Gene: PLA2G4F

255189
PLA2G4FZ
phospholipase A2 group IVF
protein-coding
15q15.1
Ensembl:ENSG00000168907 Vega:OTTHUMG00000172782 UniprotKB:Q68DD2
NC_000015.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.316e-1 (AD)  1.492e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1356410chr15:42142639 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KRT70.742
FOXE10.733
TPO0.727
IYD0.714
CASP140.713
KRTAP4-90.692
SCNN1B0.688
CALML50.681
WDR720.677
LCE3D0.674

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FEZF2-0.317
MYH7B-0.313
HHATL-0.312
SCLY-0.304
PLA2G6-0.299
LRRC45-0.296
ZNF775-0.295
SPAG8-0.295
FRS3-0.293
ASPDH-0.293

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PLA2G4F gene27153756
C075388beta-damascenonebeta-damascenone results in increased expression of PLA2G4F mRNA22982537
C006780bisphenol Abisphenol A results in decreased expression of PLA2G4F mRNA25181051
C045463leflunomideleflunomide results in increased expression of PLA2G4F mRNA28988120
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PLA2G4F mRNA"20188158
C006253pirinixic acidpirinixic acid results in increased expression of PLA2G4F mRNA20813756
D013853ThioacetamideThioacetamide results in increased expression of PLA2G4F mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PLA2G4F mRNA20133372
D014520UrethaneUrethane results in decreased expression of PLA2G4F mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of PLA2G4F gene29154799
C088658zoledronic acidzoledronic acid results in decreased expression of PLA2G4F mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004622lysophospholipase activity-TAS-  
GO:0004623phospholipase A2 activity-IBA21873635  
GO:0004623phospholipase A2 activity-TAS-  
GO:0005509calcium ion binding-IBA21873635  
GO:0005544calcium-dependent phospholipid binding-IBA21873635  
GO:0008970phosphatidylcholine 1-acylhydrolase activity-TAS-  
GO:0046872metal ion binding-IEA-  
GO:0047498calcium-dependent phospholipase A2 activity-IBA21873635  
GO:0047498calcium-dependent phospholipase A2 activity-IEA-  
GO:0102567phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)-IEA-  
GO:0102568phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001516prostaglandin biosynthetic process-IEA-  
GO:0006644phospholipid metabolic process-TAS-  
GO:0009395phospholipid catabolic process-IEA-  
GO:0036148phosphatidylglycerol acyl-chain remodeling-TAS-  
GO:0036149phosphatidylinositol acyl-chain remodeling-TAS-  
GO:0036150phosphatidylserine acyl-chain remodeling-TAS-  
GO:0036151phosphatidylcholine acyl-chain remodeling-TAS-  
GO:0036152phosphatidylethanolamine acyl-chain remodeling-TAS-  
GO:0046475glycerophospholipid catabolic process-IBA21873635  
GO:0050482arachidonic acid secretion-IEA-  
GO:0071236cellular response to antibiotic-IEA-  
GO:0071407cellular response to organic cyclic compound-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005765lysosomal membrane-IEA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0031982vesicle-IBA21873635  
GO:0031982vesicle-IEA-  
GO:0032587ruffle membrane-IBA21873635  
GO:0032587ruffle membrane-IEA-  
KEGG ID KEGG Term
hsa04666Fc gamma R-mediated phagocytosis
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1482788Acyl chain remodelling of PCTAS
R-HSA-1482801Acyl chain remodelling of PSTAS
R-HSA-1482839Acyl chain remodelling of PETAS
R-HSA-1482922Acyl chain remodelling of PITAS
R-HSA-1482925Acyl chain remodelling of PGTAS
R-HSA-1483115Hydrolysis of LPCTAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal