Gene: TAC4

255061
EK|HK-1|HK1|PPT-C
tachykinin 4
protein-coding
17q21.33
Ensembl:ENSG00000176358 MIM:607833 Vega:OTTHUMG00000161830 UniprotKB:Q86UU9
NG_029377.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.230e-1 (AD)  5.812e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MTRNR2L50.462
OR3A10.449
MEOX10.442
PPIAP100.438
PSG30.437
LMX1B0.437
OR4D10.437
TAS2R410.436
APOBEC40.436
OR2M70.434

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CAPN13-0.186
PPP1R14D-0.186
AMY1C-0.185
LCE6A-0.175
HSD11B1-0.174
GPR62-0.173
DMRTC1-0.166
TMEM253-0.163
CDRT15-0.163
UGT8-0.16

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of TAC4 mRNA26690555
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of TAC4 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TAC4 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TAC4 mRNA24449571
D001151ArsenicArsenic affects the methylation of TAC4 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TAC4 mRNA25908611
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TAC4 mRNA21839799
C006780bisphenol Abisphenol A results in decreased expression of TAC4 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of TAC4 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TAC4 mRNA21457566
D004390ChlorpyrifosChlorpyrifos results in decreased expression of TAC4 mRNA20682304
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TAC4 mRNA20938992
D003976DiazinonDiazinon results in increased expression of TAC4 mRNA20682304
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of TAC4 mRNA"25908611
D004026DieldrinDieldrin results in increased expression of TAC4 mRNA20682304
C010452estradiol-17 beta-benzoateestradiol-17 beta-benzoate results in decreased expression of TAC4 mRNA19627578
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TAC4 mRNA20938992
D007854LeadLead results in increased expression of TAC4 mRNA19921347
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TAC4 mRNA"22384199
C440499lipopolysaccharide, Escherichia coli O111 B4"SB 203580 inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TAC4 mRNA]"22384199
C440499lipopolysaccharide, Escherichia coli O111 B4"SC 514 inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TAC4 mRNA]"22384199
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TAC4 mRNA20938992
D009532NickelNickel results in decreased expression of TAC4 mRNA20682304
C028007nickel monoxidenickel monoxide results in decreased expression of TAC4 mRNA19167457
D011794QuercetinQuercetin results in increased expression of TAC4 mRNA21632981
C093642SB 203580"SB 203580 inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TAC4 mRNA]"22384199
C477523SC 514"SC 514 inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TAC4 mRNA]"22384199
C009277sodium arsenatesodium arsenate results in decreased expression of TAC4 mRNA23922661
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of TAC4 mRNA19042947
D014635Valproic AcidValproic Acid results in decreased methylation of TAC4 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006954inflammatory response-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0007217tachykinin receptor signaling pathway-IBA21873635  
GO:0008217regulation of blood pressure-IEA-  
GO:1902093positive regulation of flagellated sperm motility-IDA17437961  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA17437961  
GO:0005623cell-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26455281Novel candidate genes for alcoholism--transcriptomic analysis of prefrontal medial cortex, hippocampus and nucleus accumbens of Warsaw alcohol-preferring and non-preferring rats. (2015 Dec)Stankiewicz AMPharmacol Biochem Behav