB1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GAB1 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GAB1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GAB1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GAB1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GAB1 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of GAB1 mRNA23649840
D005485FlutamideFlutamide results in decreased expression of GAB1 mRNA24793618
D005557FormaldehydeFormaldehyde results in increased expression of GAB1 mRNA23649840
D005897GlafenineGlafenine results in decreased expression of GAB1 mRNA24136188
D017313FenretinideFenretinide results in increased expression of GAB1 mRNA28973697
D006820Hyaluronic AcidHyaluronic Acid results in increased phosphorylation of GAB1 protein16864594
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of GAB1 mRNA19339665
D008070Lipopolysaccharidesmethyldithiocarbamate promotes the reaction [Lipopolysaccharides results in increased expression of GAB1 mRNA]19339665
D014975Lutein[Cisplatin co-treated with Lutein] results in decreased expression of GAB1 mRNA24865317
D014975LuteinLutein results in decreased expression of GAB1 mRNA24865317
D008558MelphalanMelphalan results in decreased expression of GAB1 mRNA22363485
D008727MethotrexateMethotrexate results in increased expression of GAB1 mRNA24449571
C008435methyldithiocarbamatemethyldithiocarbamate promotes the reaction [Lipopolysaccharides results in increased expression of GAB1 mRNA]19339665
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GAB1 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride affects the expression of GAB1 mRNA21613230
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GAB1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GAB1 mRNA23649840
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GAB1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAB1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GAB1 mRNA]"20230807
C517284monomethyl phthalatemonomethyl phthalate affects the expression of GAB1 mRNA26924002
C038541N-benzyloxycarbonylprolylprolinalN-benzyloxycarbonylprolylprolinal results in decreased expression of GAB1 mRNA21487212
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAB1 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GAB1 mRNA]"20230807
C558013NSC 689534NSC 689534 results in increased expression of GAB1 mRNA20971185
C516714NVP-TAE684GAB1 protein promotes the reaction [HGF protein results in decreased susceptibility to NVP-TAE684]22553343
C516714NVP-TAE684HGF protein inhibits the reaction [NVP-TAE684 results in decreased phosphorylation of GAB1 protein]22553343
C516714NVP-TAE684NVP-TAE684 results in decreased phosphorylation of GAB1 protein22553343
D000073878Palm OilPalm Oil results in increased expression of GAB1 mRNA18042831
D010269ParaquatAPOD protein affects the reaction [Paraquat results in decreased expression of GAB1 mRNA]21688324
D010269ParaquatParaquat results in decreased expression of GAB1 mRNA21688324
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GAB1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GAB1 mRNA22079256|2271453
D011374ProgesteroneProgesterone results in increased expression of GAB1 mRNA23012394
C045950propiconazolepropiconazole results in decreased expression of GAB1 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of GAB1 mRNA24780913
D011794QuercetinQuercetin inhibits the reaction [HGF protein results in increased phosphorylation of GAB1 protein]25971889
D011794QuercetinQuercetin results in decreased phosphorylation of GAB1 protein25971889
C059514resveratrolresveratrol inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased localization of GAB1 protein]15849355
C059514resveratrolresveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased localization of GAB1 protein]15849355
D012406RoxarsoneRoxarsone results in increased expression of GAB1 mRNA23155029
D012822Silicon DioxideSilicon Dioxide results in increased expression of GAB1 mRNA25351596
D012834SilverSilver results in decreased expression of GAB1 mRNA19429238
D018038Sodium SeleniteSodium Selenite results in decreased expression of GAB1 mRNA23274088
D013629TamoxifenTamoxifen affects the expression of GAB1 mRNA17555576
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of GAB1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GAB1 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GAB1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GAB1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GAB1 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GAB1 mRNA19770486|1993321
