Gene: GABBR1

2550
GABABR1|GABBR1-3|GB1|GPRC3A
gamma-aminobutyric acid type B receptor subunit 1
protein-coding
6p22.1
Ensembl:ENSG00000204681 MIM:603540 Vega:OTTHUMG00000031095 UniprotKB:Q9UBS5
NG_029101.1
PubMed|SNP Mapped
1   ANCO-SNPs
CD|ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs62392942chr6:29634161 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18977283chr6:29579492GABBR1Gene body1.433e-4Alcohol use disorders26763658
cg25437807chr6:29589545GABBR1Gene body6.084e-4Alcohol use disorders26763658
cg09577455chr6:29593382GABBR12.970e-8Alcohol consumption der day27843151
cg07839627chr6:29599836GABBR13.360e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABR0.94
CLPTM10.927
DCAF110.917
ARNT20.915
TNPO20.913
NAT8L0.913
TOM1L20.911
SIRPA0.909
DESI10.909
ABAT0.905

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.782
OR4F29-0.731
CD48-0.436
TFPI2-0.431
SLAMF6-0.421
BEST3-0.404
CEACAM4-0.399
C2orf83-0.391
CST7-0.384
CCR2-0.384

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00181BaclofenSmall Molecule1134-47-0ApprovedTarget
DB00837ProgabideSmall Molecule62666-20-0Approved|InvestigationalTarget
DB00996GabapentinSmall Molecule60142-96-3Approved|InvestigationalTarget
DB01080VigabatrinSmall Molecule68506-86-5ApprovedTarget
DB01956TaurineSmall Molecule107-35-7Approved|NutraceuticalTarget
DB02530gamma-Aminobutyric acidSmall Molecule56-12-2Approved|InvestigationalTarget
DB05010SGS-742Small Molecule123690-78-8InvestigationalTarget
DB06354TezampanelSmall Molecule317819-68-4InvestigationalTarget
DB08891ArbaclofenSmall Molecule69308-37-8InvestigationalTarget
DB08892Arbaclofen PlacarbilSmall Molecule847353-30-4InvestigationalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GABBR1 mRNA"27291303
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GABBR1 mRNA"21346803
C4386072,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol"2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [3-aminopropylphosphinic acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]"15627515
C4386072,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol"2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]"15627515
C4386072,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol"Egtazic Acid inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]"15627515
C4386072,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol"Fendiline inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]"15627515
C4386072,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol"Trifluoperazine inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]"15627515
C0613883-aminopropylphosphinic acid"2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [3-aminopropylphosphinic acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]"15627515
C0613883-aminopropylphosphinic acid3-aminopropylphosphinic acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]15627515
C0613883-aminopropylphosphinic acidCalcium promotes the reaction [3-aminopropylphosphinic acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]15627515
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABBR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABBR1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of GABBR1 mRNA11752693
D020106AcrylamideAcrylamide results in decreased expression of GABBR1 mRNA28959563
D005680gamma-Aminobutyric Acid"2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]"15627515
D005680gamma-Aminobutyric AcidCalcium promotes the reaction [CGP 55845A inhibits the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]15627515
D005680gamma-Aminobutyric AcidCalcium promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]15627515
D005680gamma-Aminobutyric AcidCGP 55845A inhibits the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]15627515
D005680gamma-Aminobutyric AcidChloral Hydrate inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D005680gamma-Aminobutyric AcidChloralose promotes the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D005680gamma-Aminobutyric AcidChlorobutanol inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D005680gamma-Aminobutyric Acid"Egtazic Acid inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]"15627515
D005680gamma-Aminobutyric AcidEnflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D005680gamma-Aminobutyric AcidEther inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D005680gamma-Aminobutyric Acid"Fendiline inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]"15627515
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]15627515
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of GABBR1 protein10683198
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]11125035
D005680gamma-Aminobutyric AcidIsoflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D005680gamma-Aminobutyric AcidMethoxyflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D005680gamma-Aminobutyric Acidsevoflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D005680gamma-Aminobutyric Acidtert-Butyl Alcohol inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D005680gamma-Aminobutyric Acidtribromoethanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D005680gamma-Aminobutyric AcidTrichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D005680gamma-Aminobutyric Acid"Trifluoperazine inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]"15627515
D005680gamma-Aminobutyric AcidTrifluoroethanol inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D005680gamma-Aminobutyric Acid[gamma-Aminobutyric Acid results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]] results in increased activity of [KCNJ3 protein binds to KCNJ6 protein]11125035
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GABBR1 mRNA16483693
C032739aroclor 1221aroclor 1221 results in increased expression of GABBR1 mRNA21277884
D001151ArsenicArsenic affects the methylation of GABBR1 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of GABBR1 mRNA18231732
D001418BaclofenBaclofen binds to GABBR1 protein17496723
D001418BaclofenGABBR1 results in increased susceptibility to Baclofen16990508|2013899
D001418BaclofenBaclofen binds to and results in increased activity of GABBR1 protein11271399
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of GABBR1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GABBR1 mRNA21839799
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of GABBR1 mRNA20660070
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of GABBR1 mRNA19833106
C006780bisphenol Abisphenol A affects the expression of GABBR1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of GABBR1 promoter22457795
D002118CalciumCalcium promotes the reaction [3-aminopropylphosphinic acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]15627515
D002118CalciumCalcium promotes the reaction [CGP 55845A inhibits the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]15627515
D002118CalciumCalcium promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]15627515
D002118CalciumCalcium affects the expression of GABBR1 mRNA15913539
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GABBR1 mRNA17484886
C085075CGP 55845ACalcium promotes the reaction [CGP 55845A inhibits the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]15627515
C085075CGP 55845ACGP 55845A binds to and results in decreased activity of [GABBR1 protein binds to GABBR2 protein]15627515
C085075CGP 55845ACGP 55845A inhibits the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]15627515
C104980CGP 71872CGP 71872 inhibits the reaction [gabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]]11125035
D002697Chloral HydrateChloral Hydrate inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D002698ChloraloseChloralose promotes the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D002713ChlorineChlorine results in decreased expression of GABBR1 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of GABBR1 mRNA18636392
D002724ChlorobutanolChlorobutanol inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D002794CholineCholine affects the expression of GABBR1 mRNA alternative form17264169
D002794CholineCholine affects the expression of GABBR1 protein alternative form17264169
C418118CI 1044CI 1044 results in increased expression of GABBR1 mRNA17569694
D003024ClozapineClozapine results in decreased expression of GABBR1 mRNA17266109
D003042CocaineCocaine affects the expression of GABBR1 mRNA20187946
D003042CocaineCocaine results in decreased expression of GABBR1 mRNA16076954
D003042CocaineCocaine results in increased expression of GABBR1 mRNA11793422
C510079conotoxin alpha-RgIA, Conus regius"conotoxin alpha-RgIA, Conus regius analog results in decreased activity of GABBR1 protein"21888386
C510079conotoxin alpha-RgIA, Conus regius"conotoxin alpha-RgIA, Conus regius results in decreased activity of GABBR1 protein"21888386
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of GABBR1 mRNA23914054
D003975DiazepamDiazepam results in increased expression of GABBR1 mRNA15802192
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GABBR1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of GABBR1 mRNA15620428
D019422Dietary SucroseDietary Sucrose results in increased expression of GABBR1 mRNA26033743
D004229DithiothreitolDithiothreitol affects the stability of GABBR1 protein14760512
D004533Egtazic Acid"Egtazic Acid inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]"15627515
D004737EnfluraneEnflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased expression of GABBR1 mRNA21277884
D004986EtherEther inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D005275Fendiline"Fendiline inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]"15627515
C040029gabapentinCGP 71872 inhibits the reaction [gabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]]11125035
C040029gabapentingabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]11125035
C040029gabapentin[gabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]] results in increased activity of [KCNJ3 protein binds to KCNJ6 protein]11125035
C010974glyphosateglyphosate results in increased expression of GABBR1 mRNA26302742
D006582HexachloropheneHexachlorophene results in decreased expression of GABBR1 mRNA29301063
D017313FenretinideFenretinide results in decreased expression of GABBR1 mRNA28973697
D017313FenretinideFenretinide results in increased expression of GABBR1 mRNA28973697
D012978Sodium OxybateGABBR1 results in increased susceptibility to Sodium Oxybate16990508
D002112CalcifediolCalcifediol deficiency results in decreased expression of GABBR1 mRNA17293106
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GABBR1 mRNA25613284
D007530IsofluraneIsoflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
C544151jinfukangjinfukang results in increased expression of GABBR1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GABBR1 mRNA23086925
D007854LeadLead affects the expression of GABBR1 mRNA28903495
C045463leflunomideleflunomide results in increased expression of GABBR1 mRNA19751817
C018584linaloollinalool results in increased expression of GABBR1 mRNA20536181
D008733MethoxyfluraneMethoxyflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GABBR1 mRNA23103053
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GABBR1 mRNA"20188158|2625132
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of GABBR1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of GABBR1 mRNA25729387
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of GABBR1 mRNA18636392
D010269ParaquatParaquat results in decreased expression of GABBR1 mRNA21371552
D010269ParaquatParaquat results in decreased expression of GABBR1 protein24521700
D010622PhencyclidinePhencyclidine results in decreased expression of GABBR1 mRNA17266109
C033457phenobarbital quinidinephenobarbital quinidine results in increased expression of GABBR1 mRNA15802192
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABBR1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of GABBR1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of GABBR1 mRNA19162173
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of GABBR1 mRNA20660070
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of GABBR1 mRNA19833106
C095804(+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid"(+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid binds to and results in decreased activity of GABBR1 protein"11271399
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in increased expression of GABBR1 mRNA17540011
C009250sevofluranesevoflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D013605T-2 ToxinT-2 Toxin results in increased expression of GABBR1 mRNA26141394
D020002tert-Butyl Alcoholtert-Butyl Alcohol inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GABBR1 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GABBR1 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GABBR1 mRNA25613284
D019284ThapsigarginThapsigargin affects the localization of GABBR1 protein24668805
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of GABBR1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of GABBR1 mRNA21934132
C062527tribromoethanoltribromoethanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D014241TrichloroethyleneTrichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D014268Trifluoperazine"Trifluoperazine inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]"15627515
D014270TrifluoroethanolTrifluoroethanol inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]10683198
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of GABBR1 mRNA17982090
D014635Valproic AcidValproic Acid affects the expression of GABBR1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GABBR1 mRNA28001369
D014635Valproic AcidValproic Acid affects the expression of GABBR1 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004965G-protein coupled GABA receptor activity-IDA10328880  
GO:0004965G-protein coupled GABA receptor activitycontributes_toIDA9872316  
GO:0005515protein binding-IPI16724110  17474147  20195357  24658140  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IDA10328880  
GO:0007194negative regulation of adenylate cyclase activity-TAS9069281  
GO:0007214gamma-aminobutyric acid signaling pathway-IDA9872316  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA9872316  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IEA-  
GO:0038039G-protein coupled receptor heterodimeric complex-IPI9872316  
GO:0042734presynaptic membrane-IEA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1296041Activation of G protein gated Potassium channelsTAS
R-HSA-1296059G protein gated Potassium channelsTAS
R-HSA-1296065Inwardly rectifying K+ channelsTAS
R-HSA-1296071Potassium ChannelsTAS
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-420499Class C/3 (Metabotropic glutamate/pheromone receptors)TAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-977443GABA receptor activationTAS
R-HSA-977444GABA B receptor activationTAS
R-HSA-991365Activation of GABAB receptorsTAS
R-HSA-997272Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25262781Expression of glutamatergic genes in healthy humans across 16 brain regions; altered expression in the hippocampus after chronic exposure to alcohol or cocaine. (2014 Nov)Enoch MAGenes Brain Behav
25191505GABA Receptors Genes Polymorphisms and Alcohol Dependence: No Evidence of an Association in an Italian Male Population. (2014 Aug)Terranova CClin Psychopharmacol Neurosci
19763258Association and interaction analyses of GABBR1 and GABBR2 with nicotine dependence in European- and African-American populations. (2009 Sep 18)Li MDPLoS One
26727527GABBR1 and SLC6A1, Two Genes Involved in Modulation of GABA Synaptic Transmission, Influence Risk for Alcoholism: Results from Three Ethnically Diverse Populations. (2016 Jan)Enoch MAAlcohol Clin Exp Res
28440896Genome-wide meta-analysis identifies a novel susceptibility signal at CACNA2D3 for nicotine dependence. (2017 Apr 25)Yin XAm J Med Genet B Neuropsychiatr Genet