C009495titanium dioxidetitanium dioxide results in increased expression of GAB1 mRNA23557971
C057693troglitazonetroglitazone results in decreased expression of GAB1 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of GAB1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GAB1 mRNA23179753|2800136

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005070SH3/SH2 adaptor activity-TAS8596638  
GO:0005515protein binding-IPI9658397  10913131  10978177  11323411  11453982  12475979  
12855672  14665621  14701753  15574420  16638574  19167335  
19380743  20308328  20936779  21278788  22536782  23397142  
24658140  24728074  25241761  25416956  
GO:00163031-phosphatidylinositol-3-kinase activity-TAS-  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IMP17178724  
GO:0007173epidermal growth factor receptor signaling pathway-TAS-  
GO:0007411axon guidance-TAS-  
GO:0008283cell proliferation-TAS8596638  
GO:0008286insulin receptor signaling pathway-TAS8596638  
GO:0031532actin cytoskeleton reorganization-IMP17178724  
GO:0035728response to hepatocyte growth factor-IEA-  
GO:0036092phosphatidylinositol-3-phosphate biosynthetic process-IEA-  
GO:0038084vascular endothelial growth factor signaling pathway-IMP17178724  
GO:0038089positive regulation of cell migration by vascular endothelial growth factor signaling pathway-ISS-  
GO:0038128ERBB2 signaling pathway-TAS-  
GO:0045766positive regulation of angiogenesis-IMP25217442  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0090668endothelial cell chemotaxis to vascular endothelial growth factor-IMP17178724  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04012ErbB signaling pathway
hsa04722Neurotrophin signaling pathway
hsa05100Bacterial invasion of epithelial cells
hsa05211Renal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-109704PI3K CascadeTAS
R-HSA-112399IRS-mediated signallingTAS
R-HSA-1226099Signaling by FGFR in diseaseTAS
R-HSA-1227986Signaling by ERBB2TAS
R-HSA-1236382Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsTAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-1643713Signaling by EGFR in CancerTAS
R-HSA-166520Signaling by NTRKsIEA
R-HSA-177929Signaling by EGFRTAS
R-HSA-180292GAB1 signalosomeTAS
R-HSA-190236Signaling by FGFRTAS
R-HSA-1963642PI3K events in ERBB2 signalingTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)TAS
R-HSA-2428924IGF1R signaling cascadeTAS
R-HSA-2428928IRS-related events triggered by IGF1RTAS
R-HSA-422475Axon guidanceTAS
R-HSA-5637810Constitutive Signaling by EGFRvIIITAS
R-HSA-5637812Signaling by EGFRvIII in CancerTAS
R-HSA-5637815Signaling by Ligand-Responsive EGFR Variants in CancerTAS
R-HSA-5654687Downstream signaling of activated FGFR1TAS
R-HSA-5654689PI-3K cascade:FGFR1TAS
R-HSA-5654695PI-3K cascade:FGFR2TAS
R-HSA-5654696Downstream signaling of activated FGFR2TAS
R-HSA-5654708Downstream signaling of activated FGFR3TAS
R-HSA-5654710PI-3K cascade:FGFR3TAS
R-HSA-5654716Downstream signaling of activated FGFR4TAS
R-HSA-5654720PI-3K cascade:FGFR4TAS
R-HSA-5654736Signaling by FGFR1TAS
R-HSA-5654738Signaling by FGFR2TAS
R-HSA-5654741Signaling by FGFR3TAS
R-HSA-5654743Signaling by FGFR4TAS
R-HSA-5655253Signaling by FGFR2 in diseaseTAS
R-HSA-5655291Signaling by FGFR4 in diseaseTAS
R-HSA-5655302Signaling by FGFR1 in diseaseTAS
R-HSA-5655332Signaling by FGFR3 in diseaseTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-6806834Signaling by METTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-74751Insulin receptor signalling cascadeTAS
R-HSA-74752Signaling by Insulin receptorTAS
R-HSA-8851907MET activates PI3K/AKT signalingTAS
R-HSA-8853334Signaling by FGFR3 fusions in cancerTAS
R-HSA-8853338Signaling by FGFR3 point mutants in cancerTAS
R-HSA-8853659RET signalingTAS
R-HSA-8865999MET activates PTPN11TAS
R-HSA-8875555MET activates RAP1 and RAC1TAS
R-HSA-8875656MET receptor recyclingTAS
R-HSA-8875878MET promotes cell motilityTAS
R-HSA-9006115Signaling by NTRK2 (TRKB)IEA
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-9028335Activated NTRK2 signals through PI3KIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25217982Essential role of polymorphism of Gab1, EGFR, and EGF for the susceptibility of biliary tract cancer. (2014 Dec)Meng LQTumour Biol
29212272Polymorphisms of rs1347093 and rs1397529 are associated with lung cancer risk in northeast Chinese population. (2017 Nov 7)Li XOncotarget